JP2013506704A5 - - Google Patents
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- Publication number
- JP2013506704A5 JP2013506704A5 JP2012532579A JP2012532579A JP2013506704A5 JP 2013506704 A5 JP2013506704 A5 JP 2013506704A5 JP 2012532579 A JP2012532579 A JP 2012532579A JP 2012532579 A JP2012532579 A JP 2012532579A JP 2013506704 A5 JP2013506704 A5 JP 2013506704A5
- Authority
- JP
- Japan
- Prior art keywords
- langerhans
- adjuvant
- use according
- transplant
- medicament
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 claims 12
- 239000002671 adjuvant Substances 0.000 claims 8
- 210000004153 islets of langerhan Anatomy 0.000 claims 7
- 150000001875 compounds Chemical class 0.000 claims 4
- 239000003112 inhibitor Substances 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 2
- -1 4-isobutylphenyl Chemical group 0.000 claims 2
- 102100036166 C-X-C chemokine receptor type 1 Human genes 0.000 claims 2
- 102100028989 C-X-C chemokine receptor type 2 Human genes 0.000 claims 2
- 101000947174 Homo sapiens C-X-C chemokine receptor type 1 Proteins 0.000 claims 2
- 108010018951 Interleukin-8B Receptors Proteins 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 230000007774 longterm Effects 0.000 claims 2
- 230000007257 malfunction Effects 0.000 claims 2
- HNQIVZYLYMDVSB-UHFFFAOYSA-N methanesulfonimidic acid Chemical compound CS(N)(=O)=O HNQIVZYLYMDVSB-UHFFFAOYSA-N 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 claims 2
- 159000000000 sodium salts Chemical class 0.000 claims 2
- 230000004083 survival effect Effects 0.000 claims 2
- 206010052779 Transplant rejections Diseases 0.000 claims 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 210000001821 langerhans cell Anatomy 0.000 claims 1
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09172364.3 | 2009-10-06 | ||
| EP09172364A EP2308484A1 (en) | 2009-10-06 | 2009-10-06 | Inhibitors of cxcr1/2 as adjuvants in the transplant of pancreatic islets |
| PCT/EP2010/064921 WO2011042466A1 (en) | 2009-10-06 | 2010-10-06 | Inhibitors of cxcr1/2 as adjuvants in the transplant of pancreatic islets |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015077750A Division JP6097328B2 (ja) | 2009-10-06 | 2015-04-06 | ランゲルハンス島の移植におけるアジュバントとしてのｃｘｃｒ１／２の阻害薬 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013506704A JP2013506704A (ja) | 2013-02-28 |
| JP2013506704A5 true JP2013506704A5 (https=) | 2013-11-28 |
| JP5834010B2 JP5834010B2 (ja) | 2015-12-16 |
Family
ID=41818891
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012532579A Expired - Fee Related JP5834010B2 (ja) | 2009-10-06 | 2010-10-06 | ランゲルハンス島の移植におけるアジュバントとしてのｃｘｃｒ１／２の阻害薬 |
| JP2015077750A Expired - Fee Related JP6097328B2 (ja) | 2009-10-06 | 2015-04-06 | ランゲルハンス島の移植におけるアジュバントとしてのｃｘｃｒ１／２の阻害薬 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015077750A Expired - Fee Related JP6097328B2 (ja) | 2009-10-06 | 2015-04-06 | ランゲルハンス島の移植におけるアジュバントとしてのｃｘｃｒ１／２の阻害薬 |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US20120202884A1 (https=) |
| EP (2) | EP2308484A1 (https=) |
| JP (2) | JP5834010B2 (https=) |
| KR (2) | KR101759362B1 (https=) |
| CN (2) | CN104906572A (https=) |
| AU (1) | AU2010305385B2 (https=) |
| BR (1) | BR112012007991B8 (https=) |
| CA (1) | CA2775902C (https=) |
| CY (1) | CY1115018T1 (https=) |
| DK (1) | DK2485723T3 (https=) |
| EA (1) | EA021298B1 (https=) |
| ES (1) | ES2451349T3 (https=) |
| HK (1) | HK1213777A1 (https=) |
| HR (1) | HRP20140202T1 (https=) |
| IL (1) | IL219037A (https=) |
| ME (1) | ME01719B (https=) |
| MX (1) | MX2012004082A (https=) |
| NZ (1) | NZ599172A (https=) |
| PL (1) | PL2485723T3 (https=) |
| PT (1) | PT2485723E (https=) |
| RS (1) | RS53249B (https=) |
| SI (1) | SI2485723T1 (https=) |
| SM (1) | SMT201400033B (https=) |
| WO (1) | WO2011042466A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2308484A1 (en) * | 2009-10-06 | 2011-04-13 | Dompé S.p.a. | Inhibitors of cxcr1/2 as adjuvants in the transplant of pancreatic islets |
| EP2308485A1 (en) * | 2009-10-06 | 2011-04-13 | Dompé S.p.a. | Sulfonamides for the prevention of diabetes |
| CN103159652B (zh) * | 2011-12-19 | 2016-06-08 | 天津市国际生物医药联合研究院 | 亚磺酰胺类化合物的制备及其应用 |
| WO2014205127A2 (en) | 2013-06-18 | 2014-12-24 | New York University | Cellular factors involved in the cytotoxicity of staphylococcus aureus leukocidins: novel therapeutic targets |
| US11291641B2 (en) * | 2016-10-03 | 2022-04-05 | The Children's Medical Center Corporation | Prevention and treatment of diabetic nephropathy |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1303249B1 (it) | 1998-10-23 | 2000-11-06 | Dompe Spa | Alcune n-(2-aril-propionil)-solfonammidi e preparazionifarmaceutiche che le contengono. |
| AU2001253496A1 (en) * | 2000-04-14 | 2001-10-30 | Millennium Pharmaceuticals, Inc. | Treating graft rejection with cxcr3 inhibitors |
| US20020042370A1 (en) * | 2000-04-14 | 2002-04-11 | Millennium Pharmaceuticals, Inc. | Method of treating graft rejection using inhibitors of CCR2 function |
| ITMI20010206A1 (it) * | 2001-02-02 | 2002-08-02 | Dompe Spa | Uso della metansolfonammide di (r)-ibuprofene e dei suoi sali non tossici per la preparazione di medicamenti per il trattamento e la prevenz |
| ATE444286T1 (de) | 2004-03-23 | 2009-10-15 | Dompe Pha R Ma Spa Res & Mfg | 2-phenylpropionsäurederivate und diese enthaltende pharmazeutische zusammensetzung |
| PT1579859E (pt) | 2004-03-25 | 2007-03-30 | Dompe Pha R Ma Spa Res & Mfg | Utilização de n-(2-aril-propionil)-sulfonamidas pata o tratamento de lesões da medula espinal |
| US20050261762A1 (en) * | 2004-05-21 | 2005-11-24 | Medtronic Vascular, Inc. | Medical devices to prevent or inhibit restenosis |
| EP1790637B1 (en) * | 2004-09-13 | 2014-01-29 | Ono Pharmaceutical Co., Ltd. | Derivatives of N-4-piperidyl urea and medicaments containing them as active ingredient |
| JP5232144B2 (ja) * | 2006-06-28 | 2013-07-10 | サノフイ | Ｃｘｃｒ２阻害剤 |
| WO2008039876A1 (en) * | 2006-09-26 | 2008-04-03 | Case Western Reserve University | Cytokine signaling |
| CN102088993A (zh) | 2008-03-20 | 2011-06-08 | 卡罗勒斯治疗公司 | 炎症的治疗方法 |
| EP2308484A1 (en) * | 2009-10-06 | 2011-04-13 | Dompé S.p.a. | Inhibitors of cxcr1/2 as adjuvants in the transplant of pancreatic islets |
-
2009
- 2009-10-06 EP EP09172364A patent/EP2308484A1/en not_active Withdrawn
-
2010
- 2010-10-06 ME MEP-2014-24A patent/ME01719B/me unknown
- 2010-10-06 PT PT107610180T patent/PT2485723E/pt unknown
- 2010-10-06 PL PL10761018T patent/PL2485723T3/pl unknown
- 2010-10-06 NZ NZ599172A patent/NZ599172A/en not_active IP Right Cessation
- 2010-10-06 ES ES10761018.0T patent/ES2451349T3/es active Active
- 2010-10-06 AU AU2010305385A patent/AU2010305385B2/en not_active Ceased
- 2010-10-06 WO PCT/EP2010/064921 patent/WO2011042466A1/en not_active Ceased
- 2010-10-06 SI SI201030553T patent/SI2485723T1/sl unknown
- 2010-10-06 CN CN201510089937.5A patent/CN104906572A/zh active Pending
- 2010-10-06 JP JP2012532579A patent/JP5834010B2/ja not_active Expired - Fee Related
- 2010-10-06 RS RS20140102A patent/RS53249B/sr unknown
- 2010-10-06 DK DK10761018.0T patent/DK2485723T3/en active
- 2010-10-06 CN CN201080045208.5A patent/CN102665703B/zh not_active Expired - Fee Related
- 2010-10-06 KR KR1020127010732A patent/KR101759362B1/ko not_active Expired - Fee Related
- 2010-10-06 HR HRP20140202AT patent/HRP20140202T1/hr unknown
- 2010-10-06 KR KR1020177015626A patent/KR101817912B1/ko not_active Expired - Fee Related
- 2010-10-06 CA CA2775902A patent/CA2775902C/en not_active Expired - Fee Related
- 2010-10-06 US US13/500,544 patent/US20120202884A1/en not_active Abandoned
- 2010-10-06 MX MX2012004082A patent/MX2012004082A/es active IP Right Grant
- 2010-10-06 EP EP10761018.0A patent/EP2485723B1/en active Active
- 2010-10-06 EA EA201270513A patent/EA021298B1/ru unknown
- 2010-10-06 BR BR112012007991A patent/BR112012007991B8/pt not_active IP Right Cessation
-
2012
- 2012-04-04 IL IL219037A patent/IL219037A/en active IP Right Grant
-
2014
- 2014-03-07 CY CY20141100185T patent/CY1115018T1/el unknown
- 2014-03-19 SM SM201400033T patent/SMT201400033B/xx unknown
-
2015
- 2015-04-06 JP JP2015077750A patent/JP6097328B2/ja not_active Expired - Fee Related
-
2016
- 2016-02-18 HK HK16101720.7A patent/HK1213777A1/zh unknown
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