AU2010298519B2 - Identification of antigenic peptides from multiple myeloma cells - Google Patents

Identification of antigenic peptides from multiple myeloma cells Download PDF

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Publication number
AU2010298519B2
AU2010298519B2 AU2010298519A AU2010298519A AU2010298519B2 AU 2010298519 B2 AU2010298519 B2 AU 2010298519B2 AU 2010298519 A AU2010298519 A AU 2010298519A AU 2010298519 A AU2010298519 A AU 2010298519A AU 2010298519 B2 AU2010298519 B2 AU 2010298519B2
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seq
cells
activated
lymphocytes
peptide
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AU2010298519A1 (en
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Zeling Cai
Xuejun P. Liu
Wei-Xing Shi
Jiejun Wu
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Janssen Pharmaceutica NV
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/08Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/10Cellular immunotherapy characterised by the cell type used
    • A61K40/11T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/40Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41Vertebrate antigens
    • A61K40/42Cancer antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
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    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
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    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
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    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0636T lymphocytes
    • C12N5/0638Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/57Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20Cytokines; Chemokines
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    • C12N2501/2302Interleukin-2 (IL-2)
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    • C12N2501/20Cytokines; Chemokines
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    • C12N2501/50Cell markers; Cell surface determinants
    • C12N2501/58Adhesion molecules, e.g. ICAM, VCAM, CD18 (ligand), CD11 (ligand), CD49 (ligand)
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    • C12N2502/00Coculture with; Conditioned medium produced by
    • C12N2502/99Coculture with; Conditioned medium produced by genetically modified cells

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  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
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  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
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  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Mycology (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AU2010298519A 2009-09-22 2010-09-20 Identification of antigenic peptides from multiple myeloma cells Ceased AU2010298519B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12/564,501 2009-09-22
US12/564,501 US8075895B2 (en) 2009-09-22 2009-09-22 Identification of antigenic peptides from multiple myeloma cells
PCT/US2010/049466 WO2011037859A2 (en) 2009-09-22 2010-09-20 Identification of antigenic peptides from multiple myeloma cells

Publications (2)

Publication Number Publication Date
AU2010298519A1 AU2010298519A1 (en) 2012-04-12
AU2010298519B2 true AU2010298519B2 (en) 2015-11-05

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AU2010298519A Ceased AU2010298519B2 (en) 2009-09-22 2010-09-20 Identification of antigenic peptides from multiple myeloma cells

Country Status (8)

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US (4) US8075895B2 (https=)
EP (1) EP2480562B1 (https=)
JP (1) JP5916613B2 (https=)
AU (1) AU2010298519B2 (https=)
CA (1) CA2774946A1 (https=)
IL (1) IL218720A0 (https=)
NZ (1) NZ598932A (https=)
WO (1) WO2011037859A2 (https=)

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AU2016306209B2 (en) 2015-08-07 2023-07-06 Seattle Children's Hospital (dba Seattle Children's Research Institute) Bispecific CAR T-cells for solid tumor targeting
WO2017147058A1 (en) 2016-02-26 2017-08-31 Beth Israel Deaconess Medical Center, Inc. Niacinamide (nam) in ischemic tissue injury
CN109715196A (zh) 2016-06-13 2019-05-03 转矩医疗股份有限公司 用于促进免疫细胞功能的组合物和方法
WO2018057776A1 (en) 2016-09-22 2018-03-29 Regeneron Pharmaceuticals, Inc. Methods for treating severe atopic dermatitis by administering an il-4r inhibitor
US11408005B2 (en) 2016-12-12 2022-08-09 Seattle Children's Hospital Chimeric transcription factor variants with augmented sensitivity to drug ligand induction of transgene expression in mammalian cells
CN110199017A (zh) 2017-01-20 2019-09-03 国立大学法人京都大学 CD8α+β+细胞毒性T细胞的制备方法
CA3074826A1 (en) 2017-09-05 2019-03-14 Torque Therapeutics, Inc. Therapeutic protein compositions and methods of making and using the same
SG11202104611YA (en) * 2018-11-08 2021-06-29 Neximmune Inc T cell compositions with improved phenotypic properties

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Publication number Publication date
WO2011037859A3 (en) 2011-05-19
US20120046645A1 (en) 2012-02-23
NZ598932A (en) 2014-10-31
US8323965B2 (en) 2012-12-04
US20110070185A1 (en) 2011-03-24
JP2013505296A (ja) 2013-02-14
US20120045829A1 (en) 2012-02-23
US8232101B2 (en) 2012-07-31
JP5916613B2 (ja) 2016-05-11
US8323655B2 (en) 2012-12-04
EP2480562A4 (en) 2013-03-13
IL218720A0 (en) 2012-06-28
EP2480562A2 (en) 2012-08-01
US20120045466A1 (en) 2012-02-23
EP2480562B1 (en) 2015-10-21
US8075895B2 (en) 2011-12-13
AU2010298519A1 (en) 2012-04-12
WO2011037859A2 (en) 2011-03-31
CA2774946A1 (en) 2011-03-31

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