JP2013504331A5 - - Google Patents
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- JP2013504331A5 JP2013504331A5 JP2012528991A JP2012528991A JP2013504331A5 JP 2013504331 A5 JP2013504331 A5 JP 2013504331A5 JP 2012528991 A JP2012528991 A JP 2012528991A JP 2012528991 A JP2012528991 A JP 2012528991A JP 2013504331 A5 JP2013504331 A5 JP 2013504331A5
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- JP
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- Prior art keywords
- mir
- protein
- biomarker
- tau
- gfap
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 claims 16
- 239000000090 biomarker Substances 0.000 claims 11
- 102000004169 proteins and genes Human genes 0.000 claims 11
- 108090000623 proteins and genes Proteins 0.000 claims 11
- 239000007857 degradation product Substances 0.000 claims 9
- 101710193519 Glial fibrillary acidic protein Proteins 0.000 claims 6
- 102100039289 Glial fibrillary acidic protein Human genes 0.000 claims 6
- 102000012338 Poly(ADP-ribose) Polymerases Human genes 0.000 claims 6
- 108010061844 Poly(ADP-ribose) Polymerases Proteins 0.000 claims 6
- 229920000776 Poly(Adenosine diphosphate-ribose) polymerase Polymers 0.000 claims 6
- 210000005046 glial fibrillary acidic protein Anatomy 0.000 claims 6
- 150000001413 amino acids Chemical class 0.000 claims 5
- 238000003776 cleavage reaction Methods 0.000 claims 5
- 230000007017 scission Effects 0.000 claims 5
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 238000001514 detection method Methods 0.000 claims 4
- 108090000371 Esterases Proteins 0.000 claims 3
- 101000891579 Homo sapiens Microtubule-associated protein tau Proteins 0.000 claims 3
- 102100031874 Spectrin alpha chain, non-erythrocytic 1 Human genes 0.000 claims 3
- 101710157175 Spectrin alpha chain, non-erythrocytic 1 Proteins 0.000 claims 3
- 102000044159 Ubiquitin Human genes 0.000 claims 3
- 108090000848 Ubiquitin Proteins 0.000 claims 3
- 239000012472 biological sample Substances 0.000 claims 3
- 102000057063 human MAPT Human genes 0.000 claims 3
- 208000004051 Chronic Traumatic Encephalopathy Diseases 0.000 claims 2
- 102100028652 Gamma-enolase Human genes 0.000 claims 2
- 101000979001 Homo sapiens Methionine aminopeptidase 2 Proteins 0.000 claims 2
- 101000969087 Homo sapiens Microtubule-associated protein 2 Proteins 0.000 claims 2
- 102000009664 Microtubule-Associated Proteins Human genes 0.000 claims 2
- 108010020004 Microtubule-Associated Proteins Proteins 0.000 claims 2
- 102100021118 Microtubule-associated protein 2 Human genes 0.000 claims 2
- 102100023057 Neurofilament light polypeptide Human genes 0.000 claims 2
- 108010019965 Spectrin Proteins 0.000 claims 2
- 102000005890 Spectrin Human genes 0.000 claims 2
- 108010055170 Synaptotagmin I Proteins 0.000 claims 2
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- 208000027418 Wounds and injury Diseases 0.000 claims 2
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- 101000934069 Homo sapiens Calpain-1 catalytic subunit Proteins 0.000 claims 1
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- 101000979321 Homo sapiens Neurofilament medium polypeptide Proteins 0.000 claims 1
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- 102100025087 Insulin receptor substrate 1 Human genes 0.000 claims 1
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- 108091028080 MiR-132 Proteins 0.000 claims 1
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- 102100030610 Mothers against decapentaplegic homolog 5 Human genes 0.000 claims 1
- 101710143113 Mothers against decapentaplegic homolog 5 Proteins 0.000 claims 1
- 102100024007 Neurofilament heavy polypeptide Human genes 0.000 claims 1
- 101710159895 Neurofilament heavy polypeptide Proteins 0.000 claims 1
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- 102100023206 Neuromodulin Human genes 0.000 claims 1
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- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 102000008880 Peptidase C12, ubiquitin carboxyl-terminal hydrolases Human genes 0.000 claims 1
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- 108010022181 Phosphopyruvate Hydratase Proteins 0.000 claims 1
- 101100480719 Rattus norvegicus Mapt gene Proteins 0.000 claims 1
- 102000013008 Semaphorin-3A Human genes 0.000 claims 1
- 108010090319 Semaphorin-3A Proteins 0.000 claims 1
- 102000017299 Synapsin-1 Human genes 0.000 claims 1
- 108050005241 Synapsin-1 Proteins 0.000 claims 1
- 102100040541 Synaptotagmin-like protein 1 Human genes 0.000 claims 1
- 208000030886 Traumatic Brain injury Diseases 0.000 claims 1
- 102100035071 Vimentin Human genes 0.000 claims 1
- 108010065472 Vimentin Proteins 0.000 claims 1
- 108010011385 alpha-internexin Proteins 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
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- 208000029028 brain injury Diseases 0.000 claims 1
- 108010044208 calpastatin Proteins 0.000 claims 1
- ZXJCOYBPXOBJMU-HSQGJUDPSA-N calpastatin peptide Ac 184-210 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CCSC)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC(O)=O)NC(C)=O)[C@@H](C)O)C1=CC=C(O)C=C1 ZXJCOYBPXOBJMU-HSQGJUDPSA-N 0.000 claims 1
- 230000015556 catabolic process Effects 0.000 claims 1
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims 1
- 230000000593 degrading effect Effects 0.000 claims 1
- 102000051520 human GFAP Human genes 0.000 claims 1
- 210000005049 internexin Anatomy 0.000 claims 1
- 230000004807 localization Effects 0.000 claims 1
- 108091055434 miR-124a stem-loop Proteins 0.000 claims 1
- 108091082871 miR-124a-2 stem-loop Proteins 0.000 claims 1
- 108091050112 miR-124a-4 stem-loop Proteins 0.000 claims 1
- 108091054623 miR-124a-5 stem-loop Proteins 0.000 claims 1
- 108091024680 miR-124a-6 stem-loop Proteins 0.000 claims 1
- 108091024609 miR-124b stem-loop Proteins 0.000 claims 1
- 108091081188 miR-124b-1 stem-loop Proteins 0.000 claims 1
- 108091060300 miR-124b-2 stem-loop Proteins 0.000 claims 1
- 108091044988 miR-125a stem-loop Proteins 0.000 claims 1
- 108091049513 miR-125a-1 stem-loop Proteins 0.000 claims 1
- 108091040046 miR-125a-2 stem-loop Proteins 0.000 claims 1
- 108091070946 miR-128 stem-loop Proteins 0.000 claims 1
- 108091029379 miR-139 stem-loop Proteins 0.000 claims 1
- 108091033783 miR-153 stem-loop Proteins 0.000 claims 1
- 108091029500 miR-183 stem-loop Proteins 0.000 claims 1
- 108091058965 miR-218a stem-loop Proteins 0.000 claims 1
- 108091063841 miR-219 stem-loop Proteins 0.000 claims 1
- 108091080321 miR-222 stem-loop Proteins 0.000 claims 1
- 108091074487 miR-34 stem-loop Proteins 0.000 claims 1
- 108091092493 miR-34-1 stem-loop Proteins 0.000 claims 1
- 108091059780 miR-34-2 stem-loop Proteins 0.000 claims 1
- 108091055813 miR-6 stem-loop Proteins 0.000 claims 1
- 108091065445 miR-6-4 stem-loop Proteins 0.000 claims 1
- 108091053743 miR-6-5 stem-loop Proteins 0.000 claims 1
- 108091055911 miR-6-6 stem-loop Proteins 0.000 claims 1
- 108091047084 miR-9 stem-loop Proteins 0.000 claims 1
- 108091038507 miR-92b stem-loop Proteins 0.000 claims 1
- 108091081014 miR-92b-1 stem-loop Proteins 0.000 claims 1
- 108091032846 miR-92b-2 stem loop Proteins 0.000 claims 1
- 108091070501 miRNA Proteins 0.000 claims 1
- 239000002679 microRNA Substances 0.000 claims 1
- 208000037890 multiple organ injury Diseases 0.000 claims 1
- 230000001537 neural effect Effects 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 210000002569 neuron Anatomy 0.000 claims 1
- 108010080874 neuroserpin Proteins 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 150000007523 nucleic acids Chemical group 0.000 claims 1
- 210000002381 plasma Anatomy 0.000 claims 1
- 239000000047 product Substances 0.000 claims 1
- 102000000568 rho-Associated Kinases Human genes 0.000 claims 1
- 108010041788 rho-Associated Kinases Proteins 0.000 claims 1
- 210000003296 saliva Anatomy 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 102000003137 synaptotagmin Human genes 0.000 claims 1
- 108060008004 synaptotagmin Proteins 0.000 claims 1
- 238000003786 synthesis reaction Methods 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 230000009529 traumatic brain injury Effects 0.000 claims 1
- 210000002700 urine Anatomy 0.000 claims 1
- 210000005048 vimentin Anatomy 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24212309P | 2009-09-14 | 2009-09-14 | |
| US61/242,123 | 2009-09-14 | ||
| US35450410P | 2010-06-14 | 2010-06-14 | |
| US61/354,504 | 2010-06-14 | ||
| US35577910P | 2010-06-17 | 2010-06-17 | |
| US61/355,779 | 2010-06-17 | ||
| US38015810P | 2010-09-03 | 2010-09-03 | |
| US61/380,158 | 2010-09-03 | ||
| PCT/US2010/048789 WO2011032155A2 (en) | 2009-09-14 | 2010-09-14 | Micro-rna, autoantibody and protein markers for diagnosis of neuronal injury |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015253708A Division JP2016105097A (ja) | 2009-09-14 | 2015-12-25 | ニューロン損傷診断のためのマイクロｒｎａ、自己抗体およびタンパク質マーカー |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013504331A JP2013504331A (ja) | 2013-02-07 |
| JP2013504331A5 true JP2013504331A5 (enExample) | 2013-12-19 |
| JP5909447B2 JP5909447B2 (ja) | 2016-04-26 |
Family
ID=43733138
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012528991A Active JP5909447B2 (ja) | 2009-09-14 | 2010-09-14 | ニューロン損傷診断のためのマイクロｒｎａ、自己抗体およびタンパク質マーカー |
| JP2015253708A Pending JP2016105097A (ja) | 2009-09-14 | 2015-12-25 | ニューロン損傷診断のためのマイクロｒｎａ、自己抗体およびタンパク質マーカー |
| JP2017111070A Active JP6469760B2 (ja) | 2009-09-14 | 2017-06-05 | ニューロン損傷診断のためのマイクロｒｎａ、自己抗体およびタンパク質マーカー |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015253708A Pending JP2016105097A (ja) | 2009-09-14 | 2015-12-25 | ニューロン損傷診断のためのマイクロｒｎａ、自己抗体およびタンパク質マーカー |
| JP2017111070A Active JP6469760B2 (ja) | 2009-09-14 | 2017-06-05 | ニューロン損傷診断のためのマイクロｒｎａ、自己抗体およびタンパク質マーカー |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US20130022982A1 (enExample) |
| EP (1) | EP2478360B1 (enExample) |
| JP (3) | JP5909447B2 (enExample) |
| AU (2) | AU2010291933B2 (enExample) |
| CA (1) | CA2774173A1 (enExample) |
| ES (1) | ES2687469T3 (enExample) |
| HU (1) | HUE040281T2 (enExample) |
| WO (1) | WO2011032155A2 (enExample) |
Families Citing this family (77)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8492107B2 (en) | 2004-04-15 | 2013-07-23 | University Of Florida Research Foundation, Inc. | Neural proteins as biomarkers for nervous system injury and other neural disorders |
| NO2324360T3 (enExample) | 2008-08-11 | 2018-06-30 | ||
| AU2010262952B2 (en) * | 2009-06-19 | 2016-01-07 | Banyan Biomarkers, Inc. | Biomarker assay of neurological condition |
| US20170315136A9 (en) * | 2009-06-19 | 2017-11-02 | Banyan Biomarkers, Inc. | Biomarker assay of neurological condition |
| HUE040281T2 (hu) | 2009-09-14 | 2019-03-28 | Banyan Biomarkers Inc | Autoantitest markerek traumás agysérülés diagnózisára |
| WO2012045324A1 (en) * | 2010-10-07 | 2012-04-12 | Mediagnost Gesellschaft Fur Forschung Und Herstellung Von Diagnostika Gmbh | Method for detecting a parkinson's disease and test system |
| EP2628013B1 (en) | 2010-10-14 | 2019-06-12 | The Johns Hopkins University | Biomarkers of brain injury |
| DE102011011280A1 (de) * | 2011-02-15 | 2012-08-16 | Euroimmun Medizinische Labordiagnostika Ag | Diagnosekit sowie ein Verfahren zur Untersuchung einer menschlichen Patientenprobe auf das Vorhandensein von Neuromyelitis-optica-spezifischen Antikörpern |
| WO2012142301A2 (en) | 2011-04-12 | 2012-10-18 | Quanterix Corporation | Methods of determining a treatment protocol for and/or a prognosis of a patients recovery from a brain injury |
| GB201111361D0 (en) * | 2011-07-04 | 2011-08-17 | Nordic Bioscience As | Biochemical markers for neurodegenerative conditions |
| US20140206777A1 (en) * | 2011-08-16 | 2014-07-24 | Rosetta Genomics Ltd. | Methods and compositions for diagnosis of alzheimer's disease |
| HK1206425A1 (en) | 2012-03-13 | 2016-01-08 | The Johns Hopkins University | Citrullinated brain and neurological proteins as biomarkers of brain injury or neurodegeneration |
| WO2013173596A1 (en) * | 2012-05-16 | 2013-11-21 | Trustees Of Boston University | Chronic traumatic encephalopathy in blast-exposed individuals |
| KR20150036346A (ko) * | 2012-07-03 | 2015-04-07 | 워싱턴 유니버시티 | Tau에 대한 항체 |
| US20140073524A1 (en) * | 2012-09-07 | 2014-03-13 | Institute For Systems Biology | Markers and methods for detecting posttraumatic stress disorder (ptsd) |
| US9856532B2 (en) * | 2012-09-07 | 2018-01-02 | Institute For Systems Biology | Markers and methods for detecting posttraumatic stress disorder (PTSD) |
| WO2015009907A1 (en) | 2013-07-17 | 2015-01-22 | The Johns Hopkins University | A multi-protein biomarker assay for brain injury detection and outcome |
| GB201319761D0 (en) * | 2013-11-08 | 2013-12-25 | Nordic Bioscience As | Biomarkers of disease progression |
| CN103656685B (zh) * | 2014-01-10 | 2016-01-13 | 厦门大学 | microRNA-219在制备抗癫痫药物中的应用 |
| WO2015134551A1 (en) * | 2014-03-03 | 2015-09-11 | Banyan Biomarkers, Inc. | Micro rna markers for diagnosis of a neurological condition |
| US9605315B2 (en) * | 2014-03-26 | 2017-03-28 | The University Of Montana | Detection of traumatic brain injury |
| US20170023591A1 (en) * | 2014-04-07 | 2017-01-26 | Iron Horse Diagnostics, Inc. | Traumatic Brain Injury and Neurodegenerative Biomarkers, Methods, and Systems |
| WO2015157390A1 (en) * | 2014-04-08 | 2015-10-15 | University Of Florida Research Foundation, Incorporated | Protein biomarkers for acute, subacute and chronic traumatic injuries of the central nervous system |
| WO2015160391A1 (en) * | 2014-04-15 | 2015-10-22 | The Government Of The United States, As Represented By The Secretary Of The Army, On Behalf Of Walter Reed Army Institute Of Research | Diagnosis and treatment of tauopathy and chronic traumatic encephalopathy |
| WO2015196191A1 (en) * | 2014-06-20 | 2015-12-23 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Microrna biomarkers for traumatic brain injury and methods of use thereof |
| US10358679B2 (en) * | 2014-09-26 | 2019-07-23 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | MicroRNA biomarkers for posttraumatic stress disorder and methods of use thereof |
| EP3702786A1 (en) * | 2014-10-06 | 2020-09-02 | Université de Genève | Markers and their use in brain injury |
| US20180024145A1 (en) | 2015-02-05 | 2018-01-25 | Immunarray USA, Inc. | Methods and compositions for diagnosing brain injury or neurodegeneration |
| WO2016205730A1 (en) * | 2015-06-18 | 2016-12-22 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Citrullinated proteins and their breakdown products as tbi biomarkers |
| EP3329005B1 (en) * | 2015-07-29 | 2020-05-13 | The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. | Microrna biomarkers for traumatic brain injury and methods of use thereof |
| WO2017044650A1 (en) * | 2015-09-08 | 2017-03-16 | The Translational Genomics Research Institute | Biomarkers and methods of diagnosing and prognosing mild traumatic brain injuries |
| US20180327845A1 (en) * | 2015-11-18 | 2018-11-15 | Dignity Health | Methods of diagnosing epilepsy |
| GB201603967D0 (en) | 2016-03-08 | 2016-04-20 | Univ Birmingham | Biomarkers of traumatic brain injury |
| JP6430680B2 (ja) * | 2016-04-28 | 2018-11-28 | 一般財団法人生産技術研究奨励会 | 神経細胞を培養する装置、神経細胞を培養する方法、培養された神経細胞、軸索束内のプロテインを解析及び同定する方法並びに神経細胞の使用方法 |
| US20190137490A1 (en) * | 2016-05-06 | 2019-05-09 | Duke University | Methods and kits for diagnosing and treating nervous system disease or injury |
| WO2018048884A1 (en) * | 2016-09-09 | 2018-03-15 | Mayo Foundation For Medical Education And Research | Methods and materials for identifying and treating autoimmune gfap astrocytopathy |
| IT201600093825A1 (it) * | 2016-09-19 | 2018-03-19 | Fondazione St Italiano Tecnologia | Composizione farmaceutica di miRNA e suoi usi terapeutici. |
| US11078298B2 (en) | 2016-10-28 | 2021-08-03 | Banyan Biomarkers, Inc. | Antibodies to ubiquitin C-terminal hydrolase L1 (UCH-L1) and glial fibrillary acidic protein (GFAP) and related methods |
| US20190293662A1 (en) * | 2016-11-23 | 2019-09-26 | Randox Laboratories Ltd | Gfap derivatives for stroke diagnostics |
| WO2018148294A2 (en) * | 2017-02-07 | 2018-08-16 | Bioregency, Inc. | S100β AND ISOFORMS FOR DETECTION OF NEUROLOGICAL CONDITIONS |
| BR112019017021A2 (pt) | 2017-02-17 | 2020-04-14 | Denali Therapeutics Inc | anticorpos anti-tau e métodos de uso dos mesmos |
| US11016092B2 (en) | 2017-03-23 | 2021-05-25 | Abbott Laboratories | Methods for aiding in the diagnosis and determination of the extent of traumatic brain injury in a human subject using the early biomarker ubiquitin carboxy-terminal hydrolase L1 |
| WO2018190365A1 (ja) * | 2017-04-12 | 2018-10-18 | 国立大学法人九州大学 | 神経障害性疼痛マーカー及びその使用 |
| CN110546513A (zh) | 2017-04-15 | 2019-12-06 | 雅培实验室 | 使用早期生物标记物帮助超急性诊断和确定人类受试者中的创伤性脑损伤的方法 |
| JP7080899B2 (ja) | 2017-04-28 | 2022-06-06 | アボット・ラボラトリーズ | 同じヒト対象に由来する少なくとも２つの試料に対して早期バイオマーカーを使用する、外傷性脳損傷の超急性の診断及び決定の一助となるための方法 |
| EP3631465A1 (en) | 2017-05-25 | 2020-04-08 | Abbott Laboratories | Methods for aiding in the determination of whether to perform imaging on a human subject who has sustained or may have sustained an injury to the head using early biomarkers |
| WO2018222783A1 (en) | 2017-05-30 | 2018-12-06 | Abbott Laboratories | Methods for aiding in diagnosing and evaluating a mild traumatic brain injury in a human subject using cardiac troponin i and early biomarkers |
| CN110998321A (zh) * | 2017-06-02 | 2020-04-10 | 约翰霍普金斯大学 | 帕金森氏症患者脑脊液中par的检测方法 |
| KR20200026834A (ko) | 2017-06-02 | 2020-03-11 | 더 존스 홉킨스 유니버시티 | 파킨슨병에 걸린 환자의 csf 중 par의 검출 |
| US11739384B2 (en) * | 2017-06-19 | 2023-08-29 | St. John's University | Circulating serum microRNA biomarkers and methods for Parkinson's disease prognosis |
| US11169159B2 (en) | 2017-07-03 | 2021-11-09 | Abbott Laboratories | Methods for measuring ubiquitin carboxy-terminal hydrolase L1 levels in blood |
| AU2018355325B2 (en) | 2017-10-25 | 2024-11-28 | Ac Immune S.A. | Compositions of phosphorylated tau peptides and uses thereof |
| JP6942036B2 (ja) * | 2017-11-30 | 2021-09-29 | 藤倉化成株式会社 | 脳梗塞の発症リスクを高感度に検出する体液抗体バイオマーカー |
| CN110892266A (zh) | 2017-12-09 | 2020-03-17 | 雅培实验室 | 使用gfap和uch-l1的组合辅助诊断和评价人类受试者中创伤性脑损伤的方法 |
| JP7344801B2 (ja) | 2017-12-09 | 2023-09-14 | アボット・ラボラトリーズ | グリア原線維性酸性タンパク質（ｇｆａｐ）及び／又はユビキチンカルボキシ末端ヒドロラーゼｌ１（ｕｃｈ－ｌ１）を使用する、整形外科損傷を負っており、軽度外傷性脳損傷（ｔｂｉ）などの頭部への損傷を負ったか又は負った可能性がある対象についての診断及び査定の一助となるための方法 |
| CN111699391A (zh) | 2017-12-29 | 2020-09-22 | 雅培实验室 | 用于诊断和评估创伤性脑损伤的新型生物标志物和方法 |
| KR102026675B1 (ko) * | 2018-02-12 | 2019-09-30 | 강원대학교산학협력단 | miR-135a-5p 및 p62에 의한 알레르기 반응 조절 메커니즘 및 이의 이용 |
| WO2019173703A1 (en) * | 2018-03-08 | 2019-09-12 | Meso Scale Technologies, Llc. | Genetic marker and/or biomarkers for traumatic brain injury, and ultrasensitive assays for biomarkers of traumatic brain injury |
| JP6499342B2 (ja) * | 2018-03-19 | 2019-04-10 | 隆樹 日和佐 | 脳梗塞の診断マーカー |
| WO2019207159A1 (en) * | 2018-04-27 | 2019-10-31 | Fondazione Ebri Rita Levi-Montalcini | Antibody directed against a tau-derived neurotoxic peptide and uses thereof |
| JP2021531043A (ja) * | 2018-07-25 | 2021-11-18 | スルナリティクス インコーポレイテッド | アルツハイマー病に対する低分子ｒｎａ予測因子 |
| CN110824156B (zh) * | 2018-08-14 | 2023-08-11 | 欧蒙医学诊断（中国）有限公司 | 神经自身免疫疾病的诊断 |
| WO2020037311A1 (en) * | 2018-08-17 | 2020-02-20 | University Of Florida Research Foundation, Inc. | Protein and peptide biomarkers for traumatic injury to the central nervous system |
| US20220316006A1 (en) * | 2018-10-17 | 2022-10-06 | Ochsner Health System | Plasma and cerebrospinal fluid mirna biomarkers in intracerebral and subarachnoid hemorrhage |
| CN109266739A (zh) * | 2018-11-29 | 2019-01-25 | 成都仕康美生物科技有限公司 | 一种检测脑损伤的miRNA标志物、试剂盒、应用 |
| CN113383090A (zh) * | 2018-12-04 | 2021-09-10 | 拉筹伯大学 | 诊断疾病状态的方法 |
| US11684576B2 (en) | 2019-02-08 | 2023-06-27 | Ac Immune Sa | Method of safe administration of phosphorylated tau peptide vaccine |
| GEAP202515717A (en) * | 2019-02-14 | 2025-06-10 | Marker Diagnostics Uk Ltd | Salivary biomarkers of brain injury |
| GB201909393D0 (en) * | 2019-06-28 | 2019-08-14 | Gen2 Neuroscience Ltd | Tau epitope and binding molecules |
| CN110551809A (zh) * | 2019-08-21 | 2019-12-10 | 昆明医科大学第一附属医院 | miR-124在脊髓损伤修复中的用途 |
| US11644463B2 (en) * | 2019-08-30 | 2023-05-09 | Euroimmun Medizinische Labordiagnostika Ag | Detection of an autoantibody |
| US20230250480A1 (en) * | 2020-07-09 | 2023-08-10 | University Of Florida Research Foundation, Incorporated | Biofluid-based protein and mirna biomarkers for neonatal hypoxic-ischemic encephalopathy |
| US20240228623A1 (en) * | 2020-08-24 | 2024-07-11 | Marabio Systems, Inc. | Methods for reducing maternal autoantibodies |
| KR102357260B1 (ko) * | 2020-12-10 | 2022-02-08 | 주식회사 레피겐엠디 | 마이크로rna를 이용한 당뇨병성 신경병증의 예측 및 진단 방법 및 이를 위한 키트 |
| CN113238045B (zh) * | 2021-04-27 | 2021-12-28 | 南方医科大学南方医院 | Crmp2及抗crmp2抗体的应用 |
| KR102759445B1 (ko) * | 2021-11-16 | 2025-01-24 | 한국한의학연구원 | 치료에 따른 보행 장애 개선 판별용 바이오마커 및 이의 용도 |
| US20240212139A1 (en) * | 2022-12-22 | 2024-06-27 | National Taiwan University | Automatic calculation method of gray-to-white-matter ratio for head computed tomography of patients with cardiac arrest |
Family Cites Families (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5660985A (en) | 1990-06-11 | 1997-08-26 | Nexstar Pharmaceuticals, Inc. | High affinity nucleic acid ligands containing modified nucleotides |
| US5496938A (en) | 1990-06-11 | 1996-03-05 | Nexstar Pharmaceuticals, Inc. | Nucleic acid ligands to HIV-RT and HIV-1 rev |
| US5270163A (en) | 1990-06-11 | 1993-12-14 | University Research Corporation | Methods for identifying nucleic acid ligands |
| US5637459A (en) | 1990-06-11 | 1997-06-10 | Nexstar Pharmaceuticals, Inc. | Systematic evolution of ligands by exponential enrichment: chimeric selex |
| US5475096A (en) | 1990-06-11 | 1995-12-12 | University Research Corporation | Nucleic acid ligands |
| US5683867A (en) | 1990-06-11 | 1997-11-04 | Nexstar Pharmaceuticals, Inc. | Systematic evolution of ligands by exponential enrichment: blended SELEX |
| US5567588A (en) | 1990-06-11 | 1996-10-22 | University Research Corporation | Systematic evolution of ligands by exponential enrichment: Solution SELEX |
| US6011020A (en) | 1990-06-11 | 2000-01-04 | Nexstar Pharmaceuticals, Inc. | Nucleic acid ligand complexes |
| US5707796A (en) | 1990-06-11 | 1998-01-13 | Nexstar Pharmaceuticals, Inc. | Method for selecting nucleic acids on the basis of structure |
| AU2414092A (en) * | 1991-08-01 | 1993-03-02 | Paul H. Voorheis | Diagnostic method for alzheimer's disease |
| US5731410A (en) | 1994-11-28 | 1998-03-24 | University Of Utah Research Foundation | Peptide for blocking autoantibody-evoked activation of glutamate receptor type 3 (GLUR3) |
| BR9913112A (pt) | 1998-09-08 | 2001-05-08 | Innogenetics Nv | Tau como um marcador para dano inicial de cns |
| US20020002270A1 (en) | 1999-06-16 | 2002-01-03 | Raymond P. Zinkowski | Purified antigen for alzheimer's disease, and methods of obtaining and using same |
| US6589746B1 (en) * | 1999-10-21 | 2003-07-08 | University Of Cincinnati | Method of detecting axonally-derived protein tau in patients with traumatic CNS injury |
| US20040253637A1 (en) | 2001-04-13 | 2004-12-16 | Biosite Incorporated | Markers for differential diagnosis and methods of use thereof |
| US20030199000A1 (en) | 2001-08-20 | 2003-10-23 | Valkirs Gunars E. | Diagnostic markers of stroke and cerebral injury and methods of use thereof |
| US7713705B2 (en) | 2002-12-24 | 2010-05-11 | Biosite, Inc. | Markers for differential diagnosis and methods of use thereof |
| US20040203083A1 (en) | 2001-04-13 | 2004-10-14 | Biosite, Inc. | Use of thrombus precursor protein and monocyte chemoattractant protein as diagnostic and prognostic indicators in vascular diseases |
| US20020172676A1 (en) * | 2001-05-16 | 2002-11-21 | George Jackowski | Method of treatment of alzheimer's disease and device therefor |
| US7144708B2 (en) | 2001-06-25 | 2006-12-05 | The Cleveland Clinic Foundation | Markers of blood barrier disruption and methods of using same |
| DE60233949D1 (de) | 2001-08-20 | 2009-11-19 | Biosite Inc | Diagnostische marker für schlaganfall und hirntrauma sowie verfahren zur verwendung davon |
| WO2003032894A2 (en) * | 2001-10-12 | 2003-04-24 | Pfizer Products Inc. | Method of monitoring neuroprotective treatment |
| WO2004078204A1 (en) | 2002-06-12 | 2004-09-16 | The Cleveland Clinic Foundation | Markers of blood barrier permeability and methods of using same |
| EP2211176A3 (en) | 2002-09-11 | 2010-12-08 | University Of Florida | Analyzing nerve cell damage |
| CA2511501A1 (en) | 2002-12-24 | 2004-07-15 | Biosite Incorporated | Markers for differential diagnosis and methods of use thereof |
| DK2357477T3 (en) | 2003-09-20 | 2018-02-05 | Electrophoretics Ltd | Diagnostic approach for brain injury-related disorders based on detection of NDKA |
| EP1519194A1 (en) | 2003-09-24 | 2005-03-30 | Roche Diagnostics GmbH | Use of gfap for identification of intracerebral hemorrhage |
| EP1745149A4 (en) | 2004-04-15 | 2008-08-06 | Univ Florida | NEURALE PROTEINS AS BIOMARKERS FOR INJURY TO THE NERVOUS SYSTEM AND OTHER NEURAL DISORDERS |
| US7456027B2 (en) | 2004-04-15 | 2008-11-25 | University Of Florida Research Foundation, Inc. | Proteolytic biomarkers for traumatic injury to the nervous system |
| US20140303041A1 (en) | 2004-04-15 | 2014-10-09 | University Of Florida Research Foundation Inc. | In vitro diagnostic devices for nervous system injury and other neural disorders |
| US8492107B2 (en) | 2004-04-15 | 2013-07-23 | University Of Florida Research Foundation, Inc. | Neural proteins as biomarkers for nervous system injury and other neural disorders |
| GB2428240A (en) | 2005-07-14 | 2007-01-24 | Univ Gen Ve | Diagnostic method for brain damage-related disorders |
| WO2007046811A2 (en) | 2005-10-20 | 2007-04-26 | Biosite, Inc. | Diagnostic markers of stroke and cerebral injury and methods of use thereof |
| US8563291B2 (en) | 2006-02-15 | 2013-10-22 | Mie University | Method of constructing recombinant proteoliposome for diagnostic use |
| WO2007136617A2 (en) * | 2006-05-18 | 2007-11-29 | Walter Reed Army Institute Of Research (Wrair) | Endothelial-monocyte activating polypeptide ii, a biomarker for use in diagnosis of brain injury |
| EP2024395A4 (en) | 2006-05-26 | 2009-07-01 | Biosite Inc | USE OF NATRIURETIC PEPTIDES AS DIAGNOSTIC AND PROGNOSTIC INDICATORS IN VASCULAR DISEASES |
| CA2715248A1 (en) * | 2008-02-04 | 2009-08-13 | Banyan Biomarkers, Inc. | Process to diagnose or treat brain injury |
| EP2143735A1 (en) | 2008-07-10 | 2010-01-13 | Institut Pasteur | Variable domains of camelid heavy-chain antibodies directed against glial fibrillary acidic proteins |
| NO2324360T3 (enExample) | 2008-08-11 | 2018-06-30 | ||
| US20140342381A1 (en) | 2008-08-11 | 2014-11-20 | Banyan Biomarkers, Inc. | Devices and methods for biomarker detection process and assay of neurological condition |
| WO2010059242A2 (en) | 2008-11-21 | 2010-05-27 | The Johns Hopkins University | Neurodegenerative disease diagnostic compositions and methods of use |
| US20170315136A9 (en) | 2009-06-19 | 2017-11-02 | Banyan Biomarkers, Inc. | Biomarker assay of neurological condition |
| AU2010262952B2 (en) * | 2009-06-19 | 2016-01-07 | Banyan Biomarkers, Inc. | Biomarker assay of neurological condition |
| WO2011011334A2 (en) | 2009-07-18 | 2011-01-27 | Banyan Biomarkers, Inc. | SYNERGISTIC BIOMARKER ASSAY OF NEUROLGICAL CONDITION USING S-100β |
| HUE040281T2 (hu) | 2009-09-14 | 2019-03-28 | Banyan Biomarkers Inc | Autoantitest markerek traumás agysérülés diagnózisára |
| CN102918397A (zh) | 2010-04-01 | 2013-02-06 | 班扬生物标记公司 | 用于神经毒性检测的标志物和测定方法 |
| WO2011160096A2 (en) | 2010-06-17 | 2011-12-22 | Banyan Biomarkers, Inc. | Glial fibrillary acidic protein, autoantigens and autoantibodies thereto as biomarkers of neural injury or neurological disorder or condition |
| CA2846625A1 (en) | 2011-09-14 | 2013-03-21 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Processes and kits to detect and monitor for diagnostic biomarkers for post traumatic stress disorder (ptsd) and to differentiate between suicidal and non-suicidal form of the disorder |
| US20140024053A1 (en) | 2012-07-20 | 2014-01-23 | Banyan Biomarkers, Inc. | Methods, kits and devices for detecting bii-spectrin, and breakdown products thereof, as biomarkers for the diagnosis of neural injury |
| US20140275294A1 (en) | 2013-03-15 | 2014-09-18 | Banyan Biomarkers, Inc. | Devices and methods for biomarker detection process and assay of liver injury |
| WO2014194329A1 (en) | 2013-05-31 | 2014-12-04 | Banyan Biomarkers, Inc. | NEURAL SPECIFIC S100β FOR BIOMARKER ASSAYS AND DEVICES FOR DETECTION OF A NEUROLOGICAL CONDITION |
-
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- 2010-09-14 HU HUE10816275A patent/HUE040281T2/hu unknown
- 2010-09-14 EP EP10816275.1A patent/EP2478360B1/en not_active Revoked
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-
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-
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-
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