JP2013507132A5 - - Google Patents
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- Publication number
- JP2013507132A5 JP2013507132A5 JP2012533384A JP2012533384A JP2013507132A5 JP 2013507132 A5 JP2013507132 A5 JP 2013507132A5 JP 2012533384 A JP2012533384 A JP 2012533384A JP 2012533384 A JP2012533384 A JP 2012533384A JP 2013507132 A5 JP2013507132 A5 JP 2013507132A5
- Authority
- JP
- Japan
- Prior art keywords
- isolated polypeptide
- binding
- polypeptide
- amino acids
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229920001184 polypeptide Polymers 0.000 claims 7
- 102100008982 IL17A Human genes 0.000 claims 3
- 101710003110 IL17A Proteins 0.000 claims 3
- 102100004545 IL17RA Human genes 0.000 claims 3
- 101710035970 IL17RA Proteins 0.000 claims 3
- 102000013691 Interleukin-17 Human genes 0.000 claims 2
- 108050003558 Interleukin-17 family Proteins 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 102100015975 IL17F Human genes 0.000 claims 1
- 101700007032 IL17F Proteins 0.000 claims 1
Claims (5)
- ＩＬ−１７ＲＡのＩＬ−１７結合決定基を含む単離されたポリペプチドであって、前記ポリペプチドがＩＬ−１７ＲＡの細胞外ドメインと同一ではないポリペプチド。
- ＩＬ−１７結合決定基が、ＩＬ−１７ＲＡ（配列番号１４）のアミノ酸２２〜３６、８３〜９６、１１８〜１４７、１５２〜１７９及び２５６〜２７１から成る群から選択される、請求項１に記載の単離されたポリペプチド。
- ＩＬ−１７Ｆ及び／又はＩＬ−１７Ａを結合することが可能である、請求項１又は２に記載の単離されたポリペプチド。
- ポリペプチドのＩＬ−１７Ａとの結合が、ＩＬ−１７Ａの略２１〜３９、４０〜７６、８０〜１０１及び１０２〜１３１から成る群から選択される１以上のアミノ酸との接触を含む、請求項１、２又は３に記載の単離されたポリペプチド。
- 請求項１〜４のいずれか１項に記載の単離されたポリペプチドを含む組成物。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27877909P | 2009-10-10 | 2009-10-10 | |
| US61/278,779 | 2009-10-10 | ||
| PCT/US2010/052194 WO2011044563A2 (en) | 2009-10-10 | 2010-10-11 | Il-17 family cytokine compositions and uses |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013507132A JP2013507132A (ja) | 2013-03-04 |
| JP2013507132A5 true JP2013507132A5 (ja) | 2013-11-28 |
Family
ID=43857433
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012533384A Pending JP2013507132A (ja) | 2009-10-10 | 2010-10-11 | Ｉｌ−１７ファミリーサイトカイン組成物及び使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20130064788A1 (ja) |
| EP (1) | EP2485763A4 (ja) |
| JP (1) | JP2013507132A (ja) |
| KR (1) | KR20120093932A (ja) |
| CN (1) | CN102648002A (ja) |
| AU (1) | AU2010303166A1 (ja) |
| BR (1) | BR112012008444A2 (ja) |
| CA (1) | CA2777222A1 (ja) |
| EA (1) | EA201270528A1 (ja) |
| IL (1) | IL219209A0 (ja) |
| WO (1) | WO2011044563A2 (ja) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7833527B2 (en) | 2006-10-02 | 2010-11-16 | Amgen Inc. | Methods of treating psoriasis using IL-17 Receptor A antibodies |
| EP3243835B1 (en) | 2009-02-11 | 2024-04-10 | Albumedix Ltd | Albumin variants and conjugates |
| GB2488077A (en) | 2009-10-30 | 2012-08-15 | Novozymes Biopharma Dk As | Albumin variants |
| JP5969458B2 (ja) | 2010-04-09 | 2016-08-17 | アルブミディクス アクティーゼルスカブ | アルブミン誘導体及び変異体 |
| CN107337735B (zh) | 2010-07-29 | 2021-06-22 | 巴扎德制药公司 | 嵌合il-1受体i型激动剂和拮抗剂 |
| US20140105855A1 (en) * | 2011-04-06 | 2014-04-17 | Kenan Christopher Garcia | Structural based design of il-17 dominant negative mutants |
| WO2013016220A1 (en) * | 2011-07-22 | 2013-01-31 | Amgen Inc. | Il-17 receptor a is required for il-17c biology |
| LT2768859T (lt) * | 2011-10-19 | 2018-06-11 | Morphosys Ag | Il17c antagonistai, skirti uždegiminių ligų gydymui |
| US20140314798A1 (en) * | 2011-10-21 | 2014-10-23 | Baylor College Of Medicine | Method to measure inflammation in the conjunctiva of patients with tear dysfunction |
| US20140315817A1 (en) | 2011-11-18 | 2014-10-23 | Eleven Biotherapeutics, Inc. | Variant serum albumin with improved half-life and other properties |
| MX2014010278A (es) | 2012-03-16 | 2015-03-05 | Novozymes Biopharma Dk As | Variantes de albumina. |
| JP2013253842A (ja) * | 2012-06-06 | 2013-12-19 | Univ Of Tokyo | ｐＨ依存的に標的分子に結合するペプチドのスクリーニング方法 |
| US9834601B2 (en) | 2012-06-12 | 2017-12-05 | Orega Biotech | Antagonists of IL-17 isoforms and their uses |
| EP3417878A1 (en) * | 2012-06-12 | 2018-12-26 | Orega Biotech | Antagonists of il-17 isoforms and their uses |
| CA2890766A1 (en) | 2012-11-08 | 2014-05-15 | Novozymes Biopharma Dk A/S | Albumin variants |
| BR112015022587A2 (pt) | 2013-03-13 | 2017-10-24 | Eleven Biotherapeutics Inc | formulações de citocina quimérica para entrega ocular |
| SG10201912901YA (en) * | 2013-04-17 | 2020-02-27 | Genzyme Corp | Compositions and methods for treating and preventing macular degeneration |
| AU2016308504A1 (en) | 2015-08-20 | 2018-01-18 | Albumedix Ltd. | Albumin variants and conjugates |
| CN108883166B (zh) * | 2016-03-25 | 2023-06-02 | 国立大学法人大阪大学 | 以成为疾病主要原因的生物体内蛋白质为靶标的结合疫苗 |
| EP3445352A4 (en) * | 2016-04-19 | 2019-12-11 | Azura Opthalmics Ltd. | COMPOSITIONS FOR THE TREATMENT OF HYPERKERATOSIS RELATED DISORDERS |
| CN111093678A (zh) * | 2017-07-21 | 2020-05-01 | 克利夫兰诊所基金会 | 用于治疗IL-17a相关疾病和病状的SBE适体 |
| BR112020023167A2 (pt) | 2018-05-14 | 2021-02-09 | Werewolf Therapeutics, Inc. | polipeptídeos de citocina ativáveis e métodos de uso destes |
| EP3794024B1 (en) | 2018-05-14 | 2023-05-10 | Werewolf Therapeutics, Inc. | Activatable interleukin-2 polypeptides and methods of use thereof |
| JP2022527345A (ja) | 2019-04-03 | 2022-06-01 | オレガ・バイオテック | Ｐｄ１阻害剤及びｉｌ－１７ｂ阻害剤に基づく複合療法 |
| CN114450022A (zh) | 2019-05-14 | 2022-05-06 | 狼人治疗公司 | 分离部分及其使用方法 |
| US20220281967A1 (en) * | 2019-08-02 | 2022-09-08 | Orega Biotech | Novel il-17b antibodies |
| KR102265435B1 (ko) * | 2019-08-20 | 2021-06-15 | 주식회사 케어젠 | 피부 미백 활성을 갖는 펩타이드 및 이의 용도 |
| CA3166357A1 (en) | 2020-01-10 | 2021-07-15 | Azura Ophthalmics Ltd. | Instructions for composition and sensitivity |
| EP4110810A1 (en) | 2020-02-28 | 2023-01-04 | Orega Biotech | Combination therapies based on ctla4 and il-17b inhibitors |
| WO2022032592A1 (en) * | 2020-08-13 | 2022-02-17 | Tsinghua University | Interleukin-17d and cd93 as a new cytokine-receptor pair in the immune system |
| CN113403259B (zh) * | 2021-06-04 | 2023-01-17 | 华南农业大学 | 一种提高克隆胚胎发育质量的添加剂及其应用 |
| CN113563453A (zh) * | 2021-07-23 | 2021-10-29 | 四川大学 | 鸡白细胞介素17b重组乳酸菌免疫制剂的制备和应用 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| JP4373495B2 (ja) * | 1995-03-23 | 2009-11-25 | イミュネックス・コーポレーション | Ｉｌ−１７受容体 |
| US6569419B2 (en) * | 2000-02-29 | 2003-05-27 | Zymogenetics, Inc. | Methods for promoting production of myelin by Schwann cells |
| US20030203451A1 (en) * | 2000-08-24 | 2003-10-30 | Genentech, Inc. | IL-17 homologous polypeptides and therapeutic uses thereof |
| US6333410B1 (en) | 2000-08-18 | 2001-12-25 | Immunogen, Inc. | Process for the preparation and purification of thiol-containing maytansinoids |
| US20060083713A1 (en) * | 2000-10-13 | 2006-04-20 | Eli Lilly And Company | Methods of using a human il-17 related polypeptide to treat disease |
| US7709461B2 (en) | 2000-10-18 | 2010-05-04 | Massachusetts Institute Of Technology | Methods and products related to pulmonary delivery of polysaccharides |
| CA2425506A1 (en) * | 2000-10-18 | 2002-08-01 | Immunex Corporation | Methods for treating rheumatoid arthritis using il-17 antagonists |
| US20040115191A1 (en) * | 2002-01-24 | 2004-06-17 | Moore Emma E | Method for treating psoriasis |
| WO2002076386A2 (en) * | 2001-03-26 | 2002-10-03 | Zymogenetics, Inc. | Method of inducing proliferation of retinal stem cells |
| US20070160576A1 (en) * | 2001-06-05 | 2007-07-12 | Genentech, Inc. | IL-17A/F heterologous polypeptides and therapeutic uses thereof |
| US20040142325A1 (en) * | 2001-09-14 | 2004-07-22 | Liat Mintz | Methods and systems for annotating biomolecular sequences |
| US20040132101A1 (en) | 2002-09-27 | 2004-07-08 | Xencor | Optimized Fc variants and methods for their generation |
| ES2751414T5 (es) * | 2003-07-08 | 2024-04-23 | Novartis Pharma Ag | Anticuerpos antagonistas a polipéptidos heterólogos IL-17 A/F |
| GB0417487D0 (en) * | 2004-08-05 | 2004-09-08 | Novartis Ag | Organic compound |
| EP1996616A1 (en) * | 2006-02-10 | 2008-12-03 | Zymogenetics, Inc. | Truncated il-17ra soluble receptor and methods of using in inflammation |
| EP1996622A2 (en) * | 2006-03-10 | 2008-12-03 | Zymogenetics, Inc. | Antibodies that bind both il-17a and il-17f and methods of using the same |
| GB0612928D0 (en) * | 2006-06-29 | 2006-08-09 | Ucb Sa | Biological products |
| MX2009001620A (es) * | 2006-08-11 | 2009-02-23 | Schering Corp | Anticuerpos para il-17a. |
| US7833527B2 (en) * | 2006-10-02 | 2010-11-16 | Amgen Inc. | Methods of treating psoriasis using IL-17 Receptor A antibodies |
| US7790676B2 (en) | 2007-03-28 | 2010-09-07 | Zymogenetics, Inc. | Soluble IL-17RA/RC fusion proteins |
| EP2144928A2 (en) * | 2007-04-20 | 2010-01-20 | Amgen Inc. | Jacquelinidentification and method for using the pre-ligand assembly domain of the il-17 receptor |
| EP2142568B1 (en) * | 2007-04-27 | 2014-03-19 | ZymoGenetics, Inc. | Antibodies that bind both il-17a and il-17f and methods of using the same |
| EP2182943B1 (en) * | 2007-07-23 | 2016-10-26 | Janssen Biotech, Inc. | Methods and compositions for treating fibrosis related disorders using il-17 antagonists |
-
2010
- 2010-10-11 CN CN2010800536540A patent/CN102648002A/zh active Pending
- 2010-10-11 WO PCT/US2010/052194 patent/WO2011044563A2/en active Application Filing
- 2010-10-11 EP EP10822826.3A patent/EP2485763A4/en not_active Withdrawn
- 2010-10-11 EA EA201270528A patent/EA201270528A1/ru unknown
- 2010-10-11 JP JP2012533384A patent/JP2013507132A/ja active Pending
- 2010-10-11 AU AU2010303166A patent/AU2010303166A1/en not_active Abandoned
- 2010-10-11 CA CA2777222A patent/CA2777222A1/en not_active Abandoned
- 2010-10-11 KR KR1020127011769A patent/KR20120093932A/ko not_active Application Discontinuation
- 2010-10-11 US US13/501,244 patent/US20130064788A1/en not_active Abandoned
- 2010-10-11 BR BR112012008444A patent/BR112012008444A2/pt not_active IP Right Cessation
-
2012
- 2012-04-15 IL IL219209A patent/IL219209A0/en unknown
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