JP2013506437A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2013506437A5 JP2013506437A5 JP2012533282A JP2012533282A JP2013506437A5 JP 2013506437 A5 JP2013506437 A5 JP 2013506437A5 JP 2012533282 A JP2012533282 A JP 2012533282A JP 2012533282 A JP2012533282 A JP 2012533282A JP 2013506437 A5 JP2013506437 A5 JP 2013506437A5
- Authority
- JP
- Japan
- Prior art keywords
- vector
- item
- nucleic acid
- agent
- toll
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000013598 vector Substances 0.000 claims description 31
- 206010028980 Neoplasm Diseases 0.000 claims description 17
- 150000007523 nucleic acids Chemical class 0.000 claims description 17
- 102000039446 nucleic acids Human genes 0.000 claims description 17
- 108020004707 nucleic acids Proteins 0.000 claims description 17
- 241000124008 Mammalia Species 0.000 claims description 12
- 239000003795 chemical substances by application Substances 0.000 claims description 12
- 108010040721 Flagellin Proteins 0.000 claims description 10
- 239000003814 drug Substances 0.000 claims description 8
- 102000002689 Toll-like receptor Human genes 0.000 claims description 7
- 108020000411 Toll-like receptor Proteins 0.000 claims description 7
- 108010051696 Growth Hormone Proteins 0.000 claims description 6
- 102100038803 Somatotropin Human genes 0.000 claims description 6
- 201000011510 cancer Diseases 0.000 claims description 6
- 208000015181 infectious disease Diseases 0.000 claims description 6
- 229940123384 Toll-like receptor (TLR) agonist Drugs 0.000 claims description 5
- 229940079593 drug Drugs 0.000 claims description 5
- 239000003970 toll like receptor agonist Substances 0.000 claims description 5
- 102000004127 Cytokines Human genes 0.000 claims description 4
- 108090000695 Cytokines Proteins 0.000 claims description 4
- 239000013604 expression vector Substances 0.000 claims description 4
- 239000000122 growth hormone Substances 0.000 claims description 4
- 229960001438 immunostimulant agent Drugs 0.000 claims description 4
- 239000003022 immunostimulating agent Substances 0.000 claims description 4
- 241000894006 Bacteria Species 0.000 claims description 3
- 208000035473 Communicable disease Diseases 0.000 claims description 3
- 241000233866 Fungi Species 0.000 claims description 3
- 241000700605 Viruses Species 0.000 claims description 3
- 230000003308 immunostimulating effect Effects 0.000 claims description 3
- 101000669460 Homo sapiens Toll-like receptor 5 Proteins 0.000 claims description 2
- 241000713666 Lentivirus Species 0.000 claims description 2
- 206010025323 Lymphomas Diseases 0.000 claims description 2
- 102100024819 Prolactin Human genes 0.000 claims description 2
- 108010057464 Prolactin Proteins 0.000 claims description 2
- 206010039491 Sarcoma Diseases 0.000 claims description 2
- 102100039357 Toll-like receptor 5 Human genes 0.000 claims description 2
- 229930003316 Vitamin D Natural products 0.000 claims description 2
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims description 2
- 150000001413 amino acids Chemical class 0.000 claims description 2
- 210000000481 breast Anatomy 0.000 claims description 2
- 210000001072 colon Anatomy 0.000 claims description 2
- 230000000694 effects Effects 0.000 claims description 2
- 210000003238 esophagus Anatomy 0.000 claims description 2
- 210000003734 kidney Anatomy 0.000 claims description 2
- 208000032839 leukemia Diseases 0.000 claims description 2
- 239000002502 liposome Substances 0.000 claims description 2
- 210000004072 lung Anatomy 0.000 claims description 2
- 201000001441 melanoma Diseases 0.000 claims description 2
- 210000003739 neck Anatomy 0.000 claims description 2
- 210000001672 ovary Anatomy 0.000 claims description 2
- 210000000496 pancreas Anatomy 0.000 claims description 2
- 230000003071 parasitic effect Effects 0.000 claims description 2
- 210000003800 pharynx Anatomy 0.000 claims description 2
- 229940097325 prolactin Drugs 0.000 claims description 2
- 210000002307 prostate Anatomy 0.000 claims description 2
- 210000000130 stem cell Anatomy 0.000 claims description 2
- 210000002784 stomach Anatomy 0.000 claims description 2
- 210000001685 thyroid gland Anatomy 0.000 claims description 2
- 241000701161 unidentified adenovirus Species 0.000 claims description 2
- 239000011710 vitamin D Substances 0.000 claims description 2
- 235000019166 vitamin D Nutrition 0.000 claims description 2
- 150000003710 vitamin D derivatives Chemical class 0.000 claims description 2
- 229940046008 vitamin d Drugs 0.000 claims description 2
- 230000003248 secreting effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 description 14
- 244000045947 parasite Species 0.000 description 1
- 239000008177 pharmaceutical agent Substances 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24925309P | 2009-10-06 | 2009-10-06 | |
| US61/249,253 | 2009-10-06 | ||
| US24959609P | 2009-10-07 | 2009-10-07 | |
| US61/249,596 | 2009-10-07 | ||
| PCT/US2010/051646 WO2011044246A1 (en) | 2009-10-06 | 2010-10-06 | Use of toll-like receptor and agonist for treating cancer |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015128384A Division JP2015165821A (ja) | 2009-10-06 | 2015-06-26 | がんを処置するためのトール様受容体およびトール様受容体アゴニストの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013506437A JP2013506437A (ja) | 2013-02-28 |
| JP2013506437A5 true JP2013506437A5 (enExample) | 2013-11-14 |
| JP5796014B2 JP5796014B2 (ja) | 2015-10-21 |
Family
ID=43857117
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012533282A Expired - Fee Related JP5796014B2 (ja) | 2009-10-06 | 2010-10-06 | がんを処置するためのトール様受容体およびトール様受容体アゴニストの使用 |
| JP2015128384A Pending JP2015165821A (ja) | 2009-10-06 | 2015-06-26 | がんを処置するためのトール様受容体およびトール様受容体アゴニストの使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015128384A Pending JP2015165821A (ja) | 2009-10-06 | 2015-06-26 | がんを処置するためのトール様受容体およびトール様受容体アゴニストの使用 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US9205095B2 (enExample) |
| EP (1) | EP2486134B1 (enExample) |
| JP (2) | JP5796014B2 (enExample) |
| KR (1) | KR20120104177A (enExample) |
| CN (1) | CN104136614B (enExample) |
| AP (1) | AP2012006253A0 (enExample) |
| AU (1) | AU2010303464B2 (enExample) |
| BR (1) | BR112012011331B8 (enExample) |
| CA (1) | CA2777198C (enExample) |
| EA (1) | EA021842B1 (enExample) |
| ES (1) | ES2457518T3 (enExample) |
| IL (1) | IL219060A (enExample) |
| MX (1) | MX2012004095A (enExample) |
| MY (1) | MY163110A (enExample) |
| WO (1) | WO2011044246A1 (enExample) |
| ZA (1) | ZA201202500B (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006069198A1 (en) | 2004-12-22 | 2006-06-29 | Cleveland Clinic Foundation | Flagellin related polypeptides and uses thereof |
| ES2412237T3 (es) | 2008-08-01 | 2013-07-10 | Cleveland Biolabs, Inc. | Métodos para tratar lesiones por reperfusión |
| SG191830A1 (en) | 2011-01-10 | 2013-08-30 | Cleveland Biolabs Inc | Use of toll-like receptor agonist for treating cancer |
| WO2014098649A1 (en) * | 2012-12-18 | 2014-06-26 | Obschestvo S Ogranichennoy Otvetstvennostyu "Panacela Labs" | Compositions and methods using toll-like receptor 5 and toll-like receptor agonist |
| WO2015080631A1 (en) * | 2013-11-27 | 2015-06-04 | Obschestvo S Ogranichennoy Otvetstvennost`Yu "Panacela Labs" | Improved expression vector for toll-like receptor and agonist and use for treating cancer |
| ES2816630T3 (es) * | 2014-07-30 | 2021-04-05 | Genome Prot Inc | Composiciones de flagelina y usos |
| JP6423889B2 (ja) | 2014-10-07 | 2018-11-14 | サイトリミック株式会社 | Ｈｓｐ７０由来のペプチド、これを用いた癌の治療又は予防のための医薬組成物、免疫誘導剤、及び抗原提示細胞の製造方法 |
| US10183056B2 (en) | 2014-10-16 | 2019-01-22 | Cleveland Biolabs, Inc. | Methods and compositions for the treatment of radiation-related disorders |
| EP3269733B1 (en) | 2015-03-09 | 2020-06-17 | Cytlimic Inc. | Peptide derived from gpc3, pharmaceutical composition for treatment or prevention of cancer using same, immunity inducer, and method for producing antigen-presenting cells |
| US10842848B2 (en) * | 2015-04-07 | 2020-11-24 | Cytlimic Inc. | Method for treating cancer by adminstering poly I:C and LAG-3-IgG fusion protein |
| KR101634380B1 (ko) | 2015-06-23 | 2016-06-28 | 한국생산기술연구원 | Tlr5 아고니스트 단백질의 생산방법 |
| CN105801709B (zh) * | 2016-04-29 | 2019-10-08 | 北京纽莱福生物科技有限公司 | CBLB502-Fc融合蛋白及其制备方法 |
| EP3527216B1 (en) | 2016-10-11 | 2024-02-14 | NEC Corporation | A medicine comprising a toll-like receptor agonist, lag-3 protein, a hsp70-derived peptide and a gpc3-derived peptide |
| RU2741228C2 (ru) * | 2016-11-14 | 2021-01-22 | Общество С Ограниченной Ответственностью "Панацела Лабс" | Противоопухолевые эффекты вирусного вектора, кодирующего толл-подобный рецептор и агонист толл-подобного рецептора |
| US11029609B2 (en) * | 2016-12-28 | 2021-06-08 | Asml Netherlands B.V. | Simulation-assisted alignment between metrology image and design |
| CN108853144A (zh) * | 2017-05-16 | 2018-11-23 | 科济生物医药（上海）有限公司 | Toll样受体激动剂与免疫效应细胞的联用 |
| EP3668529A4 (en) | 2017-07-20 | 2021-07-14 | Spogen Biotech Inc. | BIOACTIVE POLYPEPTIDES ALLOWING IMPROVEMENTS IN PROTECTION, GROWTH AND PRODUCTIVITY OF PLANTS |
| LT3768284T (lt) | 2018-03-19 | 2022-04-11 | 4D Pharma Research Limited | Enterecoccus flagelino kompozicijos, skirtos panaudoti terapijai |
| US12440536B2 (en) | 2018-05-18 | 2025-10-14 | The University Of Hong Kong | Compositions of toll-like receptor 5 (TLR5) agonist and methods of use thereof |
| WO2020163370A1 (en) | 2019-02-04 | 2020-08-13 | Codiak Biosciences, Inc. | Membrane protein scaffolds for exosome engineering |
| US12233356B2 (en) | 2019-03-21 | 2025-02-25 | Lonza Sales Ag | Process for preparing extracellular vesicles |
| US20240108747A1 (en) | 2019-03-21 | 2024-04-04 | Lonza Sales Ag | Extracellular vesicle conjugates and uses thereof |
| SG11202109702QA (en) | 2019-03-21 | 2021-10-28 | Codiak Biosciences Inc | Extracellular vesicles for vaccine delivery |
| WO2021003445A1 (en) | 2019-07-03 | 2021-01-07 | Codiak Biosciences, Inc. | Extracellular vesicles targeting t cells and uses thereof |
| US20230181758A1 (en) | 2019-07-03 | 2023-06-15 | Codiak Biosciences, Inc. | Extracellular vesicles targeting dendritic cells and uses thereof |
| EP4034081A1 (en) | 2019-09-25 | 2022-08-03 | Codiak BioSciences, Inc. | Extracellular vesicle compositions |
| EP4117717A1 (en) | 2020-03-13 | 2023-01-18 | Codiak BioSciences, Inc. | Extracellular vesicles for treating neurological disorders |
| EP4121450A2 (en) | 2020-03-20 | 2023-01-25 | Codiak BioSciences, Inc. | Extracellular vesicles for therapy |
| WO2021237100A1 (en) | 2020-05-21 | 2021-11-25 | Codiak Biosciences, Inc. | Methods of targeting extracellular vesicles to lung |
| KR102720967B1 (ko) * | 2020-06-04 | 2024-10-23 | 가톨릭대학교 산학협력단 | 플라젤린으로부터 유도된 tlr5 작용제를 유효성분으로 포함하는 면역관문억제제의 항암 효과 증진용 약학 조성물 |
| US20230220068A1 (en) | 2020-06-05 | 2023-07-13 | Codiak Biosciences, Inc. | Anti-transferrin extracellular vesicles |
| WO2022066928A2 (en) | 2020-09-23 | 2022-03-31 | Codiak Biosciences, Inc. | Process for preparing extracellular vesicles |
| EP4216993A2 (en) | 2020-09-23 | 2023-08-02 | Codiak BioSciences, Inc. | Methods of producing extracellular vesicles |
| WO2022066883A1 (en) | 2020-09-23 | 2022-03-31 | Codiak Biosciences, Inc. | Extracellular vesicles comprising kras antigens and uses thereof |
| EP4620482A1 (en) * | 2024-03-18 | 2025-09-24 | Istituto Europeo di Oncologia S.r.l. | Flagellin-related peptides and uses thereof |
| WO2025196053A1 (en) * | 2024-03-18 | 2025-09-25 | Istituto Europeo Di Oncologia S.R.L. | Flagellin-related peptides and uses thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8703146B2 (en) * | 2001-04-20 | 2014-04-22 | Institute For Systems Biology | Toll-like receptor 5 ligands and methods of use |
| US8580321B2 (en) * | 2003-12-02 | 2013-11-12 | The Cleveland Clinic Foundation | Method for reducing the effects of chemotherapy using flagellin related polypeptides |
| WO2006069198A1 (en) * | 2004-12-22 | 2006-06-29 | Cleveland Clinic Foundation | Flagellin related polypeptides and uses thereof |
| JP2008527009A (ja) * | 2005-01-19 | 2008-07-24 | バクシネート コーポレーション | 病原体関連分子パターンおよび抗原を含む組成物ならびに免疫応答を刺激するためのそれらの使用 |
-
2010
- 2010-10-06 MY MYPI2012001519A patent/MY163110A/en unknown
- 2010-10-06 JP JP2012533282A patent/JP5796014B2/ja not_active Expired - Fee Related
- 2010-10-06 CA CA2777198A patent/CA2777198C/en active Active
- 2010-10-06 AP AP2012006253A patent/AP2012006253A0/xx unknown
- 2010-10-06 KR KR1020127008759A patent/KR20120104177A/ko not_active Ceased
- 2010-10-06 AU AU2010303464A patent/AU2010303464B2/en not_active Ceased
- 2010-10-06 EP EP10822611.9A patent/EP2486134B1/en active Active
- 2010-10-06 US US13/500,552 patent/US9205095B2/en active Active
- 2010-10-06 CN CN201080055226.1A patent/CN104136614B/zh not_active Expired - Fee Related
- 2010-10-06 EA EA201290140A patent/EA021842B1/ru unknown
- 2010-10-06 ES ES10822611.9T patent/ES2457518T3/es active Active
- 2010-10-06 MX MX2012004095A patent/MX2012004095A/es active IP Right Grant
- 2010-10-06 WO PCT/US2010/051646 patent/WO2011044246A1/en not_active Ceased
- 2010-10-06 BR BR112012011331A patent/BR112012011331B8/pt not_active IP Right Cessation
-
2012
- 2012-04-04 IL IL219060A patent/IL219060A/en active IP Right Grant
- 2012-04-05 ZA ZA2012/02500A patent/ZA201202500B/en unknown
-
2015
- 2015-06-26 JP JP2015128384A patent/JP2015165821A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2013506437A5 (enExample) | ||
| Jin et al. | Nanoparticle‐mediated delivery of inhaled immunotherapeutics for treating lung metastasis | |
| Akkın et al. | A review on cancer immunotherapy and applications of nanotechnology to chemoimmunotherapy of different cancers | |
| Luo et al. | Activation of stimulation of interferon genes (STING) signal and cancer immunotherapy | |
| Huang et al. | The role of toll-like receptor agonists and their nanomedicines for tumor immunotherapy | |
| Yan et al. | pH-responsive nanoparticles for cancer immunotherapy: a brief review | |
| Martins et al. | Vaccine adjuvant uses of poly-IC and derivatives | |
| Aderibigbe et al. | Design and efficacy of nanogels formulations for intranasal administration | |
| Gutjahr et al. | Biodegradable polymeric nanoparticles-based vaccine adjuvants for lymph nodes targeting | |
| Vasilakos et al. | The use of Toll-like receptor 7/8 agonists as vaccine adjuvants | |
| Kayamuro et al. | Interleukin-1 family cytokines as mucosal vaccine adjuvants for induction of protective immunity against influenza virus | |
| Gosu et al. | Therapeutic applications of nucleic acids and their analogues in Toll-like receptor signaling | |
| Shirai et al. | Lipid nanoparticle acts as a potential adjuvant for influenza split vaccine without inducing inflammatory responses | |
| Nagatomo et al. | Cholesteryl pullulan encapsulated TNF‐α nanoparticles are an effective mucosal vaccine adjuvant against influenza virus | |
| CY1118373T1 (el) | Υψηλης συγκεντρωσης υγρες μορφοποιησεις anti-tnfa αντισωματος | |
| Ramos et al. | Forms and methods for interferon’s encapsulation | |
| JP6603216B2 (ja) | 殺腫瘍性および抗菌性の組成物ならびに方法 | |
| WO2023031392A3 (en) | Novel lipid nanoparticles for delivery of nucleic acids comprising phosphatidylserine | |
| US20110218169A1 (en) | Pirfenidone/Toll-Like Receptor (TLR) Agonist Compounds and Methods of Treating Neutropenia | |
| Wakita et al. | An indispensable role of type-1 IFNs for inducing CTL-mediated complete eradication of established tumor tissue by CpG-liposome co-encapsulated with model tumor antigen | |
| Collier et al. | Delivery of host cell-directed therapeutics for intracellular pathogen clearance | |
| Chen et al. | Maximizing TLR9 activation in cancer immunotherapy with dual-adjuvanted spherical nucleic acids | |
| Andón et al. | Innate and adaptive responses of intratumoral immunotherapy with endosomal toll-like receptor agonists | |
| JP2006502228A5 (enExample) | ||
| RU2015121574A (ru) | Препарат для биспецифических активаторов т-клеток(bite) |