JP2009535304A - 口内温度にて水溶性であるグリシルレチン酸の塩を含んだ口内パッチ - Google Patents
口内温度にて水溶性であるグリシルレチン酸の塩を含んだ口内パッチ Download PDFInfo
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- adhesive
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- glycyrrhetinic acid
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- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical compound C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 title claims abstract description 82
- 229960003720 enoxolone Drugs 0.000 title claims abstract description 43
- MPDGHEJMBKOTSU-UHFFFAOYSA-N Glycyrrhetinsaeure Natural products C12C(=O)C=C3C4CC(C)(C(O)=O)CCC4(C)CCC3(C)C1(C)CCC1C2(C)CCC(O)C1(C)C MPDGHEJMBKOTSU-UHFFFAOYSA-N 0.000 title claims abstract description 39
- 150000003839 salts Chemical class 0.000 title claims abstract description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title claims abstract description 10
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims abstract description 9
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 claims abstract description 8
- 229960004949 glycyrrhizic acid Drugs 0.000 claims abstract description 8
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 claims abstract description 8
- 235000019410 glycyrrhizin Nutrition 0.000 claims abstract description 8
- 238000011282 treatment Methods 0.000 claims abstract description 8
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 claims abstract description 7
- VTAJIXDZFCRWBR-UHFFFAOYSA-N Licoricesaponin B2 Natural products C1C(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2)C(O)=O)C)(C)CC2)(C)C2C(C)(C)CC1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O VTAJIXDZFCRWBR-UHFFFAOYSA-N 0.000 claims abstract description 6
- 239000001685 glycyrrhizic acid Substances 0.000 claims abstract description 6
- 239000000126 substance Substances 0.000 claims abstract description 6
- 229910052783 alkali metal Inorganic materials 0.000 claims abstract description 5
- -1 alkali metal salt Chemical class 0.000 claims abstract description 5
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- 208000025865 Ulcer Diseases 0.000 claims description 4
- BLFLLBZGZJTVJG-UHFFFAOYSA-N benzocaine Chemical compound CCOC(=O)C1=CC=C(N)C=C1 BLFLLBZGZJTVJG-UHFFFAOYSA-N 0.000 claims description 4
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- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 2
- 206010011224 Cough Diseases 0.000 description 1
- AEMOLEFTQBMNLQ-AQKNRBDQSA-N D-glucopyranuronic acid Chemical compound OC1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-AQKNRBDQSA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
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- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 description 1
- 229920002907 Guar gum Polymers 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010033799 Paralysis Diseases 0.000 description 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
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- 208000002399 aphthous stomatitis Diseases 0.000 description 1
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- 239000000451 gelidium spp. gum Substances 0.000 description 1
- 229940097043 glucuronic acid Drugs 0.000 description 1
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- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
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- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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Abstract
【解決手段】局部組織内への多量吸収、すなわち使用される薬剤量に比して薬効が高い治療(副作用のリスクを最低にする)のために、グリシルリチン甘草抽出物の水溶塩(SGE)を使用することが望ましい。SGEは口内温度で水溶性である1群のグリシルリチン酸の化学塩を含む。それらにはグリシルレチン酸のカリウム塩とグリシルレチン酸のアルカリ金属塩が含まれる。
【選択図】図2
Description
Claims (21)
- 口内潰瘍を治療する方法であって、
(a)接着性口内パッチを準備するステップであって、該口内パッチは、少なくとも5mm四方または5mm径であり、口内温度で水溶性であるグリシルリチン酸の塩を含有しており、唾液に曝露されるとグリシルレチン酸を放出することを特徴とするステップと、
(b)前記パッチの使用者に対して、口内潰瘍の治療のために潰瘍上またはその近辺で該パッチを保持するように指示するステップと、
を含んでいることを特徴とする方法。 - 塩はグリシルレチン酸のアルカリ金属塩であることを特徴とする請求項1記載の方法。
- 塩はグリシルレチン酸のカリウム塩であることを特徴とする請求項1記載の方法。
- パッチは唾液内で溶解するゴムを含んでいることを特徴とする請求項1記載の方法。
- ゴムはキサンタンゴムであることを特徴とする請求項4記載の方法。
- ゴムはコニャックゴムであることを特徴とする請求項4記載の方法。
- ゴムはゼラチンであることを特徴とする請求項4記載の方法。
- ゴムはイナゴマメゴムであることを特徴とする請求項4記載の方法。
- ゴムはアカシアゴムであることを特徴とする請求項4記載の方法。
- 接着パッチであって、少なくとも5mm四方または5mm径であり、口内に保持されると一度に口内の複数箇所に分散することのない単一物質として残留してゆっくりと溶解し、持続的にグリシルレチン酸を放出するものであり、乾燥重量で、
(a)口内温度で水溶性である1%から10%のグリシルレチン酸の塩と、
(b)50%から99%の結合剤成分と、
から本質的に成ることを特徴とする接着パッチ。 - 塩はグリシルレチン酸のアルカリ金属塩であることを特徴とする請求項10記載の接着パッチ。
- 塩はグリシルレチン酸のカリウム塩であることを特徴とする請求項11記載の接着パッチ。
- グリシルレチン酸は2%から6%であることを特徴とする請求項10記載の接着パッチ。
- 歯または歯列矯正器具に接着する凹部を有した接着トローチであって、
少なくとも2方向で少なくとも5mmのサイズである凸面と、該凸面の反対側の凹面とを有したトローチを含んでおり、前記凹面は接着剤を含んでいることを特徴とする接着トローチ。 - 口内に保持されると溶解することを特徴とする請求項14記載の接着トローチ。
- グリシルレチン酸を放出することを特徴とする請求項14記載の接着トローチ。
- ベンゾカインを放出することを特徴とする請求項14記載の接着トローチ。
- コラーゲンを放出することを特徴とする請求項14記載の接着トローチ。
- 凹面は少なくとも0.5mmの深さを有していることを特徴とする請求項14記載の接着トローチ。
- 接着剤はアカシアゴムを含んでいることを特徴とする請求項14記載の接着トローチ。
- 接着剤はコラーゲンを含んでいることを特徴とする請求項14記載の接着トローチ。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US79212106P | 2006-04-13 | 2006-04-13 | |
PCT/US2007/009032 WO2007120768A1 (en) | 2006-04-13 | 2007-04-13 | Oral patch with salt of glycyrrhetinic acid water soluble at human mouth temperatures |
Related Child Applications (1)
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JP2013151530A Division JP5897509B2 (ja) | 2006-04-13 | 2013-07-22 | 口内で使用される窪みのある接着性口内パッチ |
Publications (2)
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JP2009535304A true JP2009535304A (ja) | 2009-10-01 |
JP2009535304A5 JP2009535304A5 (ja) | 2010-05-27 |
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JP2009505479A Pending JP2009535304A (ja) | 2006-04-13 | 2007-04-13 | 口内温度にて水溶性であるグリシルレチン酸の塩を含んだ口内パッチ |
JP2013151530A Active JP5897509B2 (ja) | 2006-04-13 | 2013-07-22 | 口内で使用される窪みのある接着性口内パッチ |
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JP2013151530A Active JP5897509B2 (ja) | 2006-04-13 | 2013-07-22 | 口内で使用される窪みのある接着性口内パッチ |
Country Status (6)
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US (1) | US20070243238A1 (ja) |
EP (1) | EP2012768B1 (ja) |
JP (2) | JP2009535304A (ja) |
CN (1) | CN101466369B (ja) |
ES (1) | ES2529585T3 (ja) |
WO (1) | WO2007120768A1 (ja) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2011201817A (ja) * | 2010-03-26 | 2011-10-13 | Nrl Pharma Inc | 口腔貼付用錠剤 |
JP2013216692A (ja) * | 2006-04-13 | 2013-10-24 | Orahealth Corp | 口内で使用される窪みのある接着性口内パッチ |
JP2015507021A (ja) * | 2012-02-19 | 2015-03-05 | オラヘルス コーポレーション | 口内接着ディスクのためのアルカリ化されたアラビアゴムの接着剤 |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2544669A1 (en) * | 2010-03-11 | 2013-01-16 | Sylphar | Adhesive patch for therapeutic agent delivery |
BE1019216A3 (nl) * | 2010-03-11 | 2012-04-03 | Sylphar | Kleefpleister voor de toediening van therapeutische agentia. |
CN104856979A (zh) * | 2015-06-05 | 2015-08-26 | 黄焱 | 一种甘珀酸钠的口腔贴剂及其制备和应用 |
US11612564B2 (en) | 2018-04-21 | 2023-03-28 | Quest Products, Llc | Bilayer adhering lozenge effective to mask undesirable flavor |
ES2777899A1 (es) * | 2019-02-06 | 2020-08-06 | Hector Alfredo Duilio Polizzi | Apósito oral con efecto anestésico |
CN117100426B (zh) * | 2023-10-17 | 2023-12-26 | 上海马可菲斯医疗技术有限公司 | 一种具有可溶性颗粒的膜片及其在牙套中的应用 |
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JPS56100714A (en) * | 1980-01-16 | 1981-08-12 | Teijin Ltd | Pharmaceutical adhering to oral mucous membrane or nasal mucous membrane |
JP2000256189A (ja) * | 1999-03-03 | 2000-09-19 | Nitto Denko Corp | 口腔内貼付製剤 |
JP2005508980A (ja) * | 2001-11-05 | 2005-04-07 | オラヘルス コーポレーション | 治癒を促進し、痛みを緩和させるパッチによる口内炎治療法 |
JP2006505614A (ja) * | 2002-11-05 | 2006-02-16 | ハーレイ,ジェフリー,ティ. | コラーゲン及び網状活性成分を含んだ溶解性口内パッチ |
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US5578315A (en) * | 1993-12-01 | 1996-11-26 | Rutgers, The State University Of New Jersey | Mucosal adhesive device for long-acting delivery of pharmaceutical combinations in oral cavity |
US6197331B1 (en) * | 1997-07-24 | 2001-03-06 | Perio Products Ltd. | Pharmaceutical oral patch for controlled release of pharmaceutical agents in the oral cavity |
US6149615A (en) * | 1998-11-23 | 2000-11-21 | Gallamore; Deborah | Opto-cupped pedia patch |
US6967023B1 (en) * | 2000-01-10 | 2005-11-22 | Foamix, Ltd. | Pharmaceutical and cosmetic carrier or composition for topical application |
US6319523B1 (en) * | 2000-06-29 | 2001-11-20 | James H. Zhou | Composition and method for inhibiting oral bacteria |
WO2002047638A1 (en) * | 2000-12-15 | 2002-06-20 | Unilever N.V. | Oral bleaching composition |
US7201930B2 (en) * | 2001-11-05 | 2007-04-10 | Haley Jeffrey T | Licorice root extract oral patch for treating canker sores |
KR20030054221A (ko) * | 2001-12-24 | 2003-07-02 | 애경산업(주) | 구강용 적층 필름 조성물 및 그 제조방법 |
US20030124178A1 (en) | 2001-12-28 | 2003-07-03 | Haley Jeffrey T. | Soft, adherent, soluble oral patch |
BR0315955A (pt) * | 2002-11-21 | 2005-09-13 | Lg Household & Health Care Ltd | Emplastros de tipo seco, seguros para as gengivas |
KR20050055858A (ko) * | 2003-12-09 | 2005-06-14 | 주식회사 엘지생활건강 | 구강 약물 전달 시스템 |
JP2005349046A (ja) * | 2004-06-11 | 2005-12-22 | Nippon Dental Support:Kk | マウスピース脱落防止具及びマウスピース並びにこれらを具備した歯科矯正具 |
US20070243238A1 (en) * | 2006-04-13 | 2007-10-18 | Haley Jeffrey T | Treating mouth sores with patches adhered to teeth |
-
2006
- 2006-12-15 US US11/639,982 patent/US20070243238A1/en not_active Abandoned
-
2007
- 2007-04-13 ES ES07755339.4T patent/ES2529585T3/es active Active
- 2007-04-13 WO PCT/US2007/009032 patent/WO2007120768A1/en active Application Filing
- 2007-04-13 JP JP2009505479A patent/JP2009535304A/ja active Pending
- 2007-04-13 EP EP07755339.4A patent/EP2012768B1/en active Active
- 2007-04-13 CN CN200780022250.3A patent/CN101466369B/zh active Active
-
2013
- 2013-07-22 JP JP2013151530A patent/JP5897509B2/ja active Active
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JPS56100714A (en) * | 1980-01-16 | 1981-08-12 | Teijin Ltd | Pharmaceutical adhering to oral mucous membrane or nasal mucous membrane |
JP2000256189A (ja) * | 1999-03-03 | 2000-09-19 | Nitto Denko Corp | 口腔内貼付製剤 |
JP2005508980A (ja) * | 2001-11-05 | 2005-04-07 | オラヘルス コーポレーション | 治癒を促進し、痛みを緩和させるパッチによる口内炎治療法 |
JP2006505614A (ja) * | 2002-11-05 | 2006-02-16 | ハーレイ,ジェフリー,ティ. | コラーゲン及び網状活性成分を含んだ溶解性口内パッチ |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2013216692A (ja) * | 2006-04-13 | 2013-10-24 | Orahealth Corp | 口内で使用される窪みのある接着性口内パッチ |
JP2011201817A (ja) * | 2010-03-26 | 2011-10-13 | Nrl Pharma Inc | 口腔貼付用錠剤 |
JP2015507021A (ja) * | 2012-02-19 | 2015-03-05 | オラヘルス コーポレーション | 口内接着ディスクのためのアルカリ化されたアラビアゴムの接着剤 |
Also Published As
Publication number | Publication date |
---|---|
WO2007120768A1 (en) | 2007-10-25 |
EP2012768B1 (en) | 2014-11-26 |
JP5897509B2 (ja) | 2016-03-30 |
JP2013216692A (ja) | 2013-10-24 |
EP2012768A1 (en) | 2009-01-14 |
EP2012768A4 (en) | 2009-07-22 |
CN101466369B (zh) | 2015-07-01 |
CN101466369A (zh) | 2009-06-24 |
US20070243238A1 (en) | 2007-10-18 |
ES2529585T3 (es) | 2015-02-23 |
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