JP2013504630A5 - - Google Patents

Download PDF

Info

Publication number
JP2013504630A5
JP2013504630A5 JP2012529881A JP2012529881A JP2013504630A5 JP 2013504630 A5 JP2013504630 A5 JP 2013504630A5 JP 2012529881 A JP2012529881 A JP 2012529881A JP 2012529881 A JP2012529881 A JP 2012529881A JP 2013504630 A5 JP2013504630 A5 JP 2013504630A5
Authority
JP
Japan
Prior art keywords
composition
use according
cancer
administered
subject
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2012529881A
Other languages
English (en)
Japanese (ja)
Other versions
JP2013504630A (ja
JP5855568B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2010/048973 external-priority patent/WO2011034954A1/en
Publication of JP2013504630A publication Critical patent/JP2013504630A/ja
Publication of JP2013504630A5 publication Critical patent/JP2013504630A5/ja
Application granted granted Critical
Publication of JP5855568B2 publication Critical patent/JP5855568B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2012529881A 2009-09-15 2010-09-15 癌の治療法 Expired - Fee Related JP5855568B2 (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US24275209P 2009-09-15 2009-09-15
US61/242,752 2009-09-15
US31703910P 2010-03-24 2010-03-24
US61/317,039 2010-03-24
US33215010P 2010-05-06 2010-05-06
US61/332,150 2010-05-06
US38185110P 2010-09-10 2010-09-10
US61/381,851 2010-09-10
PCT/US2010/048973 WO2011034954A1 (en) 2009-09-15 2010-09-15 Treatment of cancer

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2014223985A Division JP2015025020A (ja) 2009-09-15 2014-11-04 癌の治療法

Publications (3)

Publication Number Publication Date
JP2013504630A JP2013504630A (ja) 2013-02-07
JP2013504630A5 true JP2013504630A5 (OSRAM) 2013-10-17
JP5855568B2 JP5855568B2 (ja) 2016-02-09

Family

ID=43758997

Family Applications (6)

Application Number Title Priority Date Filing Date
JP2012529881A Expired - Fee Related JP5855568B2 (ja) 2009-09-15 2010-09-15 癌の治療法
JP2014223985A Withdrawn JP2015025020A (ja) 2009-09-15 2014-11-04 癌の治療法
JP2016045695A Pending JP2016106143A (ja) 2009-09-15 2016-03-09 癌の治療法
JP2017196769A Withdrawn JP2017226708A (ja) 2009-09-15 2017-10-10 癌の治療法
JP2020109574A Pending JP2020164547A (ja) 2009-09-15 2020-06-25 癌の治療法
JP2022135758A Withdrawn JP2022166327A (ja) 2009-09-15 2022-08-29 癌の治療法

Family Applications After (5)

Application Number Title Priority Date Filing Date
JP2014223985A Withdrawn JP2015025020A (ja) 2009-09-15 2014-11-04 癌の治療法
JP2016045695A Pending JP2016106143A (ja) 2009-09-15 2016-03-09 癌の治療法
JP2017196769A Withdrawn JP2017226708A (ja) 2009-09-15 2017-10-10 癌の治療法
JP2020109574A Pending JP2020164547A (ja) 2009-09-15 2020-06-25 癌の治療法
JP2022135758A Withdrawn JP2022166327A (ja) 2009-09-15 2022-08-29 癌の治療法

Country Status (11)

Country Link
US (5) US20110160159A1 (OSRAM)
EP (1) EP2477985B1 (OSRAM)
JP (6) JP5855568B2 (OSRAM)
CN (1) CN102666533A (OSRAM)
AU (1) AU2010295646B2 (OSRAM)
BR (1) BR112012005594A2 (OSRAM)
CA (2) CA2774015A1 (OSRAM)
EA (1) EA201200486A1 (OSRAM)
IL (1) IL218575A0 (OSRAM)
MX (2) MX366955B (OSRAM)
WO (1) WO2011034954A1 (OSRAM)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9770517B2 (en) 2002-03-01 2017-09-26 Immunomedics, Inc. Anti-Trop-2 antibody-drug conjugates and uses thereof
BR122012021252B8 (pt) 2002-09-06 2021-05-25 Cerulean Pharma Inc polímeros à base de ciclodextrina para o fornecimento de agentes terapêuticos ligados a eles por covalência
US10058621B2 (en) 2015-06-25 2018-08-28 Immunomedics, Inc. Combination therapy with anti-HLA-DR antibodies and kinase inhibitors in hematopoietic cancers
US9707302B2 (en) 2013-07-23 2017-07-18 Immunomedics, Inc. Combining anti-HLA-DR or anti-Trop-2 antibodies with microtubule inhibitors, PARP inhibitors, bruton kinase inhibitors or phosphoinositide 3-kinase inhibitors significantly improves therapeutic outcome in cancer
US20080176958A1 (en) 2007-01-24 2008-07-24 Insert Therapeutics, Inc. Cyclodextrin-based polymers for therapeutics delivery
US20120114658A1 (en) * 2009-09-15 2012-05-10 John Ryan Treatment of cancer
PL2493466T3 (pl) 2009-10-29 2021-11-15 Sanofi Mature Ip Nowe przeciwguzowe zastosowanie kabazytakselu
US20120064107A1 (en) * 2010-05-18 2012-03-15 Cerulean Pharma Inc. Compositions and methods for treatment of autoimmune and other disease
US20130196906A1 (en) * 2012-01-31 2013-08-01 Cerulean Pharma Inc. Cyclodextrin-based polymers for therapeutic delivery
US9382329B2 (en) 2012-08-14 2016-07-05 Ibc Pharmaceuticals, Inc. Disease therapy by inducing immune response to Trop-2 expressing cells
US20140094432A1 (en) 2012-10-02 2014-04-03 Cerulean Pharma Inc. Methods and systems for polymer precipitation and generation of particles
HK1214128A1 (zh) * 2012-10-05 2016-07-22 Bluelink Pharmaceuticals, Inc. 癌症的治療
US9931417B2 (en) 2012-12-13 2018-04-03 Immunomedics, Inc. Antibody-SN-38 immunoconjugates with a CL2A linker
US12310958B2 (en) 2012-12-13 2025-05-27 Immunomedics, Inc. Antibody-drug conjugates and uses thereof
US9492566B2 (en) 2012-12-13 2016-11-15 Immunomedics, Inc. Antibody-drug conjugates and uses thereof
US10206918B2 (en) 2012-12-13 2019-02-19 Immunomedics, Inc. Efficacy of anti-HLA-DR antiboddy drug conjugate IMMU-140 (hL243-CL2A-SN-38) in HLA-DR positive cancers
BR112015013444B1 (pt) 2012-12-13 2022-11-01 Immunomedics, Inc Uso de um imunoconjugado
US20240148873A1 (en) 2012-12-13 2024-05-09 Immunomedics, Inc. Dosages of immunoconjugates of antibodies and sn-38 for improved efficacy and decreased toxicity
US10137196B2 (en) 2012-12-13 2018-11-27 Immunomedics, Inc. Dosages of immunoconjugates of antibodies and SN-38 for improved efficacy and decreased toxicity
US10744129B2 (en) 2012-12-13 2020-08-18 Immunomedics, Inc. Therapy of small-cell lung cancer (SCLC) with a topoisomerase-I inhibiting antibody-drug conjugate (ADC) targeting Trop-2
US9107960B2 (en) 2012-12-13 2015-08-18 Immunimedics, Inc. Antibody-SN-38 immunoconjugates with a CL2A linker
US10413539B2 (en) 2012-12-13 2019-09-17 Immunomedics, Inc. Therapy for metastatic urothelial cancer with the antibody-drug conjugate, sacituzumab govitecan (IMMU-132)
EA201500851A1 (ru) 2013-02-21 2016-02-29 Байер Фарма Акциенгезельшафт ЭСТРА-1,3,5(10),16-ТЕТРАЕН-3-КАРБОКСАМИДЫ ДЛЯ ИНГИБИРОВАНИЯ 17β-ГИДРОКСИСТЕРОИД-ДЕГИДРОГЕНАЗЫ (AKR1C3)
EP2801370A1 (en) * 2013-05-07 2014-11-12 Fundació Privada Institut d'Investigació Oncològica de Vall Hebron Methods and compositions for the treatment of cancer
US11253606B2 (en) 2013-07-23 2022-02-22 Immunomedics, Inc. Combining anti-HLA-DR or anti-Trop-2 antibodies with microtubule inhibitors, PARP inhibitors, Bruton kinase inhibitors or phosphoinositide 3-kinase inhibitors significantly improves therapeutic outcome in cancer
EP3049078B1 (en) * 2013-09-27 2018-06-27 BlueLink Pharmaceuticals, Inc. Treatment of cancer
CA2937015C (en) * 2014-01-24 2022-08-02 Sirtex Medical Limited Treatment of neoplasia
AU2016219204B2 (en) * 2015-02-12 2021-01-21 Beyondspring Pharmaceuticals, Inc. Use of Plinabulin in combination with immune checkpoint inhibitors
JP6769982B2 (ja) 2015-03-06 2020-10-14 ビヨンドスプリング ファーマシューティカルズ，インコーポレイテッド Ｒａｓ変異と関連するがんの治療方法
EP3286224A4 (en) 2015-04-22 2018-11-14 Immunomedics, Inc. Isolation, detection, diagnosis and/or characterization of circulating trop-2-positive cancer cells
US10195175B2 (en) 2015-06-25 2019-02-05 Immunomedics, Inc. Synergistic effect of anti-Trop-2 antibody-drug conjugate in combination therapy for triple-negative breast cancer when used with microtubule inhibitors or PARP inhibitors
ES2910035T3 (es) 2015-07-13 2022-05-11 Beyondspring Pharmaceuticals Inc Composiciones de plinabulina
WO2017031442A1 (en) 2015-08-20 2017-02-23 Merrimack Pharmaceuticals, Inc. Combination therapy using liposomal irinotecan and a parp inhibitor for cancer treatment
FR3040860B1 (fr) * 2015-09-10 2020-05-15 Universite de Bordeaux Milieu de conservation injectable pour la conservation de cellules du sang placentaire, de la moelle osseuse et du sang peripherique
CN114632069A (zh) * 2015-11-03 2022-06-17 纳米珀特伊根公司 聚合纳米颗粒
CA3013467A1 (en) 2016-02-08 2017-08-17 Beyondspring Pharmaceuticals, Inc. Compositions containing tucaresol or its analogs
WO2017139623A1 (en) 2016-02-10 2017-08-17 Immunomedics, Inc. Combination of abcg2 inhibitors with sacituzumab govitecan (immu-132) overcomes resistance to sn-38 in trop-2 expressing cancers
WO2017177055A1 (en) * 2016-04-08 2017-10-12 Liang Zhao Cyclodextrin-based polymers for therapeutic delivery
AU2017257254B2 (en) 2016-04-27 2022-02-24 Immunomedics, Inc. Efficacy of anti-Trop-2-SN-38 antibody drug conjugates for therapy of tumors relapsed/refractory to checkpoint inhibitors
EP3463337A4 (en) 2016-06-06 2020-02-12 Beyondspring Pharmaceuticals, Inc. COMPOSITION AND METHOD FOR REDUCING NEUTROPENIA
US20200093932A1 (en) * 2016-12-01 2020-03-26 Bluelink Pharmaceuticals, Inc. Treatment of cancer
CN110431135A (zh) 2017-01-06 2019-11-08 大连万春布林医药有限公司 微管蛋白结合化合物及其治疗用途
KR20190109479A (ko) 2017-02-01 2019-09-25 비욘드스프링 파마수티컬스, 인코포레이티드. 호중구감소증의 감소 방법
RU2758234C2 (ru) 2017-03-27 2021-10-26 Иммьюномедикс, Инк. ЛЕЧЕНИЕ ТРИЖДЫ НЕГАТИВНОГО РАКА МОЛОЧНОЙ ЖЕЛЕЗЫ, ХАРАКТЕРИЗУЮЩЕГОСЯ ЭКСПРЕССИЕЙ Trop-2, С ПОМОЩЬЮ САЦИТУЗУМАБА ГОВИТЕКАНА И ИНГИБИТОРА Rad51
CN110352201A (zh) 2017-04-03 2019-10-18 免疫医疗公司 用于癌症疗法的抗体药物缀合物的皮下施用
SG11202006985TA (en) 2018-01-24 2020-08-28 Beyondspring Pharmaceuticals Inc Composition and method for reducing thrombocytopenia via the administration of plinabulin
WO2019232257A1 (en) * 2018-06-01 2019-12-05 Beyondspring Pharmaceuticals, Inc. Composition and method of treating cancer associated with egfr mutation
US12291570B2 (en) 2018-10-17 2025-05-06 Biolinerx Ltd. Treatment of metastatic pancreatic adenocarcinoma
EP3911353A1 (en) 2019-01-17 2021-11-24 BioLineRx Ltd. Specific combination therapy for treatment of pancreatic cancer
WO2020148744A1 (en) 2019-01-17 2020-07-23 Biolinerx Ltd. Combination therapy for treatment of pancreatic cancer
US20230017661A1 (en) * 2019-12-13 2023-01-19 Veri Nano Inc. Compositions and modular nano- and microparticles for the delivery of various agents and use thereof
CA3166732A1 (en) * 2020-01-22 2021-07-29 Medimmune Limited Compounds and conjugates thereof
AU2022206272A1 (en) * 2021-01-08 2023-07-27 Starton Therapeutics, Inc. Stable solutions of immunomodulatory imide compounds for parenteral use
CN114904013A (zh) * 2021-02-08 2022-08-16 中国科学院上海药物研究所 硫酸乙酰肝素-骨化三醇偶联物，包含其的乙酰肝素酶响应性纳米粒，其制备方法及用途
CN115109258A (zh) * 2021-03-19 2022-09-27 江西中医药大学 7-乙基-10-羟基喜树碱聚合物、制备方法及其应用
WO2022216908A1 (en) 2021-04-09 2022-10-13 Beyondspring Pharmaceuticals, Inc. Therapeutic compositions and methods for treating tumors

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3378250D1 (en) 1982-04-22 1988-11-24 Ici Plc Continuous release formulations
US4438253A (en) 1982-11-12 1984-03-20 American Cyanamid Company Poly(glycolic acid)/poly(alkylene glycol) block copolymers and method of manufacturing the same
JPS60100516A (ja) 1983-11-04 1985-06-04 Takeda Chem Ind Ltd 徐放型マイクロカプセルの製造法
EP0258780B1 (en) 1986-09-05 1993-06-23 American Cyanamid Company Polyesters containing alkylene oxide blocks as drug delivery systems
JP2670680B2 (ja) 1988-02-24 1997-10-29 株式会社ビーエムジー 生理活性物質含有ポリ乳酸系微小球およびその製造法
FR2665169A1 (fr) 1990-07-30 1992-01-31 Rhone Poulenc Chimie Composes d'inclusion de cyclodextrines enfermant des antioxydants phenoliques et leur utilisation dans les polymeres.
US5330768A (en) 1991-07-05 1994-07-19 Massachusetts Institute Of Technology Controlled drug delivery using polymer/pluronic blends
GB9211268D0 (en) 1992-05-28 1992-07-15 Ici Plc Salts of basic peptides with carboxyterminated polyesters
IL111785A0 (en) 1993-12-03 1995-01-24 Ferring Bv Dp-iv inhibitors and pharmaceutical compositions containing them
DE122010000020I1 (de) 1996-04-25 2010-07-08 Prosidion Ltd Verfahren zur Senkung des Blutglukosespiegels in Säugern
TW492957B (en) 1996-11-07 2002-07-01 Novartis Ag N-substituted 2-cyanopyrrolidnes
US5990237A (en) * 1997-05-21 1999-11-23 Shearwater Polymers, Inc. Poly(ethylene glycol) aldehyde hydrates and related polymers and applications in modifying amines
US6630124B1 (en) * 1998-10-16 2003-10-07 Ramot-University Authority For Applied Research And Industrial Development Ltd. Combination therapy with VIP antagonist
CO5150173A1 (es) 1998-12-10 2002-04-29 Novartis Ag Compuestos n-(glicilo sustituido)-2-cianopirrolidinas inhibidores de peptidasa de dipeptidilo-iv (dpp-iv) los cuales son efectivos en el tratamiento de condiciones mediadas por la inhibicion de dpp-iv
AUPP913999A0 (en) * 1999-03-12 1999-04-01 Biota Scientific Management Pty Ltd Novel chemical compounds and their use
US6420378B1 (en) * 1999-10-15 2002-07-16 Supergen, Inc. Inhibition of abnormal cell proliferation with camptothecin and combinations including the same
AU2003243561A1 (en) * 2002-06-14 2003-12-31 Bristol-Myers Squibb Company Combination of epothilone analogs and chemotherapeutic agents for the treatment of proliferative diseases
US20040047835A1 (en) * 2002-09-06 2004-03-11 Cell Therapeutics, Inc. Combinatorial drug therapy using polymer drug conjugates
BR122012021252B8 (pt) 2002-09-06 2021-05-25 Cerulean Pharma Inc polímeros à base de ciclodextrina para o fornecimento de agentes terapêuticos ligados a eles por covalência
WO2004052315A2 (en) * 2002-12-11 2004-06-24 Merck & Co., Inc. Tyrosine kinase inhibitors
US7358262B2 (en) * 2003-01-29 2008-04-15 Whitehead Institute For Biomedical Research Identification of genotype-selective anti-tumor agents
CN1216057C (zh) * 2003-03-28 2005-08-24 贵州省生物研究所 喜树碱类似物的衍生物及其制备方法
WO2006004574A2 (en) * 2004-02-19 2006-01-12 Abbott Laboratories Method for using gamma cyclodextrin to control blood glucose and insulin secretion
EP3042964A1 (en) * 2004-06-04 2016-07-13 Genentech, Inc. Egfr mutations
TW200640493A (en) * 2005-02-16 2006-12-01 Insert Therapeutics Inc Cyclodextrin-based polymers for therapeutics delivery
WO2007001868A1 (en) * 2005-06-28 2007-01-04 Genentech, Inc. Egfr and kras mutations
US8143236B2 (en) * 2005-12-13 2012-03-27 Bionumerik Pharmaceuticals, Inc. Chemoprotective methods
KR100917809B1 (ko) * 2006-05-22 2009-09-18 에스케이케미칼주식회사 우수한 저장안정성을 갖는 도세탁셀 함유 주사제 조성물
US20100112077A1 (en) * 2006-11-06 2010-05-06 Abraxis Bioscience, Llc Nanoparticles of paclitaxel and albumin in combination with bevacizumab against cancer
US20110177161A1 (en) * 2007-05-24 2011-07-21 Dr. Reddy's Laboratories Limited Pharmaceutical compositions of [5(s)-(2'-hydroxyethoxy)-20(s)-camptothecin
US20100056555A1 (en) * 2008-08-29 2010-03-04 Enzon Pharmaceuticals, Inc. Method of treating ras associated cancer
BRPI1014854A2 (pt) * 2009-03-30 2016-05-03 Cerulean Pharma Inc "conjugados polímero-agente, partículas, composições, e métodos de uso relacionados"
US20120114658A1 (en) * 2009-09-15 2012-05-10 John Ryan Treatment of cancer

Similar Documents

Publication Publication Date Title
JP2013504630A5 (OSRAM)
Matsumura Poly (amino acid) micelle nanocarriers in preclinical and clinical studies
Varela-Moreira et al. Clinical application of polymeric micelles for the treatment of cancer
Monneret Platinum anticancer drugs. From serendipity to rational design
Matsumura Polymeric micellar delivery systems in oncology
JP2020514311A5 (OSRAM)
KR102446673B1 (ko) 암 치료를 위한 약물의 제조에 있어서 항-pd-1 항체 및 vegfr 억제제의 조합의 용도
ES2576289T3 (es) Nanopartículas de paclitaxel y albúmina en combinación con bevacizumab contra el cáncer
JP2011511072A5 (OSRAM)
JP2011511071A (ja) 肺癌を治療するためのピコプラチンおよびアムルビシン
RU2013103027A (ru) Введение гипоксически активируемых пролекарств и средств, препятствующих ангиогенезу, для лечения рака
JP2013527233A5 (OSRAM)
JP2013503174A5 (OSRAM)
JP2020517696A5 (OSRAM)
JP6229865B2 (ja) エピルビシン複合化ブロック共重合体と、抗癌剤とを含むミセル、及び当該ミセルを含む癌又は耐性癌、転移癌の治療に適用可能な医薬組成物
KR20210019116A (ko) 카복시아미도트리아졸 오로테이트를 사용하여 화학치료제 및 표적화된 약물에 대해 내성을 획득한 암을 치료하기 위한 방법 및 조성물
JP2010534682A5 (OSRAM)
JP2018536655A5 (OSRAM)
JP2007511509A (ja) Ｅｔ−７４３およびパクリタキセルの使用を含むガンの併用療法
Koizumi et al. Phase I/II study of bi-weekly irinotecan plus cisplatin in the treatment of advanced gastric cancer
CN114173785B (zh) 用于治疗非小细胞肺癌的氨基吡啶衍生物
Hu et al. Current status of CPT and its analogues in the treatment of malignancies
Luo et al. Efficacy and tolerability of docetaxel and cisplatin plus S-1 for advanced gastric cancer
CN116672345A (zh) Parp抑制剂和细胞毒性剂的联合产品及其用途
Pujade-Lauraine Bevacizumab and oral metronomic cyclophosphamide in platinum-resistant ovarian cancer