JP2013506697A - 治療薬を輸送するための組成物と方法 - Google Patents
治療薬を輸送するための組成物と方法 Download PDFInfo
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- JP2013506697A JP2013506697A JP2012532429A JP2012532429A JP2013506697A JP 2013506697 A JP2013506697 A JP 2013506697A JP 2012532429 A JP2012532429 A JP 2012532429A JP 2012532429 A JP2012532429 A JP 2012532429A JP 2013506697 A JP2013506697 A JP 2013506697A
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- polypeptide
- glp
- disease
- compound
- gly
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- XKBVMJXPJPTGHS-CWWPDDBSSA-N C[C@H](OC[C@H]1O[C@H]([C@@H]2O)O[C@@H]([C@@H](CO3)[C@@H](C4c(cc5OC)cc(OC)c5OC(CN(C)C)=O)C3=O)c3c4cc4OCOc4c3)O[C@H]1[C@@H]2O Chemical compound C[C@H](OC[C@H]1O[C@H]([C@@H]2O)O[C@@H]([C@@H](CO3)[C@@H](C4c(cc5OC)cc(OC)c5OC(CN(C)C)=O)C3=O)c3c4cc4OCOc4c3)O[C@H]1[C@@H]2O XKBVMJXPJPTGHS-CWWPDDBSSA-N 0.000 description 1
Classifications
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- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
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- A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
- C07K14/8117—Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
- C07K7/083—Neurotensin
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Neurology (AREA)
- Biochemistry (AREA)
- Neurosurgery (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Dispersion Chemistry (AREA)
- Nanotechnology (AREA)
- Obesity (AREA)
- Child & Adolescent Psychology (AREA)
- Immunology (AREA)
- Endocrinology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24915209P | 2009-10-06 | 2009-10-06 | |
| US61/249,152 | 2009-10-06 | ||
| PCT/CA2010/001596 WO2011041897A1 (en) | 2009-10-06 | 2010-10-05 | Compositions and methods for the transport of therapeutic agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013506697A true JP2013506697A (ja) | 2013-02-28 |
| JP2013506697A5 JP2013506697A5 (https=) | 2013-11-28 |
Family
ID=43856341
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012532429A Pending JP2013506697A (ja) | 2009-10-06 | 2010-10-05 | 治療薬を輸送するための組成物と方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20120277158A1 (https=) |
| EP (1) | EP2486061A4 (https=) |
| JP (1) | JP2013506697A (https=) |
| CN (1) | CN102781965A (https=) |
| AU (1) | AU2010305284A1 (https=) |
| CA (1) | CA2777096A1 (https=) |
| MX (1) | MX2012004247A (https=) |
| WO (1) | WO2011041897A1 (https=) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017503781A (ja) * | 2013-12-23 | 2017-02-02 | ビーシーエヌ ペプタイズ エセ.ア.Bcn Peptides S.A. | リソソーム蓄積障害または糖原病の処置における使用のためのエキソサイトーシス活性化化合物としてのビカルタミド類似体または(s)−ビカルタミド |
| WO2017094792A1 (ja) * | 2015-11-30 | 2017-06-08 | 株式会社Quarrymen&Co. | カルボシランデンドリマーを用いた薬物送達システム用標的型シェル |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2004060403A2 (en) | 2003-01-06 | 2004-07-22 | Angiochem Inc. | Aprotinin and anglos as carriers across the blood-brain barrier |
| ES2744225T3 (es) | 2005-07-15 | 2020-02-24 | Angiochem Inc | Uso de polipéptidos de aprotinina como portadores en conjugados farmacéuticos |
| JP2010506860A (ja) | 2006-10-19 | 2010-03-04 | アンジオケム,インコーポレーテッド | P−糖タンパク質機能を刺激するための化合物およびその使用 |
| US9365634B2 (en) | 2007-05-29 | 2016-06-14 | Angiochem Inc. | Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues |
| ES2798257T3 (es) | 2008-09-08 | 2020-12-10 | Childrens Medical Center | Administración mucosa de moléculas, proteínas o partículas terapéuticas acopladas a lípidos de ceramida |
| EP2342340A1 (en) | 2008-09-22 | 2011-07-13 | Rxi Pharmaceuticals Corporation | Rna interference in skin indications |
| CA2740316A1 (en) | 2008-10-15 | 2010-04-22 | Angiochem Inc. | Conjugates of glp-1 agonists and uses thereof |
| CN102272151B (zh) | 2008-11-04 | 2014-08-20 | 詹森药业有限公司 | Crhr2肽激动剂及其用途 |
| CA2745524C (en) | 2008-12-05 | 2020-06-09 | Angiochem Inc. | Conjugates of neurotensin or neurotensin analogs and uses thereof |
| US8853353B2 (en) | 2008-12-17 | 2014-10-07 | Angiochem, Inc. | Membrane type-1 matrix metalloprotein inhibitors and uses thereof |
| MX2011011023A (es) | 2009-04-20 | 2012-01-20 | Angiochem Inc | Tratamiento de cancer de ovarios usando un agente anti-cancer conjugado con un analogo de angiopep-2. |
| RU2012103240A (ru) | 2009-07-02 | 2013-08-10 | Ангиокем Инк. | Мультимерные пептидные конъюгаты и их применение |
| EP3560503B1 (en) | 2010-03-24 | 2021-11-17 | Phio Pharmaceuticals Corp. | Rna interference in dermal and fibrotic indications |
| CN104145015A (zh) * | 2011-12-01 | 2014-11-12 | 安吉奥开米公司 | 靶向的溶酶体酶化合物 |
| BR112014013250A2 (pt) * | 2011-12-01 | 2019-09-24 | Angiochem Inc | compostos com enzima alvo e usos dos mesmos |
| US20140377244A1 (en) * | 2011-12-23 | 2014-12-25 | Shire Human Genetic Therapies, Inc. | Stable formulations for cns delivery of arylsulfatase a |
| WO2013127004A1 (en) | 2012-03-02 | 2013-09-06 | The Governing Council Of The University Of Toronto | Polymeric nanoparticles useful in theranostics |
| MX2014011836A (es) * | 2012-03-30 | 2015-03-09 | Shire Human Genetic Therapies | Administracion subcutanea de iduronato-2-sulfatasa. |
| AU2013273894A1 (en) * | 2012-06-15 | 2015-02-05 | Angiochem Inc. | Targeted iduronidase compounds |
| JP2015526434A (ja) * | 2012-08-14 | 2015-09-10 | アンジオケム インコーポレーテッド | ペプチド−デンドリマーコンジュゲート及びその使用 |
| WO2014031883A1 (en) * | 2012-08-23 | 2014-02-27 | Susan Marie Metcalfe | Neurotherapeutic nanoparticle compositions and devices |
| US20150241456A1 (en) * | 2012-09-20 | 2015-08-27 | Manas K. Haldar | Methods for using lipid particles |
| US9730679B1 (en) * | 2012-12-21 | 2017-08-15 | University Of South Florida | Device for sterile uterine sampling and drug delivery |
| KR20150098675A (ko) * | 2012-12-24 | 2015-08-28 | 라모트 앳 텔-아비브 유니버시티 리미티드 | 넌센스 돌연변이로부터 생긴 유전적 질환을 치료하기 위한 물질 및 이를 확인하는 방법 |
| CA2902433A1 (en) * | 2013-03-01 | 2014-09-04 | Astex Pharmaceuticals, Inc. | Drug combinations |
| AU2014228231B2 (en) * | 2013-03-15 | 2019-02-21 | Amicus Therapeutics, Inc. | Chemical crosslinkers |
| WO2014191502A1 (en) | 2013-05-28 | 2014-12-04 | Sinvent As | Process for preparing stealth nanoparticles |
| WO2014194429A1 (en) * | 2013-06-06 | 2014-12-11 | Angiochem Inc. | Targeted enzyme compounds and uses thereof |
| US9198973B2 (en) * | 2013-06-17 | 2015-12-01 | Fundacion Fraunhofer Chile Research | PAMAM, spacer molecule and cafestol polymers |
| PL3027750T3 (pl) * | 2013-07-30 | 2019-09-30 | Inofea Ag | Kompozycja biokatalityczna |
| CN103405783B (zh) * | 2013-08-05 | 2015-08-12 | 中山大学孙逸仙纪念医院 | OX26/CTX-PL/pC27复合物及其在治疗神经胶质瘤中的应用 |
| US20150093399A1 (en) | 2013-08-28 | 2015-04-02 | Bioasis Technologies, Inc. | Cns-targeted conjugates having modified fc regions and methods of use thereof |
| IN2013MU03918A (https=) * | 2013-12-13 | 2015-09-25 | Cipla Ltd | |
| ES2981281T3 (es) | 2014-01-20 | 2024-10-08 | Univ Utah Res Found | Composiciones y métodos para modificar la superficie de las células y métodos de uso |
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| US20110117627A1 (en) * | 2008-07-10 | 2011-05-19 | The Board Of Trustees Of The University Of Illinois | Regulation of apoptosis by neural specific splice variants of ig20 |
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| JP2017503781A (ja) * | 2013-12-23 | 2017-02-02 | ビーシーエヌ ペプタイズ エセ.ア.Bcn Peptides S.A. | リソソーム蓄積障害または糖原病の処置における使用のためのエキソサイトーシス活性化化合物としてのビカルタミド類似体または(s)−ビカルタミド |
| WO2017094792A1 (ja) * | 2015-11-30 | 2017-06-08 | 株式会社Quarrymen&Co. | カルボシランデンドリマーを用いた薬物送達システム用標的型シェル |
| JPWO2017094792A1 (ja) * | 2015-11-30 | 2018-09-27 | 株式会社Quarrymen&Co. | カルボシランデンドリマーを用いた薬物送達システム用標的型シェル |
| US10772973B2 (en) | 2015-11-30 | 2020-09-15 | Quarrymen & Co. Inc. | Targeted shell for use in drug delivery system utilizing carbosilane dendrimer |
| WO2017204337A1 (ja) * | 2016-05-27 | 2017-11-30 | 国立大学法人埼玉大学 | カルボシランデンドリマーを用いた標的組織特異的送達型ドラッグデリバリーシステム用カプセル |
| JPWO2017204337A1 (ja) * | 2016-05-27 | 2019-04-04 | 国立大学法人埼玉大学 | カルボシランデンドリマーを用いた標的組織特異的送達型ドラッグデリバリーシステム用カプセル |
| US11160877B2 (en) | 2016-05-27 | 2021-11-02 | Saitama University | Capsule for drug delivery systems of targeted tissue-specific delivery type using carbosilane dendrimer |
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| US20120277158A1 (en) | 2012-11-01 |
| CN102781965A (zh) | 2012-11-14 |
| CA2777096A1 (en) | 2011-04-14 |
| AU2010305284A1 (en) | 2012-05-03 |
| WO2011041897A1 (en) | 2011-04-14 |
| US20150174267A1 (en) | 2015-06-25 |
| MX2012004247A (es) | 2012-06-25 |
| EP2486061A4 (en) | 2013-08-28 |
| EP2486061A1 (en) | 2012-08-15 |
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