JP2013506410A - Ｄｌｌ４結合分子 - Google Patents
Ｄｌｌ４結合分子 Download PDFInfo
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- JP2013506410A JP2013506410A JP2012531450A JP2012531450A JP2013506410A JP 2013506410 A JP2013506410 A JP 2013506410A JP 2012531450 A JP2012531450 A JP 2012531450A JP 2012531450 A JP2012531450 A JP 2012531450A JP 2013506410 A JP2013506410 A JP 2013506410A
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| PCT/EP2010/064693 WO2011039368A2 (en) | 2009-10-02 | 2010-10-01 | Dll4-binding molecules |
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| US20130078247A1 (en) * | 2011-04-01 | 2013-03-28 | Boehringer Ingelheim International Gmbh | Bispecific binding molecules binding to dii4 and ang2 |
| US9527925B2 (en) | 2011-04-01 | 2016-12-27 | Boehringer Ingelheim International Gmbh | Bispecific binding molecules binding to VEGF and ANG2 |
| DK2758073T3 (en) | 2011-09-23 | 2019-01-14 | Oncomed Pharm Inc | VEGF / DLL4 BINDING AGENTS AND APPLICATIONS THEREOF |
| KR101535341B1 (ko) | 2012-07-02 | 2015-07-13 | 한화케미칼 주식회사 | Dll4에 특이적으로 결합하는 신규한 단일클론항체 및 이의 용도 |
| KR102089591B1 (ko) | 2013-07-29 | 2020-03-18 | 삼성전자주식회사 | 항 EGFR scFv 단편 및 이를 포함하는 항 c-Met/항 EGFR 이중 특이 항체 |
| IL274151B (en) | 2015-05-21 | 2022-07-01 | Harpoon Therapeutics Inc | Trispecific binding proteins and methods of use |
| JP6967003B2 (ja) | 2015-09-23 | 2021-11-17 | メレオ バイオファーマ ５ インコーポレイテッド | がんの処置のための方法および組成物 |
| US11623958B2 (en) | 2016-05-20 | 2023-04-11 | Harpoon Therapeutics, Inc. | Single chain variable fragment CD3 binding proteins |
| WO2017201488A1 (en) | 2016-05-20 | 2017-11-23 | Harpoon Therapeutics, Inc. | Single domain serum albumin binding protein |
| EA201991168A1 (ru) | 2016-11-23 | 2019-12-30 | Харпун Терапьютикс, Инк. | Белок, связывающий простатический специфический мембранный антиген |
| CA3044729A1 (en) | 2016-11-23 | 2018-05-31 | Harpoon Therapeutics, Inc. | Psma targeting trispecific proteins and methods of use |
| WO2018160754A2 (en) | 2017-02-28 | 2018-09-07 | Harpoon Therapeutics, Inc. | Inducible monovalent antigen binding protein |
| BR112019023856A2 (pt) | 2017-05-12 | 2020-06-09 | Harpoon Therapeutics Inc | proteínas triespecíficas que visam msln e métodos de utilização |
| WO2018209298A1 (en) | 2017-05-12 | 2018-11-15 | Harpoon Therapeutics, Inc. | Mesothelin binding proteins |
| EP3694529B1 (en) | 2017-10-13 | 2024-06-26 | Harpoon Therapeutics, Inc. | Trispecific proteins and methods of use |
| CR20200195A (es) | 2017-10-13 | 2020-08-14 | Harpoon Therapeutics Inc | Proteínas de unión a antigenos de maduraciòn de celulas b |
| CN109160948B (zh) * | 2018-09-21 | 2021-07-16 | 成都阿帕克生物科技有限公司 | 一种乙肝表面抗原纳米抗体及核酸分子和应用 |
| AU2019346466A1 (en) | 2018-09-25 | 2021-05-20 | Harpoon Therapeutics, Inc. | DLL3 binding proteins and methods of use |
| EP4106806A4 (en) | 2020-02-21 | 2024-07-24 | Harpoon Therapeutics Inc | FLT3 BINDING PROTEINS AND METHODS OF USE |
| CN111875706B (zh) * | 2020-07-16 | 2021-03-30 | 广州康盛生物科技股份有限公司 | 一种抗人IgE蛋白的单域抗体及其应用 |
| CN116547006B (zh) * | 2021-08-06 | 2024-09-20 | 贝达药业股份有限公司 | 抗pd-l1纳米抗体及其应用 |
| WO2024089627A1 (en) * | 2022-10-26 | 2024-05-02 | Berking Biotechnology Spa | Single domain antibody - sdab/vhh against the nucleoprotein of sars-cov-2 virus |
| CN117659194B (zh) * | 2023-11-30 | 2024-08-13 | 科弈(浙江)药业科技有限公司 | 靶向egfr的纳米抗体、药物偶联物及其用途 |
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| WO2008070513A1 (en) * | 2006-12-01 | 2008-06-12 | Alcon Research, Ltd. | Modulation of polysialylated neural adhesion molecules (psa-ncam) as a regulator of ocular disease |
| WO2008076379A2 (en) * | 2006-12-14 | 2008-06-26 | Regeneron Pharmaceuticals, Inc. | Human antibodies to human delta like ligand 4 |
| WO2008139202A1 (en) * | 2007-05-15 | 2008-11-20 | Smart Targeting Limited | Neutralizing monoclonal antibody against human dll4 |
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| EP1087013B1 (en) | 1992-08-21 | 2009-01-07 | Vrije Universiteit Brussel | Immunoglobulins devoid of light chains |
| EP0739981A1 (en) | 1995-04-25 | 1996-10-30 | Vrije Universiteit Brussel | Variable fragments of immunoglobulins - use for therapeutic or veterinary purposes |
| US6329516B1 (en) | 1997-04-28 | 2001-12-11 | Fmc Corporation | Lepidopteran GABA-gated chloride channels |
| CA2405557C (en) | 2000-04-12 | 2013-09-24 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| EP2316951A1 (en) | 2001-01-17 | 2011-05-04 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
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| NZ540194A (en) | 2002-11-08 | 2008-07-31 | Ablynx Nv | Single domain antibodies directed against tumour necrosis factor-alpha and uses therefor |
| WO2004060965A2 (en) | 2002-12-31 | 2004-07-22 | Nektar Therapeutics Al, Corporation | Hydrolytically stable maleimide-terminated polymers |
| SI1639011T1 (sl) | 2003-06-30 | 2009-04-30 | Domantis Ltd | Pegilirana protitelesa z enojno domeno (dAb) |
| DE60334645D1 (de) | 2003-11-07 | 2010-12-02 | Ablynx Nv | Camelidae schwere ketten antikörper vhhs gegen epidermalen wachstumfaktor rezeptor (egfr) und ihre verwendung |
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| BRPI0518151A2 (pt) | 2004-10-13 | 2009-06-16 | Ablynx Nv | polipetìdeos contra amiloide-beta, ácido nucléico que codifica tal polipetìdeo, composição compreendendo tal polipetìdeo, método para produzir um polipetìdeo e uso do mesmo |
| US8048418B2 (en) * | 2004-10-29 | 2011-11-01 | Regeneron Pharmaceuticals, Inc. | Therapeutic methods for inhibiting tumor growth with combination of Dll4 antagonists and VEGF antagonists |
| SI1888641T1 (sl) | 2005-05-18 | 2012-05-31 | Ablynx Nv | Proteini ki vežejo serum albumin |
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| TW200815467A (en) * | 2006-06-06 | 2008-04-01 | Genentech Inc | Anti-DLL4 antibodies and methods using same |
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| WO2009095489A2 (en) | 2008-02-01 | 2009-08-06 | Ablynx N.V. | Improved amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of diseases and disorders associated with il-6-mediated signalling |
| GB2470328A (en) | 2008-03-05 | 2010-11-17 | Ablynx Nv | Novel antigen binding dimer complexes, methods of making and uses thereof |
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2010
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- 2010-09-30 UY UY32917A patent/UY32917A/es not_active Application Discontinuation
- 2010-10-01 TW TW99133558A patent/TW201124532A/zh unknown
- 2010-10-01 AU AU2010302587A patent/AU2010302587A1/en not_active Abandoned
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- 2010-10-01 IN IN2715DEN2012 patent/IN2012DN02715A/en unknown
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- 2010-10-01 KR KR20127011414A patent/KR20120115217A/ko not_active Application Discontinuation
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2012
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- 2012-04-25 EC ECSP12011828 patent/ECSP12011828A/es unknown
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| WO2008070513A1 (en) * | 2006-12-01 | 2008-06-12 | Alcon Research, Ltd. | Modulation of polysialylated neural adhesion molecules (psa-ncam) as a regulator of ocular disease |
| WO2008076379A2 (en) * | 2006-12-14 | 2008-06-26 | Regeneron Pharmaceuticals, Inc. | Human antibodies to human delta like ligand 4 |
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| EP2483313A2 (en) | 2012-08-08 |
| AP2012006167A0 (en) | 2012-04-30 |
| IN2012DN02715A (pt) | 2015-09-11 |
| MA33609B1 (fr) | 2012-09-01 |
| EA201200549A1 (ru) | 2012-12-28 |
| AR078516A1 (es) | 2011-11-16 |
| US20110195494A1 (en) | 2011-08-11 |
| UY32917A (es) | 2011-04-29 |
| WO2011039368A3 (en) | 2011-06-23 |
| TN2012000144A1 (en) | 2013-09-19 |
| CL2012000818A1 (es) | 2012-10-19 |
| CA2775420A1 (en) | 2011-04-07 |
| ECSP12011828A (es) | 2012-05-30 |
| MX2012003797A (es) | 2012-06-28 |
| WO2011039368A2 (en) | 2011-04-07 |
| BR112012007294A2 (pt) | 2016-11-22 |
| TW201124532A (en) | 2011-07-16 |
| AU2010302587A1 (en) | 2012-04-05 |
| KR20120115217A (ko) | 2012-10-17 |
| IL218544A0 (en) | 2012-05-31 |
| PE20121184A1 (es) | 2012-09-16 |
| NZ598650A (en) | 2014-03-28 |
| CN102648210A (zh) | 2012-08-22 |
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