JP2013505296A5 - - Google Patents
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- JP2013505296A5 JP2013505296A5 JP2012530955A JP2012530955A JP2013505296A5 JP 2013505296 A5 JP2013505296 A5 JP 2013505296A5 JP 2012530955 A JP2012530955 A JP 2012530955A JP 2012530955 A JP2012530955 A JP 2012530955A JP 2013505296 A5 JP2013505296 A5 JP 2013505296A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- activated
- lymphocytes
- cells
- antigenic peptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 210000001744 T-lymphocyte Anatomy 0.000 claims description 76
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 37
- 238000000034 method Methods 0.000 claims description 33
- 210000004027 cell Anatomy 0.000 claims description 31
- 230000000890 antigenic effect Effects 0.000 claims description 20
- 241000255581 Drosophila <fruit fly, genus> Species 0.000 claims description 19
- 108010002350 Interleukin-2 Proteins 0.000 claims description 13
- 239000000427 antigen Substances 0.000 claims description 13
- 102000036639 antigens Human genes 0.000 claims description 13
- 108091007433 antigens Proteins 0.000 claims description 13
- 108010002586 Interleukin-7 Proteins 0.000 claims description 12
- 102000000704 Interleukin-7 Human genes 0.000 claims description 12
- 239000000203 mixture Substances 0.000 claims description 12
- 102000004127 Cytokines Human genes 0.000 claims description 10
- 108090000695 Cytokines Proteins 0.000 claims description 10
- 208000034578 Multiple myelomas Diseases 0.000 claims description 10
- 206010035226 Plasma cell myeloma Diseases 0.000 claims description 10
- 230000004069 differentiation Effects 0.000 claims description 9
- 102000003812 Interleukin-15 Human genes 0.000 claims description 8
- 108090000172 Interleukin-15 Proteins 0.000 claims description 8
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 8
- 206010028980 Neoplasm Diseases 0.000 claims description 7
- 230000001464 adherent effect Effects 0.000 claims description 7
- 201000011510 cancer Diseases 0.000 claims description 7
- 230000012010 growth Effects 0.000 claims description 7
- 108010074108 interleukin-21 Proteins 0.000 claims description 7
- 230000035755 proliferation Effects 0.000 claims description 7
- 231100000433 cytotoxic Toxicity 0.000 claims description 6
- 230000001472 cytotoxic effect Effects 0.000 claims description 6
- 230000001737 promoting effect Effects 0.000 claims description 6
- 210000000612 antigen-presenting cell Anatomy 0.000 claims description 5
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 5
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims description 4
- 102000013462 Interleukin-12 Human genes 0.000 claims description 4
- 108010065805 Interleukin-12 Proteins 0.000 claims description 4
- 108090000978 Interleukin-4 Proteins 0.000 claims description 4
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims description 4
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims description 4
- 230000003213 activating effect Effects 0.000 claims description 4
- -1 IFN-g Proteins 0.000 claims description 3
- 102000013691 Interleukin-17 Human genes 0.000 claims description 3
- 108050003558 Interleukin-17 Proteins 0.000 claims description 3
- 108010071384 Peptide T Proteins 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 102000014314 Dynamin-1-like proteins Human genes 0.000 description 4
- 108050003303 Dynamin-1-like proteins Proteins 0.000 description 4
- 230000003321 amplification Effects 0.000 description 4
- 239000013592 cell lysate Substances 0.000 description 4
- 238000003199 nucleic acid amplification method Methods 0.000 description 4
- 238000001262 western blot Methods 0.000 description 4
- 230000010261 cell growth Effects 0.000 description 3
- 101000946889 Homo sapiens Monocyte differentiation antigen CD14 Proteins 0.000 description 2
- 102100035877 Monocyte differentiation antigen CD14 Human genes 0.000 description 2
- 230000004913 activation Effects 0.000 description 2
- 230000004663 cell proliferation Effects 0.000 description 2
- 238000002659 cell therapy Methods 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 210000004366 CD4-positive T-lymphocyte Anatomy 0.000 description 1
- 241000283707 Capra Species 0.000 description 1
- 241000283074 Equus asinus Species 0.000 description 1
- 102100037850 Interferon gamma Human genes 0.000 description 1
- 108010074328 Interferon-gamma Proteins 0.000 description 1
- 101710102907 Interferon-induced GTP-binding protein Mx Proteins 0.000 description 1
- 108010002352 Interleukin-1 Proteins 0.000 description 1
- 102100030703 Interleukin-22 Human genes 0.000 description 1
- 108010002616 Interleukin-5 Proteins 0.000 description 1
- 108090001005 Interleukin-6 Proteins 0.000 description 1
- 239000000020 Nitrocellulose Substances 0.000 description 1
- 206010042618 Surgical procedure repeated Diseases 0.000 description 1
- 210000000447 Th1 cell Anatomy 0.000 description 1
- 210000004241 Th2 cell Anatomy 0.000 description 1
- 230000006037 cell lysis Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 210000004748 cultured cell Anatomy 0.000 description 1
- 230000009089 cytolysis Effects 0.000 description 1
- 231100000135 cytotoxicity Toxicity 0.000 description 1
- 230000003013 cytotoxicity Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 239000006166 lysate Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 210000003071 memory t lymphocyte Anatomy 0.000 description 1
- 229920001220 nitrocellulos Polymers 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/564,501 | 2009-09-22 | ||
| US12/564,501 US8075895B2 (en) | 2009-09-22 | 2009-09-22 | Identification of antigenic peptides from multiple myeloma cells |
| PCT/US2010/049466 WO2011037859A2 (en) | 2009-09-22 | 2010-09-20 | Identification of antigenic peptides from multiple myeloma cells |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013505296A JP2013505296A (ja) | 2013-02-14 |
| JP2013505296A5 true JP2013505296A5 (https=) | 2015-07-30 |
| JP5916613B2 JP5916613B2 (ja) | 2016-05-11 |
Family
ID=43756801
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012530955A Expired - Fee Related JP5916613B2 (ja) | 2009-09-22 | 2010-09-20 | 多発性骨髄腫細胞からの抗原ペプチドの同定 |
Country Status (8)
| Country | Link |
|---|---|
| US (4) | US8075895B2 (https=) |
| EP (1) | EP2480562B1 (https=) |
| JP (1) | JP5916613B2 (https=) |
| AU (1) | AU2010298519B2 (https=) |
| CA (1) | CA2774946A1 (https=) |
| IL (1) | IL218720A0 (https=) |
| NZ (1) | NZ598932A (https=) |
| WO (1) | WO2011037859A2 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10611837B2 (en) | 2014-04-10 | 2020-04-07 | Seattle Children's Hospital | Transgene genetic tags and methods of use |
| AU2016306209B2 (en) | 2015-08-07 | 2023-07-06 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Bispecific CAR T-cells for solid tumor targeting |
| WO2017147058A1 (en) | 2016-02-26 | 2017-08-31 | Beth Israel Deaconess Medical Center, Inc. | Niacinamide (nam) in ischemic tissue injury |
| CN109715196A (zh) | 2016-06-13 | 2019-05-03 | 转矩医疗股份有限公司 | 用于促进免疫细胞功能的组合物和方法 |
| WO2018057776A1 (en) | 2016-09-22 | 2018-03-29 | Regeneron Pharmaceuticals, Inc. | Methods for treating severe atopic dermatitis by administering an il-4r inhibitor |
| US11408005B2 (en) | 2016-12-12 | 2022-08-09 | Seattle Children's Hospital | Chimeric transcription factor variants with augmented sensitivity to drug ligand induction of transgene expression in mammalian cells |
| CN110199017A (zh) | 2017-01-20 | 2019-09-03 | 国立大学法人京都大学 | CD8α+β+细胞毒性T细胞的制备方法 |
| CA3074826A1 (en) | 2017-09-05 | 2019-03-14 | Torque Therapeutics, Inc. | Therapeutic protein compositions and methods of making and using the same |
| SG11202104611YA (en) * | 2018-11-08 | 2021-06-29 | Neximmune Inc | T cell compositions with improved phenotypic properties |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5766920A (en) | 1982-08-11 | 1998-06-16 | Cellcor, Inc. | Ex vivo activation of immune cells |
| US4690915A (en) | 1985-08-08 | 1987-09-01 | The United States Of America As Represented By The Department Of Health And Human Services | Adoptive immunotherapy as a treatment modality in humans |
| WO1988000970A2 (en) | 1986-08-08 | 1988-02-11 | Regents Of The University Of Minnesota | Method of culturing leukocytes |
| US4844893A (en) | 1986-10-07 | 1989-07-04 | Scripps Clinic And Research Foundation | EX vivo effector cell activation for target cell killing |
| US5126132A (en) | 1989-08-21 | 1992-06-30 | The United States Of America As Represented By The Department Of Health And Human Services | Tumor infiltrating lymphocytes as a treatment modality for human cancer |
| US5728388A (en) | 1989-10-03 | 1998-03-17 | Terman; David S. | Method of cancer treatment |
| EP0726941B1 (en) | 1993-08-06 | 2002-04-03 | Epimmune Inc. | Methods for (ex vivo) therapy using peptide-loaded antigen presenting cells for the activation of ctl |
| IL109540A0 (en) * | 1994-05-03 | 1994-08-26 | Yeda Res & Dev | Synthetic peptides and their use in tumor diagnosis and therapy |
| US5827642A (en) | 1994-08-31 | 1998-10-27 | Fred Hutchinson Cancer Research Center | Rapid expansion method ("REM") for in vitro propagation of T lymphocytes |
| WO1996018409A1 (en) | 1994-12-14 | 1996-06-20 | The Scripps Research Institute | In vivo activation of tumor-specific cytotoxic t cells |
| CA2214649C (en) | 1995-03-08 | 2007-06-12 | Zeling Cai | Antigen presenting system and methods for activation of t-cells |
| ES2278390T3 (es) | 1996-05-23 | 2007-08-01 | The Scripps Research Institute | Sistema de presentacion de antigenos de clase ii de cmh y procedimientos de activacion de linfocitos t cd4+. |
| CA2278847A1 (en) | 1997-01-31 | 1998-08-06 | Hemosol Inc. | Method for the production of selected lymphocytes |
| US6790662B1 (en) | 1999-03-12 | 2004-09-14 | Ortho-Mcneil Pharmaceutical, Inc. | Method of isolating CD8+ cells, and related hybridoma cells antibodies and polypeptides |
| AU3087801A (en) * | 2000-02-04 | 2001-08-14 | Molecular Dynamics Inc | Human genome-derived single exon nucleic acid probes useful for analysis of geneexpression in human breast and hbl 100 cells |
| US20020048763A1 (en) * | 2000-02-04 | 2002-04-25 | Penn Sharron Gaynor | Human genome-derived single exon nucleic acid probes useful for gene expression analysis |
| ES2292619T3 (es) | 2000-09-15 | 2008-03-16 | Ortho-Mcneil Pharmaceutical, Inc. | Composiciones y metodos para inducir respuestas citologicas especificas de la celula t. |
| US20090062512A1 (en) * | 2000-10-10 | 2009-03-05 | Hildebrand William H | Comparative ligand mapping from MHC class I positive cells |
| US7919467B2 (en) * | 2000-12-04 | 2011-04-05 | Immunotope, Inc. | Cytotoxic T-lymphocyte-inducing immunogens for prevention, treatment, and diagnosis of cancer |
| US20040071671A1 (en) | 2001-02-20 | 2004-04-15 | Leturcq Didier J. | Cell therapy method for the treatment of tumors |
| US7811816B2 (en) * | 2001-05-15 | 2010-10-12 | Ortho-Mcneil Pharmaeutical, Inc. | Isolated CD8 +T lymphocytes specifically cytotoxic for a disease causing target cell |
| US20050053918A1 (en) * | 2001-05-16 | 2005-03-10 | Technion Research & Development Foundation Ltd. | Method of identifying peptides capable of binding to MHC molecules, peptides identified thereby and their uses |
| JP2004527263A (ja) | 2001-05-30 | 2004-09-09 | フォンダツィオーネ テレソン | 免疫抑制活性を有するエクスビボ単離ｃｄ２５＋ｃｄ４＋ｔ細胞とその使用 |
| DE10148236A1 (de) * | 2001-09-29 | 2003-04-24 | Immugenics Ag | Tumor-Peptidantigene aus humanem PRDI-BF1-Protein |
| WO2003033667A2 (en) * | 2001-10-18 | 2003-04-24 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Use of mx gtpases in the prognosis and treatment of cancer |
| US7371736B2 (en) * | 2001-11-07 | 2008-05-13 | The Board Of Trustees Of The University Of Arkansas | Gene expression profiling based identification of DKK1 as a potential therapeutic targets for controlling bone loss |
| DE10225144A1 (de) * | 2002-05-29 | 2003-12-18 | Immatics Biotechnologies Gmbh | An MHC-Moleküle bindende Tumor-assoziierte Peptide |
| US8222033B2 (en) | 2002-08-12 | 2012-07-17 | Argos Therapeutics, Inc. | CD4+CD25− T cells and Tr1-like regulatory T cells |
| DE102004026135A1 (de) * | 2004-05-25 | 2006-01-05 | Immatics Biotechnologies Gmbh | An MHC-Moleküle bindende Tumor-assoziierte Peptide |
| CN101160524A (zh) * | 2005-02-24 | 2008-04-09 | 西米尼斯公司 | 用于生物样品分类的组合物和方法 |
| WO2007035717A2 (en) * | 2005-09-19 | 2007-03-29 | The Rockefeller University | Glycolipids and analogues thereof as antigents for nk t cells |
| AU2006328945B2 (en) * | 2005-12-21 | 2011-06-30 | Sentoclone International Ab | Method for treating malignant melanoma |
| CA2643337C (en) | 2006-03-01 | 2016-01-12 | Janssen Pharmaceutica N.V. | Cancer treatment combining lymphodepleting agent with ctls and cytokines |
| JP5543207B2 (ja) | 2006-10-04 | 2014-07-09 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 不活性化された人工抗原提示細胞の調製および細胞治療におけるそれらの使用 |
| US20090028847A1 (en) * | 2007-04-12 | 2009-01-29 | Trustees Of Boston University | Multiple myeloma and al amyloid immunotherapy targeting immunoglobulin light chains and uses thereof |
-
2009
- 2009-09-22 US US12/564,501 patent/US8075895B2/en not_active Expired - Fee Related
-
2010
- 2010-09-20 CA CA2774946A patent/CA2774946A1/en not_active Abandoned
- 2010-09-20 WO PCT/US2010/049466 patent/WO2011037859A2/en not_active Ceased
- 2010-09-20 JP JP2012530955A patent/JP5916613B2/ja not_active Expired - Fee Related
- 2010-09-20 EP EP10819298.0A patent/EP2480562B1/en active Active
- 2010-09-20 NZ NZ598932A patent/NZ598932A/en not_active IP Right Cessation
- 2010-09-20 AU AU2010298519A patent/AU2010298519B2/en not_active Ceased
-
2011
- 2011-10-31 US US13/285,459 patent/US8232101B2/en not_active Expired - Fee Related
- 2011-10-31 US US13/285,491 patent/US8323965B2/en not_active Expired - Fee Related
- 2011-10-31 US US13/285,517 patent/US8323655B2/en not_active Expired - Fee Related
-
2012
- 2012-03-19 IL IL218720A patent/IL218720A0/en not_active IP Right Cessation
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