ES2547715T3 - Análisis de ácido nucleico - Google Patents
Análisis de ácido nucleico Download PDFInfo
- Publication number
- ES2547715T3 ES2547715T3 ES10800649.5T ES10800649T ES2547715T3 ES 2547715 T3 ES2547715 T3 ES 2547715T3 ES 10800649 T ES10800649 T ES 10800649T ES 2547715 T3 ES2547715 T3 ES 2547715T3
- Authority
- ES
- Spain
- Prior art keywords
- rna
- microvesicles
- urine
- nucleic acid
- extraction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
- C12N15/1017—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by filtration, e.g. using filters, frits, membranes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Analytical Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Plant Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pathology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Public Health (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22602509P | 2009-07-16 | 2009-07-16 | |
| US22610609P | 2009-07-16 | 2009-07-16 | |
| US226025P | 2009-07-16 | ||
| US226106P | 2009-07-16 | ||
| PCT/US2010/042365 WO2011009104A1 (en) | 2009-07-16 | 2010-07-16 | Nucleic acid analysis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2547715T3 true ES2547715T3 (es) | 2015-10-08 |
Family
ID=43449850
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES10800649.5T Active ES2547715T3 (es) | 2009-07-16 | 2010-07-16 | Análisis de ácido nucleico |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US20110195426A1 (enExample) |
| EP (1) | EP2454588B1 (enExample) |
| JP (3) | JP5909444B2 (enExample) |
| KR (2) | KR20180029105A (enExample) |
| CN (2) | CN105779436A (enExample) |
| AU (1) | AU2010273928A1 (enExample) |
| BR (1) | BR112012001077A2 (enExample) |
| CA (1) | CA2768371A1 (enExample) |
| DK (1) | DK2454588T3 (enExample) |
| ES (1) | ES2547715T3 (enExample) |
| IN (1) | IN2012DN00866A (enExample) |
| SG (2) | SG177677A1 (enExample) |
| WO (1) | WO2011009104A1 (enExample) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2880460T3 (es) * | 2006-03-09 | 2021-11-24 | Aethlon Medical Inc | Eliminación extracorpórea de partículas microvesiculares |
| US11266736B2 (en) | 2008-04-17 | 2022-03-08 | Vin De Bona Trading Company Pte Ltd | Method of painting micro vesicles |
| US20130029339A1 (en) | 2009-09-09 | 2013-01-31 | The General Hospital Corporation | Use of microvesicles in analyzing kras mutations |
| EP2475988B1 (en) * | 2009-09-09 | 2018-11-14 | The General Hospital Corporation | Use of microvesicles in analyzing nucleic acid profiles |
| JP5755326B2 (ja) * | 2010-06-11 | 2015-07-29 | 日立化成株式会社 | 腎機能の特徴を決定する方法 |
| WO2012031008A2 (en) | 2010-08-31 | 2012-03-08 | The General Hospital Corporation | Cancer-related biological materials in microvesicles |
| CA2817111C (en) | 2010-11-10 | 2019-03-05 | Exosome Diagnostics, Inc. | Method for isolation of nucleic acid containing particles and extraction of nucleic acids therefrom |
| EP2670868A4 (en) * | 2011-01-31 | 2015-05-06 | Esoterix Genetic Lab Llc | PROCESS FOR ENRICHING MICROPARTICLES OR NUCLEIC ACIDS BY MEANS OF BONDING MOLECULES |
| CA2835641C (en) * | 2011-05-11 | 2019-05-28 | Exosome Diagnostics, Inc. | Nucleic acid extraction from heterogeneous biological materials |
| WO2012170037A1 (en) | 2011-06-10 | 2012-12-13 | Hitachi Chemical Co., Ltd. | Vesicle capturing devices and methods for using same |
| EP3492606B1 (en) | 2011-08-22 | 2023-10-04 | Exosome Diagnostics, Inc. | Urine biomarkers |
| EP2776587A4 (en) * | 2011-11-10 | 2015-07-15 | Exosome Diagnostics Inc | LIQUOR ASSAY |
| US11136627B2 (en) | 2012-08-30 | 2021-10-05 | Exosome Diagnostics, Inc. | Controls for nucleic acid assays |
| US20150252428A1 (en) | 2012-10-03 | 2015-09-10 | Exosome Diagnostics, Inc. | Use of microvesicles in diagnosis, prognosis, and treatment of medical diseases and conditions |
| US20150275301A1 (en) * | 2012-10-05 | 2015-10-01 | Hitachi Chemical Co., Ltd. | URINE EXOSOME mRNAS AND METHODS OF USING SAME TO DETECT DIABETIC NEPHROPATHY |
| US20150233800A1 (en) | 2012-10-11 | 2015-08-20 | Vin-De-Bona Trading Company Pte Ltd | Method of painting microvesicles |
| AU2014244618A1 (en) | 2013-03-13 | 2015-10-08 | University Of Miami | Method for isolation and purification of microvesicles from cell culture supernatants and biological fluids |
| US12558316B2 (en) | 2013-03-13 | 2026-02-24 | University Of Miami | Methods and compositions for the treatment of epidermolysis bullosa |
| WO2014182330A1 (en) | 2013-05-06 | 2014-11-13 | Hitachi Chemical Company Ltd | Devices and methods for capturing target molecules |
| CA2920429C (en) | 2013-08-06 | 2021-11-16 | Exosome Diagnostics, Inc. | Urine biomarker cohorts, gene expression signatures, and methods of use thereof |
| ES2738289T3 (es) * | 2013-11-06 | 2020-01-21 | Hospital Clinic Barcelona | Procedimiento para el subtipado de tipos de linfoma por medio de perfiles de expresión |
| WO2015082372A1 (en) * | 2013-12-02 | 2015-06-11 | Albert-Ludwigs-Universität Freiburg | Process for the diagnosis of cancer by using exosomes |
| WO2015153732A2 (en) | 2014-04-01 | 2015-10-08 | Cornell University | Use of double-stranded dna in exosomes: a novel biomarker in cancer detection |
| EP3134524A4 (en) * | 2014-04-22 | 2017-11-29 | Trovagene, Inc. | Concentrating nucleic acids in urine |
| CN104031915A (zh) * | 2014-06-17 | 2014-09-10 | 复旦大学附属肿瘤医院 | 用于结直肠癌预后的基因片段及其应用 |
| US10266895B2 (en) | 2014-11-05 | 2019-04-23 | Hitachi Chemical Company Ltd. | Exosomes and microvesicles in intestinal luminal fluids and stool and use of same for the assessment of inflammatory bowel disease |
| WO2016077537A1 (en) | 2014-11-12 | 2016-05-19 | Hitachi Chemical Co., Ltd. | Method and device for diagnosing organ injury |
| WO2016172598A1 (en) * | 2015-04-22 | 2016-10-27 | The Broad Institute Inc. | Exosomes and uses thereof |
| GB2539497A (en) | 2015-06-19 | 2016-12-21 | Airbus Operations Ltd | A Rotational Joint For An Aircraft Folding Wing |
| JP6624704B2 (ja) | 2015-08-31 | 2019-12-25 | 日立化成株式会社 | 尿路上皮疾患の評価のための分子法 |
| WO2017181161A1 (en) | 2016-04-15 | 2017-10-19 | Predicine, Inc. | Systems and methods for detecting genetic alterations |
| WO2018057820A1 (en) | 2016-09-21 | 2018-03-29 | Predicine, Inc. | Systems and methods for combined detection of genetic alterations |
| JP7037504B2 (ja) * | 2016-05-13 | 2022-03-16 | エクソサム ダイアグノスティクス，インコーポレイティド | 生体液からの細胞外小胞の単離及びセルフリーｄｎａの同時単離のための自動及び手動方法 |
| WO2018213392A1 (en) | 2017-05-17 | 2018-11-22 | Exosome Diagnostics, Inc. | Microvesicle nucleic acids and/or proteins and uses thereof as markers of renal transplant rejection |
| EP3652315A4 (en) | 2017-07-12 | 2021-09-01 | Exosome Diagnostics, Inc. | METHODS FOR ISOLATION AND ENRICHMENT OF EXTRACELLULAR VESICLE POPULATIONS DERIVED FROM BIOFLUIDS, AND ASSOCIATED METHODS OF USE |
| JP7069587B2 (ja) * | 2017-07-31 | 2022-05-18 | 東ソー株式会社 | 分析機器の洗浄方法 |
| WO2019116234A1 (en) * | 2017-12-12 | 2019-06-20 | Nestec S.A. | Methods for determining microbiome ribosomal rna composition changes |
| JP7444386B2 (ja) * | 2018-06-07 | 2024-03-06 | 株式会社Ｌｓｉメディエンス | ヒト尿からのマイクロベシクルの分離方法及び分析方法 |
| EP3884045B1 (en) | 2018-11-20 | 2023-01-11 | Exosome Diagnostics, Inc. | Methods for internal controls of microvesicle isolations |
| CN109856259A (zh) * | 2018-12-29 | 2019-06-07 | 南通大学附属医院 | 一种血清胰腺癌外泌体特异蛋白及其再验证过程 |
| CN114958834A (zh) * | 2020-03-09 | 2022-08-30 | 中山大学 | 一种adar蛋白细胞内高效结合底物及应用 |
| AU2021281287A1 (en) | 2020-05-29 | 2023-01-19 | Bio-Techne Corporation | Use of microvesicle signature for the diagnosis and treatment of kidney transplant rejection |
| EP4196611A1 (en) | 2020-08-15 | 2023-06-21 | Regeneron Pharmaceuticals, Inc. | Treatment of obesity in subjects having variant nucleic acid molecules encoding calcitonin receptor (calcr) |
| US20250075258A1 (en) | 2021-07-16 | 2025-03-06 | Exosome Diagnostics, Inc. | Methods of detecting sjogren's syndrome using salivary exosomes |
| WO2023158869A1 (en) | 2022-02-18 | 2023-08-24 | Exosome Diagnostics, Inc. | Use of microvesicle signatures in the identification and treatment of renal disorders |
| CN114480656B (zh) * | 2022-03-07 | 2023-12-26 | 温州医科大学附属眼视光医院 | Slc12a3和/或slc12a9在作为葡萄膜黑色素瘤治疗和预后检测指标中的应用 |
| WO2024054572A1 (en) | 2022-09-07 | 2024-03-14 | Exosome Diagnostics, Inc. | Methods of detecting sjögren's syndrome using salivary exosomes |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US5639611A (en) | 1988-12-12 | 1997-06-17 | City Of Hope | Allele specific polymerase chain reaction |
| US5219727A (en) | 1989-08-21 | 1993-06-15 | Hoffmann-Laroche Inc. | Quantitation of nucleic acids using the polymerase chain reaction |
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| US5639606A (en) | 1993-04-06 | 1997-06-17 | The University Of Rochester | Method for quantitative measurement of gene expression using multiplex competitive reverse transcriptase-polymerase chain reaction |
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| CA2733672C (en) * | 2007-08-16 | 2018-09-11 | The Royal Institution For The Advancement Of Learning/Mcgill University | Tumor cell-derived microvesicles |
| JP5602018B2 (ja) * | 2007-09-05 | 2014-10-08 | ローレンシャン ユニバーシティー | 癌患者における化学療法に対する応答を測定するために腫瘍のｒｎａ完全性を用いる方法 |
| BRPI0816852A2 (pt) * | 2007-09-14 | 2017-06-06 | Univ Ohio State Res Found | método de diagnosticar ou prognosticar doença ou desordem em sujeito, biomarcador, método para determinar e/ou prever se sujeito tem diferenciação da desordem, biomarcador para desordem pulmonar, método para diagnosticar se sujeito tem, ou está em risco de desenvolver doença ou desordem, método de inibir a proliferação de doença ou desordem e método para identificar agente terapêutico do câncer. |
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-
2010
- 2010-07-16 DK DK10800649.5T patent/DK2454588T3/en active
- 2010-07-16 US US12/838,413 patent/US20110195426A1/en not_active Abandoned
- 2010-07-16 KR KR1020187006847A patent/KR20180029105A/ko not_active Ceased
- 2010-07-16 KR KR1020127003940A patent/KR20120037992A/ko not_active Ceased
- 2010-07-16 WO PCT/US2010/042365 patent/WO2011009104A1/en not_active Ceased
- 2010-07-16 IN IN866DEN2012 patent/IN2012DN00866A/en unknown
- 2010-07-16 CN CN201610128465.4A patent/CN105779436A/zh active Pending
- 2010-07-16 SG SG2012003141A patent/SG177677A1/en unknown
- 2010-07-16 BR BR112012001077-8A patent/BR112012001077A2/pt not_active IP Right Cessation
- 2010-07-16 ES ES10800649.5T patent/ES2547715T3/es active Active
- 2010-07-16 JP JP2012520829A patent/JP5909444B2/ja active Active
- 2010-07-16 EP EP10800649.5A patent/EP2454588B1/en active Active
- 2010-07-16 SG SG2014014617A patent/SG2014014617A/en unknown
- 2010-07-16 AU AU2010273928A patent/AU2010273928A1/en not_active Abandoned
- 2010-07-16 CN CN201080041496.7A patent/CN102498397B/zh active Active
- 2010-07-16 CA CA2768371A patent/CA2768371A1/en not_active Abandoned
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2015
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2016
- 2016-07-11 US US15/206,747 patent/US20160348095A1/en not_active Abandoned
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Also Published As
| Publication number | Publication date |
|---|---|
| EP2454588A1 (en) | 2012-05-23 |
| SG177677A1 (en) | 2012-02-28 |
| WO2011009104A1 (en) | 2011-01-20 |
| CN105779436A (zh) | 2016-07-20 |
| CN102498397A (zh) | 2012-06-13 |
| US20110195426A1 (en) | 2011-08-11 |
| HK1173213A1 (en) | 2013-05-10 |
| IN2012DN00866A (enExample) | 2015-07-10 |
| CN102498397B (zh) | 2016-04-06 |
| EP2454588A4 (en) | 2012-12-12 |
| HK1171083A1 (zh) | 2013-03-15 |
| US20170114389A1 (en) | 2017-04-27 |
| JP2017131244A (ja) | 2017-08-03 |
| KR20180029105A (ko) | 2018-03-19 |
| AU2010273928A2 (en) | 2012-02-09 |
| JP2016116512A (ja) | 2016-06-30 |
| SG2014014617A (en) | 2014-05-29 |
| AU2010273928A1 (en) | 2012-02-09 |
| EP2454588B1 (en) | 2015-07-15 |
| US20160348095A1 (en) | 2016-12-01 |
| JP5909444B2 (ja) | 2016-04-26 |
| KR20120037992A (ko) | 2012-04-20 |
| JP2012533308A (ja) | 2012-12-27 |
| DK2454588T3 (en) | 2015-09-28 |
| CA2768371A1 (en) | 2011-01-20 |
| BR112012001077A2 (pt) | 2020-08-11 |
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