CN104906572A - 在胰岛移植中作为佐剂的cxcr1/2抑制剂 - Google Patents
在胰岛移植中作为佐剂的cxcr1/2抑制剂 Download PDFInfo
- Publication number
- CN104906572A CN104906572A CN201510089937.5A CN201510089937A CN104906572A CN 104906572 A CN104906572 A CN 104906572A CN 201510089937 A CN201510089937 A CN 201510089937A CN 104906572 A CN104906572 A CN 104906572A
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- Prior art keywords
- repertaxin
- mice
- islet transplantation
- islets
- cxcr1
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- Pending
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
- C07C311/51—Y being a hydrogen or a carbon atom
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Transplantation (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09172364.3 | 2009-10-06 | ||
| EP09172364A EP2308484A1 (en) | 2009-10-06 | 2009-10-06 | Inhibitors of cxcr1/2 as adjuvants in the transplant of pancreatic islets |
| CN201080045208.5A CN102665703B (zh) | 2009-10-06 | 2010-10-06 | 在胰岛移植中作为佐剂的cxcr1/2抑制剂 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201080045208.5A Division CN102665703B (zh) | 2009-10-06 | 2010-10-06 | 在胰岛移植中作为佐剂的cxcr1/2抑制剂 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104906572A true CN104906572A (zh) | 2015-09-16 |
Family
ID=41818891
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510089937.5A Pending CN104906572A (zh) | 2009-10-06 | 2010-10-06 | 在胰岛移植中作为佐剂的cxcr1/2抑制剂 |
| CN201080045208.5A Expired - Fee Related CN102665703B (zh) | 2009-10-06 | 2010-10-06 | 在胰岛移植中作为佐剂的cxcr1/2抑制剂 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201080045208.5A Expired - Fee Related CN102665703B (zh) | 2009-10-06 | 2010-10-06 | 在胰岛移植中作为佐剂的cxcr1/2抑制剂 |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US20120202884A1 (https=) |
| EP (2) | EP2308484A1 (https=) |
| JP (2) | JP5834010B2 (https=) |
| KR (2) | KR101759362B1 (https=) |
| CN (2) | CN104906572A (https=) |
| AU (1) | AU2010305385B2 (https=) |
| BR (1) | BR112012007991B8 (https=) |
| CA (1) | CA2775902C (https=) |
| CY (1) | CY1115018T1 (https=) |
| DK (1) | DK2485723T3 (https=) |
| EA (1) | EA021298B1 (https=) |
| ES (1) | ES2451349T3 (https=) |
| HK (1) | HK1213777A1 (https=) |
| HR (1) | HRP20140202T1 (https=) |
| IL (1) | IL219037A (https=) |
| ME (1) | ME01719B (https=) |
| MX (1) | MX2012004082A (https=) |
| NZ (1) | NZ599172A (https=) |
| PL (1) | PL2485723T3 (https=) |
| PT (1) | PT2485723E (https=) |
| RS (1) | RS53249B (https=) |
| SI (1) | SI2485723T1 (https=) |
| SM (1) | SMT201400033B (https=) |
| WO (1) | WO2011042466A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2308484A1 (en) * | 2009-10-06 | 2011-04-13 | Dompé S.p.a. | Inhibitors of cxcr1/2 as adjuvants in the transplant of pancreatic islets |
| EP2308485A1 (en) * | 2009-10-06 | 2011-04-13 | Dompé S.p.a. | Sulfonamides for the prevention of diabetes |
| CN103159652B (zh) * | 2011-12-19 | 2016-06-08 | 天津市国际生物医药联合研究院 | 亚磺酰胺类化合物的制备及其应用 |
| WO2014205127A2 (en) | 2013-06-18 | 2014-12-24 | New York University | Cellular factors involved in the cytotoxicity of staphylococcus aureus leukocidins: novel therapeutic targets |
| US11291641B2 (en) * | 2016-10-03 | 2022-04-05 | The Children's Medical Center Corporation | Prevention and treatment of diabetic nephropathy |
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| WO2002062330A2 (en) * | 2001-02-02 | 2002-08-15 | Dompé S.p.A. | Use of (r)-ibuprofen methanesulfonamide and salts thereof in the treatment and prevention of rejection reactions of transplanted organs |
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| WO2008000407A1 (en) * | 2006-06-28 | 2008-01-03 | Sanofi-Aventis | Inhibitors of cxcr2 |
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| AU2001253496A1 (en) * | 2000-04-14 | 2001-10-30 | Millennium Pharmaceuticals, Inc. | Treating graft rejection with cxcr3 inhibitors |
| US20020042370A1 (en) * | 2000-04-14 | 2002-04-11 | Millennium Pharmaceuticals, Inc. | Method of treating graft rejection using inhibitors of CCR2 function |
| ATE444286T1 (de) | 2004-03-23 | 2009-10-15 | Dompe Pha R Ma Spa Res & Mfg | 2-phenylpropionsäurederivate und diese enthaltende pharmazeutische zusammensetzung |
| PT1579859E (pt) | 2004-03-25 | 2007-03-30 | Dompe Pha R Ma Spa Res & Mfg | Utilização de n-(2-aril-propionil)-sulfonamidas pata o tratamento de lesões da medula espinal |
| US20050261762A1 (en) * | 2004-05-21 | 2005-11-24 | Medtronic Vascular, Inc. | Medical devices to prevent or inhibit restenosis |
| WO2008039876A1 (en) * | 2006-09-26 | 2008-04-03 | Case Western Reserve University | Cytokine signaling |
| CN102088993A (zh) | 2008-03-20 | 2011-06-08 | 卡罗勒斯治疗公司 | 炎症的治疗方法 |
| EP2308484A1 (en) * | 2009-10-06 | 2011-04-13 | Dompé S.p.a. | Inhibitors of cxcr1/2 as adjuvants in the transplant of pancreatic islets |
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| WO2002062330A2 (en) * | 2001-02-02 | 2002-08-15 | Dompé S.p.A. | Use of (r)-ibuprofen methanesulfonamide and salts thereof in the treatment and prevention of rejection reactions of transplanted organs |
| EP1790637A1 (en) * | 2004-09-13 | 2007-05-30 | Ono Pharmaceutical Co., Ltd. | Nitrogenous heterocyclic derivative and medicine containing the same as an active ingredient |
| WO2008000407A1 (en) * | 2006-06-28 | 2008-01-03 | Sanofi-Aventis | Inhibitors of cxcr2 |
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