JP2012533308A5 - - Google Patents
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- Publication number
- JP2012533308A5 JP2012533308A5 JP2012520829A JP2012520829A JP2012533308A5 JP 2012533308 A5 JP2012533308 A5 JP 2012533308A5 JP 2012520829 A JP2012520829 A JP 2012520829A JP 2012520829 A JP2012520829 A JP 2012520829A JP 2012533308 A5 JP2012533308 A5 JP 2012533308A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- concentration
- extract
- rrna
- rna
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22610609P | 2009-07-16 | 2009-07-16 | |
| US22602509P | 2009-07-16 | 2009-07-16 | |
| US61/226,106 | 2009-07-16 | ||
| US61/226,025 | 2009-07-16 | ||
| PCT/US2010/042365 WO2011009104A1 (en) | 2009-07-16 | 2010-07-16 | Nucleic acid analysis |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015246006A Division JP2016116512A (ja) | 2009-07-16 | 2015-12-17 | 核酸分析 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012533308A JP2012533308A (ja) | 2012-12-27 |
| JP2012533308A5 true JP2012533308A5 (enExample) | 2013-08-29 |
| JP5909444B2 JP5909444B2 (ja) | 2016-04-26 |
Family
ID=43449850
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012520829A Active JP5909444B2 (ja) | 2009-07-16 | 2010-07-16 | 核酸分析 |
| JP2015246006A Pending JP2016116512A (ja) | 2009-07-16 | 2015-12-17 | 核酸分析 |
| JP2017086218A Pending JP2017131244A (ja) | 2009-07-16 | 2017-04-25 | 核酸分析 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015246006A Pending JP2016116512A (ja) | 2009-07-16 | 2015-12-17 | 核酸分析 |
| JP2017086218A Pending JP2017131244A (ja) | 2009-07-16 | 2017-04-25 | 核酸分析 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US20110195426A1 (enExample) |
| EP (1) | EP2454588B1 (enExample) |
| JP (3) | JP5909444B2 (enExample) |
| KR (2) | KR20120037992A (enExample) |
| CN (2) | CN105779436A (enExample) |
| AU (1) | AU2010273928A1 (enExample) |
| BR (1) | BR112012001077A2 (enExample) |
| CA (1) | CA2768371A1 (enExample) |
| DK (1) | DK2454588T3 (enExample) |
| ES (1) | ES2547715T3 (enExample) |
| IN (1) | IN2012DN00866A (enExample) |
| SG (2) | SG2014014617A (enExample) |
| WO (1) | WO2011009104A1 (enExample) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2736726T3 (es) * | 2006-03-09 | 2020-01-07 | Aethlon Medical Inc | Eliminación extracorpórea de partículas microvesiculares |
| US11266736B2 (en) | 2008-04-17 | 2022-03-08 | Vin De Bona Trading Company Pte Ltd | Method of painting micro vesicles |
| EP3461912B1 (en) * | 2009-09-09 | 2022-07-13 | The General Hospital Corporation | Use of microvesicles in analyzing nucleic acid profiles |
| EP2475989A4 (en) | 2009-09-09 | 2013-02-27 | Gen Hospital Corp | USE OF MICROVESICLES IN THE ANALYSIS OF KRAS MUTATIONS |
| JP5755326B2 (ja) * | 2010-06-11 | 2015-07-29 | 日立化成株式会社 | 腎機能の特徴を決定する方法 |
| US20140045915A1 (en) | 2010-08-31 | 2014-02-13 | The General Hospital Corporation | Cancer-related biological materials in microvesicles |
| EP2638057B1 (en) * | 2010-11-10 | 2019-03-06 | Exosome Diagnostics, Inc. | Method for isolation of nucleic acid containing particles and extraction of nucleic acids therefrom |
| US20120196285A1 (en) * | 2011-01-31 | 2012-08-02 | Esoterix Genetic Laboratories, Llc | Methods for Enriching Microparticles or Nucleic Acids Using Binding Molecules |
| EP3569607A1 (en) | 2011-05-11 | 2019-11-20 | Exosome Diagnostics, Inc. | Nucleic acid extraction from heterogeneous biological materials |
| WO2012170037A1 (en) | 2011-06-10 | 2012-12-13 | Hitachi Chemical Co., Ltd. | Vesicle capturing devices and methods for using same |
| EP2748335B1 (en) | 2011-08-22 | 2018-10-03 | Exosome Diagnostics, Inc. | Urine biomarkers |
| US10174361B2 (en) * | 2011-11-10 | 2019-01-08 | Exosome Diagnostics, Inc. | Cerebrospinal fluid assay |
| CN104995311A (zh) | 2012-08-30 | 2015-10-21 | 外来体诊断公司 | 用于核酸测定的对照 |
| CN105025878A (zh) * | 2012-10-03 | 2015-11-04 | 外来体诊断公司 | 微泡在医学疾病和病况的诊断、预后和治疗中的用途 |
| US20150275301A1 (en) * | 2012-10-05 | 2015-10-01 | Hitachi Chemical Co., Ltd. | URINE EXOSOME mRNAS AND METHODS OF USING SAME TO DETECT DIABETIC NEPHROPATHY |
| DK2906717T3 (en) | 2012-10-11 | 2019-04-01 | Vin De Bona Trading Company Pte Ltd | PROCEDURE FOR PAINTING MICROVESICS |
| CN105209881B (zh) | 2013-03-13 | 2021-01-22 | 迈阿密大学 | 从细胞培养上清液和生物流体分离并纯化微泡的方法 |
| DE212013000295U1 (de) | 2013-05-06 | 2016-02-02 | Hitachi Chemical Co. America, Ltd. | Vorrichtungen zum Einfangen von Zielmolekülen |
| US10301681B2 (en) | 2013-08-06 | 2019-05-28 | Exosome Diagnostics, Inc. | Methods of treating a subject with a high gleason score prostate cancer |
| ES2923942T3 (es) | 2013-11-06 | 2022-10-03 | Us Health | Procedimiento para el subtipado de tipos de linfoma por medio de perfiles de expresión |
| US10494676B2 (en) * | 2013-12-02 | 2019-12-03 | Albert-Ludwigs-Universitaet Freiburg | Process for the diagnosis of cancer by using exosomes |
| EP3125907A4 (en) | 2014-04-01 | 2017-11-29 | Cornell University | Use of double-stranded dna in exosomes: a novel biomarker in cancer detection |
| WO2015164435A1 (en) * | 2014-04-22 | 2015-10-29 | Trovagene, Inc. | Concentrating nucleic acids in urine |
| CN104031915A (zh) * | 2014-06-17 | 2014-09-10 | 复旦大学附属肿瘤医院 | 用于结直肠癌预后的基因片段及其应用 |
| US10266895B2 (en) | 2014-11-05 | 2019-04-23 | Hitachi Chemical Company Ltd. | Exosomes and microvesicles in intestinal luminal fluids and stool and use of same for the assessment of inflammatory bowel disease |
| WO2016077537A1 (en) | 2014-11-12 | 2016-05-19 | Hitachi Chemical Co., Ltd. | Method and device for diagnosing organ injury |
| WO2016172598A1 (en) * | 2015-04-22 | 2016-10-27 | The Broad Institute Inc. | Exosomes and uses thereof |
| GB2539497A (en) | 2015-06-19 | 2016-12-21 | Airbus Operations Ltd | A Rotational Joint For An Aircraft Folding Wing |
| WO2017040520A1 (en) | 2015-08-31 | 2017-03-09 | Hitachi Chemical Co., Ltd. | Molecular methods for assessing urothelial disease |
| US11702702B2 (en) | 2016-04-15 | 2023-07-18 | Predicine, Inc. | Systems and methods for detecting genetic alterations |
| WO2017197399A1 (en) * | 2016-05-13 | 2017-11-16 | Exosome Diagnostics, Inc. | Automated and manual methods for isolation of extracellular vesicles and co-isolation of cell-free dna from biofluids |
| US11174503B2 (en) | 2016-09-21 | 2021-11-16 | Predicine, Inc. | Systems and methods for combined detection of genetic alterations |
| CN110945145B (zh) | 2017-05-17 | 2024-06-11 | 外来体诊断公司 | 微泡核酸和/或蛋白及其作为肾移植排斥的标志物的应用 |
| EP3652315A4 (en) | 2017-07-12 | 2021-09-01 | Exosome Diagnostics, Inc. | METHODS FOR ISOLATION AND ENRICHMENT OF EXTRACELLULAR VESICLE POPULATIONS DERIVED FROM BIOFLUIDS, AND ASSOCIATED METHODS OF USE |
| JP7069587B2 (ja) * | 2017-07-31 | 2022-05-18 | 東ソー株式会社 | 分析機器の洗浄方法 |
| WO2019116234A1 (en) * | 2017-12-12 | 2019-06-20 | Nestec S.A. | Methods for determining microbiome ribosomal rna composition changes |
| JP7444386B2 (ja) * | 2018-06-07 | 2024-03-06 | 株式会社Lsiメディエンス | ヒト尿からのマイクロベシクルの分離方法及び分析方法 |
| WO2020106853A1 (en) | 2018-11-20 | 2020-05-28 | Exosome Diagnostics, Inc. | Compositions and methods for internal controls of microvesicle isolations |
| CN109856259A (zh) * | 2018-12-29 | 2019-06-07 | 南通大学附属医院 | 一种血清胰腺癌外泌体特异蛋白及其再验证过程 |
| CN111593093B (zh) * | 2020-03-09 | 2022-03-04 | 中山大学 | 一种获取adar蛋白细胞内高效结合的底物序列的方法及底物序列和应用 |
| US20230203587A1 (en) | 2020-05-29 | 2023-06-29 | Exosome Diagnostics, Inc. | Use of microvesicle signature for the diagnosis and treatment of kidney transplant rejection |
| CA3190604A1 (en) | 2020-08-15 | 2022-02-24 | Regeneron Pharmaceuticals, Inc. | Treatment of obesity in subjects having variant nucleic acid molecules encoding calcitonin receptor (calcr) |
| US20250075258A1 (en) | 2021-07-16 | 2025-03-06 | Exosome Diagnostics, Inc. | Methods of detecting sjogren's syndrome using salivary exosomes |
| KR20240161644A (ko) | 2022-02-18 | 2024-11-12 | 엑소좀 디아그노스틱스, 인크. | 신장 장애의 식별 및 치료에 있어서의 미세 소포 시그니처의 용도 |
| CN114480656B (zh) * | 2022-03-07 | 2023-12-26 | 温州医科大学附属眼视光医院 | Slc12a3和/或slc12a9在作为葡萄膜黑色素瘤治疗和预后检测指标中的应用 |
| WO2024054572A1 (en) | 2022-09-07 | 2024-03-14 | Exosome Diagnostics, Inc. | Methods of detecting sjögren's syndrome using salivary exosomes |
Family Cites Families (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5639611A (en) | 1988-12-12 | 1997-06-17 | City Of Hope | Allele specific polymerase chain reaction |
| US5219727A (en) | 1989-08-21 | 1993-06-15 | Hoffmann-Laroche Inc. | Quantitation of nucleic acids using the polymerase chain reaction |
| US5840867A (en) | 1991-02-21 | 1998-11-24 | Gilead Sciences, Inc. | Aptamer analogs specific for biomolecules |
| CA2218875C (en) | 1991-07-23 | 2000-11-07 | The Research Foundation Of State University Of New York | Improvements in the in situ pcr |
| US5582981A (en) | 1991-08-14 | 1996-12-10 | Gilead Sciences, Inc. | Method for identifying an oligonucleotide aptamer specific for a target |
| US5605798A (en) | 1993-01-07 | 1997-02-25 | Sequenom, Inc. | DNA diagnostic based on mass spectrometry |
| US5639606A (en) | 1993-04-06 | 1997-06-17 | The University Of Rochester | Method for quantitative measurement of gene expression using multiplex competitive reverse transcriptase-polymerase chain reaction |
| US5556773A (en) | 1993-08-06 | 1996-09-17 | Yourno; Joseph | Method and apparatus for nested polymerase chain reaction (PCR) with single closed reaction tubes |
| ES2347854T5 (es) * | 1996-03-26 | 2014-07-24 | Michael S. Kopreski | Método que permite el uso de RNA extracelular extraído de plasma o suero para detectar, monitorizar o evaluar un cáncer |
| CA2270132A1 (en) | 1996-11-06 | 1998-05-14 | Sequenom, Inc. | Dna diagnostics based on mass spectrometry |
| EP0985148A4 (en) | 1997-05-28 | 2004-03-10 | Inst Medical W & E Hall | DIAGNOSIS OF NUCLEIC ACIDS BY MASS SPECTROMETRY, MASS SEPARATION AND BASE-SPECIFIC CLEAVING |
| US6004755A (en) | 1998-04-07 | 1999-12-21 | Incyte Pharmaceuticals, Inc. | Quantitative microarray hybridizaton assays |
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| FR2788780B1 (fr) | 1999-01-27 | 2001-03-30 | Ap Cells Inc | Procede de preparation de vesicules membranaires |
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| EP1927604A1 (en) * | 2000-01-28 | 2008-06-04 | MIP Technologies AB | Functional monomers for molecular recognition and catalysis |
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| US6812023B1 (en) | 2000-04-27 | 2004-11-02 | Anosys, Inc. | Methods of producing membrane vesicles |
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| US6525154B1 (en) | 2000-07-20 | 2003-02-25 | The Regents Of The University Of California | Molecular imprinting for the recognition of peptides in aqueous solution |
| WO2002092763A2 (en) * | 2001-05-11 | 2002-11-21 | Regents Of The University Of Minnesota | Intron associated with myotonic dystrophy type 2 and methods of use |
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| US20030162190A1 (en) | 2001-11-15 | 2003-08-28 | Gorenstein David G. | Phosphoromonothioate and phosphorodithioate oligonucleotide aptamer chip for functional proteomics |
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| KR20070058441A (ko) * | 2004-07-01 | 2007-06-08 | 유니버시티 오브 피츠버그 오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 | 면역억제성 엑소솜 |
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| EP2176665B1 (en) * | 2007-08-16 | 2016-03-02 | The Royal Institution for the Advancement of Learning / McGill University | Tumor cell-derived microvesicles |
| EP2198296B1 (en) * | 2007-09-05 | 2015-11-11 | Laurentian University | Method of using tumour rna integrity to measure response to chemotherapy in cancer patients |
| US8455199B2 (en) * | 2007-09-14 | 2013-06-04 | The Ohio State University Research Foundation | MicroRNA expression in human peripheral blood microvesicles and uses thereof |
| EP2604704B1 (en) * | 2008-02-01 | 2018-10-03 | The General Hospital Corporation | Use of microvesicles in diagnosis and prognosis of brain tumor |
-
2010
- 2010-07-16 US US12/838,413 patent/US20110195426A1/en not_active Abandoned
- 2010-07-16 CN CN201610128465.4A patent/CN105779436A/zh active Pending
- 2010-07-16 CN CN201080041496.7A patent/CN102498397B/zh active Active
- 2010-07-16 IN IN866DEN2012 patent/IN2012DN00866A/en unknown
- 2010-07-16 AU AU2010273928A patent/AU2010273928A1/en not_active Abandoned
- 2010-07-16 WO PCT/US2010/042365 patent/WO2011009104A1/en not_active Ceased
- 2010-07-16 DK DK10800649.5T patent/DK2454588T3/en active
- 2010-07-16 EP EP10800649.5A patent/EP2454588B1/en active Active
- 2010-07-16 BR BR112012001077-8A patent/BR112012001077A2/pt not_active IP Right Cessation
- 2010-07-16 CA CA2768371A patent/CA2768371A1/en not_active Abandoned
- 2010-07-16 SG SG2014014617A patent/SG2014014617A/en unknown
- 2010-07-16 ES ES10800649.5T patent/ES2547715T3/es active Active
- 2010-07-16 KR KR1020127003940A patent/KR20120037992A/ko not_active Ceased
- 2010-07-16 SG SG2012003141A patent/SG177677A1/en unknown
- 2010-07-16 KR KR1020187006847A patent/KR20180029105A/ko not_active Ceased
- 2010-07-16 JP JP2012520829A patent/JP5909444B2/ja active Active
-
2015
- 2015-12-17 JP JP2015246006A patent/JP2016116512A/ja active Pending
-
2016
- 2016-07-11 US US15/206,747 patent/US20160348095A1/en not_active Abandoned
- 2016-12-09 US US15/374,766 patent/US20170114389A1/en not_active Abandoned
-
2017
- 2017-04-25 JP JP2017086218A patent/JP2017131244A/ja active Pending
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