JP2013504331A5 - - Google Patents
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- JP2013504331A5 JP2013504331A5 JP2012528991A JP2012528991A JP2013504331A5 JP 2013504331 A5 JP2013504331 A5 JP 2013504331A5 JP 2012528991 A JP2012528991 A JP 2012528991A JP 2012528991 A JP2012528991 A JP 2012528991A JP 2013504331 A5 JP2013504331 A5 JP 2013504331A5
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- Prior art keywords
- mir
- protein
- biomarker
- tau
- gfap
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 claims 16
- 239000000090 biomarker Substances 0.000 claims 11
- 102000004169 proteins and genes Human genes 0.000 claims 11
- 108090000623 proteins and genes Proteins 0.000 claims 11
- 239000007857 degradation product Substances 0.000 claims 9
- 101710193519 Glial fibrillary acidic protein Proteins 0.000 claims 6
- 102100039289 Glial fibrillary acidic protein Human genes 0.000 claims 6
- 102000012338 Poly(ADP-ribose) Polymerases Human genes 0.000 claims 6
- 108010061844 Poly(ADP-ribose) Polymerases Proteins 0.000 claims 6
- 229920000776 Poly(Adenosine diphosphate-ribose) polymerase Polymers 0.000 claims 6
- 210000005046 glial fibrillary acidic protein Anatomy 0.000 claims 6
- 150000001413 amino acids Chemical class 0.000 claims 5
- 238000003776 cleavage reaction Methods 0.000 claims 5
- 230000007017 scission Effects 0.000 claims 5
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 238000001514 detection method Methods 0.000 claims 4
- 108090000371 Esterases Proteins 0.000 claims 3
- 101000891579 Homo sapiens Microtubule-associated protein tau Proteins 0.000 claims 3
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- 101710157175 Spectrin alpha chain, non-erythrocytic 1 Proteins 0.000 claims 3
- 102000044159 Ubiquitin Human genes 0.000 claims 3
- 108090000848 Ubiquitin Proteins 0.000 claims 3
- 239000012472 biological sample Substances 0.000 claims 3
- 102000057063 human MAPT Human genes 0.000 claims 3
- 208000004051 Chronic Traumatic Encephalopathy Diseases 0.000 claims 2
- 102100028652 Gamma-enolase Human genes 0.000 claims 2
- 101000979001 Homo sapiens Methionine aminopeptidase 2 Proteins 0.000 claims 2
- 101000969087 Homo sapiens Microtubule-associated protein 2 Proteins 0.000 claims 2
- 102000009664 Microtubule-Associated Proteins Human genes 0.000 claims 2
- 108010020004 Microtubule-Associated Proteins Proteins 0.000 claims 2
- 102100021118 Microtubule-associated protein 2 Human genes 0.000 claims 2
- 102100023057 Neurofilament light polypeptide Human genes 0.000 claims 2
- 108010019965 Spectrin Proteins 0.000 claims 2
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- 108010055170 Synaptotagmin I Proteins 0.000 claims 2
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- 101000979321 Homo sapiens Neurofilament medium polypeptide Proteins 0.000 claims 1
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- 108091028080 MiR-132 Proteins 0.000 claims 1
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- 102100030610 Mothers against decapentaplegic homolog 5 Human genes 0.000 claims 1
- 101710143113 Mothers against decapentaplegic homolog 5 Proteins 0.000 claims 1
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- 102000008880 Peptidase C12, ubiquitin carboxyl-terminal hydrolases Human genes 0.000 claims 1
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- 108010022181 Phosphopyruvate Hydratase Proteins 0.000 claims 1
- 101100480719 Rattus norvegicus Mapt gene Proteins 0.000 claims 1
- 102000013008 Semaphorin-3A Human genes 0.000 claims 1
- 108010090319 Semaphorin-3A Proteins 0.000 claims 1
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- 108010044208 calpastatin Proteins 0.000 claims 1
- ZXJCOYBPXOBJMU-HSQGJUDPSA-N calpastatin peptide Ac 184-210 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CCSC)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC(O)=O)NC(C)=O)[C@@H](C)O)C1=CC=C(O)C=C1 ZXJCOYBPXOBJMU-HSQGJUDPSA-N 0.000 claims 1
- 230000015556 catabolic process Effects 0.000 claims 1
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims 1
- 230000000593 degrading effect Effects 0.000 claims 1
- 102000051520 human GFAP Human genes 0.000 claims 1
- 210000005049 internexin Anatomy 0.000 claims 1
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- 108091055434 miR-124a stem-loop Proteins 0.000 claims 1
- 108091082871 miR-124a-2 stem-loop Proteins 0.000 claims 1
- 108091050112 miR-124a-4 stem-loop Proteins 0.000 claims 1
- 108091054623 miR-124a-5 stem-loop Proteins 0.000 claims 1
- 108091024680 miR-124a-6 stem-loop Proteins 0.000 claims 1
- 108091024609 miR-124b stem-loop Proteins 0.000 claims 1
- 108091081188 miR-124b-1 stem-loop Proteins 0.000 claims 1
- 108091060300 miR-124b-2 stem-loop Proteins 0.000 claims 1
- 108091044988 miR-125a stem-loop Proteins 0.000 claims 1
- 108091049513 miR-125a-1 stem-loop Proteins 0.000 claims 1
- 108091040046 miR-125a-2 stem-loop Proteins 0.000 claims 1
- 108091070946 miR-128 stem-loop Proteins 0.000 claims 1
- 108091029379 miR-139 stem-loop Proteins 0.000 claims 1
- 108091033783 miR-153 stem-loop Proteins 0.000 claims 1
- 108091029500 miR-183 stem-loop Proteins 0.000 claims 1
- 108091058965 miR-218a stem-loop Proteins 0.000 claims 1
- 108091063841 miR-219 stem-loop Proteins 0.000 claims 1
- 108091080321 miR-222 stem-loop Proteins 0.000 claims 1
- 108091074487 miR-34 stem-loop Proteins 0.000 claims 1
- 108091092493 miR-34-1 stem-loop Proteins 0.000 claims 1
- 108091059780 miR-34-2 stem-loop Proteins 0.000 claims 1
- 108091055813 miR-6 stem-loop Proteins 0.000 claims 1
- 108091065445 miR-6-4 stem-loop Proteins 0.000 claims 1
- 108091053743 miR-6-5 stem-loop Proteins 0.000 claims 1
- 108091055911 miR-6-6 stem-loop Proteins 0.000 claims 1
- 108091047084 miR-9 stem-loop Proteins 0.000 claims 1
- 108091038507 miR-92b stem-loop Proteins 0.000 claims 1
- 108091081014 miR-92b-1 stem-loop Proteins 0.000 claims 1
- 108091032846 miR-92b-2 stem loop Proteins 0.000 claims 1
- 108091070501 miRNA Proteins 0.000 claims 1
- 239000002679 microRNA Substances 0.000 claims 1
- 208000037890 multiple organ injury Diseases 0.000 claims 1
- 230000001537 neural effect Effects 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
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- 108010080874 neuroserpin Proteins 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 150000007523 nucleic acids Chemical group 0.000 claims 1
- 210000002381 plasma Anatomy 0.000 claims 1
- 239000000047 product Substances 0.000 claims 1
- 102000000568 rho-Associated Kinases Human genes 0.000 claims 1
- 108010041788 rho-Associated Kinases Proteins 0.000 claims 1
- 210000003296 saliva Anatomy 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 102000003137 synaptotagmin Human genes 0.000 claims 1
- 108060008004 synaptotagmin Proteins 0.000 claims 1
- 238000003786 synthesis reaction Methods 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 230000009529 traumatic brain injury Effects 0.000 claims 1
- 210000002700 urine Anatomy 0.000 claims 1
- 210000005048 vimentin Anatomy 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24212309P | 2009-09-14 | 2009-09-14 | |
| US61/242,123 | 2009-09-14 | ||
| US35450410P | 2010-06-14 | 2010-06-14 | |
| US61/354,504 | 2010-06-14 | ||
| US35577910P | 2010-06-17 | 2010-06-17 | |
| US61/355,779 | 2010-06-17 | ||
| US38015810P | 2010-09-03 | 2010-09-03 | |
| US61/380,158 | 2010-09-03 | ||
| PCT/US2010/048789 WO2011032155A2 (en) | 2009-09-14 | 2010-09-14 | Micro-rna, autoantibody and protein markers for diagnosis of neuronal injury |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015253708A Division JP2016105097A (ja) | 2009-09-14 | 2015-12-25 | ニューロン損傷診断のためのマイクロｒｎａ、自己抗体およびタンパク質マーカー |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013504331A JP2013504331A (ja) | 2013-02-07 |
| JP2013504331A5 true JP2013504331A5 (enExample) | 2013-12-19 |
| JP5909447B2 JP5909447B2 (ja) | 2016-04-26 |
Family
ID=43733138
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012528991A Active JP5909447B2 (ja) | 2009-09-14 | 2010-09-14 | ニューロン損傷診断のためのマイクロｒｎａ、自己抗体およびタンパク質マーカー |
| JP2015253708A Pending JP2016105097A (ja) | 2009-09-14 | 2015-12-25 | ニューロン損傷診断のためのマイクロｒｎａ、自己抗体およびタンパク質マーカー |
| JP2017111070A Active JP6469760B2 (ja) | 2009-09-14 | 2017-06-05 | ニューロン損傷診断のためのマイクロｒｎａ、自己抗体およびタンパク質マーカー |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015253708A Pending JP2016105097A (ja) | 2009-09-14 | 2015-12-25 | ニューロン損傷診断のためのマイクロｒｎａ、自己抗体およびタンパク質マーカー |
| JP2017111070A Active JP6469760B2 (ja) | 2009-09-14 | 2017-06-05 | ニューロン損傷診断のためのマイクロｒｎａ、自己抗体およびタンパク質マーカー |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US20130022982A1 (enExample) |
| EP (1) | EP2478360B1 (enExample) |
| JP (3) | JP5909447B2 (enExample) |
| AU (2) | AU2010291933B2 (enExample) |
| CA (1) | CA2774173A1 (enExample) |
| ES (1) | ES2687469T3 (enExample) |
| HU (1) | HUE040281T2 (enExample) |
| WO (1) | WO2011032155A2 (enExample) |
Families Citing this family (77)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8492107B2 (en) | 2004-04-15 | 2013-07-23 | University Of Florida Research Foundation, Inc. | Neural proteins as biomarkers for nervous system injury and other neural disorders |
| WO2010019553A2 (en) | 2008-08-11 | 2010-02-18 | Banyan Biomarkers, Inc. | Biomarker detection process and assay of neurological condition |
| CA2766057A1 (en) * | 2009-06-19 | 2010-12-23 | Banyan Biomarkers, Inc. | Biomarker assay of neurological condition |
| US20170315136A9 (en) * | 2009-06-19 | 2017-11-02 | Banyan Biomarkers, Inc. | Biomarker assay of neurological condition |
| AU2010291933B2 (en) | 2009-09-14 | 2016-09-08 | Banyan Biomarkers, Inc. | Micro-RNA, autoantibody and protein markers for diagnosis of neuronal injury |
| WO2012045324A1 (en) * | 2010-10-07 | 2012-04-12 | Mediagnost Gesellschaft Fur Forschung Und Herstellung Von Diagnostika Gmbh | Method for detecting a parkinson's disease and test system |
| WO2012051519A2 (en) | 2010-10-14 | 2012-04-19 | The Johns Hopkins University | Biomarkers of brain injury |
| DE102011011280A1 (de) * | 2011-02-15 | 2012-08-16 | Euroimmun Medizinische Labordiagnostika Ag | Diagnosekit sowie ein Verfahren zur Untersuchung einer menschlichen Patientenprobe auf das Vorhandensein von Neuromyelitis-optica-spezifischen Antikörpern |
| WO2012142301A2 (en) | 2011-04-12 | 2012-10-18 | Quanterix Corporation | Methods of determining a treatment protocol for and/or a prognosis of a patients recovery from a brain injury |
| GB201111361D0 (en) * | 2011-07-04 | 2011-08-17 | Nordic Bioscience As | Biochemical markers for neurodegenerative conditions |
| US20140206777A1 (en) * | 2011-08-16 | 2014-07-24 | Rosetta Genomics Ltd. | Methods and compositions for diagnosis of alzheimer's disease |
| US9709573B2 (en) | 2012-03-13 | 2017-07-18 | The Johns Hopkins University | Citrullinated brain and neurological proteins as biomarkers of brain injury or neurodegeneration |
| WO2013173596A1 (en) * | 2012-05-16 | 2013-11-21 | Trustees Of Boston University | Chronic traumatic encephalopathy in blast-exposed individuals |
| NZ703423A (en) * | 2012-07-03 | 2018-02-23 | Univ Washington | Antibodies to tau |
| US20140073524A1 (en) * | 2012-09-07 | 2014-03-13 | Institute For Systems Biology | Markers and methods for detecting posttraumatic stress disorder (ptsd) |
| US9856532B2 (en) * | 2012-09-07 | 2018-01-02 | Institute For Systems Biology | Markers and methods for detecting posttraumatic stress disorder (PTSD) |
| EP3022322A4 (en) | 2013-07-17 | 2017-05-17 | The Johns Hopkins University | A multi-protein biomarker assay for brain injury detection and outcome |
| GB201319761D0 (en) * | 2013-11-08 | 2013-12-25 | Nordic Bioscience As | Biomarkers of disease progression |
| CN103656685B (zh) * | 2014-01-10 | 2016-01-13 | 厦门大学 | microRNA-219在制备抗癫痫药物中的应用 |
| WO2015134551A1 (en) * | 2014-03-03 | 2015-09-11 | Banyan Biomarkers, Inc. | Micro rna markers for diagnosis of a neurological condition |
| US9605315B2 (en) | 2014-03-26 | 2017-03-28 | The University Of Montana | Detection of traumatic brain injury |
| CN106461645A (zh) * | 2014-04-07 | 2017-02-22 | 铁马诊断公司 | 外伤性脑损伤和神经退行性生物标记物、方法和系统 |
| EP3129788A4 (en) * | 2014-04-08 | 2018-04-04 | University of Florida Research Foundation, Incorporated | Protein biomarkers for acute, subacute and chronic traumatic injuries of the central nervous system |
| WO2015160391A1 (en) * | 2014-04-15 | 2015-10-22 | The Government Of The United States, As Represented By The Secretary Of The Army, On Behalf Of Walter Reed Army Institute Of Research | Diagnosis and treatment of tauopathy and chronic traumatic encephalopathy |
| WO2015196191A1 (en) * | 2014-06-20 | 2015-12-23 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Microrna biomarkers for traumatic brain injury and methods of use thereof |
| US10358679B2 (en) * | 2014-09-26 | 2019-07-23 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | MicroRNA biomarkers for posttraumatic stress disorder and methods of use thereof |
| US20180238907A1 (en) * | 2014-10-06 | 2018-08-23 | Université de Genéve | Markers and their use in brain injury |
| EP3254106A4 (en) * | 2015-02-05 | 2018-10-03 | Immunarray USA, Inc. | Methods and compositions for diagnosing brain injury or neurodegeneration |
| WO2016205730A1 (en) * | 2015-06-18 | 2016-12-22 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Citrullinated proteins and their breakdown products as tbi biomarkers |
| WO2017019976A2 (en) * | 2015-07-29 | 2017-02-02 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Microrna biomarkers for traumatic brain injury and methods of use thereof |
| WO2017044650A1 (en) * | 2015-09-08 | 2017-03-16 | The Translational Genomics Research Institute | Biomarkers and methods of diagnosing and prognosing mild traumatic brain injuries |
| EP3377074B1 (en) * | 2015-11-18 | 2024-01-03 | Dignity Health | Methods of diagnosing post traumatic epilepsy |
| GB201603967D0 (en) | 2016-03-08 | 2016-04-20 | Univ Birmingham | Biomarkers of traumatic brain injury |
| CN109219655A (zh) * | 2016-04-28 | 2019-01-15 | 般财团法人生产技术研究奖励会 | 用于培养神经细胞的装置、用于培养神经细胞的方法、培养的神经细胞、用于分析和鉴定轴突束中蛋白质的方法、以及用于使用神经细胞的方法 |
| JP2019521319A (ja) * | 2016-05-06 | 2019-07-25 | デューク ユニバーシティ | 神経系疾患または損傷を診断および治療するための方法並びにキット |
| US11402379B2 (en) | 2016-09-09 | 2022-08-02 | Mayo Foundation For Medical Education And Research | Methods and materials for identifying and treating autoimmune GFAP astrocytopathy |
| IT201600093825A1 (it) * | 2016-09-19 | 2018-03-19 | Fondazione St Italiano Tecnologia | Composizione farmaceutica di miRNA e suoi usi terapeutici. |
| US11078298B2 (en) | 2016-10-28 | 2021-08-03 | Banyan Biomarkers, Inc. | Antibodies to ubiquitin C-terminal hydrolase L1 (UCH-L1) and glial fibrillary acidic protein (GFAP) and related methods |
| EP3545311B1 (en) * | 2016-11-23 | 2024-03-27 | Randox Laboratories Ltd | Gfap derivatives for stroke diagnostics |
| WO2018148294A2 (en) * | 2017-02-07 | 2018-08-16 | Bioregency, Inc. | S100β AND ISOFORMS FOR DETECTION OF NEUROLOGICAL CONDITIONS |
| MX2019009817A (es) | 2017-02-17 | 2019-11-21 | Denali Therapeutics Inc | Anticuerpos anti-tau y metodos de uso de los mismos. |
| WO2018175942A1 (en) | 2017-03-23 | 2018-09-27 | Abbott Laboratories | Methods for aiding in the diagnosis and determination of the extent of traumatic brain injury in a human subject using the early biomarker ubiquitin carboxy-terminal hydrolase l1 |
| WO2018190365A1 (ja) * | 2017-04-12 | 2018-10-18 | 国立大学法人九州大学 | 神経障害性疼痛マーカー及びその使用 |
| EP3610268B1 (en) | 2017-04-15 | 2025-09-24 | Abbott Laboratories | Methods for aiding in the hyperacute diagnosis and determination of traumatic brain injury in a human subject using early biomarkers |
| BR112019022476A2 (pt) | 2017-04-28 | 2020-05-12 | Abbott Laboratories | Métodos para o auxílio no diagnóstico e determinação hiperagudos de lesão cerebral traumática usando biomarcadores iniciais em pelo menos duas amostras a partir do mesmo ser humano |
| WO2018218169A1 (en) | 2017-05-25 | 2018-11-29 | Abbott Laboratories | Methods for aiding in the determination of whether to perform imaging on a human subject who has sustained or may have sustained an injury to the head using early biomarkers |
| CA3059607A1 (en) | 2017-05-30 | 2018-12-06 | Abbott Laboratories | Methods for aiding in diagnosing and evaluating a mild traumatic brain injury in a human subject using cardiac troponin i |
| CN110998321A (zh) * | 2017-06-02 | 2020-04-10 | 约翰霍普金斯大学 | 帕金森氏症患者脑脊液中par的检测方法 |
| US20210148898A1 (en) | 2017-06-02 | 2021-05-20 | The Johns Hopkins University | Detection of par in the csf of patients with parkinson's disease |
| US11739384B2 (en) * | 2017-06-19 | 2023-08-29 | St. John's University | Circulating serum microRNA biomarkers and methods for Parkinson's disease prognosis |
| JP7454945B2 (ja) | 2017-07-03 | 2024-03-25 | アボット・ラボラトリーズ | 血液中のユビキチンカルボキシ末端ヒドロラーゼｌ１レベルを測定するための、改善された方法 |
| IL302108A (en) | 2017-10-25 | 2023-06-01 | Ac Immune Sa | Preparations of phosphorylated tau peptides and uses thereof |
| JP6942036B2 (ja) * | 2017-11-30 | 2021-09-29 | 藤倉化成株式会社 | 脳梗塞の発症リスクを高感度に検出する体液抗体バイオマーカー |
| CA3067055A1 (en) | 2017-12-09 | 2019-06-13 | Abbott Laboratories | Methods for aiding in diagnosing and evaluating a traumatic brain injury in a human subject using a combination of gfap and uch-l1 |
| BR112019028254A2 (pt) | 2017-12-09 | 2020-07-14 | Abbott Laboratories | métodos para ajudar no diagnóstico e avaliação de um paciente que sofreu uma lesão ortopédica e que sofreu ou pode ter sofrido uma lesão na cabeça, tal como uma lesão cerebral traumática (lct) leve, usando a proteína ácida fibrilar glial (gfap) e/ou a hidrolase carbóxi-terminal da ubiquitina l1 (uch-l1) |
| EP3732489B1 (en) | 2017-12-29 | 2025-10-22 | Abbott Laboratories | Novel biomarkers and methods for diagnosing and evaluating traumatic brain injury |
| KR102026675B1 (ko) * | 2018-02-12 | 2019-09-30 | 강원대학교산학협력단 | miR-135a-5p 및 p62에 의한 알레르기 반응 조절 메커니즘 및 이의 이용 |
| EP4403923A3 (en) * | 2018-03-08 | 2024-11-27 | Meso Scale Technologies, LLC | Genetic marker and/or biomarkers for traumatic brain injury, and ultrasensitive assays for biomarkers of traumatic brain injury |
| JP6499342B2 (ja) * | 2018-03-19 | 2019-04-10 | 隆樹 日和佐 | 脳梗塞の診断マーカー |
| WO2019207159A1 (en) * | 2018-04-27 | 2019-10-31 | Fondazione Ebri Rita Levi-Montalcini | Antibody directed against a tau-derived neurotoxic peptide and uses thereof |
| CN118460695A (zh) * | 2018-07-25 | 2024-08-09 | 斯纳利蒂克斯股份有限公司 | 用于阿尔茨海默氏病的小rna预测因子 |
| CN110824156B (zh) * | 2018-08-14 | 2023-08-11 | 欧蒙医学诊断（中国）有限公司 | 神经自身免疫疾病的诊断 |
| WO2020037311A1 (en) * | 2018-08-17 | 2020-02-20 | University Of Florida Research Foundation, Inc. | Protein and peptide biomarkers for traumatic injury to the central nervous system |
| CN113195740A (zh) * | 2018-10-17 | 2021-07-30 | 奥克斯纳健康系统公司 | 在脑内出血和蛛网膜下腔出血中的血浆和脑脊液miRNA生物标志物 |
| CN109266739A (zh) * | 2018-11-29 | 2019-01-25 | 成都仕康美生物科技有限公司 | 一种检测脑损伤的miRNA标志物、试剂盒、应用 |
| EP3891295A4 (en) * | 2018-12-04 | 2022-12-07 | La Trobe University | PROCEDURE FOR DIAGNOSIS OF A DISEASE CONDITION |
| CA3129252A1 (en) | 2019-02-08 | 2020-08-13 | Ac Immune S.A. | Method of safe administration of phosphorylated tau peptide vaccine |
| CA3129034A1 (en) * | 2019-02-14 | 2020-08-20 | Marker Diagnostics Uk Limited | Salivary biomarkers of brain injury |
| GB201909393D0 (en) * | 2019-06-28 | 2019-08-14 | Gen2 Neuroscience Ltd | Tau epitope and binding molecules |
| CN110551809A (zh) * | 2019-08-21 | 2019-12-10 | 昆明医科大学第一附属医院 | miR-124在脊髓损伤修复中的用途 |
| US11644463B2 (en) * | 2019-08-30 | 2023-05-09 | Euroimmun Medizinische Labordiagnostika Ag | Detection of an autoantibody |
| US20230250480A1 (en) * | 2020-07-09 | 2023-08-10 | University Of Florida Research Foundation, Incorporated | Biofluid-based protein and mirna biomarkers for neonatal hypoxic-ischemic encephalopathy |
| CN116829950A (zh) * | 2020-08-24 | 2023-09-29 | 玛拉生物系统公司 | 用于减少母体自身抗体的方法 |
| KR102357260B1 (ko) * | 2020-12-10 | 2022-02-08 | 주식회사 레피겐엠디 | 마이크로rna를 이용한 당뇨병성 신경병증의 예측 및 진단 방법 및 이를 위한 키트 |
| CN113238045B (zh) * | 2021-04-27 | 2021-12-28 | 南方医科大学南方医院 | Crmp2及抗crmp2抗体的应用 |
| KR102759445B1 (ko) * | 2021-11-16 | 2025-01-24 | 한국한의학연구원 | 치료에 따른 보행 장애 개선 판별용 바이오마커 및 이의 용도 |
| TWI853766B (zh) * | 2022-12-22 | 2024-08-21 | 國立臺灣大學 | 用於心跳停止病患頭部電腦斷層之灰白質比率自動計算方法 |
Family Cites Families (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5637459A (en) | 1990-06-11 | 1997-06-10 | Nexstar Pharmaceuticals, Inc. | Systematic evolution of ligands by exponential enrichment: chimeric selex |
| US5683867A (en) | 1990-06-11 | 1997-11-04 | Nexstar Pharmaceuticals, Inc. | Systematic evolution of ligands by exponential enrichment: blended SELEX |
| US5270163A (en) | 1990-06-11 | 1993-12-14 | University Research Corporation | Methods for identifying nucleic acid ligands |
| US6011020A (en) | 1990-06-11 | 2000-01-04 | Nexstar Pharmaceuticals, Inc. | Nucleic acid ligand complexes |
| US5496938A (en) | 1990-06-11 | 1996-03-05 | Nexstar Pharmaceuticals, Inc. | Nucleic acid ligands to HIV-RT and HIV-1 rev |
| ATE160821T1 (de) | 1990-06-11 | 1997-12-15 | Nexstar Pharmaceuticals Inc | Nukleinsäureliganden |
| US5567588A (en) | 1990-06-11 | 1996-10-22 | University Research Corporation | Systematic evolution of ligands by exponential enrichment: Solution SELEX |
| US5660985A (en) | 1990-06-11 | 1997-08-26 | Nexstar Pharmaceuticals, Inc. | High affinity nucleic acid ligands containing modified nucleotides |
| US5707796A (en) | 1990-06-11 | 1998-01-13 | Nexstar Pharmaceuticals, Inc. | Method for selecting nucleic acids on the basis of structure |
| WO1993003369A1 (en) * | 1991-08-01 | 1993-02-18 | Voorheis Paul H | Diagnostic method for alzheimer's disease |
| US5731410A (en) | 1994-11-28 | 1998-03-24 | University Of Utah Research Foundation | Peptide for blocking autoantibody-evoked activation of glutamate receptor type 3 (GLUR3) |
| ES2229817T3 (es) * | 1998-09-08 | 2005-04-16 | Innogenetics N.V. | Uso de la tau como un marcador para la deteccion temprana del daño del sistema nervioso central (cns). |
| US20020002270A1 (en) | 1999-06-16 | 2002-01-03 | Raymond P. Zinkowski | Purified antigen for alzheimer's disease, and methods of obtaining and using same |
| US6589746B1 (en) * | 1999-10-21 | 2003-07-08 | University Of Cincinnati | Method of detecting axonally-derived protein tau in patients with traumatic CNS injury |
| US7713705B2 (en) | 2002-12-24 | 2010-05-11 | Biosite, Inc. | Markers for differential diagnosis and methods of use thereof |
| US20040203083A1 (en) | 2001-04-13 | 2004-10-14 | Biosite, Inc. | Use of thrombus precursor protein and monocyte chemoattractant protein as diagnostic and prognostic indicators in vascular diseases |
| US20040253637A1 (en) | 2001-04-13 | 2004-12-16 | Biosite Incorporated | Markers for differential diagnosis and methods of use thereof |
| US20030199000A1 (en) | 2001-08-20 | 2003-10-23 | Valkirs Gunars E. | Diagnostic markers of stroke and cerebral injury and methods of use thereof |
| US20020172676A1 (en) * | 2001-05-16 | 2002-11-21 | George Jackowski | Method of treatment of alzheimer's disease and device therefor |
| US7144708B2 (en) | 2001-06-25 | 2006-12-05 | The Cleveland Clinic Foundation | Markers of blood barrier disruption and methods of using same |
| CA2457775A1 (en) | 2001-08-20 | 2003-02-27 | Biosite Incorporated | Diagnostic markers of stroke and cerebral injury and methods of use thereof |
| WO2003032894A2 (en) * | 2001-10-12 | 2003-04-24 | Pfizer Products Inc. | Method of monitoring neuroprotective treatment |
| WO2004078204A1 (en) | 2002-06-12 | 2004-09-16 | The Cleveland Clinic Foundation | Markers of blood barrier permeability and methods of using same |
| CA2498614C (en) | 2002-09-11 | 2013-04-16 | University Of Florida | Analyzing nerve cell damage |
| AU2003302340B8 (en) | 2002-12-24 | 2008-09-11 | Biosite Incorporated | Markers for differential diagnosis and methods of use thereof |
| AU2004274710B2 (en) | 2003-09-20 | 2011-05-19 | Electrophoretics Limited | Diagnostic method for brain damage-related disorders |
| EP1519194A1 (en) | 2003-09-24 | 2005-03-30 | Roche Diagnostics GmbH | Use of gfap for identification of intracerebral hemorrhage |
| EP1745149A4 (en) | 2004-04-15 | 2008-08-06 | Univ Florida | NEURALE PROTEINS AS BIOMARKERS FOR INJURY TO THE NERVOUS SYSTEM AND OTHER NEURAL DISORDERS |
| ES2367311T3 (es) | 2004-04-15 | 2011-11-02 | University Of Florida Research Foundation, Inc. | Productos de degradación proteolítica de map-2 como biomarcadores de diagnóstico para las lesiones neurales. |
| US8492107B2 (en) | 2004-04-15 | 2013-07-23 | University Of Florida Research Foundation, Inc. | Neural proteins as biomarkers for nervous system injury and other neural disorders |
| US20140303041A1 (en) | 2004-04-15 | 2014-10-09 | University Of Florida Research Foundation Inc. | In vitro diagnostic devices for nervous system injury and other neural disorders |
| GB2428240A (en) * | 2005-07-14 | 2007-01-24 | Univ Gen Ve | Diagnostic method for brain damage-related disorders |
| WO2007046811A2 (en) | 2005-10-20 | 2007-04-26 | Biosite, Inc. | Diagnostic markers of stroke and cerebral injury and methods of use thereof |
| JP5266459B2 (ja) | 2006-02-15 | 2013-08-21 | 国立大学法人三重大学 | 診断用組換えプロテオリポソームの作製法 |
| WO2007136617A2 (en) * | 2006-05-18 | 2007-11-29 | Walter Reed Army Institute Of Research (Wrair) | Endothelial-monocyte activating polypeptide ii, a biomarker for use in diagnosis of brain injury |
| EP2024395A4 (en) | 2006-05-26 | 2009-07-01 | Biosite Inc | USE OF NATRIURETIC PEPTIDES AS DIAGNOSTIC AND PROGNOSTIC INDICATORS IN VASCULAR DISEASES |
| JP2011511301A (ja) * | 2008-02-04 | 2011-04-07 | バンヤン・バイオマーカーズ・インコーポレイテッド | 脳損傷を診断または治療するための方法 |
| EP2143735A1 (en) | 2008-07-10 | 2010-01-13 | Institut Pasteur | Variable domains of camelid heavy-chain antibodies directed against glial fibrillary acidic proteins |
| WO2010019553A2 (en) | 2008-08-11 | 2010-02-18 | Banyan Biomarkers, Inc. | Biomarker detection process and assay of neurological condition |
| US20140342381A1 (en) | 2008-08-11 | 2014-11-20 | Banyan Biomarkers, Inc. | Devices and methods for biomarker detection process and assay of neurological condition |
| WO2010059242A2 (en) | 2008-11-21 | 2010-05-27 | The Johns Hopkins University | Neurodegenerative disease diagnostic compositions and methods of use |
| CA2766057A1 (en) * | 2009-06-19 | 2010-12-23 | Banyan Biomarkers, Inc. | Biomarker assay of neurological condition |
| US20170315136A9 (en) | 2009-06-19 | 2017-11-02 | Banyan Biomarkers, Inc. | Biomarker assay of neurological condition |
| US20120202231A1 (en) | 2009-07-18 | 2012-08-09 | Kevin Ka-Wang Wang | Synergistic biomarker assay of neurological condition using s-100b |
| AU2010291933B2 (en) | 2009-09-14 | 2016-09-08 | Banyan Biomarkers, Inc. | Micro-RNA, autoantibody and protein markers for diagnosis of neuronal injury |
| WO2011123844A2 (en) * | 2010-04-01 | 2011-10-06 | Banyan Biomarkers, Inc. | Markers and assays for detection of neurotoxicity |
| WO2011160096A2 (en) | 2010-06-17 | 2011-12-22 | Banyan Biomarkers, Inc. | Glial fibrillary acidic protein, autoantigens and autoantibodies thereto as biomarkers of neural injury or neurological disorder or condition |
| CN103959067B (zh) | 2011-09-14 | 2018-04-24 | 促进军事医学的亨利·M·杰克逊基金会公司 | 用于检测和监测用于创伤后应激障碍（ptsd）的诊断生物标志物以及用于区分自杀式与非自杀式障碍的试剂盒 |
| US20140024053A1 (en) | 2012-07-20 | 2014-01-23 | Banyan Biomarkers, Inc. | Methods, kits and devices for detecting bii-spectrin, and breakdown products thereof, as biomarkers for the diagnosis of neural injury |
| US20140275294A1 (en) | 2013-03-15 | 2014-09-18 | Banyan Biomarkers, Inc. | Devices and methods for biomarker detection process and assay of liver injury |
| WO2014194329A1 (en) | 2013-05-31 | 2014-12-04 | Banyan Biomarkers, Inc. | NEURAL SPECIFIC S100β FOR BIOMARKER ASSAYS AND DEVICES FOR DETECTION OF A NEUROLOGICAL CONDITION |
-
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