JP2013216692A - 口内で使用される窪みのある接着性口内パッチ - Google Patents
口内で使用される窪みのある接着性口内パッチ Download PDFInfo
- Publication number
- JP2013216692A JP2013216692A JP2013151530A JP2013151530A JP2013216692A JP 2013216692 A JP2013216692 A JP 2013216692A JP 2013151530 A JP2013151530 A JP 2013151530A JP 2013151530 A JP2013151530 A JP 2013151530A JP 2013216692 A JP2013216692 A JP 2013216692A
- Authority
- JP
- Japan
- Prior art keywords
- adhesive
- patch
- gum
- salt
- mouth
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000853 adhesive Substances 0.000 title claims description 26
- 230000001070 adhesive effect Effects 0.000 title claims description 25
- 210000000214 mouth Anatomy 0.000 title description 20
- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical compound C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 claims abstract description 78
- 229960003720 enoxolone Drugs 0.000 claims abstract description 43
- MPDGHEJMBKOTSU-UHFFFAOYSA-N Glycyrrhetinsaeure Natural products C12C(=O)C=C3C4CC(C)(C(O)=O)CCC4(C)CCC3(C)C1(C)CCC1C2(C)CCC(O)C1(C)C MPDGHEJMBKOTSU-UHFFFAOYSA-N 0.000 claims abstract description 39
- 150000003839 salts Chemical class 0.000 claims abstract description 13
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims abstract description 8
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 claims abstract description 7
- 229960004949 glycyrrhizic acid Drugs 0.000 claims abstract description 7
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 claims abstract description 7
- 235000019410 glycyrrhizin Nutrition 0.000 claims abstract description 7
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 claims abstract description 7
- 239000000126 substance Substances 0.000 claims abstract description 6
- 229910052783 alkali metal Inorganic materials 0.000 claims abstract description 5
- -1 alkalimetal salt Chemical class 0.000 claims abstract description 5
- 206010028034 Mouth ulceration Diseases 0.000 claims description 17
- 238000000034 method Methods 0.000 claims description 13
- 239000011230 binding agent Substances 0.000 claims description 12
- 210000003296 saliva Anatomy 0.000 claims description 10
- 229920000591 gum Polymers 0.000 claims description 8
- 108010010803 Gelatin Proteins 0.000 claims description 7
- 239000008273 gelatin Substances 0.000 claims description 7
- 229920000159 gelatin Polymers 0.000 claims description 7
- 235000019322 gelatine Nutrition 0.000 claims description 7
- 235000011852 gelatine desserts Nutrition 0.000 claims description 7
- 102000008186 Collagen Human genes 0.000 claims description 6
- 108010035532 Collagen Proteins 0.000 claims description 6
- 229920000084 Gum arabic Polymers 0.000 claims description 6
- 229920002752 Konjac Polymers 0.000 claims description 6
- 235000010489 acacia gum Nutrition 0.000 claims description 6
- 239000000205 acacia gum Substances 0.000 claims description 6
- 229920001436 collagen Polymers 0.000 claims description 6
- 239000000252 konjac Substances 0.000 claims description 6
- 235000019823 konjac gum Nutrition 0.000 claims description 6
- 238000011282 treatment Methods 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- VTAJIXDZFCRWBR-UHFFFAOYSA-N Licoricesaponin B2 Natural products C1C(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2)C(O)=O)C)(C)CC2)(C)C2C(C)(C)CC1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O VTAJIXDZFCRWBR-UHFFFAOYSA-N 0.000 claims description 5
- 239000001685 glycyrrhizic acid Substances 0.000 claims description 5
- 239000000230 xanthan gum Substances 0.000 claims description 5
- 229920001285 xanthan gum Polymers 0.000 claims description 5
- 235000010493 xanthan gum Nutrition 0.000 claims description 5
- 229940082509 xanthan gum Drugs 0.000 claims description 5
- 208000025865 Ulcer Diseases 0.000 claims description 4
- BLFLLBZGZJTVJG-UHFFFAOYSA-N benzocaine Chemical compound CCOC(=O)C1=CC=C(N)C=C1 BLFLLBZGZJTVJG-UHFFFAOYSA-N 0.000 claims description 4
- 231100000397 ulcer Toxicity 0.000 claims description 4
- 229920000161 Locust bean gum Polymers 0.000 claims description 3
- 208000007117 Oral Ulcer Diseases 0.000 claims description 3
- 235000010420 locust bean gum Nutrition 0.000 claims description 3
- 239000000711 locust bean gum Substances 0.000 claims description 3
- 229960005274 benzocaine Drugs 0.000 claims description 2
- 229940079593 drug Drugs 0.000 abstract description 16
- 239000003814 drug Substances 0.000 abstract description 16
- 230000000694 effects Effects 0.000 abstract description 8
- 229940069445 licorice extract Drugs 0.000 abstract description 5
- 239000004378 Glycyrrhizin Substances 0.000 abstract description 2
- 208000006595 Necrotizing Ulcerative Gingivitis Diseases 0.000 description 16
- 201000008587 ulcerative stomatitis Diseases 0.000 description 16
- 239000000203 mixture Substances 0.000 description 6
- 230000035876 healing Effects 0.000 description 5
- 210000001519 tissue Anatomy 0.000 description 5
- 239000000284 extract Substances 0.000 description 4
- 239000000796 flavoring agent Substances 0.000 description 4
- 235000019634 flavors Nutrition 0.000 description 4
- 239000000499 gel Substances 0.000 description 4
- 235000012054 meals Nutrition 0.000 description 4
- 230000003204 osmotic effect Effects 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- 208000003265 stomatitis Diseases 0.000 description 4
- 239000003826 tablet Substances 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 3
- 210000002615 epidermis Anatomy 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 239000000416 hydrocolloid Substances 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000002985 plastic film Substances 0.000 description 3
- 244000215068 Acacia senegal Species 0.000 description 2
- 229920001817 Agar Polymers 0.000 description 2
- 229920003043 Cellulose fiber Polymers 0.000 description 2
- 102000053187 Glucuronidase Human genes 0.000 description 2
- 108010060309 Glucuronidase Proteins 0.000 description 2
- 244000303040 Glycyrrhiza glabra Species 0.000 description 2
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 description 2
- 235000017443 Hedysarum boreale Nutrition 0.000 description 2
- 235000007858 Hedysarum occidentale Nutrition 0.000 description 2
- 235000010419 agar Nutrition 0.000 description 2
- 235000010418 carrageenan Nutrition 0.000 description 2
- 239000000679 carrageenan Substances 0.000 description 2
- 229920001525 carrageenan Polymers 0.000 description 2
- 229940113118 carrageenan Drugs 0.000 description 2
- 230000003628 erosive effect Effects 0.000 description 2
- 235000003599 food sweetener Nutrition 0.000 description 2
- 239000001947 glycyrrhiza glabra rhizome/root Substances 0.000 description 2
- 150000004677 hydrates Chemical class 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 239000011092 plastic-coated paper Substances 0.000 description 2
- 210000003491 skin Anatomy 0.000 description 2
- 239000003765 sweetening agent Substances 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 2
- 206010011224 Cough Diseases 0.000 description 1
- 244000303965 Cyamopsis psoralioides Species 0.000 description 1
- AEMOLEFTQBMNLQ-AQKNRBDQSA-N D-glucopyranuronic acid Chemical compound OC1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-AQKNRBDQSA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010033799 Paralysis Diseases 0.000 description 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 230000003444 anaesthetic effect Effects 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 208000002399 aphthous stomatitis Diseases 0.000 description 1
- 239000006286 aqueous extract Substances 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 208000020670 canker sore Diseases 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 235000013325 dietary fiber Nutrition 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 229940126534 drug product Drugs 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000000451 gelidium spp. gum Substances 0.000 description 1
- 229940097043 glucuronic acid Drugs 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000007373 indentation Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000011221 initial treatment Methods 0.000 description 1
- 239000007937 lozenge Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 210000003097 mucus Anatomy 0.000 description 1
- 239000005416 organic matter Substances 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 239000001054 red pigment Substances 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 235000019615 sensations Nutrition 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Alternative & Traditional Medicine (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Emergency Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
【解決手段】局部組織内への多量吸収、すなわち使用される薬剤量に比して薬効が高い治療(副作用のリスクを最低にする)のために、グリシルリチン甘草抽出物の水溶塩(SGE)を使用することが望ましい。SGEは口内温度で水溶性である一群のグリシルリチン酸の化学塩を含む。それらにはグリシルレチン酸のカリウム塩とグリシルレチン酸のアルカリ金属塩が含まれる。
【選択図】図3
Description
ここで使用する「パッチ」には一箇所に固定されることなく移動し、所望の箇所に高濃度の放出薬剤を維持できない咳止めドロップや喉飴といった薬剤は含まれない。さらに唾液内で噛み砕かれたり、唾液内に置かれると粉末化またはペースト化するような、粉末形態、液体形態、ペースト形態、粘液ゲル形態または錠剤形態あるいはトローチ形態といった、口内で保持されたときに固体形状を維持できないような薬剤も含まれない。2002年11月5日に出願された米国特許出願第10/287,843号(特許文献1)にて本願と同一の発明者によって開示された接着式溶出口内パッチのような、口内に保持されても一体性を維持するハイドロコロイドで形成された接着性薬剤物は含まれる。
図1は完全に溶解する(より正確には、分子が水和するに連れて次第に浸食される)接着性口内パッチを図示する。口内ではこのパッチは硬質ガムキャンディのような感触と肌触りを提供する。このパッチは持続的に分解するハイドロコロイドで製造されており、典型的には完全溶解するまで口内で1時間から6時間持続する。このパッチは錠剤形態またはドロップ形態あるいはウェハー形態に成型でき、またはどのような他の所望形状であってもよい。好適な形状は図1aで示すような一方側がほぼ平坦な薄いレンズ形状である。
2 外層
3 潰瘍性口内炎
Claims (21)
- 口内潰瘍を治療する方法であって、
(a)接着性口内パッチを準備するステップであって、該口内パッチは、少なくとも5mm四方または5mm径であり、口内温度で水溶性であるグリシルリチン酸の塩を含有しており、唾液に曝露されるとグリシルレチン酸を放出することを特徴とするステップと、
(b)前記パッチの使用者に対して、口内潰瘍の治療のために潰瘍上またはその近辺で該パッチを保持するように指示するステップと、
を含んでいることを特徴とする方法。 - 塩はグリシルレチン酸のアルカリ金属塩であることを特徴とする請求項1記載の方法。
- 塩はグリシルレチン酸のカリウム塩であることを特徴とする請求項1記載の方法。
- パッチは唾液内で溶解するガムを含んでいることを特徴とする請求項1記載の方法。
- ガムはキサンタンガムであることを特徴とする請求項4記載の方法。
- ガムはコンニャクガムであることを特徴とする請求項4記載の方法。
- ガムはゼラチンであることを特徴とする請求項4記載の方法。
- ガムはローカストビーンガムであることを特徴とする請求項4記載の方法。
- ガムはアカシアガムであることを特徴とする請求項4記載の方法。
- 接着パッチであって、少なくとも5mm四方または5mm径であり、口内に保持されると一度に口内の複数箇所に分散することのない単一物質として残留してゆっくりと溶解し、持続的にグリシルレチン酸を放出するものであり、乾燥重量で、
(a)口内温度で水溶性である1%から10%のグリシルレチン酸の塩と、
(b)50%から99%の結合剤成分と、
から本質的に成ることを特徴とする接着パッチ。 - 塩はグリシルレチン酸のアルカリ金属塩であることを特徴とする請求項10記載の接着パッチ。
- 塩はグリシルレチン酸のカリウム塩であることを特徴とする請求項11記載の接着パッチ。
- グリシルレチン酸は2%から6%であることを特徴とする請求項10記載の接着パッチ。
- 歯または歯列矯正器具に接着する凹部を有した接着トローチであって、
少なくとも2方向で少なくとも5mmのサイズである凸面と、該凸面の反対側の凹面とを有したトローチを含んでおり、前記凹面は接着剤を含んでいることを特徴とする接着トローチ。 - 口内に保持されると溶解することを特徴とする請求項14記載の接着トローチ。
- グリシルレチン酸を放出することを特徴とする請求項14記載の接着トローチ。
- ベンゾカインを放出することを特徴とする請求項14記載の接着トローチ。
- コラーゲンを放出することを特徴とする請求項14記載の接着トローチ。
- 凹面は少なくとも0.5mmの深さを有していることを特徴とする請求項14記載の接着トローチ。
- 接着剤はアカシアガムを含んでいることを特徴とする請求項14記載の接着トローチ。
- 接着剤はコラーゲンを含んでいることを特徴とする請求項14記載の接着トローチ。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US79212106P | 2006-04-13 | 2006-04-13 | |
US60/792,121 | 2006-04-13 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2009505479A Division JP2009535304A (ja) | 2006-04-13 | 2007-04-13 | 口内温度にて水溶性であるグリシルレチン酸の塩を含んだ口内パッチ |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2013216692A true JP2013216692A (ja) | 2013-10-24 |
JP5897509B2 JP5897509B2 (ja) | 2016-03-30 |
Family
ID=38609833
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2009505479A Pending JP2009535304A (ja) | 2006-04-13 | 2007-04-13 | 口内温度にて水溶性であるグリシルレチン酸の塩を含んだ口内パッチ |
JP2013151530A Active JP5897509B2 (ja) | 2006-04-13 | 2013-07-22 | 口内で使用される窪みのある接着性口内パッチ |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2009505479A Pending JP2009535304A (ja) | 2006-04-13 | 2007-04-13 | 口内温度にて水溶性であるグリシルレチン酸の塩を含んだ口内パッチ |
Country Status (6)
Country | Link |
---|---|
US (1) | US20070243238A1 (ja) |
EP (1) | EP2012768B1 (ja) |
JP (2) | JP2009535304A (ja) |
CN (1) | CN101466369B (ja) |
ES (1) | ES2529585T3 (ja) |
WO (1) | WO2007120768A1 (ja) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20070243238A1 (en) * | 2006-04-13 | 2007-10-18 | Haley Jeffrey T | Treating mouth sores with patches adhered to teeth |
BE1019216A3 (nl) * | 2010-03-11 | 2012-04-03 | Sylphar | Kleefpleister voor de toediening van therapeutische agentia. |
WO2011110225A1 (en) * | 2010-03-11 | 2011-09-15 | Sylphar | Adhesive patch for therapeutic agent delivery |
JP2011201817A (ja) * | 2010-03-26 | 2011-10-13 | Nrl Pharma Inc | 口腔貼付用錠剤 |
KR20140124375A (ko) * | 2012-02-19 | 2014-10-24 | 오라헬쓰 코포레이션 | 구강 접착 정제용 알칼리성 아카시아 검 |
CN104856979A (zh) * | 2015-06-05 | 2015-08-26 | 黄焱 | 一种甘珀酸钠的口腔贴剂及其制备和应用 |
WO2019204708A1 (en) | 2018-04-21 | 2019-10-24 | Quest Products, Llc | Bilayer adhering lozenge effective to mask undesirable flavor |
ES2777899A1 (es) * | 2019-02-06 | 2020-08-06 | Hector Alfredo Duilio Polizzi | Apósito oral con efecto anestésico |
CN117100426B (zh) * | 2023-10-17 | 2023-12-26 | 上海马可菲斯医疗技术有限公司 | 一种具有可溶性颗粒的膜片及其在牙套中的应用 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6197331B1 (en) * | 1997-07-24 | 2001-03-06 | Perio Products Ltd. | Pharmaceutical oral patch for controlled release of pharmaceutical agents in the oral cavity |
JP2005349046A (ja) * | 2004-06-11 | 2005-12-22 | Nippon Dental Support:Kk | マウスピース脱落防止具及びマウスピース並びにこれらを具備した歯科矯正具 |
JP2006509036A (ja) * | 2002-11-21 | 2006-03-16 | エル・ジー ハウスホールド アンド ヘルスケア リミティッド | 歯肉に安全なドライタイプのパッチ |
JP2009535304A (ja) * | 2006-04-13 | 2009-10-01 | オラヘルス コーポレーション | 口内温度にて水溶性であるグリシルレチン酸の塩を含んだ口内パッチ |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS56100714A (en) * | 1980-01-16 | 1981-08-12 | Teijin Ltd | Pharmaceutical adhering to oral mucous membrane or nasal mucous membrane |
ZA82361B (en) * | 1981-02-06 | 1982-12-29 | Biorex Laboratories Ltd | Pharmaceutical composition for treating diseases of the oral cavity |
US5455033A (en) * | 1993-05-21 | 1995-10-03 | Degree/Silverman M.D. Inc. | Medicinal composition for treatment of inflammation |
US5578315A (en) * | 1993-12-01 | 1996-11-26 | Rutgers, The State University Of New Jersey | Mucosal adhesive device for long-acting delivery of pharmaceutical combinations in oral cavity |
US6149615A (en) * | 1998-11-23 | 2000-11-21 | Gallamore; Deborah | Opto-cupped pedia patch |
JP4808294B2 (ja) * | 1999-03-03 | 2011-11-02 | 日東電工株式会社 | 口腔内貼付製剤 |
US6967023B1 (en) * | 2000-01-10 | 2005-11-22 | Foamix, Ltd. | Pharmaceutical and cosmetic carrier or composition for topical application |
US6319523B1 (en) * | 2000-06-29 | 2001-11-20 | James H. Zhou | Composition and method for inhibiting oral bacteria |
AU2002216059A1 (en) * | 2000-12-15 | 2002-06-24 | Joiner, Andrew | Oral bleaching composition |
US7201930B2 (en) * | 2001-11-05 | 2007-04-10 | Haley Jeffrey T | Licorice root extract oral patch for treating canker sores |
CN1309425C (zh) * | 2001-11-05 | 2007-04-11 | 奥拉黑尔斯公司 | 用贴片治疗口腔溃疡以加速痊愈和缓解疼痛的方法 |
KR20030054221A (ko) * | 2001-12-24 | 2003-07-02 | 애경산업(주) | 구강용 적층 필름 조성물 및 그 제조방법 |
US20030124178A1 (en) * | 2001-12-28 | 2003-07-03 | Haley Jeffrey T. | Soft, adherent, soluble oral patch |
JP2006505614A (ja) * | 2002-11-05 | 2006-02-16 | ハーレイ,ジェフリー,ティ. | コラーゲン及び網状活性成分を含んだ溶解性口内パッチ |
KR20050055858A (ko) * | 2003-12-09 | 2005-06-14 | 주식회사 엘지생활건강 | 구강 약물 전달 시스템 |
-
2006
- 2006-12-15 US US11/639,982 patent/US20070243238A1/en not_active Abandoned
-
2007
- 2007-04-13 EP EP07755339.4A patent/EP2012768B1/en active Active
- 2007-04-13 ES ES07755339.4T patent/ES2529585T3/es active Active
- 2007-04-13 WO PCT/US2007/009032 patent/WO2007120768A1/en active Application Filing
- 2007-04-13 CN CN200780022250.3A patent/CN101466369B/zh active Active
- 2007-04-13 JP JP2009505479A patent/JP2009535304A/ja active Pending
-
2013
- 2013-07-22 JP JP2013151530A patent/JP5897509B2/ja active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6197331B1 (en) * | 1997-07-24 | 2001-03-06 | Perio Products Ltd. | Pharmaceutical oral patch for controlled release of pharmaceutical agents in the oral cavity |
JP2006509036A (ja) * | 2002-11-21 | 2006-03-16 | エル・ジー ハウスホールド アンド ヘルスケア リミティッド | 歯肉に安全なドライタイプのパッチ |
JP2005349046A (ja) * | 2004-06-11 | 2005-12-22 | Nippon Dental Support:Kk | マウスピース脱落防止具及びマウスピース並びにこれらを具備した歯科矯正具 |
JP2009535304A (ja) * | 2006-04-13 | 2009-10-01 | オラヘルス コーポレーション | 口内温度にて水溶性であるグリシルレチン酸の塩を含んだ口内パッチ |
Also Published As
Publication number | Publication date |
---|---|
CN101466369B (zh) | 2015-07-01 |
CN101466369A (zh) | 2009-06-24 |
US20070243238A1 (en) | 2007-10-18 |
EP2012768A4 (en) | 2009-07-22 |
WO2007120768A1 (en) | 2007-10-25 |
JP5897509B2 (ja) | 2016-03-30 |
EP2012768B1 (en) | 2014-11-26 |
ES2529585T3 (es) | 2015-02-23 |
JP2009535304A (ja) | 2009-10-01 |
EP2012768A1 (en) | 2009-01-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP5897509B2 (ja) | 口内で使用される窪みのある接着性口内パッチ | |
US9161909B2 (en) | Adhesive compositions for the treatment of xerostomia | |
Mizrahi et al. | Mucoadhesive polymers for delivery of drugs to the oral cavity | |
JP2010163451A (ja) | 潰瘍治療用の甘草根抽出物口内パッチ | |
JP2003095947A (ja) | ニコチン含有フィルム製剤 | |
BR9914064B1 (pt) | pelìcula consumìvel de dissolução rápida por via oral. | |
PT2059243E (pt) | Discos de buprenorfina para terapia de substituição de drogas | |
BRPI0713574A2 (pt) | composições herbais para o tratamento de doenças da cavidade oral | |
JPH059412B2 (ja) | ||
US7201930B2 (en) | Licorice root extract oral patch for treating canker sores | |
JP2009538913A (ja) | コバラミン調合物および粘膜炎の治療法または予防法 | |
RU2693384C2 (ru) | Лечение повреждений слизистой оболочки с использованием гиалуронана, доставляемого из приклеивающейся пастилки | |
JP2005508980A5 (ja) | ||
US8945606B2 (en) | Oral adhering disc with dimple on adhering side | |
US20150110851A1 (en) | Oral adhering patch with dimple on adhering side | |
US20220323343A1 (en) | Diclofenac and hyaluronic acid combination treatment for oral leukpoplakia | |
JPH04173730A (ja) | 徐放性口腔内疾患治療剤およびその製法 | |
Bhowmik et al. | Buccal drug delivery system-a novel drug delivery system | |
JPH0466205B2 (ja) | ||
JPS60237018A (ja) | 口腔内付着性組成物 | |
WO2024126751A1 (en) | Oral film with multiple regions for therapy of periodontal and dental diseases or disorders | |
AU2007264709B2 (en) | Herbal compositions for the treatment of diseases of the oral cavity | |
JP2011201817A (ja) | 口腔貼付用錠剤 | |
JP2017513867A (ja) | 経口送達システム | |
KR20200059932A (ko) | 구강 패치 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20130724 |
|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20130819 |
|
A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20140516 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20140610 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20140729 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20141209 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20150304 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20150804 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20151028 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20160209 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20160302 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 5897509 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
S111 | Request for change of ownership or part of ownership |
Free format text: JAPANESE INTERMEDIATE CODE: R313113 |
|
S531 | Written request for registration of change of domicile |
Free format text: JAPANESE INTERMEDIATE CODE: R313531 |
|
S533 | Written request for registration of change of name |
Free format text: JAPANESE INTERMEDIATE CODE: R313533 |
|
R350 | Written notification of registration of transfer |
Free format text: JAPANESE INTERMEDIATE CODE: R350 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |