JP2013237682A5 - - Google Patents
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- Publication number
- JP2013237682A5 JP2013237682A5 JP2013147411A JP2013147411A JP2013237682A5 JP 2013237682 A5 JP2013237682 A5 JP 2013237682A5 JP 2013147411 A JP2013147411 A JP 2013147411A JP 2013147411 A JP2013147411 A JP 2013147411A JP 2013237682 A5 JP2013237682 A5 JP 2013237682A5
- Authority
- JP
- Japan
- Prior art keywords
- crystalline form
- aripiprazole crystalline
- degrees
- aripiprazole
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- CEUORZQYGODEFX-UHFFFAOYSA-N Aripirazole Chemical compound ClC1=CC=CC(N2CCN(CCCCOC=3C=C4NC(=O)CCC4=CC=3)CC2)=C1Cl CEUORZQYGODEFX-UHFFFAOYSA-N 0.000 claims 15
- 229960004372 aripiprazole Drugs 0.000 claims 15
- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- 238000000034 method Methods 0.000 claims 6
- 238000002441 X-ray diffraction Methods 0.000 claims 5
- 229940125904 compound 1 Drugs 0.000 claims 3
- 238000001035 drying Methods 0.000 claims 3
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 201000000980 schizophrenia Diseases 0.000 claims 2
- 230000037396 body weight Effects 0.000 claims 1
- 230000001747 exhibiting effect Effects 0.000 claims 1
- 238000002844 melting Methods 0.000 claims 1
- 230000008018 melting Effects 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53029703P | 2003-12-16 | 2003-12-16 | |
| US60/530,297 | 2003-12-16 | ||
| US53383103P | 2003-12-30 | 2003-12-30 | |
| US60/533,831 | 2003-12-30 | ||
| US61840404P | 2004-10-13 | 2004-10-13 | |
| US60/618,404 | 2004-10-13 | ||
| US61896004P | 2004-10-14 | 2004-10-14 | |
| US60/618,960 | 2004-10-14 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006545583A Division JP5546717B2 (ja) | 2003-12-16 | 2004-12-16 | アリピプラゾール結晶質形態を調製する方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013237682A JP2013237682A (ja) | 2013-11-28 |
| JP2013237682A5 true JP2013237682A5 (cg-RX-API-DMAC7.html) | 2014-06-19 |
Family
ID=34705304
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006545583A Expired - Lifetime JP5546717B2 (ja) | 2003-12-16 | 2004-12-16 | アリピプラゾール結晶質形態を調製する方法 |
| JP2013147411A Pending JP2013237682A (ja) | 2003-12-16 | 2013-07-16 | アリピプラゾール結晶質形態を調製する方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006545583A Expired - Lifetime JP5546717B2 (ja) | 2003-12-16 | 2004-12-16 | アリピプラゾール結晶質形態を調製する方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US7504504B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1613598B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP5546717B2 (cg-RX-API-DMAC7.html) |
| AT (1) | ATE529409T1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2550726A1 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2374922T3 (cg-RX-API-DMAC7.html) |
| IL (1) | IL175512A (cg-RX-API-DMAC7.html) |
| PL (1) | PL1613598T3 (cg-RX-API-DMAC7.html) |
| PT (1) | PT1613598E (cg-RX-API-DMAC7.html) |
| TW (1) | TW200529850A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2005058835A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7456181B2 (en) * | 2003-07-25 | 2008-11-25 | Hetero Drugs Limited | Aripiprazole crystalline forms |
| US7714129B2 (en) | 2003-12-16 | 2010-05-11 | Teva Pharmaceutical Industries Ltd. | Methods of preparing anhydrous aripiprazole form II |
| EP1732610A2 (en) | 2004-03-26 | 2006-12-20 | Baylor University | Targeted serotonin reuptake inhibitors |
| EP1797039A1 (en) | 2004-09-13 | 2007-06-20 | Matrix Laboratories Ltd | Process for the preparation of polymorphs, solvates of aripiprazole using aripiprazole acid salts |
| EP1812396A1 (en) | 2004-11-18 | 2007-08-01 | Synthon B.V. | Crystalline aripiprazole solvates |
| CN102627603A (zh) * | 2004-11-18 | 2012-08-08 | 斯索恩有限公司 | 制备结晶阿立哌唑的方法 |
| EP1686117A1 (en) * | 2005-01-27 | 2006-08-02 | Sandoz AG | Polymorph and solvates of aripiprazole |
| WO2006097344A1 (en) | 2005-03-17 | 2006-09-21 | Synthon B.V. | Pharmaceutical tablets of crystalline type ii aripiprazole |
| WO2006097343A1 (en) † | 2005-03-17 | 2006-09-21 | Synthon B.V. | Process of making crystalline type ii aripiprazole |
| WO2007004061A1 (en) * | 2005-04-15 | 2007-01-11 | Medichem, S.A. | Syntheses and preparations of polymorphs of crystalline aripiprazole |
| JP2008521835A (ja) * | 2005-09-29 | 2008-06-26 | テバ ファーマシューティカル インダストリーズ リミティド | 無水アリピプラゾールフォームｉｉの調製方法 |
| JP2008537540A (ja) * | 2005-12-22 | 2008-09-18 | テバ ファーマシューティカル インダストリーズ リミティド | アリピプラゾールの粒径を小さくする方法 |
| ATE429906T1 (de) * | 2006-01-05 | 2009-05-15 | Teva Pharma | Trockene aripiprazolformulierungen |
| ATE419837T1 (de) * | 2006-01-05 | 2009-01-15 | Teva Pharma | Feuchtgranulierungsmethode zur herstellung pharmazeutischer aripiprazolzusammensetzungen |
| TWI394753B (zh) | 2006-03-17 | 2013-05-01 | Otsuka Pharma Co Ltd | 新穎替妥牟拉（ｔｅｔｏｍｉｌａｓｔ）晶體 |
| EP2082735B1 (en) | 2008-01-23 | 2010-09-29 | Helm AG | Amorphous Aripiprazole and Process for the Preparation thereof |
| EP1880714A1 (en) | 2006-07-20 | 2008-01-23 | Helm AG | Amorphous Aripiprazole and Process for the Preparation thereof |
| US7799790B2 (en) | 2006-07-20 | 2010-09-21 | Helm Ag | Amorphous aripiprazole and process for the preparation thereof |
| WO2008020453A2 (en) * | 2006-08-17 | 2008-02-21 | Unichem Laboratories Limited | A process for the preparation of a novel crystalline polymorph of aripiprazole |
| GB0618879D0 (en) | 2006-09-26 | 2006-11-01 | Zysis Ltd | Pharmaceutical compositions |
| EP2079723B1 (en) * | 2006-10-24 | 2012-12-19 | Cambrex Charles City, Inc. | Process for preparing anhydrous aripiprazole type i |
| EP2238976B1 (en) | 2009-04-03 | 2012-06-27 | Hexal AG | Oral films comprising 7-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy]-3,4-dihydro- 1H-quinolin-2-one base or salts or hydrates thereof |
| CN101948426A (zh) * | 2010-09-13 | 2011-01-19 | 浙江华海药业股份有限公司 | 一种制备阿立哌唑晶型b的新方法 |
| BR112013010190B1 (pt) * | 2010-10-28 | 2019-12-31 | Aequus Pharmaceuticals Inc | composição farmacêutica |
| US9757374B2 (en) | 2010-10-28 | 2017-09-12 | Aequus Pharmaceuticals Inc. | Aripiprazole compositions and methods for its transdermal delivery |
| WO2012077134A1 (en) * | 2010-12-07 | 2012-06-14 | Ind-Swift Laboratories Limted | Process for preparing aripiprazole polymorphs |
| KR101340214B1 (ko) * | 2011-03-31 | 2013-12-10 | 주식회사 대웅제약 | 무수 아리피프라졸 ⅱ형 결정의 제조방법 |
| CN102850268B (zh) * | 2011-06-27 | 2015-07-15 | 上海中西制药有限公司 | 阿立哌唑ⅰ型微晶、阿立哌唑固体制剂及制备方法 |
| KR101372840B1 (ko) * | 2012-08-02 | 2014-03-12 | 주식회사 에스텍파마 | 무수 아리피프라졸 결정의 제조방법 |
| EP3065700A1 (en) | 2013-11-07 | 2016-09-14 | Synthon B.V. | Orodispersible pharmaceutical compositions comprising aripiprazole |
| CN114890943A (zh) | 2013-11-15 | 2022-08-12 | 阿克比治疗有限公司 | {[5-(3-氯苯基)-3-羟基吡啶-2-羰基]氨基}乙酸固体形式，组合物和用途 |
| CN106474058B (zh) | 2015-08-31 | 2020-01-07 | 南京诺瑞特医药科技有限公司 | 具有延长的保质期的阿立哌唑可注射悬浮液制剂 |
| TWI665194B (zh) * | 2016-02-19 | 2019-07-11 | 諾瑞特國際藥業股份有限公司 | 阿立哌唑的新晶型 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS54130587A (en) | 1978-03-30 | 1979-10-09 | Otsuka Pharmaceut Co Ltd | Carbostyryl derivative |
| US5006528A (en) | 1988-10-31 | 1991-04-09 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives |
| JP2608788B2 (ja) | 1988-10-31 | 1997-05-14 | 大塚製薬 株式会社 | 精神分裂病治療剤 |
| JP3282731B2 (ja) | 1990-06-15 | 2002-05-20 | メルク エンド カムパニー インコーポレーテッド | 結晶の構造および大きさを改良する結晶化方法 |
| US6221153B1 (en) | 1998-06-09 | 2001-04-24 | Trevor Percival Castor | Method for producing large crystals of complex molecules |
| AU2001250892A1 (en) | 2000-03-20 | 2001-10-03 | Teva Pharmaceutical Industries Ltd. | Processes for preparing 6-hydroxy-3,4-dihydroquinolinone, cilostazol and n-(4-methoxyphenyl)-3-chloropropionamide |
| AR033485A1 (es) * | 2001-09-25 | 2003-12-26 | Otsuka Pharma Co Ltd | Sustancia medicinal de aripiprazol de baja higroscopicidad y proceso para la preparacion de la misma |
| ITMI20021209A1 (it) | 2002-06-04 | 2003-12-04 | Chemi Spa | Processo di preparazione di azitromicina ad elevata purezza |
| HRP20050149B1 (hr) * | 2002-08-20 | 2014-09-12 | Otsuka Pharmaceutical Co., Ltd. | Formulacija aripiprazol kompleksa i postupak |
| DE60302139T3 (de) | 2003-01-09 | 2011-02-24 | Otsuka Pharmaceutical Co., Ltd. | Verfahren zur herstellung von aripiprazole |
| US7491726B2 (en) | 2003-03-21 | 2009-02-17 | Hetero Drugs Limited | Crystalline forms of aripiprazole |
| EP1618103A2 (en) * | 2003-04-25 | 2006-01-25 | Cadila Healthcare Ltd. | Polymorphs of aripiprazole |
| CA2428237C (en) | 2003-05-08 | 2010-07-20 | Delmar Chemicals Inc. | Process for the preparation of carbostyril derivatives |
| US7456181B2 (en) | 2003-07-25 | 2008-11-25 | Hetero Drugs Limited | Aripiprazole crystalline forms |
| US7166418B2 (en) | 2003-09-03 | 2007-01-23 | Matsushita Electric Industrial Co., Ltd. | Sulfonamide compound, polymer compound, resist material and pattern formation method |
| TWI371274B (en) | 2003-10-23 | 2012-09-01 | Bristol Myers Squibb Co | Process for making sterile aripiprazole of desired mean particle size |
| US20050277650A1 (en) | 2004-04-20 | 2005-12-15 | Sundaram Venkataraman | Process for preparing aripirazole hydrate |
| US7507823B2 (en) * | 2004-05-06 | 2009-03-24 | Bristol-Myers Squibb Company | Process of making aripiprazole particles |
| WO2006012237A2 (en) | 2004-06-25 | 2006-02-02 | Shanghai Institute Of Pharmaceutical Industry | Aripiprazole crystaline forms and associated methods |
| EP1797039A1 (en) | 2004-09-13 | 2007-06-20 | Matrix Laboratories Ltd | Process for the preparation of polymorphs, solvates of aripiprazole using aripiprazole acid salts |
| US20060079689A1 (en) * | 2004-10-12 | 2006-04-13 | Vladimir Naddaka | Processes for preparing and purifying carbostyril compounds such as aripiprazole and 7-(4-halobutoxy)-3,4-dihydro-2(1H)-quinolinones |
| US20060079690A1 (en) | 2004-10-12 | 2006-04-13 | Vladimir Naddaka | Processes for preparing 7-hydroxy-3,4-dihydro-2(1H)-quinolinone and the use in aripiprazole preparation thereof |
| EP1812396A1 (en) * | 2004-11-18 | 2007-08-01 | Synthon B.V. | Crystalline aripiprazole solvates |
| CN102627603A (zh) * | 2004-11-18 | 2012-08-08 | 斯索恩有限公司 | 制备结晶阿立哌唑的方法 |
| EP1686117A1 (en) * | 2005-01-27 | 2006-08-02 | Sandoz AG | Polymorph and solvates of aripiprazole |
| CA2622758A1 (en) * | 2005-09-15 | 2007-03-29 | Elan Pharma International, Limited | Nanoparticulate aripiprazole formulations |
| JP2008537540A (ja) * | 2005-12-22 | 2008-09-18 | テバ ファーマシューティカル インダストリーズ リミティド | アリピプラゾールの粒径を小さくする方法 |
| US20070213535A1 (en) * | 2006-03-07 | 2007-09-13 | Chemagis Ltd. | Process for the manufacture of aripiprazole by using purified carbostyril compounds such as 7-(4-halobutoxy)-3,4-dihydro-2(1H)-quinolinones |
| US20060223820A1 (en) * | 2006-03-21 | 2006-10-05 | Chemagis Ltd. | Crystalline aripiprazole salts and processes for preparation and purification thereof |
| WO2007113846A1 (en) * | 2006-04-03 | 2007-10-11 | Alembic Limited | A process for the preparation of aripiprazole |
| EP1845088B1 (en) * | 2006-04-10 | 2009-07-22 | Ranbaxy Laboratories Limited | An improved process for the preparation of aripipirazole |
| EP1880714A1 (en) * | 2006-07-20 | 2008-01-23 | Helm AG | Amorphous Aripiprazole and Process for the Preparation thereof |
-
2004
- 2004-12-16 AT AT04815093T patent/ATE529409T1/de active
- 2004-12-16 TW TW093139149A patent/TW200529850A/zh unknown
- 2004-12-16 CA CA002550726A patent/CA2550726A1/en not_active Abandoned
- 2004-12-16 WO PCT/US2004/042976 patent/WO2005058835A2/en not_active Ceased
- 2004-12-16 US US11/015,068 patent/US7504504B2/en not_active Expired - Fee Related
- 2004-12-16 PL PL04815093T patent/PL1613598T3/pl unknown
- 2004-12-16 PT PT04815093T patent/PT1613598E/pt unknown
- 2004-12-16 JP JP2006545583A patent/JP5546717B2/ja not_active Expired - Lifetime
- 2004-12-16 ES ES04815093T patent/ES2374922T3/es not_active Expired - Lifetime
- 2004-12-16 EP EP04815093A patent/EP1613598B1/en not_active Expired - Lifetime
-
2006
- 2006-05-09 IL IL175512A patent/IL175512A/en active IP Right Grant
-
2008
- 2008-12-04 US US12/315,867 patent/US20090156813A1/en not_active Abandoned
-
2013
- 2013-07-16 JP JP2013147411A patent/JP2013237682A/ja active Pending