JP2013502212A5 - - Google Patents
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- Publication number
- JP2013502212A5 JP2013502212A5 JP2012525165A JP2012525165A JP2013502212A5 JP 2013502212 A5 JP2013502212 A5 JP 2013502212A5 JP 2012525165 A JP2012525165 A JP 2012525165A JP 2012525165 A JP2012525165 A JP 2012525165A JP 2013502212 A5 JP2013502212 A5 JP 2013502212A5
- Authority
- JP
- Japan
- Prior art keywords
- enzyme
- stabilized
- dehydrogenase
- stored
- independently
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 102000004190 Enzymes Human genes 0.000 claims 39
- 108090000790 Enzymes Proteins 0.000 claims 39
- 238000000034 method Methods 0.000 claims 15
- 239000005515 coenzyme Substances 0.000 claims 7
- 150000001875 compounds Chemical class 0.000 claims 7
- XJLXINKUBYWONI-DQQFMEOOSA-N [[(2r,3r,4r,5r)-5-(6-aminopurin-9-yl)-3-hydroxy-4-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2s,3r,4s,5s)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate Chemical compound NC(=O)C1=CC=C[N+]([C@@H]2[C@H]([C@@H](O)[C@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](OP(O)(O)=O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 XJLXINKUBYWONI-DQQFMEOOSA-N 0.000 claims 6
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 claims 6
- BAWFJGJZGIEFAR-NNYOXOHSSA-N NAD zwitterion Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 BAWFJGJZGIEFAR-NNYOXOHSSA-N 0.000 claims 5
- 229950006238 nadide Drugs 0.000 claims 5
- 102100031126 6-phosphogluconolactonase Human genes 0.000 claims 4
- 108010029731 6-phosphogluconolactonase Proteins 0.000 claims 4
- 108010021809 Alcohol dehydrogenase Proteins 0.000 claims 4
- 102000007698 Alcohol dehydrogenase Human genes 0.000 claims 4
- 108010018962 Glucosephosphate Dehydrogenase Proteins 0.000 claims 4
- 102000035195 Peptidases Human genes 0.000 claims 4
- 108091005804 Peptidases Proteins 0.000 claims 4
- DEFLNOSTNCSZRB-IDTAVKCVSA-N 9-[(2r,3r,4r,5r)-3,4-dimethoxy-5-(methoxymethyl)oxolan-2-yl]-n-methoxypurin-6-amine Chemical compound CO[C@@H]1[C@H](OC)[C@@H](COC)O[C@H]1N1C2=NC=NC(NOC)=C2N=C1 DEFLNOSTNCSZRB-IDTAVKCVSA-N 0.000 claims 3
- 108700001448 Aldo-keto reductase family 1 member A1 Proteins 0.000 claims 3
- 108700035271 EC 1.1.1.2 Proteins 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 235000019833 protease Nutrition 0.000 claims 3
- 229910052717 sulfur Inorganic materials 0.000 claims 3
- 108010050375 Glucose 1-Dehydrogenase Proteins 0.000 claims 2
- 239000003153 chemical reaction reagent Substances 0.000 claims 2
- 125000004122 cyclic group Chemical group 0.000 claims 2
- 239000002274 desiccant Substances 0.000 claims 2
- 238000001514 detection method Methods 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 claims 2
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 claims 2
- 230000000087 stabilizing effect Effects 0.000 claims 2
- GVNVAWHJIKLAGL-UHFFFAOYSA-N 2-(cyclohexen-1-yl)cyclohexan-1-one Chemical compound O=C1CCCCC1C1=CCCCC1 GVNVAWHJIKLAGL-UHFFFAOYSA-N 0.000 claims 1
- 102000034279 3-hydroxybutyrate dehydrogenases Human genes 0.000 claims 1
- 108090000124 3-hydroxybutyrate dehydrogenases Proteins 0.000 claims 1
- 229930024421 Adenine Natural products 0.000 claims 1
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 claims 1
- 101150065749 Churc1 gene Proteins 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 101000892220 Geobacillus thermodenitrificans (strain NG80-2) Long-chain-alcohol dehydrogenase 1 Proteins 0.000 claims 1
- 108030000198 L-amino-acid dehydrogenases Proteins 0.000 claims 1
- 102000003855 L-lactate dehydrogenase Human genes 0.000 claims 1
- 108700023483 L-lactate dehydrogenases Proteins 0.000 claims 1
- 108010026217 Malate Dehydrogenase Proteins 0.000 claims 1
- 102000013460 Malate Dehydrogenase Human genes 0.000 claims 1
- 102100038239 Protein Churchill Human genes 0.000 claims 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 1
- 229960000643 adenine Drugs 0.000 claims 1
- 239000012491 analyte Substances 0.000 claims 1
- 125000002837 carbocyclic group Chemical group 0.000 claims 1
- 238000006356 dehydrogenation reaction Methods 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 230000026045 iodination Effects 0.000 claims 1
- 238000006192 iodination reaction Methods 0.000 claims 1
- 239000007791 liquid phase Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
Images
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09168327A EP2292751A1 (de) | 2009-08-20 | 2009-08-20 | Stabilisierung von Enzymen mit stabilen Coenzymen |
| EP09168327.6 | 2009-08-20 | ||
| PCT/EP2010/062045 WO2011020856A1 (de) | 2009-08-20 | 2010-08-18 | Stabilisierung von enzymen mit stabilen coenzymen |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013502212A JP2013502212A (ja) | 2013-01-24 |
| JP2013502212A5 true JP2013502212A5 (https=) | 2013-08-15 |
| JP5851401B2 JP5851401B2 (ja) | 2016-02-03 |
Family
ID=41211921
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012525165A Active JP5851401B2 (ja) | 2009-08-20 | 2010-08-18 | 安定な補酵素による酵素の安定化 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US9540702B2 (https=) |
| EP (2) | EP2292751A1 (https=) |
| JP (1) | JP5851401B2 (https=) |
| KR (2) | KR101554457B1 (https=) |
| CN (1) | CN102471767B (https=) |
| CA (1) | CA2770249C (https=) |
| MX (1) | MX2012001946A (https=) |
| WO (1) | WO2011020856A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102471793B (zh) * | 2009-07-27 | 2014-04-30 | 霍夫曼-拉罗奇有限公司 | Carba-nad的酶促合成 |
| EP2292751A1 (de) * | 2009-08-20 | 2011-03-09 | Roche Diagnostics GmbH | Stabilisierung von Enzymen mit stabilen Coenzymen |
| US8787944B2 (en) | 2011-08-18 | 2014-07-22 | Rivada Research, Llc | Method and system for providing enhanced location based information for wireless handsets |
| EP2636750A1 (en) | 2012-03-06 | 2013-09-11 | Roche Diagniostics GmbH | Compatible solute ectoine as well as derivatives thereof for enzyme stabilization |
| US20150192575A1 (en) * | 2012-08-09 | 2015-07-09 | Stichting Dienst Landbouwkundig Onderzoek | Membrane assembly and a lateral flow immunoassay device comprising such membrane assembly |
| US8921061B2 (en) * | 2012-11-02 | 2014-12-30 | Roche Diagnostics Operations, Inc. | Reagent materials and associated test elements |
| EP2770064A1 (de) * | 2013-02-22 | 2014-08-27 | F. Hoffmann-La Roche AG | Hocheffiziente Herstellung von Blutglucose-Teststreifen |
| EP3097406A1 (en) | 2014-01-24 | 2016-11-30 | Roche Diabetes Care GmbH | Method of manufacturing uni- and no-code test stripes |
| KR102372113B1 (ko) | 2016-10-05 | 2022-03-07 | 에프. 호프만-라 로슈 아게 | 다중 분석물 진단 테스트 엘리먼트들을 위한 검출 시약들 및 전극 배열들, 그리고 그것을 사용하는 방법들 |
| EP3339431A1 (en) * | 2016-12-22 | 2018-06-27 | Roche Diabetes Care GmbH | Glucose dehydrogenase variants with improved properties |
| EP3963058A4 (en) | 2019-05-01 | 2024-01-03 | Codexis, Inc. | MODIFIED GLUCOSE DEHYDROGENASES AND PROCESSES FOR THE REDUCTIVE AMINATION OF KETONE AND AMINO COMPOUNDS |
| WO2020242967A1 (en) * | 2019-05-28 | 2020-12-03 | W. L. Gore & Associates, Inc. | Stabilized medical device and method for making it |
| JP7473632B2 (ja) * | 2019-08-30 | 2024-04-23 | アボット ダイアベティス ケア インコーポレイテッド | アルコールの検出のための分析物センサ |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2061984C3 (de) | 1970-12-16 | 1974-04-11 | Boehringer Mannheim Gmbh, 6800 Mannheim | Reagens zur Bestimmung der Lactat-Dehydrogenase im Farbtest |
| US5032506A (en) | 1986-12-16 | 1991-07-16 | Enzymatics, Inc. | Color control system |
| US5609718A (en) | 1995-09-29 | 1997-03-11 | Micron Technology, Inc. | Method and apparatus for measuring a change in the thickness of polishing pads used in chemical-mechanical planarization of semiconductor wafers |
| DE19543493A1 (de) * | 1995-11-22 | 1997-05-28 | Boehringer Mannheim Gmbh | Stabilisierte Coenzym-Lösungen und deren Verwendung zur Bestimmung von Dehydrogenasen bzw. deren Substrate im alkalischen Milieu |
| US5801006A (en) | 1997-02-04 | 1998-09-01 | Specialty Assays, Inc. | Use of NADPH and NADH analogs in the measurement of enzyme activities and metabolites |
| US6380380B1 (en) | 1999-01-04 | 2002-04-30 | Specialty Assays, Inc. | Use of nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucliotide phosphate (NADP) analogs to measure enzyme activities metabolites and substrates |
| US6710770B2 (en) * | 2000-02-11 | 2004-03-23 | Canesta, Inc. | Quasi-three-dimensional method and apparatus to detect and localize interaction of user-object and virtual transfer device |
| AU2001262702A1 (en) | 2000-06-07 | 2001-12-17 | Asahi Kasei Kabushiki Kaisha | Coenzyme derivatives and enzymes appropriate therefor |
| CN100439513C (zh) | 2002-05-16 | 2008-12-03 | 霍夫曼-拉罗奇有限公司 | 含有非再生酶-辅酶复合体的方法和试剂体系 |
| CA2535147A1 (en) | 2003-08-11 | 2005-05-19 | Codexis, Inc. | Improved glucose dehydrogenase polypeptides and related polynucleotides |
| DE102005035461A1 (de) * | 2005-07-28 | 2007-02-15 | Roche Diagnostics Gmbh | Stabile NAD/NADH-Derivate |
| DE102006035020B4 (de) * | 2005-07-28 | 2018-08-23 | Roche Diabetes Care Gmbh | Stabilisierung von NAD/NADH |
| US7553615B2 (en) | 2005-07-28 | 2009-06-30 | Roche Diagnostics Operations, Inc. | Compounds, methods, complexes, apparatuses and uses relating to stabile forms of NAD/NADH |
| US20070196899A1 (en) | 2005-11-29 | 2007-08-23 | Sony Corporation | Mutant protein having diaphorase activity |
| GB0625671D0 (en) | 2006-12-21 | 2007-01-31 | Oxford Biosensors Ltd | Protein formulation |
| EP1964927A1 (de) * | 2007-02-27 | 2008-09-03 | F. Hoffmann-La Roche AG | Chinone als Mediatoren für photometrische Teste |
| EP2093284A1 (de) * | 2008-02-19 | 2009-08-26 | F.Hoffmann-La Roche Ag | Stabilisierung von Dehydrogenasen mit stabilen Coenzymen |
| EP2292751A1 (de) * | 2009-08-20 | 2011-03-09 | Roche Diagnostics GmbH | Stabilisierung von Enzymen mit stabilen Coenzymen |
| EP2287605A1 (de) * | 2009-08-20 | 2011-02-23 | Roche Diagnostics GmbH | Vereinfachte Magazinierung integrierter Systeme |
| EP2333544A1 (de) * | 2009-12-11 | 2011-06-15 | F. Hoffmann-La Roche AG | Sterilisierbare Chemie für Testelemente |
| MX2012006706A (es) * | 2009-12-16 | 2012-07-03 | Hoffmann La Roche | Deteccion de la descomposicion de las enzimas en un elemento de prueba mediante la liberacion controlada de analito protegido. |
-
2009
- 2009-08-20 EP EP09168327A patent/EP2292751A1/de not_active Ceased
-
2010
- 2010-08-18 WO PCT/EP2010/062045 patent/WO2011020856A1/de not_active Ceased
- 2010-08-18 CN CN201080036800.9A patent/CN102471767B/zh active Active
- 2010-08-18 MX MX2012001946A patent/MX2012001946A/es active IP Right Grant
- 2010-08-18 JP JP2012525165A patent/JP5851401B2/ja active Active
- 2010-08-18 KR KR1020157015319A patent/KR101554457B1/ko active Active
- 2010-08-18 EP EP10757053.3A patent/EP2467478B1/de active Active
- 2010-08-18 KR KR1020127007136A patent/KR20120064076A/ko not_active Ceased
- 2010-08-18 CA CA2770249A patent/CA2770249C/en active Active
-
2012
- 2012-02-20 US US13/400,209 patent/US9540702B2/en active Active
-
2016
- 2016-11-29 US US15/363,038 patent/US20170073661A1/en not_active Abandoned
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