JP2013501791A5 - - Google Patents
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- Publication number
- JP2013501791A5 JP2013501791A5 JP2012524769A JP2012524769A JP2013501791A5 JP 2013501791 A5 JP2013501791 A5 JP 2013501791A5 JP 2012524769 A JP2012524769 A JP 2012524769A JP 2012524769 A JP2012524769 A JP 2012524769A JP 2013501791 A5 JP2013501791 A5 JP 2013501791A5
- Authority
- JP
- Japan
- Prior art keywords
- temozolomide
- paclitaxel
- brain metastasis
- combination
- mixture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 210000004556 brain Anatomy 0.000 claims 9
- 206010027476 Metastases Diseases 0.000 claims 8
- 229930012538 Paclitaxel Natural products 0.000 claims 8
- BPEGJWRSRHCHSN-UHFFFAOYSA-N Temozolomide Chemical compound O=C1N(C)N=NC2=C(C(N)=O)N=CN21 BPEGJWRSRHCHSN-UHFFFAOYSA-N 0.000 claims 8
- 230000009401 metastasis Effects 0.000 claims 8
- 229960001592 paclitaxel Drugs 0.000 claims 8
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 8
- 229960004964 temozolomide Drugs 0.000 claims 8
- 238000001959 radiotherapy Methods 0.000 claims 6
- 239000002246 antineoplastic agent Substances 0.000 claims 4
- 231100000433 cytotoxic Toxicity 0.000 claims 4
- 229940127089 cytotoxic agent Drugs 0.000 claims 4
- 230000001472 cytotoxic effect Effects 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 229940124597 therapeutic agent Drugs 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 3
- JGCMEBMXRHSZKX-UHFFFAOYSA-N macitentan Chemical compound C=1C=C(Br)C=CC=1C=1C(NS(=O)(=O)NCCC)=NC=NC=1OCCOC1=NC=C(Br)C=N1 JGCMEBMXRHSZKX-UHFFFAOYSA-N 0.000 claims 3
- 229960001039 macitentan Drugs 0.000 claims 3
- 230000003449 preventive effect Effects 0.000 claims 3
- 230000000069 prophylactic effect Effects 0.000 claims 1
- 238000002719 stereotactic radiosurgery Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23268709P | 2009-08-10 | 2009-08-10 | |
| US61/232,687 | 2009-08-10 | ||
| PCT/US2010/044832 WO2011019630A2 (en) | 2009-08-10 | 2010-08-09 | Treatment of astrocytes-tumor cells with inhibitors of endothelin receptors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013501791A JP2013501791A (ja) | 2013-01-17 |
| JP2013501791A5 true JP2013501791A5 (cg-RX-API-DMAC7.html) | 2013-09-19 |
Family
ID=42938154
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012524769A Ceased JP2013501791A (ja) | 2009-08-10 | 2010-08-09 | エンドセリン受容体の阻害剤による星状細胞−腫瘍細胞の処置 |
Country Status (27)
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2012213036A1 (en) * | 2011-02-04 | 2013-09-19 | Actelion Pharmaceuticals Ltd | Combinations comprising macitentan for the treatment of glioblastoma multiforme |
| WO2012177624A2 (en) * | 2011-06-21 | 2012-12-27 | The Johns Hopkins University | Focused radiation for augmenting immune-based therapies against neoplasms |
| SG11201707128TA (en) * | 2015-03-06 | 2017-09-28 | Beyondspring Pharmaceuticals Inc | Method of treating a brain tumor |
| AU2016229294B2 (en) | 2015-03-06 | 2021-11-04 | Beyondspring Pharmaceuticals, Inc. | Method of treating cancer associated with a RAS mutation |
| JP6969848B2 (ja) | 2015-07-13 | 2021-11-24 | ビヨンドスプリング ファーマシューティカルズ，インコーポレイテッド | プリナブリン組成物 |
| JP6903055B2 (ja) | 2015-08-03 | 2021-07-14 | イーエヌビー・セラピューティクス・インク | Ｅｔｂｒ活性化に関連した癌を治療するための組成物及び方法 |
| JP6996728B2 (ja) * | 2016-01-07 | 2022-01-17 | 学校法人自治医科大学 | グルコーストランスポーター１発現用アデノ随伴ウイルスベクター |
| KR20180105685A (ko) | 2016-02-08 | 2018-09-28 | 비욘드스프링 파마수티컬스, 인코포레이티드. | 투카레솔 또는 이의 유사체를 함유하는 조성물 |
| WO2017209272A1 (ja) * | 2016-06-03 | 2017-12-07 | 国立大学法人東京大学 | がん転移阻害剤 |
| JP7025416B2 (ja) | 2016-06-06 | 2022-02-24 | ビヨンドスプリング ファーマシューティカルズ，インコーポレイテッド | 好中球減少症を低減させるための組成物および方法 |
| WO2018129381A1 (en) | 2017-01-06 | 2018-07-12 | Beyondspring Pharmaceuticals, Inc. | Tubulin binding compounds and therapeutic use thereof |
| BR112019015974A2 (pt) | 2017-02-01 | 2020-03-31 | Beyondspring Pharmaceuticals, Inc. | Método para reduzir neutropenia |
| KR20190129046A (ko) | 2017-02-15 | 2019-11-19 | 더 리전트 오브 더 유니버시티 오브 캘리포니아 | Nk 세포를 활성화시키기 위한 조성물 및 방법 |
| JP7539151B2 (ja) | 2018-01-12 | 2024-08-23 | イーエヌビー・セラピューティクス・インク | Ｅｔｂｒ活性化に関連する癌を処置するための重水素化化合物、組成物、および方法 |
| KR20200112881A (ko) | 2018-01-24 | 2020-10-05 | 비욘드스프링 파마수티컬스, 인코포레이티드. | 플리나불린의 투여를 통해 혈소판감소증을 감소시키는 조성물 및 방법 |
| CN109232546B (zh) | 2018-09-25 | 2020-09-04 | 中国人民解放军总医院 | 一种嘧啶磺酰胺类衍生物的医药用途 |
| EP3974421B1 (en) | 2019-05-22 | 2024-09-11 | Wuxi Biocity Biopharmaceutics Co., Ltd. | Crystal form of pyrimidine sulfonamide compound and preparation method therefor |
| CN112062857B (zh) * | 2019-06-10 | 2024-08-09 | 鸿运华宁（杭州）生物医药有限公司 | Eta抗体与bnp的融合蛋白质，及其药物组合物和应用 |
| KR102951752B1 (ko) * | 2019-09-25 | 2026-04-14 | 더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 쥬니어 유니버시티 | 안와전두 피질에 대한 시상 입력은 gaba 및 불확대에 의해 매개된 광범한 뇌, 주파수-의존적 억제를 유도한다 |
| CA3215047A1 (en) | 2021-04-09 | 2022-10-13 | Lan Huang | Therapeutic compositions and methods for treating tumors |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002227984B8 (en) | 2000-12-18 | 2007-01-04 | Actelion Pharmaceuticals Ltd. | Novel sulfamides and their use as endothelin receptor antagonists |
| GB0223854D0 (en) * | 2002-10-12 | 2002-11-20 | Astrazeneca Ab | Therapeutic treatment |
| US20050043233A1 (en) | 2003-04-29 | 2005-02-24 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis |
| US20060058311A1 (en) * | 2004-08-14 | 2006-03-16 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation |
| WO2007031933A2 (en) | 2005-09-12 | 2007-03-22 | Actelion Pharmaceuticals Ltd | Stable pharmaceutical composition comprising a pyrimidine-sulfamide |
| PL2254570T3 (pl) | 2008-02-20 | 2014-05-30 | Actelion Pharmaceuticals Ltd | Połączenie zawierające paklitaksel do leczenia raka jajnika |
| AU2012213036A1 (en) | 2011-02-04 | 2013-09-19 | Actelion Pharmaceuticals Ltd | Combinations comprising macitentan for the treatment of glioblastoma multiforme |
-
2010
- 2010-08-09 PT PT107426900T patent/PT2464218E/pt unknown
- 2010-08-09 HR HRP20150890TT patent/HRP20150890T1/hr unknown
- 2010-08-09 ES ES10742690.0T patent/ES2543280T3/es active Active
- 2010-08-09 US US13/390,072 patent/US8999934B2/en not_active Expired - Fee Related
- 2010-08-09 SG SG2012009338A patent/SG178828A1/en unknown
- 2010-08-09 NZ NZ598078A patent/NZ598078A/xx not_active IP Right Cessation
- 2010-08-09 BR BR112012003103A patent/BR112012003103A2/pt not_active IP Right Cessation
- 2010-08-09 WO PCT/US2010/044832 patent/WO2011019630A2/en not_active Ceased
- 2010-08-09 MX MX2012001562A patent/MX2012001562A/es active IP Right Grant
- 2010-08-09 SI SI201031003T patent/SI2464218T1/sl unknown
- 2010-08-09 KR KR1020127006203A patent/KR20120088665A/ko not_active Ceased
- 2010-08-09 IN IN1261DEN2012 patent/IN2012DN01261A/en unknown
- 2010-08-09 HU HUE10742690A patent/HUE026005T2/en unknown
- 2010-08-09 JP JP2012524769A patent/JP2013501791A/ja not_active Ceased
- 2010-08-09 CA CA2770397A patent/CA2770397A1/en not_active Abandoned
- 2010-08-09 EA EA201270264A patent/EA023864B1/ru not_active IP Right Cessation
- 2010-08-09 EP EP10742690.0A patent/EP2464218B1/en not_active Not-in-force
- 2010-08-09 TW TW099126507A patent/TWI483938B/zh not_active IP Right Cessation
- 2010-08-09 DK DK10742690.0T patent/DK2464218T3/en active
- 2010-08-09 PL PL10742690T patent/PL2464218T3/pl unknown
- 2010-08-09 AU AU2010282744A patent/AU2010282744B2/en not_active Ceased
- 2010-08-09 CN CN201080040990.1A patent/CN102510719B/zh not_active Expired - Fee Related
-
2012
- 2012-02-02 IL IL217915A patent/IL217915A0/en unknown
- 2012-02-03 TN TNP2012000054A patent/TN2012000054A1/en unknown
- 2012-02-08 CL CL2012000333A patent/CL2012000333A1/es unknown
- 2012-02-09 ZA ZA2012/00980A patent/ZA201200980B/en unknown
- 2012-03-08 MA MA34671A patent/MA33571B1/fr unknown
-
2015
- 2015-03-06 US US14/640,662 patent/US20150352113A1/en not_active Abandoned
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