JP2013505935A - (4−フルオロ−3−ピペリジン−4−イル−ベンジル)−カルバミン酸tert−ブチルエステルの合成及びその中間体 - Google Patents
(4−フルオロ−3−ピペリジン−4−イル−ベンジル)−カルバミン酸tert−ブチルエステルの合成及びその中間体 Download PDFInfo
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- JP2013505935A JP2013505935A JP2012530984A JP2012530984A JP2013505935A JP 2013505935 A JP2013505935 A JP 2013505935A JP 2012530984 A JP2012530984 A JP 2012530984A JP 2012530984 A JP2012530984 A JP 2012530984A JP 2013505935 A JP2013505935 A JP 2013505935A
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- Prior art keywords
- tert
- acid
- hydrogenation
- fluoro
- benzyl
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- 230000015572 biosynthetic process Effects 0.000 title abstract description 7
- 238000003786 synthesis reaction Methods 0.000 title abstract description 5
- 239000000543 intermediate Substances 0.000 title abstract description 4
- MFRZZHOXGKQYOU-UHFFFAOYSA-N tert-butyl n-[(4-fluoro-3-piperidin-4-ylphenyl)methyl]carbamate Chemical compound CC(C)(C)OC(=O)NCC1=CC=C(F)C(C2CCNCC2)=C1 MFRZZHOXGKQYOU-UHFFFAOYSA-N 0.000 title 1
- 238000000034 method Methods 0.000 claims abstract description 47
- 238000005984 hydrogenation reaction Methods 0.000 claims abstract description 30
- 238000006069 Suzuki reaction reaction Methods 0.000 claims abstract description 23
- 230000008569 process Effects 0.000 claims abstract description 15
- -1 4-fluoro-3-piperidin-4-yl-benzyl Chemical group 0.000 claims abstract description 12
- PGFSQYFQVWFCSK-UHFFFAOYSA-N [2-fluoro-5-[[(2-methylpropan-2-yl)oxycarbonylamino]methyl]phenyl]boronic acid Chemical compound CC(C)(C)OC(=O)NCC1=CC=C(F)C(B(O)O)=C1 PGFSQYFQVWFCSK-UHFFFAOYSA-N 0.000 claims abstract description 8
- 238000002360 preparation method Methods 0.000 claims abstract description 6
- 238000006243 chemical reaction Methods 0.000 claims abstract description 4
- 239000002904 solvent Substances 0.000 claims description 29
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 25
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 21
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 17
- 239000003054 catalyst Substances 0.000 claims description 15
- 239000000203 mixture Substances 0.000 claims description 13
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 11
- ZADPBFCGQRWHPN-UHFFFAOYSA-N boronic acid Chemical compound OBO ZADPBFCGQRWHPN-UHFFFAOYSA-N 0.000 claims description 11
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 10
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 10
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims description 9
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims description 9
- JMMWKPVZQRWMSS-UHFFFAOYSA-N isopropyl acetate Chemical compound CC(C)OC(C)=O JMMWKPVZQRWMSS-UHFFFAOYSA-N 0.000 claims description 9
- MZRVEZGGRBJDDB-UHFFFAOYSA-N N-Butyllithium Chemical compound [Li]CCCC MZRVEZGGRBJDDB-UHFFFAOYSA-N 0.000 claims description 8
- KZPYGQFFRCFCPP-UHFFFAOYSA-N 1,1'-bis(diphenylphosphino)ferrocene Chemical compound [Fe+2].C1=CC=C[C-]1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=C[C-]1P(C=1C=CC=CC=1)C1=CC=CC=C1 KZPYGQFFRCFCPP-UHFFFAOYSA-N 0.000 claims description 7
- XTHFKEDIFFGKHM-UHFFFAOYSA-N Dimethoxyethane Chemical compound COCCOC XTHFKEDIFFGKHM-UHFFFAOYSA-N 0.000 claims description 7
- BZLVMXJERCGZMT-UHFFFAOYSA-N Methyl tert-butyl ether Chemical compound COC(C)(C)C BZLVMXJERCGZMT-UHFFFAOYSA-N 0.000 claims description 7
- LPNYRYFBWFDTMA-UHFFFAOYSA-N potassium tert-butoxide Chemical compound [K+].CC(C)(C)[O-] LPNYRYFBWFDTMA-UHFFFAOYSA-N 0.000 claims description 7
- 239000004032 superbase Substances 0.000 claims description 7
- 150000007525 superbases Chemical class 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 6
- DKPFZGUDAPQIHT-UHFFFAOYSA-N butyl acetate Chemical compound CCCCOC(C)=O DKPFZGUDAPQIHT-UHFFFAOYSA-N 0.000 claims description 6
- 239000011260 aqueous acid Substances 0.000 claims description 5
- 238000009835 boiling Methods 0.000 claims description 5
- 239000003795 chemical substances by application Substances 0.000 claims description 5
- 235000019439 ethyl acetate Nutrition 0.000 claims description 5
- 230000009467 reduction Effects 0.000 claims description 5
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 5
- VTGJPHGXZFGCMP-UHFFFAOYSA-N tert-butyl n-[(4-fluoro-3-pyridin-4-ylphenyl)methyl]carbamate Chemical compound CC(C)(C)OC(=O)NCC1=CC=C(F)C(C=2C=CN=CC=2)=C1 VTGJPHGXZFGCMP-UHFFFAOYSA-N 0.000 claims description 5
- NHDIQVFFNDKAQU-UHFFFAOYSA-N tripropan-2-yl borate Chemical compound CC(C)OB(OC(C)C)OC(C)C NHDIQVFFNDKAQU-UHFFFAOYSA-N 0.000 claims description 5
- 150000005751 4-halopyridines Chemical class 0.000 claims description 4
- XYFCBTPGUUZFHI-UHFFFAOYSA-N Phosphine Chemical compound P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 claims description 4
- 150000007524 organic acids Chemical class 0.000 claims description 4
- 101150003085 Pdcl gene Proteins 0.000 claims description 3
- 125000003118 aryl group Chemical group 0.000 claims description 3
- 239000002585 base Substances 0.000 claims description 3
- 230000008878 coupling Effects 0.000 claims description 3
- 238000010168 coupling process Methods 0.000 claims description 3
- 238000005859 coupling reaction Methods 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 150000007522 mineralic acids Chemical class 0.000 claims description 3
- 239000003880 polar aprotic solvent Substances 0.000 claims description 3
- JWUJQDFVADABEY-UHFFFAOYSA-N 2-methyltetrahydrofuran Chemical compound CC1CCCO1 JWUJQDFVADABEY-UHFFFAOYSA-N 0.000 claims description 2
- PVMNPAUTCMBOMO-UHFFFAOYSA-N 4-chloropyridine Chemical group ClC1=CC=NC=C1 PVMNPAUTCMBOMO-UHFFFAOYSA-N 0.000 claims description 2
- 125000000217 alkyl group Chemical group 0.000 claims description 2
- 239000003153 chemical reaction reagent Substances 0.000 claims description 2
- 239000004210 ether based solvent Substances 0.000 claims description 2
- 239000003446 ligand Substances 0.000 claims description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 2
- 125000001979 organolithium group Chemical group 0.000 claims description 2
- 229910052763 palladium Inorganic materials 0.000 claims description 2
- 229910000073 phosphorus hydride Inorganic materials 0.000 claims description 2
- 239000011591 potassium Substances 0.000 claims description 2
- 229910052700 potassium Inorganic materials 0.000 claims description 2
- ZRLVQFQTCMUIRM-UHFFFAOYSA-N potassium;2-methylbutan-2-olate Chemical compound [K+].CCC(C)(C)[O-] ZRLVQFQTCMUIRM-UHFFFAOYSA-N 0.000 claims description 2
- JWPPKVVTOIDXGC-UHFFFAOYSA-N tert-butyl n-[(4-fluoro-3-piperidin-4-ylphenyl)methyl]carbamate;hydrochloride Chemical compound Cl.CC(C)(C)OC(=O)NCC1=CC=C(F)C(C2CCNCC2)=C1 JWPPKVVTOIDXGC-UHFFFAOYSA-N 0.000 claims description 2
- LGQXXHMEBUOXRP-UHFFFAOYSA-N tributyl borate Chemical compound CCCCOB(OCCCC)OCCCC LGQXXHMEBUOXRP-UHFFFAOYSA-N 0.000 claims description 2
- AJSTXXYNEIHPMD-UHFFFAOYSA-N triethyl borate Chemical compound CCOB(OCC)OCC AJSTXXYNEIHPMD-UHFFFAOYSA-N 0.000 claims description 2
- WRECIMRULFAWHA-UHFFFAOYSA-N trimethyl borate Chemical group COB(OC)OC WRECIMRULFAWHA-UHFFFAOYSA-N 0.000 claims description 2
- LTEHWCSSIHAVOQ-UHFFFAOYSA-N tripropyl borate Chemical compound CCCOB(OCCC)OCCC LTEHWCSSIHAVOQ-UHFFFAOYSA-N 0.000 claims description 2
- 239000005456 alcohol based solvent Substances 0.000 claims 3
- 239000003759 ester based solvent Substances 0.000 claims 2
- QCSLIRFWJPOENV-UHFFFAOYSA-N (2-fluorophenyl)boronic acid Chemical compound OB(O)C1=CC=CC=C1F QCSLIRFWJPOENV-UHFFFAOYSA-N 0.000 claims 1
- 241000694440 Colpidium aqueous Species 0.000 claims 1
- 125000001033 ether group Chemical group 0.000 claims 1
- 238000010791 quenching Methods 0.000 claims 1
- 230000000171 quenching effect Effects 0.000 claims 1
- 238000010626 work up procedure Methods 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 abstract description 13
- QFLWZFQWSBQYPS-AWRAUJHKSA-N (3S)-3-[[(2S)-2-[[(2S)-2-[5-[(3aS,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-[1-bis(4-chlorophenoxy)phosphorylbutylamino]-4-oxobutanoic acid Chemical compound CCCC(NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)CCCCC1SC[C@@H]2NC(=O)N[C@H]12)C(C)C)P(=O)(Oc1ccc(Cl)cc1)Oc1ccc(Cl)cc1 QFLWZFQWSBQYPS-AWRAUJHKSA-N 0.000 abstract description 9
- UNILWMWFPHPYOR-KXEYIPSPSA-M 1-[6-[2-[3-[3-[3-[2-[2-[3-[[2-[2-[[(2r)-1-[[2-[[(2r)-1-[3-[2-[2-[3-[[2-(2-amino-2-oxoethoxy)acetyl]amino]propoxy]ethoxy]ethoxy]propylamino]-3-hydroxy-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-3-[(2r)-2,3-di(hexadecanoyloxy)propyl]sulfanyl-1-oxopropan-2-yl Chemical compound O=C1C(SCCC(=O)NCCCOCCOCCOCCCNC(=O)COCC(=O)N[C@@H](CSC[C@@H](COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NCC(=O)N[C@H](CO)C(=O)NCCCOCCOCCOCCCNC(=O)COCC(N)=O)CC(=O)N1CCNC(=O)CCCCCN\1C2=CC=C(S([O-])(=O)=O)C=C2CC/1=C/C=C/C=C/C1=[N+](CC)C2=CC=C(S([O-])(=O)=O)C=C2C1 UNILWMWFPHPYOR-KXEYIPSPSA-M 0.000 abstract description 6
- XMFJCIIONJPGFS-UHFFFAOYSA-N tert-butyl n-[(4-fluoro-2-pyridin-4-ylphenyl)methyl]carbamate Chemical compound CC(C)(C)OC(=O)NCC1=CC=C(F)C=C1C1=CC=NC=C1 XMFJCIIONJPGFS-UHFFFAOYSA-N 0.000 abstract description 2
- FQFILJKFZCVHNH-UHFFFAOYSA-N tert-butyl n-[3-[(5-bromo-2-chloropyrimidin-4-yl)amino]propyl]carbamate Chemical compound CC(C)(C)OC(=O)NCCCNC1=NC(Cl)=NC=C1Br FQFILJKFZCVHNH-UHFFFAOYSA-N 0.000 abstract 1
- KDLHZDBZIXYQEI-UHFFFAOYSA-N palladium Substances [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 15
- 238000000655 nuclear magnetic resonance spectrum Methods 0.000 description 6
- ZMXDDKWLCZADIW-UHFFFAOYSA-N Vilsmeier-Haack reagent Natural products CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 5
- DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 description 4
- NFHFRUOZVGFOOS-UHFFFAOYSA-N palladium;triphenylphosphane Chemical compound [Pd].C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 NFHFRUOZVGFOOS-UHFFFAOYSA-N 0.000 description 4
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 4
- QAEDZJGFFMLHHQ-UHFFFAOYSA-N trifluoroacetic anhydride Chemical compound FC(F)(F)C(=O)OC(=O)C(F)(F)F QAEDZJGFFMLHHQ-UHFFFAOYSA-N 0.000 description 4
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 3
- YJVFFLUZDVXJQI-UHFFFAOYSA-L palladium(ii) acetate Chemical compound [Pd+2].CC([O-])=O.CC([O-])=O YJVFFLUZDVXJQI-UHFFFAOYSA-L 0.000 description 3
- 239000011541 reaction mixture Substances 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- GHYOCDFICYLMRF-UTIIJYGPSA-N (2S,3R)-N-[(2S)-3-(cyclopenten-1-yl)-1-[(2R)-2-methyloxiran-2-yl]-1-oxopropan-2-yl]-3-hydroxy-3-(4-methoxyphenyl)-2-[[(2S)-2-[(2-morpholin-4-ylacetyl)amino]propanoyl]amino]propanamide Chemical compound C1(=CCCC1)C[C@@H](C(=O)[C@@]1(OC1)C)NC([C@H]([C@@H](C1=CC=C(C=C1)OC)O)NC([C@H](C)NC(CN1CCOCC1)=O)=O)=O GHYOCDFICYLMRF-UTIIJYGPSA-N 0.000 description 2
- IAZDPXIOMUYVGZ-WFGJKAKNSA-N Dimethyl sulfoxide Chemical compound [2H]C([2H])([2H])S(=O)C([2H])([2H])[2H] IAZDPXIOMUYVGZ-WFGJKAKNSA-N 0.000 description 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 2
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- 102000001400 Tryptase Human genes 0.000 description 2
- 108060005989 Tryptase Proteins 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- WGQKYBSKWIADBV-UHFFFAOYSA-N benzylamine Chemical compound NCC1=CC=CC=C1 WGQKYBSKWIADBV-UHFFFAOYSA-N 0.000 description 2
- 229940125797 compound 12 Drugs 0.000 description 2
- 239000012045 crude solution Substances 0.000 description 2
- JBTWLSYIZRCDFO-UHFFFAOYSA-N ethyl methyl carbonate Chemical compound CCOC(=O)OC JBTWLSYIZRCDFO-UHFFFAOYSA-N 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 238000004128 high performance liquid chromatography Methods 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- DLEDOFVPSDKWEF-UHFFFAOYSA-N lithium butane Chemical compound [Li+].CCC[CH2-] DLEDOFVPSDKWEF-UHFFFAOYSA-N 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 238000004809 thin layer chromatography Methods 0.000 description 2
- BWHDROKFUHTORW-UHFFFAOYSA-N tritert-butylphosphane Chemical compound CC(C)(C)P(C(C)(C)C)C(C)(C)C BWHDROKFUHTORW-UHFFFAOYSA-N 0.000 description 2
- XFQNWPYGEGCIMF-HCUGAJCMSA-N (1e,4e)-1,5-diphenylpenta-1,4-dien-3-one;palladium Chemical compound [Pd].[Pd].[Pd].[Pd].C=1C=CC=CC=1\C=C\C(=O)\C=C\C1=CC=CC=C1.C=1C=CC=CC=1\C=C\C(=O)\C=C\C1=CC=CC=C1.C=1C=CC=CC=1\C=C\C(=O)\C=C\C1=CC=CC=C1.C=1C=CC=CC=1\C=C\C(=O)\C=C\C1=CC=CC=C1.C=1C=CC=CC=1\C=C\C(=O)\C=C\C1=CC=CC=C1.C=1C=CC=CC=1\C=C\C(=O)\C=C\C1=CC=CC=C1 XFQNWPYGEGCIMF-HCUGAJCMSA-N 0.000 description 1
- WQKKKCOXJAJOOL-UHFFFAOYSA-N (4-fluoro-2-pyridin-4-ylphenyl)methylcarbamic acid Chemical compound FC1=CC(=C(CNC(O)=O)C=C1)C1=CC=NC=C1 WQKKKCOXJAJOOL-UHFFFAOYSA-N 0.000 description 1
- BSDGZUDFPKIYQG-UHFFFAOYSA-N 4-bromopyridine Chemical compound BrC1=CC=NC=C1 BSDGZUDFPKIYQG-UHFFFAOYSA-N 0.000 description 1
- XGAFCCUNHIMIRV-UHFFFAOYSA-N 4-chloropyridine;hydron;chloride Chemical compound Cl.ClC1=CC=NC=C1 XGAFCCUNHIMIRV-UHFFFAOYSA-N 0.000 description 1
- DCZHOORNNULHHT-UHFFFAOYSA-N Bc(cc(CNC(OC(C)(C)C)=O)cc1)c1F Chemical compound Bc(cc(CNC(OC(C)(C)C)=O)cc1)c1F DCZHOORNNULHHT-UHFFFAOYSA-N 0.000 description 1
- 0 CCCOc1c(*)c(C)c(C(N(CC2)CCC2c2cc(CN)ccc2F)=O)[s]1 Chemical compound CCCOc1c(*)c(C)c(C(N(CC2)CCC2c2cc(CN)ccc2F)=O)[s]1 0.000 description 1
- FKNQCJSGGFJEIZ-UHFFFAOYSA-N Cc1ccncc1 Chemical compound Cc1ccncc1 FKNQCJSGGFJEIZ-UHFFFAOYSA-N 0.000 description 1
- 238000005481 NMR spectroscopy Methods 0.000 description 1
- 108090000189 Neuropeptides Proteins 0.000 description 1
- 229920000388 Polyphosphate Polymers 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 238000007259 addition reaction Methods 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 230000031018 biological processes and functions Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 125000001246 bromo group Chemical group Br* 0.000 description 1
- 230000003523 bronchorelaxing effect Effects 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 239000007810 chemical reaction solvent Substances 0.000 description 1
- 125000001309 chloro group Chemical group Cl* 0.000 description 1
- 229940125773 compound 10 Drugs 0.000 description 1
- NXQGGXCHGDYOHB-UHFFFAOYSA-L cyclopenta-1,4-dien-1-yl(diphenyl)phosphane;dichloropalladium;iron(2+) Chemical compound [Fe+2].Cl[Pd]Cl.[CH-]1C=CC(P(C=2C=CC=CC=2)C=2C=CC=CC=2)=C1.[CH-]1C=CC(P(C=2C=CC=CC=2)C=2C=CC=CC=2)=C1 NXQGGXCHGDYOHB-UHFFFAOYSA-L 0.000 description 1
- DEZRYPDIMOWBDS-UHFFFAOYSA-N dcm dichloromethane Chemical compound ClCCl.ClCCl DEZRYPDIMOWBDS-UHFFFAOYSA-N 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000010511 deprotection reaction Methods 0.000 description 1
- MQYQOVYIJOLTNX-UHFFFAOYSA-N dichloromethane;n,n-dimethylformamide Chemical compound ClCCl.CN(C)C=O MQYQOVYIJOLTNX-UHFFFAOYSA-N 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- CETRZFQIITUQQL-UHFFFAOYSA-N dmso dimethylsulfoxide Chemical compound CS(C)=O.CS(C)=O CETRZFQIITUQQL-UHFFFAOYSA-N 0.000 description 1
- OLAMWIPURJGSKE-UHFFFAOYSA-N et2o diethylether Chemical compound CCOCC.CCOCC OLAMWIPURJGSKE-UHFFFAOYSA-N 0.000 description 1
- OCLXJTCGWSSVOE-UHFFFAOYSA-N ethanol etoh Chemical compound CCO.CCO OCLXJTCGWSSVOE-UHFFFAOYSA-N 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- OJCSPXHYDFONPU-UHFFFAOYSA-N etoac etoac Chemical compound CCOC(C)=O.CCOC(C)=O OJCSPXHYDFONPU-UHFFFAOYSA-N 0.000 description 1
- KTWOOEGAPBSYNW-UHFFFAOYSA-N ferrocene Chemical compound [Fe+2].C=1C=C[CH-]C=1.C=1C=C[CH-]C=1 KTWOOEGAPBSYNW-UHFFFAOYSA-N 0.000 description 1
- 150000005748 halopyridines Chemical class 0.000 description 1
- 125000001072 heteroaryl group Chemical group 0.000 description 1
- 229960001340 histamine Drugs 0.000 description 1
- 150000003840 hydrochlorides Chemical class 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 125000002346 iodo group Chemical group I* 0.000 description 1
- 229940011051 isopropyl acetate Drugs 0.000 description 1
- GWYFCOCPABKNJV-UHFFFAOYSA-N isovaleric acid Chemical compound CC(C)CC(O)=O GWYFCOCPABKNJV-UHFFFAOYSA-N 0.000 description 1
- ZLVXBBHTMQJRSX-VMGNSXQWSA-N jdtic Chemical compound C1([C@]2(C)CCN(C[C@@H]2C)C[C@H](C(C)C)NC(=O)[C@@H]2NCC3=CC(O)=CC=C3C2)=CC=CC(O)=C1 ZLVXBBHTMQJRSX-VMGNSXQWSA-N 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- COTNUBDHGSIOTA-UHFFFAOYSA-N meoh methanol Chemical compound OC.OC COTNUBDHGSIOTA-UHFFFAOYSA-N 0.000 description 1
- WSFSSNUMVMOOMR-BJUDXGSMSA-N methanone Chemical compound O=[11CH2] WSFSSNUMVMOOMR-BJUDXGSMSA-N 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 239000012074 organic phase Substances 0.000 description 1
- PIBWKRNGBLPSSY-UHFFFAOYSA-L palladium(II) chloride Chemical compound Cl[Pd]Cl PIBWKRNGBLPSSY-UHFFFAOYSA-L 0.000 description 1
- 239000001205 polyphosphate Substances 0.000 description 1
- 235000011176 polyphosphates Nutrition 0.000 description 1
- YSVQLWJDHYBITL-UHFFFAOYSA-N ppse Chemical compound C[Si](C)(C)OP(=O)=O YSVQLWJDHYBITL-UHFFFAOYSA-N 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- WVVOFXZIUIAPGV-UHFFFAOYSA-N tert-butyl n-[(4-fluorophenyl)methyl]carbamate Chemical compound CC(C)(C)OC(=O)NCC1=CC=C(F)C=C1 WVVOFXZIUIAPGV-UHFFFAOYSA-N 0.000 description 1
- WHRNULOCNSKMGB-UHFFFAOYSA-N tetrahydrofuran thf Chemical compound C1CCOC1.C1CCOC1 WHRNULOCNSKMGB-UHFFFAOYSA-N 0.000 description 1
- CZDYPVPMEAXLPK-UHFFFAOYSA-N tetramethylsilane Chemical compound C[Si](C)(C)C CZDYPVPMEAXLPK-UHFFFAOYSA-N 0.000 description 1
- PHCBRBWANGJMHS-UHFFFAOYSA-J tetrasodium;disulfate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O PHCBRBWANGJMHS-UHFFFAOYSA-J 0.000 description 1
- WROMPOXWARCANT-UHFFFAOYSA-N tfa trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.OC(=O)C(F)(F)F WROMPOXWARCANT-UHFFFAOYSA-N 0.000 description 1
- 229920000685 trimethylsilyl polyphosphate Polymers 0.000 description 1
- MHNHYTDAOYJUEZ-UHFFFAOYSA-N triphenylphosphane Chemical compound C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 MHNHYTDAOYJUEZ-UHFFFAOYSA-N 0.000 description 1
- 239000002750 tryptase inhibitor Substances 0.000 description 1
- 230000000304 vasodilatating effect Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J23/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
- B01J23/38—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals
- B01J23/40—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals of the platinum group metals
- B01J23/44—Palladium
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
- C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hydrogenated Pyridines (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
本発明は、4−フルオロ−3−ピペリジン−4−イル−ベンジル)−カルバミン酸tert−ブチルエステル(I)を製造するための改善された方法;より詳細には、3工程でのその合成に関する。第一の工程は、(4−フルオロ−ベンジル)−カルバミン酸tert−ブチルエステルをボロネーション(boronation)条件下で処理することによるボロン酸形成を含む。第二の工程は、第一の工程で得られた5−((tert−ブトキシカルボニル)アミノメチル)−2−フルオロベンゼンボロン酸を、4−クロロ−ピリジン又は4−ブロモ−ピリジンのような4−ハロ−ピリジンとSuzukiカップリング条件下で反応させて、(4−フルオロ−2−ピリジン−4−イル−ベンジル)−カルバミン酸tert−ブチルエステルを得ることを含む。第三の工程は、第二の工程の生成物に対して選択的水素添加条件を使用して化合物Iを得ることを含む。本発明はまた、中間体5−((tert−ブトキシカルボニル)アミノメチル)−2−フルオロベンゼンボロン酸(化合物11)、及び(4−フルオロ−2−ピリジン−4−イル−ベンジル)−カルバミン酸tert−ブチルエステル(化合物13)に関する。
本明細書全体を通して使用される以下の略語及び定義は、別の指示がなければ、以下の意味を有すると理解されるものとする:
n−BuOAc 酢酸n−ブチル
n−BuLi n−ブチルリチウム
t−Bu tert−ブチル
t−BuOH tert−ブタノール
DCM ジクロロメタン、CH2Cl2又は塩化メチレン
DMF ジメチルホルムアミド
DMSO ジメチルスルホキシド
dppf 1,1’−ビス(ジフェニルホスフィノ)フェロセン
eq 当量
Et エチル
Et2O ジエチルエーテル
EtOH エタノール
EtOAc 酢酸エチル
HPLC 高速液体クロマトグラフィー
Me メチル
MTBE メチルt−ブチルエーテル
MeOH メタノール
Na2CO3 炭酸ナトリウム
Na2SO4 硫酸ナトリウム
NMR 核磁気共鳴
Pd(PPh3)4 テトラキストリフェニルホスフィンパラジウム
Pd(PPh3)2Cl2 ビストリフェニルホスフィンパラジウム(II)ジクロリド
PdCl2dppf 1,1’−ビス(ジフェニルホスフィノ)フェロセンパラジウム(II)ジクロリド
Pd(dtbpf)Cl2 (1,1’ビス(ジ−t−ブチルホスフィノ)フェロセンパラジウムジクロリド
Pd2(dba)3 トリス(ジベンジリデンアセトン)二パラジウム(0)
Pd(OAc)2 酢酸パラジウム(II)
P(Cy)3 トリシクロヘキシルホスフィン
t−Bu3P tri−t−ブチルホスフィン
PPh3 トリフェニルホスフィン
PrOH プロパノール
i−PrOH イソプロパノール
i−PrOAc 酢酸イソプロピル
t−BuOK カリウムtert−ブトキシド
PPSE ポリリン酸トリメチルシリルエステル
rt 室温
Rt 保持時間
TFA トリフルオロ酢酸
TFAA トリフルオロ酢酸無水物
THF テトラヒドロフラン
TLC 薄層クロマトグラフィー
「水性酸」は、塩酸、リン酸などのような無機(鉱)酸の水溶液、又は酢酸などのような有機酸の水溶液を意味する。
;又はPPh3、dppf、t−Bu3P、P(Cy)3などのようなホスフィンリガンドと併用する、Pd(OAc)2、Pd2(dba)3などのようなPd触媒を意味する。
本発明の方法の特定の実施態様において、超塩基はn−ブチルリチウムとカリウムtert−ブトキシドとの組み合わせ(「Schlosser塩基」)を意味する。
以下のスキーム1に従って化合物Iを製造するための出発物質は市販されている。
工程A: 5−((tert−ブトキシカルボニル)アミノメチル)−2−フルオロベンゼンボロン酸(11)の製造
1H NMR(300MHz,DMSO−d6)δ9.30−9.10(br s,2H),7.44−7.35(m,1H),7.16−7.03(m,3H),4.08(d,J=6.0Hz,2H),3.31(br s,2H),3.20−2.87(m,3H),1.95−1.80(m,4H),1.39(s,9H)。
Claims (31)
- 5−((tert−ブトキシカルボニル)アミノメチル)−2−フルオロベンゼン−ボロン酸を製造するための方法であって、ボロネーション条件下でボロン酸形成剤を用いる4−(tert−ブトキシカルボニル)アミノメチル)−フルオロベンゼンのボロネーション工程、及び次いで得られた混合物を水性酸でクエンチして5−((tert−ブトキシカルボニル)アミノメチル)−2−フルオロ−ベンゼンボロン酸を得る工程を含む、上記方法。
- ボロネーション条件が超塩基を使用する、請求項1に記載の方法。
- 超塩基が式RLi[ここでRは1〜12個の炭素を有するアルキル基又はアリール基である]の有機リチウム試薬とカリウムtert−ブトキシド又はカリウムtert−ペントキシドなどのような嵩高いカリウムアルコキシドとの組み合わせである、請求項2に記載の方法。
- 超塩基がn−ブチルリチウムとカリウムtert−ブトキシドとの組み合わせである、請求項3に記載の方法。
- ボロネーション条件が、トリアルキルボロネートであるボロン酸形成剤を使用する、請求項1に記載の方法。
- トリアルキルボロネートが、ホウ酸トリメチル、ホウ酸トリエチル、ホウ酸トリプロピル、ホウ酸トリイソプロピル、ホウ酸トリブチルなどから選択される、請求項5に記載の方法。
- トリアルキルボロネートがホウ酸トリイソプロピルである、請求項6に記載の方法。
- ボロネーション条件が、ジエチルエーテル、THF、2−メチルテトラヒドロフラン、MTBE、ジメトキシエタンなどから選択されるエーテル溶媒であるボロネーション溶媒を使用する、請求項1に記載の方法。
- エーテル溶媒がTHFである、請求項8に記載の方法。
- ボロネーション条件が、約−100℃〜約−30℃のボロネーション反応温度を使用する、請求項1に記載の方法。
- ボロネーション反応温度が約−70〜約−45℃である、請求項10に記載の方法。
- 水性酸がHCl又はH3PO4である、請求項1に記載の方法。
- 水性酸がHClである、請求項12に記載の方法。
- (4−フルオロ−3−ピリジン−4−イル−ベンジル)−カルバミン酸tert−ブチルエステルを製造するための方法であって、請求項1に従う5−((tert−ブトキシカルボニル)アミノメチル)−2−フルオロベンゼンボロン酸と4−ハロピリジンとをSuzukiカップリング条件下でカップリングさせて4−フルオロ−3−ピリジン−4−イル−ベンジル)−カルバミン酸tert−ブチルエステルを得ることを含む、上記方法。
- Suzukiカップリング条件が、少なくともi−プロピルアルコールの沸点の沸点を有するアルコール溶媒、極性非プロトン性溶媒、若しくはエーテル溶媒、又は上述の溶媒のいずれか及び水若しくはトルエンの混合物から選択されるSuzukiカップリング溶媒を使用する、請求項14に記載の方法。
- Suzukiカップリング溶媒が、THF、トルエン、2−メチルTHF、又はジメトキシエタンから選択されるエーテル溶媒である、請求項15に記載の方法。
- エーテル溶媒がジメトキシエタンである、請求項16に記載の方法。
- Suzukiカップリング条件が、Pd(PPh3)4、Pd(PPh3)2Cl2、Pd2(dba)3、PdCl2dppf、Pd(dtbpf)Cl2などのようなPd触媒;又はPPh3、dppf、t−Bu3P、P(Cy)3などのようなホスフィンリガンド及び強塩基と併用して、Pd(OAc)2、Pd2(dba)3などのようなPd触媒を使用する、請求項14に記載の方法。
- Suzukiカップリング触媒がPd(PPh3)4である、請求項18に記載の方法。
- Suzukiカップリング条件が、約60℃〜約100℃のSuzukiカップリング反応温度を使用する、請求項14に記載の方法。
- Suzukiカップリング反応温度が約85℃である、請求項20に記載の方法。
- 4−ハロピリジンが4−クロロピリジンである、請求項14に記載の方法。
- (4−フルオロ−3−ピペリジン−4−イル−ベンジル)−カルバミン酸tert−ブチルエステル塩酸塩(I)を製造するための方法であって、請求項11に従う(4−フルオロ−3−ピリジン−4−イル−ベンジル)−カルバミン酸tert−ブチルエステルを水素添加還元条件下で還元する工程、及び次いでHCl後処理を行ってフルオロ−3−ピペリジン−4−イル−ベンジル)−カルバミン酸tert−ブチルエステル塩酸塩を得る工程を含む、上記方法。
- 水素添加還元条件が、HClなどのような無機酸、若しくは酢酸などのような有機酸を加えて、又は加えずに、Pt/C、PtO2、Pd/C、Pd(OH)2、Rh/Cなどから選択される水素添加触媒を使用する、請求項18に記載の方法。
- 水素添加触媒がPtO2である、請求項24に記載の方法。
- 水素添加還元条件が、EtOAc、i−PrOAc、BuOAcなどのようなエステル溶媒;メタノール、エタノール、イソプロピルアルコールなどのようなアルコール溶媒;若しくはAcOH;又はアルコール若しくはエステル溶媒及び水及び酢酸の混合物から選択される水素添加溶媒を使用する、物請求項18に記載の方法。
- 水素添加溶媒がi−PrOAcである、請求項26に記載の方法。
- 水素添加還元条件が約10〜約60℃の水素添加反応温度を使用する、請求項18に記載の方法。
- 水素添加反応温度が約周囲温度である、請求項18に記載の方法。
- 水素添加還元条件が、約10〜約1000psiの水素添加圧力を使用する、請求項18に記載の方法。
- 水素添加圧力が約50〜約60psiである、請求項30に記載の方法。
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PT3150575T (pt) * | 2010-09-27 | 2023-11-13 | Corteva Agriscience Llc | Método de preparação de 2-amino-n-(2,2,2- trifluoroetil)acetamida |
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JPH04500217A (ja) * | 1989-05-30 | 1992-01-16 | メルク・パテント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 弗素化ビフェニル誘導体 |
JP2004529867A (ja) * | 2001-01-11 | 2004-09-30 | クラリアント インターナショナル リミテッド | フッ素化芳香族化合物および液晶混合物におけるこの使用 |
JP2007526264A (ja) * | 2004-03-02 | 2007-09-13 | アベンティス・ファーマスーティカルズ・インコーポレイテツド | トリプターゼ阻害剤の製造方法 |
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JPH04500217A (ja) * | 1989-05-30 | 1992-01-16 | メルク・パテント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 弗素化ビフェニル誘導体 |
JP2004529867A (ja) * | 2001-01-11 | 2004-09-30 | クラリアント インターナショナル リミテッド | フッ素化芳香族化合物および液晶混合物におけるこの使用 |
JP2007526264A (ja) * | 2004-03-02 | 2007-09-13 | アベンティス・ファーマスーティカルズ・インコーポレイテツド | トリプターゼ阻害剤の製造方法 |
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JP2016179968A (ja) * | 2015-03-25 | 2016-10-13 | 公益財団法人相模中央化学研究所 | 一置換(フルオロアルキル)エチレン類及びその製造方法 |
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US20120184745A1 (en) | 2012-07-19 |
RU2012116346A (ru) | 2013-10-27 |
CA2774614A1 (en) | 2011-03-31 |
RU2543483C2 (ru) | 2015-03-10 |
EP2483243B1 (en) | 2015-03-18 |
MX2012003023A (es) | 2012-04-10 |
WO2011037947A1 (en) | 2011-03-31 |
IL218680A0 (en) | 2012-05-31 |
CN102574792A (zh) | 2012-07-11 |
SG179201A1 (en) | 2012-05-30 |
US8633321B2 (en) | 2014-01-21 |
MY155682A (en) | 2015-11-13 |
CA2774614C (en) | 2015-03-10 |
BR112012006519A2 (pt) | 2015-09-08 |
AU2010298425A1 (en) | 2012-04-19 |
EP2483243A1 (en) | 2012-08-08 |
CN102574792B (zh) | 2014-07-09 |
KR20120083357A (ko) | 2012-07-25 |
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