JP2013503897A5 - - Google Patents
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- JP2013503897A5 JP2013503897A5 JP2012528072A JP2012528072A JP2013503897A5 JP 2013503897 A5 JP2013503897 A5 JP 2013503897A5 JP 2012528072 A JP2012528072 A JP 2012528072A JP 2012528072 A JP2012528072 A JP 2012528072A JP 2013503897 A5 JP2013503897 A5 JP 2013503897A5
- Authority
- JP
- Japan
- Prior art keywords
- item
- composition
- chitosan
- formula
- substituent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229920001661 Chitosan Polymers 0.000 claims description 61
- 125000001424 substituent group Chemical group 0.000 claims description 56
- 229910052739 hydrogen Inorganic materials 0.000 claims description 45
- 239000000203 mixture Substances 0.000 claims description 43
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims description 31
- 239000001257 hydrogen Substances 0.000 claims description 31
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 29
- 125000002795 guanidino group Chemical group C(N)(=N)N* 0.000 claims description 26
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 22
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 16
- 125000003277 amino group Chemical group 0.000 claims description 16
- 150000002431 hydrogen Chemical class 0.000 claims description 15
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 11
- -1 amino, guanidino Chemical group 0.000 claims description 11
- 210000004195 gingiva Anatomy 0.000 claims description 11
- ZRALSGWEFCBTJO-UHFFFAOYSA-N guanidine group Chemical group NC(=N)N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 claims description 11
- 229910052757 nitrogen Inorganic materials 0.000 claims description 11
- 241000894006 Bacteria Species 0.000 claims description 10
- 150000001413 amino acids Chemical class 0.000 claims description 5
- 241000628997 Flos Species 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- 229940051866 mouthwash Drugs 0.000 claims description 4
- 239000007864 aqueous solution Substances 0.000 claims description 3
- 230000006196 deacetylation Effects 0.000 claims description 3
- 238000003381 deacetylation reaction Methods 0.000 claims description 3
- 206010006326 Breath odour Diseases 0.000 claims description 2
- 241000187654 Nocardia Species 0.000 claims description 2
- 241000605862 Porphyromonas gingivalis Species 0.000 claims description 2
- 208000003251 Pruritus Diseases 0.000 claims description 2
- 241000194019 Streptococcus mutans Species 0.000 claims description 2
- 241000194023 Streptococcus sanguinis Species 0.000 claims description 2
- 241000589892 Treponema denticola Species 0.000 claims description 2
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 2
- 230000015572 biosynthetic process Effects 0.000 claims description 2
- 208000002925 dental caries Diseases 0.000 claims description 2
- 230000003628 erosive effect Effects 0.000 claims description 2
- 208000007565 gingivitis Diseases 0.000 claims description 2
- 239000012535 impurity Substances 0.000 claims description 2
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 2
- 125000006239 protecting group Chemical group 0.000 claims description 2
- 239000000811 xylitol Substances 0.000 claims description 2
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical group OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 2
- 229960002675 xylitol Drugs 0.000 claims description 2
- 235000010447 xylitol Nutrition 0.000 claims description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims 1
- 230000007803 itching Effects 0.000 claims 1
- 239000000600 sorbitol Substances 0.000 claims 1
- 229940034610 toothpaste Drugs 0.000 claims 1
- 239000000606 toothpaste Substances 0.000 claims 1
- 238000000034 method Methods 0.000 description 102
- 125000000217 alkyl group Chemical group 0.000 description 40
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 5
- 229920000642 polymer Polymers 0.000 description 5
- 108010074051 C-Reactive Protein Proteins 0.000 description 2
- 102100032752 C-reactive protein Human genes 0.000 description 2
- 102000004895 Lipoproteins Human genes 0.000 description 2
- 108090001030 Lipoproteins Proteins 0.000 description 2
- 102100037611 Lysophospholipase Human genes 0.000 description 2
- 208000025157 Oral disease Diseases 0.000 description 2
- 108010058864 Phospholipases A2 Proteins 0.000 description 2
- 208000030194 mouth disease Diseases 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- 125000003287 1H-imidazol-4-ylmethyl group Chemical group [H]N1C([H])=NC(C([H])([H])[*])=C1[H] 0.000 description 1
- MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 description 1
- 125000003974 3-carbamimidamidopropyl group Chemical group C(N)(=N)NCCC* 0.000 description 1
- 125000004042 4-aminobutyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H] 0.000 description 1
- 0 CC(C(C(C1*)C(*)=N)OC(CO)C1O)OC(C(CO)OC(C(C1C(CO)OC2O)OC1C2N*)C1N*)C1O Chemical compound CC(C(C(C1*)C(*)=N)OC(CO)C1O)OC(C(CO)OC(C(C1C(CO)OC2O)OC1C2N*)C1N*)C1O 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000032770 biofilm formation Effects 0.000 description 1
- 230000001680 brushing effect Effects 0.000 description 1
- 238000001804 debridement Methods 0.000 description 1
- 239000000551 dentifrice Substances 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 229960002442 glucosamine Drugs 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23918109P | 2009-09-02 | 2009-09-02 | |
| US61/239,181 | 2009-09-02 | ||
| PCT/US2010/047759 WO2011028968A1 (en) | 2009-09-02 | 2010-09-02 | Oral care methods and compositions utilizing chitosan-derivative compounds |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014233472A Division JP2015034183A (ja) | 2009-09-02 | 2014-11-18 | キトサン誘導体化合物を用いる口腔ケア方法および組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013503897A JP2013503897A (ja) | 2013-02-04 |
| JP2013503897A5 true JP2013503897A5 (https=) | 2013-09-19 |
Family
ID=43649658
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012528072A Pending JP2013503897A (ja) | 2009-09-02 | 2010-09-02 | キトサン誘導体化合物を用いる口腔ケア方法および組成物 |
| JP2014233472A Withdrawn JP2015034183A (ja) | 2009-09-02 | 2014-11-18 | キトサン誘導体化合物を用いる口腔ケア方法および組成物 |
| JP2016040631A Active JP6650785B2 (ja) | 2009-09-02 | 2016-03-03 | キトサン誘導体化合物を用いる口腔ケア方法および組成物 |
| JP2016101300A Pending JP2016155859A (ja) | 2009-09-02 | 2016-05-20 | キトサン誘導体化合物を用いる口腔ケア方法および組成物 |
| JP2017235871A Pending JP2018058889A (ja) | 2009-09-02 | 2017-12-08 | キトサン誘導体化合物を用いる口腔ケア方法および組成物 |
| JP2019077051A Withdrawn JP2019131605A (ja) | 2009-09-02 | 2019-04-15 | キトサン誘導体化合物を用いる口腔ケア方法および組成物 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014233472A Withdrawn JP2015034183A (ja) | 2009-09-02 | 2014-11-18 | キトサン誘導体化合物を用いる口腔ケア方法および組成物 |
| JP2016040631A Active JP6650785B2 (ja) | 2009-09-02 | 2016-03-03 | キトサン誘導体化合物を用いる口腔ケア方法および組成物 |
| JP2016101300A Pending JP2016155859A (ja) | 2009-09-02 | 2016-05-20 | キトサン誘導体化合物を用いる口腔ケア方法および組成物 |
| JP2017235871A Pending JP2018058889A (ja) | 2009-09-02 | 2017-12-08 | キトサン誘導体化合物を用いる口腔ケア方法および組成物 |
| JP2019077051A Withdrawn JP2019131605A (ja) | 2009-09-02 | 2019-04-15 | キトサン誘導体化合物を用いる口腔ケア方法および組成物 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US20120301408A1 (https=) |
| EP (1) | EP2473043B1 (https=) |
| JP (6) | JP2013503897A (https=) |
| AU (4) | AU2010289418A1 (https=) |
| CA (1) | CA2806539C (https=) |
| WO (1) | WO2011028968A1 (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3144324A1 (en) | 2006-06-02 | 2017-03-22 | Synedgen, Inc. | Chitosan-derivative compounds and methods of controlling microbial populations |
| CA3004707C (en) | 2009-09-02 | 2022-05-31 | Synedgen Inc. | Methods and compositions for disrupting biofilm utilizing chitosan-derivative compounds |
| EP2555760B1 (en) | 2010-04-06 | 2019-10-16 | Synedgen, Inc. | Chitosan derivatives for the treatment of mucositis or ulceration |
| JP2013023446A (ja) * | 2011-07-15 | 2013-02-04 | Masao Yamamoto | 口腔ケア用組成物 |
| WO2014047506A1 (en) | 2012-09-20 | 2014-03-27 | Synedgen, Inc. | Methods for treatment or prevention of damage resulting from radiation, trauma or shock |
| DE102013000700A1 (de) * | 2012-10-04 | 2014-04-10 | Maria Clementine Martin Klosterfrau Vertriebsgesellschaft Mbh | Zusammensetzung, insbesondere pharmazeutische Zusammensetzung, insbesondere zur Verabreichung bei Heiserkeit und Halsschmerzen |
| KR101926871B1 (ko) | 2012-10-11 | 2018-12-07 | 부경대학교 산학협력단 | 인체면역결핍바이러스의 예방 또는 치료용 약제학적 조성물 |
| KR20150095807A (ko) * | 2012-12-14 | 2015-08-21 | 콜게이트-파아므올리브캄파니 | 치아 미백방법 |
| US10314771B2 (en) | 2013-02-28 | 2019-06-11 | University Of Tennessee Research Foundation | Methods and compositions for preventing and treating tooth erosion |
| JP6842916B2 (ja) * | 2013-03-12 | 2021-03-17 | シネジェン， インコーポレイテッド | 非発酵性糖と組み合わせたポリグルコサミン誘導体の経口製剤 |
| WO2015023773A2 (en) * | 2013-08-14 | 2015-02-19 | University Of Tennessee Research Foundation | Tooth remineralization compositions and methods |
| NO342617B1 (no) | 2014-06-18 | 2018-06-18 | Meda Otc Ab | Oral formulering omfattende et antibakterielt middel for å forebygge og/eller behandle halitose, dårlig ånde, munntørrhet eller sår hals |
| CA2960998A1 (en) | 2014-09-11 | 2016-03-17 | Synedgen, Inc. | Compositions and methods of use thereof |
| CN105919829B (zh) * | 2016-06-29 | 2018-11-09 | 贵州扬生医用器材有限公司 | 一种漱口水及其制备方法 |
| JP6730744B2 (ja) * | 2016-08-04 | 2020-07-29 | ゼノアックリソース株式会社 | 免疫賦活剤、医薬組成物および飲食品 |
| CN108096182A (zh) * | 2016-11-25 | 2018-06-01 | 哈尔滨盈聚生物科技有限公司 | 一种基于绿色抗菌材料的妇科抗菌凝胶及其制备方法 |
| KR102506599B1 (ko) * | 2018-02-06 | 2023-03-06 | 주식회사 엘지생활건강 | 해바라기유를 포함하는 구강질환 예방 또는 치료용 조성물 |
| US11541105B2 (en) | 2018-06-01 | 2023-01-03 | The Research Foundation For The State University Of New York | Compositions and methods for disrupting biofilm formation and maintenance |
| US11642199B2 (en) * | 2018-09-24 | 2023-05-09 | 3M Innovative Properties Company | Dental appliance with cosmetic therapeutic aqueous solution |
| CN110327221A (zh) * | 2019-04-16 | 2019-10-15 | 中国人民解放军第四军医大学 | 一种牙本质胶原纤维脱矿材料及其制备方法与应用 |
| WO2021221656A1 (en) | 2020-04-30 | 2021-11-04 | Synedgen, Inc. | Compositions and methods of use thereof |
| EP4422457A4 (en) * | 2021-10-28 | 2025-12-24 | Tfh Publications Inc | PET TOOTHBRUSH |
| KR102588162B1 (ko) * | 2023-03-17 | 2023-10-12 | 배광학 | 수용성 키토산을 함유한 구강제제 및 그 제조방법 |
| CN119097606B (zh) * | 2024-11-11 | 2025-02-11 | 浙江浙北药业有限公司 | 一种瑞巴派特片的制备工艺 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4229430A (en) * | 1978-08-21 | 1980-10-21 | Fahim Mostafa S | Oral composition for improving oral health |
| US4512968A (en) * | 1982-11-30 | 1985-04-23 | Lion Corporation | Oral compositions |
| US5405604A (en) * | 1992-10-16 | 1995-04-11 | The Procter & Gamble Company | Concentrated mouthrinse for efficient delivery of antimicrobials |
| JP2004517038A (ja) * | 2000-06-30 | 2004-06-10 | ザ、プロクター、エンド、ギャンブル、カンパニー | 全身の健康増進 |
| US6723305B2 (en) * | 2002-03-04 | 2004-04-20 | Colgate Palmolive Company | Anti-microbial breath freshening mouthrinse |
| US20050084551A1 (en) * | 2003-09-26 | 2005-04-21 | Jensen Claude J. | Morinda citrifolia-based oral care compositions and methods |
| WO2006005211A1 (de) | 2004-07-12 | 2006-01-19 | Gaba International Ag | Mundpflegemittel enthaltend chitosanderivat |
| US8858920B2 (en) * | 2004-12-21 | 2014-10-14 | Colgate-Palmolive Company | Anti-caries oral care composition with xylitol |
| JP2007314505A (ja) * | 2006-04-28 | 2007-12-06 | Nagasaki Univ | 機能性チューインガム |
| EP3144324A1 (en) * | 2006-06-02 | 2017-03-22 | Synedgen, Inc. | Chitosan-derivative compounds and methods of controlling microbial populations |
| US20080242794A1 (en) * | 2007-03-30 | 2008-10-02 | Sandford David W | Color stabilized antimicrobial polymer composites |
-
2010
- 2010-09-02 JP JP2012528072A patent/JP2013503897A/ja active Pending
- 2010-09-02 AU AU2010289418A patent/AU2010289418A1/en not_active Abandoned
- 2010-09-02 WO PCT/US2010/047759 patent/WO2011028968A1/en not_active Ceased
- 2010-09-02 CA CA2806539A patent/CA2806539C/en active Active
- 2010-09-02 EP EP10814537.6A patent/EP2473043B1/en active Active
-
2012
- 2012-03-02 US US13/411,208 patent/US20120301408A1/en not_active Abandoned
-
2014
- 2014-09-24 US US14/495,192 patent/US20150224044A1/en not_active Abandoned
- 2014-11-18 JP JP2014233472A patent/JP2015034183A/ja not_active Withdrawn
-
2015
- 2015-07-27 AU AU2015205973A patent/AU2015205973A1/en not_active Abandoned
-
2016
- 2016-03-03 JP JP2016040631A patent/JP6650785B2/ja active Active
- 2016-05-20 JP JP2016101300A patent/JP2016155859A/ja active Pending
-
2017
- 2017-05-04 US US15/587,215 patent/US20180049965A1/en not_active Abandoned
- 2017-09-08 AU AU2017225141A patent/AU2017225141B2/en active Active
- 2017-12-08 JP JP2017235871A patent/JP2018058889A/ja active Pending
-
2019
- 2019-04-15 JP JP2019077051A patent/JP2019131605A/ja not_active Withdrawn
- 2019-05-13 AU AU2019203345A patent/AU2019203345A1/en not_active Abandoned
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