JP2013235610A5 - - Google Patents
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- Publication number
- JP2013235610A5 JP2013235610A5 JP2013151434A JP2013151434A JP2013235610A5 JP 2013235610 A5 JP2013235610 A5 JP 2013235610A5 JP 2013151434 A JP2013151434 A JP 2013151434A JP 2013151434 A JP2013151434 A JP 2013151434A JP 2013235610 A5 JP2013235610 A5 JP 2013235610A5
- Authority
- JP
- Japan
- Prior art keywords
- library
- peptide
- antibody
- amino acid
- chain variable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US84903506P | 2006-10-02 | 2006-10-02 | |
| US60/849,035 | 2006-10-02 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009531542A Division JP5473603B2 (ja) | 2006-10-02 | 2007-09-28 | 多様な合成ペプチドおよびポリペプチドライブラリーの設計および構築 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013235610A JP2013235610A (ja) | 2013-11-21 |
| JP2013235610A5 true JP2013235610A5 (https=) | 2014-02-06 |
Family
ID=39269108
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009531542A Active JP5473603B2 (ja) | 2006-10-02 | 2007-09-28 | 多様な合成ペプチドおよびポリペプチドライブラリーの設計および構築 |
| JP2013151434A Pending JP2013235610A (ja) | 2006-10-02 | 2013-07-22 | 多様な合成ペプチドおよびポリペプチドライブラリーの設計および構築 |
| JP2013259083A Pending JP2014077004A (ja) | 2006-10-02 | 2013-12-16 | 多様な合成ペプチドおよびポリペプチドライブラリーの設計および構築 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009531542A Active JP5473603B2 (ja) | 2006-10-02 | 2007-09-28 | 多様な合成ペプチドおよびポリペプチドライブラリーの設計および構築 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013259083A Pending JP2014077004A (ja) | 2006-10-02 | 2013-12-16 | 多様な合成ペプチドおよびポリペプチドライブラリーの設計および構築 |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US8131480B2 (https=) |
| EP (1) | EP2069558B1 (https=) |
| JP (3) | JP5473603B2 (https=) |
| CN (2) | CN103541018A (https=) |
| AU (1) | AU2007303572A1 (https=) |
| CA (1) | CA2664681C (https=) |
| DK (1) | DK2069558T3 (https=) |
| IL (1) | IL197837A (https=) |
| WO (1) | WO2008042754A2 (https=) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040067532A1 (en) | 2002-08-12 | 2004-04-08 | Genetastix Corporation | High throughput generation and affinity maturation of humanized antibody |
| EP2069558B1 (en) | 2006-10-02 | 2013-05-01 | Sea Lane Biotechnologies,llc. | Design and construction of diverse synthetic peptide and polypeptide libraries |
| BRPI0809435A2 (pt) | 2007-03-27 | 2014-09-09 | Sea Lane Biotechnologies, Llc | Constructos e bibliotecas que compreendem sequências de cadeia leve substituida de anticorpos |
| US8691730B2 (en) * | 2007-09-14 | 2014-04-08 | Adimab, Llc | Rationally designed, synthetic antibody libraries and uses therefor |
| US8877688B2 (en) | 2007-09-14 | 2014-11-04 | Adimab, Llc | Rationally designed, synthetic antibody libraries and uses therefor |
| US12529164B2 (en) | 2007-09-14 | 2026-01-20 | Adimab, Llc | Rationally designed, synthetic antibody libraries and uses therefor |
| JP2009278908A (ja) * | 2008-05-22 | 2009-12-03 | Fujifilm Corp | 抗オステオカルシン抗体及びそれを用いた免疫測定方法 |
| JP5453613B2 (ja) * | 2008-09-30 | 2014-03-26 | 独立行政法人農業生物資源研究所 | 遺伝子クラスタリング装置およびプログラム |
| CN102482345A (zh) | 2009-05-13 | 2012-05-30 | 航道生物技术有限责任公司 | 针对流感病毒的中和分子 |
| US9493578B2 (en) | 2009-09-02 | 2016-11-15 | Xencor, Inc. | Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens |
| DK2593594T3 (en) | 2010-07-16 | 2017-12-11 | Adimab Llc | ANTIBODY LIBRARIES |
| EP3029066B1 (en) | 2010-07-29 | 2019-02-20 | Xencor, Inc. | Antibodies with modified isoelectric points |
| EP2640831A1 (en) | 2010-11-17 | 2013-09-25 | Sea Lane Biotechnologies,llc. | Influenza virus neutralizing agents that mimic the binding site of an influenza neutralizing antibody |
| WO2013016714A1 (en) | 2011-07-28 | 2013-01-31 | Sea Lane Biotechnologies | Sur-binding proteins against erbb3 |
| US10851178B2 (en) | 2011-10-10 | 2020-12-01 | Xencor, Inc. | Heterodimeric human IgG1 polypeptides with isoelectric point modifications |
| US12466897B2 (en) | 2011-10-10 | 2025-11-11 | Xencor, Inc. | Heterodimeric human IgG1 polypeptides with isoelectric point modifications |
| EP3446707A1 (en) | 2011-12-22 | 2019-02-27 | i2 Pharmaceuticals, Inc. | Surrogate binding proteins |
| WO2013176756A1 (en) * | 2012-05-25 | 2013-11-28 | Bayer Healthcare Llc | System and method for predicting the immunogenicity of a peptide |
| US9701759B2 (en) | 2013-01-14 | 2017-07-11 | Xencor, Inc. | Heterodimeric proteins |
| US11053316B2 (en) | 2013-01-14 | 2021-07-06 | Xencor, Inc. | Optimized antibody variable regions |
| US9605084B2 (en) | 2013-03-15 | 2017-03-28 | Xencor, Inc. | Heterodimeric proteins |
| CA2898100C (en) | 2013-01-14 | 2023-10-10 | Xencor, Inc. | Novel heterodimeric proteins |
| US10131710B2 (en) | 2013-01-14 | 2018-11-20 | Xencor, Inc. | Optimized antibody variable regions |
| US10487155B2 (en) | 2013-01-14 | 2019-11-26 | Xencor, Inc. | Heterodimeric proteins |
| US10968276B2 (en) | 2013-03-12 | 2021-04-06 | Xencor, Inc. | Optimized anti-CD3 variable regions |
| US9738722B2 (en) | 2013-01-15 | 2017-08-22 | Xencor, Inc. | Rapid clearance of antigen complexes using novel antibodies |
| US10519242B2 (en) | 2013-03-15 | 2019-12-31 | Xencor, Inc. | Targeting regulatory T cells with heterodimeric proteins |
| US10106624B2 (en) | 2013-03-15 | 2018-10-23 | Xencor, Inc. | Heterodimeric proteins |
| US10858417B2 (en) | 2013-03-15 | 2020-12-08 | Xencor, Inc. | Heterodimeric proteins |
| EP2970486B1 (en) | 2013-03-15 | 2018-05-16 | Xencor, Inc. | Modulation of t cells with bispecific antibodies and fc fusions |
| WO2015100409A2 (en) | 2013-12-26 | 2015-07-02 | Tufts University | Methods, compositions and kits for treating a subject using a recombinant neutralizing binding protein |
| JP6775422B2 (ja) | 2014-03-28 | 2020-10-28 | ゼンコー・インコーポレイテッドＸｅｎｃｏｒ、 Ｉｎｃ． | Ｃｄ３８及びｃｄ３に結合する二重特異性抗体 |
| BR112017011166A2 (pt) | 2014-11-26 | 2018-02-27 | Xencor, Inc. | anticorpos heterodiméricos que se ligam a cd3 e cd38 |
| US10259887B2 (en) | 2014-11-26 | 2019-04-16 | Xencor, Inc. | Heterodimeric antibodies that bind CD3 and tumor antigens |
| CN110894240B (zh) | 2014-11-26 | 2022-04-15 | 森科股份有限公司 | 结合cd3和肿瘤抗原的异二聚体抗体 |
| WO2016105450A2 (en) | 2014-12-22 | 2016-06-30 | Xencor, Inc. | Trispecific antibodies |
| WO2016126488A1 (en) | 2015-02-02 | 2016-08-11 | Sea Lane Biotechnologies, Llc | Anti-surrogate light chain antibodies |
| WO2016141387A1 (en) | 2015-03-05 | 2016-09-09 | Xencor, Inc. | Modulation of t cells with bispecific antibodies and fc fusions |
| IL293963A (en) | 2015-09-01 | 2022-08-01 | Univ California | Modular polypeptide libraries and methods for their preparation and use |
| JP7058219B2 (ja) | 2015-12-07 | 2022-04-21 | ゼンコア インコーポレイテッド | Ｃｄ３及びｐｓｍａに結合するヘテロ二量体抗体 |
| SI3468586T1 (sl) | 2016-06-14 | 2025-01-31 | Xencor, Inc. | Bispecifična protitelesa za zaviralce kontrolnih točk |
| WO2018005706A1 (en) | 2016-06-28 | 2018-01-04 | Xencor, Inc. | Heterodimeric antibodies that bind somatostatin receptor 2 |
| US10793632B2 (en) | 2016-08-30 | 2020-10-06 | Xencor, Inc. | Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors |
| EP3293293A1 (en) * | 2016-09-08 | 2018-03-14 | Italfarmaco SpA | Hc-cdr3-only libraries with reduced combinatorial redundancy and optimized loop length distribution |
| CN110214147A (zh) | 2016-10-14 | 2019-09-06 | Xencor股份有限公司 | IL15/IL15Rα异源二聚体FC-融合蛋白 |
| US20180196926A1 (en) * | 2017-01-06 | 2018-07-12 | Igc Bio, Inc. | System and method for generating antibody libraries |
| US11084863B2 (en) | 2017-06-30 | 2021-08-10 | Xencor, Inc. | Targeted heterodimeric Fc fusion proteins containing IL-15 IL-15alpha and antigen binding domains |
| US10981992B2 (en) | 2017-11-08 | 2021-04-20 | Xencor, Inc. | Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors |
| JP2021502100A (ja) | 2017-11-08 | 2021-01-28 | ゼンコア インコーポレイテッド | 新規抗ｐｄ−１配列を用いた二重特異性および単一特異性抗体 |
| US11034951B2 (en) | 2017-11-20 | 2021-06-15 | Nantbio, Inc. | mRNA display antibody library and methods |
| IL274780B2 (en) * | 2017-11-20 | 2025-04-01 | Nantbio Inc | mRNA library for antibody display and methods |
| US11319355B2 (en) | 2017-12-19 | 2022-05-03 | Xencor, Inc. | Engineered IL-2 Fc fusion proteins |
| WO2019195623A2 (en) | 2018-04-04 | 2019-10-10 | Xencor, Inc. | Heterodimeric antibodies that bind fibroblast activation protein |
| SG11202010163QA (en) | 2018-04-18 | 2020-11-27 | Xencor Inc | Pd-1 targeted heterodimeric fusion proteins containing il-15/il-15ra fc-fusion proteins and pd-1 antigen binding domains and uses thereof |
| US11505595B2 (en) | 2018-04-18 | 2022-11-22 | Xencor, Inc. | TIM-3 targeted heterodimeric fusion proteins containing IL-15/IL-15RA Fc-fusion proteins and TIM-3 antigen binding domains |
| EP3861016A2 (en) | 2018-10-03 | 2021-08-11 | Xencor, Inc. | Il-12 heterodimeric fc-fusion proteins |
| UA128825C2 (uk) | 2019-03-01 | 2024-10-30 | Ксенкор, Інк. | Гетеродимерні антитіла, що зв'язують enpp3 та cd3 |
| EP3767628B1 (de) * | 2019-07-18 | 2024-03-27 | Bayer Aktiengesellschaft | Selektion von antikörpern / antikörperfragmenten |
| WO2021115468A1 (zh) * | 2019-12-13 | 2021-06-17 | 南京金斯瑞生物科技有限公司 | 一种构建抗体互补决定区文库的方法 |
| WO2021231976A1 (en) | 2020-05-14 | 2021-11-18 | Xencor, Inc. | Heterodimeric antibodies that bind prostate specific membrane antigen (psma) and cd3 |
| JP2024511319A (ja) | 2021-03-09 | 2024-03-13 | ゼンコア インコーポレイテッド | Ｃｄ３及びｃｌｄｎ６に結合するヘテロ二量体抗体 |
| JP2024509274A (ja) | 2021-03-10 | 2024-02-29 | ゼンコア インコーポレイテッド | Ｃｄ３及びｇｐｃ３に結合するヘテロ二量体抗体 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7067284B1 (en) | 1992-01-27 | 2006-06-27 | The Scripps Research Institute | Methods for producing antibody libraries using universal or randomized immunoglobulin light chains |
| US5667988A (en) | 1992-01-27 | 1997-09-16 | The Scripps Research Institute | Methods for producing antibody libraries using universal or randomized immunoglobulin light chains |
| US6696248B1 (en) | 1995-08-18 | 2004-02-24 | Morphosys Ag | Protein/(poly)peptide libraries |
| AU725609C (en) | 1995-08-18 | 2002-01-03 | Morphosys Ag | Protein/(poly)peptide libraries |
| DK2067788T3 (da) | 1999-05-18 | 2015-10-19 | Dyax Corp | Fab-fragmentbiblioteker og fremgangsmåder til anvendelse deraf |
| EP1315559B1 (en) * | 2000-08-18 | 2006-03-22 | Massachusetts Institute Of Technology | Apparatus and methods for the automated synthesis of oligosaccharides |
| CA2443862A1 (en) * | 2001-04-17 | 2002-10-24 | Peizhi Luo | Structure-based construction of human antibody library |
| CN1672160B (zh) | 2002-05-20 | 2010-06-09 | 埃博马可西斯公司 | 基于前导抗体的结构构建抗体文库的方法 |
| EP1513879B1 (en) | 2002-06-03 | 2018-08-22 | Genentech, Inc. | Synthetic antibody phage libraries |
| NZ542587A (en) | 2003-03-14 | 2008-05-30 | Celltech R & D Inc | Complex comprising a TGF-beta binding protein and a BMP antagonist protein in specific association used to modulate bone mineralization |
| AU2004254352A1 (en) * | 2003-06-27 | 2005-01-13 | Roberto Crea | Look-through mutagenesis |
| AU2005230868A1 (en) * | 2004-03-31 | 2005-10-20 | Centocor, Inc. | Method and apparatus for analyzing and generating human antibody amino acid and nucleic acid sequences |
| CA2572961C (en) * | 2004-07-06 | 2016-08-16 | Bioren, Inc. | Universal antibody libraries |
| US8551920B2 (en) * | 2005-02-01 | 2013-10-08 | Morpho Sys AG | Libraries and methods for isolating antibodies |
| EP2069558B1 (en) | 2006-10-02 | 2013-05-01 | Sea Lane Biotechnologies,llc. | Design and construction of diverse synthetic peptide and polypeptide libraries |
-
2007
- 2007-09-28 EP EP07843450.3A patent/EP2069558B1/en active Active
- 2007-09-28 CN CN201310472612.6A patent/CN103541018A/zh active Pending
- 2007-09-28 AU AU2007303572A patent/AU2007303572A1/en not_active Abandoned
- 2007-09-28 JP JP2009531542A patent/JP5473603B2/ja active Active
- 2007-09-28 CN CN2007800446133A patent/CN101548034B/zh not_active Expired - Fee Related
- 2007-09-28 WO PCT/US2007/079849 patent/WO2008042754A2/en not_active Ceased
- 2007-09-28 CA CA2664681A patent/CA2664681C/en not_active Expired - Fee Related
- 2007-09-28 DK DK07843450.3T patent/DK2069558T3/da active
- 2007-09-28 US US11/864,525 patent/US8131480B2/en active Active
-
2009
- 2009-03-26 IL IL197837A patent/IL197837A/en not_active IP Right Cessation
-
2011
- 2011-12-09 US US13/374,065 patent/US20120202716A1/en not_active Abandoned
- 2011-12-14 US US13/374,203 patent/US20120129731A1/en not_active Abandoned
-
2013
- 2013-07-22 JP JP2013151434A patent/JP2013235610A/ja active Pending
- 2013-12-16 JP JP2013259083A patent/JP2014077004A/ja active Pending
-
2016
- 2016-01-22 US US15/004,742 patent/US10216897B2/en active Active
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