BR112012007991B8 - uso de inibidores de cxcr1/2 como adjuvantes no transplante de ilhotas pancreáticas - Google Patents
uso de inibidores de cxcr1/2 como adjuvantes no transplante de ilhotas pancreáticasInfo
- Publication number
- BR112012007991B8 BR112012007991B8 BR112012007991A BR112012007991A BR112012007991B8 BR 112012007991 B8 BR112012007991 B8 BR 112012007991B8 BR 112012007991 A BR112012007991 A BR 112012007991A BR 112012007991 A BR112012007991 A BR 112012007991A BR 112012007991 B8 BR112012007991 B8 BR 112012007991B8
- Authority
- BR
- Brazil
- Prior art keywords
- cxcr1
- inhibitors
- pancreatic islet
- adjuvants
- islet transplantation
- Prior art date
Links
- 239000002671 adjuvant Substances 0.000 title abstract 3
- 239000003112 inhibitor Substances 0.000 title abstract 3
- 210000004153 islets of langerhan Anatomy 0.000 title abstract 3
- 238000002054 transplantation Methods 0.000 title abstract 3
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
- C07C311/51—Y being a hydrogen or a carbon atom
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Transplantation (AREA)
- Emergency Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP09172364.3 | 2009-10-06 | ||
EP09172364A EP2308484A1 (en) | 2009-10-06 | 2009-10-06 | Inhibitors of cxcr1/2 as adjuvants in the transplant of pancreatic islets |
PCT/EP2010/064921 WO2011042466A1 (en) | 2009-10-06 | 2010-10-06 | Inhibitors of cxcr1/2 as adjuvants in the transplant of pancreatic islets |
Publications (3)
Publication Number | Publication Date |
---|---|
BR112012007991A2 BR112012007991A2 (pt) | 2017-07-25 |
BR112012007991B1 BR112012007991B1 (pt) | 2020-12-15 |
BR112012007991B8 true BR112012007991B8 (pt) | 2021-05-25 |
Family
ID=41818891
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112012007991A BR112012007991B8 (pt) | 2009-10-06 | 2010-10-06 | uso de inibidores de cxcr1/2 como adjuvantes no transplante de ilhotas pancreáticas |
Country Status (24)
Country | Link |
---|---|
US (1) | US20120202884A1 (pt) |
EP (2) | EP2308484A1 (pt) |
JP (2) | JP5834010B2 (pt) |
KR (2) | KR101759362B1 (pt) |
CN (2) | CN104906572A (pt) |
AU (1) | AU2010305385B2 (pt) |
BR (1) | BR112012007991B8 (pt) |
CA (1) | CA2775902C (pt) |
CY (1) | CY1115018T1 (pt) |
DK (1) | DK2485723T3 (pt) |
EA (1) | EA021298B1 (pt) |
ES (1) | ES2451349T3 (pt) |
HK (2) | HK1175993A1 (pt) |
HR (1) | HRP20140202T1 (pt) |
IL (1) | IL219037A (pt) |
ME (1) | ME01719B (pt) |
MX (1) | MX2012004082A (pt) |
NZ (1) | NZ599172A (pt) |
PL (1) | PL2485723T3 (pt) |
PT (1) | PT2485723E (pt) |
RS (1) | RS53249B (pt) |
SI (1) | SI2485723T1 (pt) |
SM (1) | SMT201400033B (pt) |
WO (1) | WO2011042466A1 (pt) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2308485A1 (en) | 2009-10-06 | 2011-04-13 | Dompé S.p.a. | Sulfonamides for the prevention of diabetes |
EP2308484A1 (en) * | 2009-10-06 | 2011-04-13 | Dompé S.p.a. | Inhibitors of cxcr1/2 as adjuvants in the transplant of pancreatic islets |
CN103159652B (zh) * | 2011-12-19 | 2016-06-08 | 天津市国际生物医药联合研究院 | 亚磺酰胺类化合物的制备及其应用 |
US10301378B2 (en) | 2013-06-18 | 2019-05-28 | New York University | Cellular factors involved in the cytotoxicity of Staphylococcus aureus leukocidins: novel therapeutic targets |
KR102181968B1 (ko) | 2015-12-29 | 2020-11-24 | 유오피 엘엘씨 | 무결합제 제올라이트 흡착제 및 무결합제 제올라이트 흡착제의 제조 방법 |
CA3037071A1 (en) | 2016-10-03 | 2018-04-12 | The Children's Medical Center Corporation | Prevention and treatment of diabetic nephropathy |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1303249B1 (it) | 1998-10-23 | 2000-11-06 | Dompe Spa | Alcune n-(2-aril-propionil)-solfonammidi e preparazionifarmaceutiche che le contengono. |
WO2001078708A1 (en) * | 2000-04-14 | 2001-10-25 | Millennium Pharmaceuticals, Inc. | Treating graft rejection with cxcr3 inhibitors |
WO2001078653A2 (en) * | 2000-04-14 | 2001-10-25 | Millennium Pharmaceuticals, Inc. | Graft rejection inhibition with ccr2 inhibitors |
ITMI20010206A1 (it) * | 2001-02-02 | 2002-08-02 | Dompe Spa | Uso della metansolfonammide di (r)-ibuprofene e dei suoi sali non tossici per la preparazione di medicamenti per il trattamento e la prevenz |
CN1934077B (zh) * | 2004-03-23 | 2010-09-29 | 冬姆佩制药股份公司 | 2-苯基丙酸衍生物及含有它们的药物组合物 |
DE602004003673T2 (de) | 2004-03-25 | 2007-10-04 | Dompe' Pha.R.Ma S.P.A. | Verwendung von N-(2-Aryl-propionyl)-sulfonamiden zur Behandlung von Rückenmarkverletzungen |
US20050261762A1 (en) * | 2004-05-21 | 2005-11-24 | Medtronic Vascular, Inc. | Medical devices to prevent or inhibit restenosis |
US8143404B2 (en) * | 2004-09-13 | 2012-03-27 | Ono Pharmaceutical Co., Ltd | Nitrogenous heterocylic derivative and medicine containing the same as an active ingredient |
EP2040690B1 (en) * | 2006-06-28 | 2014-08-06 | Sanofi | Inhibitors of cxcr2 |
US20090041753A1 (en) * | 2006-09-26 | 2009-02-12 | Miller Robert H | Cytokine signaling |
BRPI0910259A2 (pt) | 2008-03-20 | 2015-12-01 | Carolus Therapeutics Inc | métodos de tratamento de inflamação |
EP2308484A1 (en) * | 2009-10-06 | 2011-04-13 | Dompé S.p.a. | Inhibitors of cxcr1/2 as adjuvants in the transplant of pancreatic islets |
-
2009
- 2009-10-06 EP EP09172364A patent/EP2308484A1/en not_active Withdrawn
-
2010
- 2010-10-06 RS RS20140102A patent/RS53249B/en unknown
- 2010-10-06 BR BR112012007991A patent/BR112012007991B8/pt not_active IP Right Cessation
- 2010-10-06 EA EA201270513A patent/EA021298B1/ru unknown
- 2010-10-06 ME MEP-2014-24A patent/ME01719B/me unknown
- 2010-10-06 CN CN201510089937.5A patent/CN104906572A/zh active Pending
- 2010-10-06 KR KR1020127010732A patent/KR101759362B1/ko active IP Right Grant
- 2010-10-06 WO PCT/EP2010/064921 patent/WO2011042466A1/en active Application Filing
- 2010-10-06 SI SI201030553T patent/SI2485723T1/sl unknown
- 2010-10-06 MX MX2012004082A patent/MX2012004082A/es active IP Right Grant
- 2010-10-06 PL PL10761018T patent/PL2485723T3/pl unknown
- 2010-10-06 AU AU2010305385A patent/AU2010305385B2/en not_active Ceased
- 2010-10-06 US US13/500,544 patent/US20120202884A1/en not_active Abandoned
- 2010-10-06 CA CA2775902A patent/CA2775902C/en active Active
- 2010-10-06 JP JP2012532579A patent/JP5834010B2/ja not_active Expired - Fee Related
- 2010-10-06 EP EP10761018.0A patent/EP2485723B1/en active Active
- 2010-10-06 KR KR1020177015626A patent/KR101817912B1/ko active IP Right Grant
- 2010-10-06 ES ES10761018.0T patent/ES2451349T3/es active Active
- 2010-10-06 CN CN201080045208.5A patent/CN102665703B/zh not_active Expired - Fee Related
- 2010-10-06 NZ NZ599172A patent/NZ599172A/en not_active IP Right Cessation
- 2010-10-06 PT PT107610180T patent/PT2485723E/pt unknown
- 2010-10-06 DK DK10761018.0T patent/DK2485723T3/en active
-
2012
- 2012-04-04 IL IL219037A patent/IL219037A/en active IP Right Grant
-
2013
- 2013-03-12 HK HK13103030.1A patent/HK1175993A1/zh not_active IP Right Cessation
-
2014
- 2014-03-05 HR HRP20140202AT patent/HRP20140202T1/hr unknown
- 2014-03-07 CY CY20141100185T patent/CY1115018T1/el unknown
- 2014-03-19 SM SM201400033T patent/SMT201400033B/xx unknown
-
2015
- 2015-04-06 JP JP2015077750A patent/JP6097328B2/ja not_active Expired - Fee Related
-
2016
- 2016-02-18 HK HK16101720.7A patent/HK1213777A1/zh unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B25A | Requested transfer of rights approved |
Owner name: DOMPE FARMACEUTICI S.P.A. (IT) |
|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
B06T | Formal requirements before examination [chapter 6.20 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 15/12/2020, OBSERVADAS AS CONDICOES LEGAIS. |
|
B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 06/10/2010 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |
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B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time |
Free format text: REFERENTE A 13A ANUIDADE. |
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B24J | Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12) |
Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2743 DE 01-08-2023 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |