JP2013505223A - ＥｐＣＡＭｘＣＤ３二重特異性抗体を投与するための投与計画 - Google Patents
ＥｐＣＡＭｘＣＤ３二重特異性抗体を投与するための投与計画 Download PDFInfo
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- C—CHEMISTRY; METALLURGY
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
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- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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- C—CHEMISTRY; METALLURGY
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- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
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Landscapes
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Applications Claiming Priority (9)
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| US24365109P | 2009-09-18 | 2009-09-18 | |
| US61/243,651 | 2009-09-18 | ||
| EP09170715.8 | 2009-09-18 | ||
| EP09170715 | 2009-09-18 | ||
| US34414710P | 2010-06-01 | 2010-06-01 | |
| EP10164596.8 | 2010-06-01 | ||
| US61/344,147 | 2010-06-01 | ||
| EP10164596 | 2010-06-01 | ||
| PCT/EP2010/063795 WO2011033105A1 (en) | 2009-09-18 | 2010-09-20 | Dosage regimen for administering an epcamxcd3 bispecific antibody |
Publications (2)
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| JP2013505223A true JP2013505223A (ja) | 2013-02-14 |
| JP2013505223A5 JP2013505223A5 (OSRAM) | 2013-11-28 |
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| Country | Link |
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| US (1) | US20120244161A1 (OSRAM) |
| EP (1) | EP2477653A1 (OSRAM) |
| JP (1) | JP2013505223A (OSRAM) |
| KR (1) | KR20120083359A (OSRAM) |
| CN (1) | CN102711825A (OSRAM) |
| AU (1) | AU2010297258A1 (OSRAM) |
| BR (1) | BR112012008345A2 (OSRAM) |
| CA (1) | CA2774732A1 (OSRAM) |
| IL (1) | IL218637A0 (OSRAM) |
| IN (1) | IN2012DN03172A (OSRAM) |
| MX (1) | MX2012003175A (OSRAM) |
| NZ (1) | NZ598601A (OSRAM) |
| RU (1) | RU2012115480A (OSRAM) |
| SG (2) | SG10201405434VA (OSRAM) |
| WO (1) | WO2011033105A1 (OSRAM) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2016514098A (ja) * | 2013-02-26 | 2016-05-19 | ロシュ グリクアート アーゲー | 二重特異性ｔ細胞活性化抗原結合分子 |
| JP2018533909A (ja) * | 2015-08-28 | 2018-11-22 | アムニクス オペレーティング インコーポレイテッド | キメラポリペプチドアセンブリーならびにそれを作製および使用する方法 |
| JP2019515872A (ja) * | 2016-03-30 | 2019-06-13 | リンドホーファー，ホルスト | 尿路の新生物の治療における使用のための多重特異性抗体 |
| JP2024540461A (ja) * | 2021-11-19 | 2024-10-31 | 武▲漢▼友芝友生物制▲薬▼股▲ふん▼有限公司 | 二重特異性抗体及びその用途 |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107936121B (zh) * | 2011-05-16 | 2022-01-14 | 埃泰美德(香港)有限公司 | 多特异性fab融合蛋白及其使用方法 |
| WO2013083809A1 (en) | 2011-12-09 | 2013-06-13 | Amgen Research (Munich) Gmbh | Prevention of adverse effects caused by epcamxcd3 bispecific antibodies |
| GB201302447D0 (en) | 2013-02-12 | 2013-03-27 | Oxford Biotherapeutics Ltd | Therapeutic and diagnostic target |
| PL2956477T5 (pl) | 2013-02-15 | 2024-05-27 | Bioverativ Therapeutics Inc. | Zoptymalizowany gen czynnika viii |
| WO2015105995A2 (en) * | 2014-01-08 | 2015-07-16 | The Board Of Trustees Of The Leland Stanford Junior University | Targeted therapy for small cell lung cancer |
| WO2016004113A1 (en) | 2014-06-30 | 2016-01-07 | Biogen Ma Inc. | Optimized factor ix gene |
| ES2873846T5 (en) * | 2015-11-19 | 2025-06-23 | Revitope Ltd | Functional antibody fragment complementation for a two-components system for redirected killing of unwanted cells |
| PT3411478T (pt) | 2016-02-01 | 2022-09-13 | Bioverativ Therapeutics Inc | Genes do fator viii otimizados |
| US12128102B2 (en) | 2016-03-08 | 2024-10-29 | Takeda Pharmaceutical Company Limited | Constrained conditionally activated binding proteins |
| US10870701B2 (en) | 2016-03-15 | 2020-12-22 | Generon (Shanghai) Corporation Ltd. | Multispecific fab fusion proteins and use thereof |
| EP3409322A1 (en) * | 2017-06-01 | 2018-12-05 | F. Hoffmann-La Roche AG | Treatment method |
| KR20240170847A (ko) * | 2017-09-08 | 2024-12-04 | 다케다 야쿠힌 고교 가부시키가이샤 | 제약된 조건적으로 활성화된 결합 단백질 |
| EP3847196A4 (en) | 2018-09-07 | 2023-01-04 | ITabMed (HK) Limited | BISPECIFIC ANTIGEN BINDING PROTEINS AND USES THEREOF |
| CN120484127A (zh) | 2019-03-05 | 2025-08-15 | 武田药品工业有限公司 | 受约束的条件性活化的结合蛋白 |
| WO2021067389A1 (en) | 2019-09-30 | 2021-04-08 | Bioverativ Therapeutics Inc. | Lentiviral vector formulations |
| US12173307B2 (en) | 2020-06-24 | 2024-12-24 | Bioverativ Therapeutics Inc. | Methods for the purification of viral vectors |
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| JPH02500329A (ja) | 1987-05-21 | 1990-02-08 | クリエイテイブ・バイオマリキユールズ・インコーポレーテツド | ターゲット化多機能蛋白質 |
| KR20120125634A (ko) | 2003-10-16 | 2012-11-16 | 마이크로메트 에이지 | 다중특이적 탈면역화된 ｃｄ3-바인더 |
| WO2006114115A1 (de) * | 2005-04-26 | 2006-11-02 | Trion Pharma Gmbh | Kombination von antikörpern mit glukokortikoiden zur behandlung von krebs |
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2010
- 2010-09-20 IN IN3172DEN2012 patent/IN2012DN03172A/en unknown
- 2010-09-20 JP JP2012529298A patent/JP2013505223A/ja active Pending
- 2010-09-20 CN CN2010800523771A patent/CN102711825A/zh active Pending
- 2010-09-20 CA CA2774732A patent/CA2774732A1/en not_active Abandoned
- 2010-09-20 US US13/496,836 patent/US20120244161A1/en not_active Abandoned
- 2010-09-20 MX MX2012003175A patent/MX2012003175A/es not_active Application Discontinuation
- 2010-09-20 EP EP10755167A patent/EP2477653A1/en not_active Withdrawn
- 2010-09-20 AU AU2010297258A patent/AU2010297258A1/en not_active Abandoned
- 2010-09-20 RU RU2012115480/15A patent/RU2012115480A/ru not_active Application Discontinuation
- 2010-09-20 KR KR1020127007677A patent/KR20120083359A/ko not_active Withdrawn
- 2010-09-20 BR BR112012008345A patent/BR112012008345A2/pt not_active IP Right Cessation
- 2010-09-20 SG SG10201405434VA patent/SG10201405434VA/en unknown
- 2010-09-20 NZ NZ598601A patent/NZ598601A/en not_active IP Right Cessation
- 2010-09-20 SG SG2012016044A patent/SG179027A1/en unknown
- 2010-09-20 WO PCT/EP2010/063795 patent/WO2011033105A1/en not_active Ceased
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2012
- 2012-03-14 IL IL218637A patent/IL218637A0/en unknown
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| JPN5012016871; ＳＥＢＡＳＴＩＡＮ ＭＡＲＴＩＮ: 'ＴＲＥＡＴＭＥＮＴ ＯＦ ＭＡＬＩＧＮＡＮＴ ＰＬＥＵＲＡＬ ＥＦＦＵＳＩＯＮ ＷＩＴＨ ＴＨＥ ＴＲＩＦＵＮＣＴＩＯＮＡＬ ＡＮＴＩＢＯＤＹ 以下備考' ＪＯＵＲＮＡＬ ＯＦ ＩＭＭＵＮＯＴＨＥＲＡＰＹ Ｖ３２ Ｎ２, 200902, Ｐ１９５-２０２ * |
| JPN5012016872; ＡＭＡＮＮ ＭＡＲＩＡ: 'ＡＮＴＩＴＵＭＯＲ ＡＣＴＩＶＩＴＹ ＯＦ ＡＮ ＥＰＣＡＭ／ＣＤ３-ＢＩＳＰＥＣＩＦＩＣ ＢＩＴＥ ＡＮＴＩＢＯＤＹ ＤＵＲＩＮＧ ＬＯＮＧ-ＴＥＲＭ 以下備考' ＪＯＵＲＮＡＬ ＯＦ ＩＭＭＵＮＯＴＨＥＲＡＰＹ Ｖ３２ Ｎ５, 200906, Ｐ４５２-４６４ * |
| JPN5012016873; ＦＩＥＤＬＥＲ Ｗ: '１２５４ ＳＡＦＥＴＹ ＡＮＤ ＰＨＡＲＭＡＣＯＬＯＧＹ ＯＦ ＴＨＥ ＥＰＣＡＭ／ＣＤ３-ＢＩＳＰＥＣＩＦＩＣ ＢＩＴＥ ＡＮＴＩＢＯＤＹ ＭＴ１１０ 以下備考' ＥＵＲＯＰＥＡＮ ＪＯＵＲＮＡＬ ＯＦ ＣＡＮＣＥＲ， ＳＵＰＰＬＥＭＥＮＴ Ｖ７ Ｎ２, 20090901, Ｐ１３６-１３７, ＰＥＲＧＡＭＯＮ * |
Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7057801B2 (ja) | 2013-02-26 | 2022-04-20 | ロシュ グリクアート アーゲー | 二重特異性ｔ細胞活性化抗原結合分子 |
| JP2016514098A (ja) * | 2013-02-26 | 2016-05-19 | ロシュ グリクアート アーゲー | 二重特異性ｔ細胞活性化抗原結合分子 |
| JP2019135233A (ja) * | 2013-02-26 | 2019-08-15 | ロシュ グリクアート アーゲー | 二重特異性ｔ細胞活性化抗原結合分子 |
| US11459404B2 (en) | 2013-02-26 | 2022-10-04 | Roche Glycart Ag | Bispecific T cell activating antigen binding molecules |
| JP2020202829A (ja) * | 2013-02-26 | 2020-12-24 | ロシュ グリクアート アーゲー | 二重特異性ｔ細胞活性化抗原結合分子 |
| JP2024105275A (ja) * | 2015-08-28 | 2024-08-06 | アムニクス ファーマシューティカルズ， インコーポレイテッド | キメラポリペプチドアセンブリーならびにそれを作製および使用する方法 |
| JP2018533909A (ja) * | 2015-08-28 | 2018-11-22 | アムニクス オペレーティング インコーポレイテッド | キメラポリペプチドアセンブリーならびにそれを作製および使用する方法 |
| JP2021178831A (ja) * | 2015-08-28 | 2021-11-18 | アムニクス ファーマシューティカルズ， インコーポレイテッド | キメラポリペプチドアセンブリーならびにそれを作製および使用する方法 |
| KR102435747B1 (ko) * | 2016-03-30 | 2022-08-23 | 린톤 퍼시픽 아게 | 요로의 신생물을 치료하는데 사용하기 위한 다중특이적 항체 |
| JP2021020906A (ja) * | 2016-03-30 | 2021-02-18 | リンドホーファー，ホルスト | 尿路の新生物の治療における使用のための多重特異性抗体 |
| KR20210086722A (ko) * | 2016-03-30 | 2021-07-08 | 린톤 퍼시픽 아게 | 요로의 신생물을 치료하는데 사용하기 위한 다중특이적 항체 |
| KR20200123871A (ko) * | 2016-03-30 | 2020-10-30 | 호르스트 린트호퍼 | 요로의 신생물을 치료하는데 사용하기 위한 다중특이적 항체 |
| JP7354079B2 (ja) | 2016-03-30 | 2023-10-02 | リントン パシフィック アーゲー | 尿路の新生物の治療における使用のための多重特異性抗体 |
| JP2019515872A (ja) * | 2016-03-30 | 2019-06-13 | リンドホーファー，ホルスト | 尿路の新生物の治療における使用のための多重特異性抗体 |
| JP2024540461A (ja) * | 2021-11-19 | 2024-10-31 | 武▲漢▼友芝友生物制▲薬▼股▲ふん▼有限公司 | 二重特異性抗体及びその用途 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2477653A1 (en) | 2012-07-25 |
| MX2012003175A (es) | 2012-04-11 |
| RU2012115480A (ru) | 2013-10-27 |
| KR20120083359A (ko) | 2012-07-25 |
| AU2010297258A1 (en) | 2012-03-29 |
| US20120244161A1 (en) | 2012-09-27 |
| SG179027A1 (en) | 2012-04-27 |
| SG10201405434VA (en) | 2014-10-30 |
| IN2012DN03172A (OSRAM) | 2015-09-25 |
| CA2774732A1 (en) | 2011-03-24 |
| NZ598601A (en) | 2014-05-30 |
| BR112012008345A2 (pt) | 2016-08-09 |
| CN102711825A (zh) | 2012-10-03 |
| IL218637A0 (en) | 2012-05-31 |
| WO2011033105A1 (en) | 2011-03-24 |
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