JP2012533290A - 新規なラクトバチルス・プランタラム及びこれを含む組成物 - Google Patents
新規なラクトバチルス・プランタラム及びこれを含む組成物 Download PDFInfo
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- JP2012533290A JP2012533290A JP2012520523A JP2012520523A JP2012533290A JP 2012533290 A JP2012533290 A JP 2012533290A JP 2012520523 A JP2012520523 A JP 2012520523A JP 2012520523 A JP2012520523 A JP 2012520523A JP 2012533290 A JP2012533290 A JP 2012533290A
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- lactobacillus plantarum
- cells
- lactic acid
- plantarum cjlp55
- lactobacillus
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Abstract
【選択図】図1
Description
キムチから分離したラクトバチルス・プランタラムCJLP55菌株を1.5%寒天が含まれたMRS固体培地(Difco,USA)に塗抹して37℃で24時間培養した後、純粋分離したことが確認された集落を白金耳で取ってMRS液体培地(Difco,USA)で37℃で18-24時間培養した。
人工胃液での耐酸性実験は、Kobayashiなど(非特許文献14)の実験を変形し て製造した人工胃液を使って行った。具体的に人工胃液は、MRS液体培地を1N HClでpH 2.5になるように調整し、ペブシンを1000ユニット/mlになるように添加した後滅菌して製造した。
腸上皮細胞付着能試験のための動物細胞としてHT-29を韓国細胞株銀行(KCLB)で譲り受けて使い、実験方法は、キムなど(非特許文献16)とHiranoなど(非特許文献17)の方法を使った。
前記実施例1で分離した菌株の安全性を評価するために韓国バイオベンチャー協会団体標準で提示した安全性評価試験法により溶血現象検査、ゼラチン液化反応検査、有害代謝産物(アンモニア)生成確認、フェニルアラニンデアミナーゼ検査を遂行した。
ラクトバチルス・プランタラムCJLP55(Lactobacillus plantarum CJLP55)菌株で、卵アルブミンを投与してTh2反応に偏向したマウスの脾臟細胞を処理したときのTh1反応誘導サイトカインのIL-12生成促進力を評価するために、Fujiwaraなど(非特許文献18)とFujiwaraなど(非特許文献19)を参考にして次のように実験を行った。
ラクトバチルス・プランタラムCJLP55(Lactobacillus plantarum CJLP 55)菌株で、卵アルブミンを投与してTh2反応に偏向したマウスの脾臟細胞を処理時Th2反応誘導サイトカインのIL-4の生成抑制効果を確認するために、前記実施例5の方法でIL-12キットの代わりにIL-4キット(Biosource)を使うことだけ違って残り条件は同一に実験を行った。そのようにして測定した結果を図5に示した。
マクロファージおよび樹状細胞のような抗原提示細胞(antigen presenting cell,APC)は、IL-12およびIL-18を生成してTh0リンパ球からTh1リンパ球への分化を誘導して、他の一方ではIL-10を生成してTh1リンパ球への分化誘導を抑制する。本発明にともなう乳酸菌がマクロファージおよび樹状細胞のIL-12、IL-10、IL-18の生成に及ぼす影響を評価するために次のような実験を遂行した。
前記実施例1で同定されたプロバイオティクスのラクトバチルス・プランタラムCJLP55(Lactobacillus plantarum CJLP55)を医薬品、食品、飼料、飼料添加剤、または化粧品の原料で使用するために大量生産して、これを凍結乾燥して生菌剤化した。
Claims (9)
- ラクトバチルス・プランタラム(Lactobacillus plantarum)CJLP55 KCTC 11401BP。
- ラクトバチルス・プランタラム(Lactobacillus plantarum)CJLP55 KCTC 11401BPを含む腸疾患の予防または治療用組成物。
- ラクトバチルス・プランタラム(Lactobacillus plantarum)CJLP55 KCTC 11401BPを含む免疫増強用組成物。
- Th2反応過剰によるTh1/Th2不均衡により誘発される免疫疾患の予防または治療用であることを特徴とする請求項3に記載の組成物。
- 前記免疫疾患が、アレルギー性疾患、アトピー、癌および自家免疫疾患で構成された群から選択されることを特徴とする請求項4に記載の組成物。
- 医薬品であることを特徴とする請求項2から5のいずれか1項に記載の組成物。
- 食品であることを特徴とする請求項2から5のいずれか1項に記載の組成物。
- 飼料または飼料添加剤であることを特徴とする請求項2から5のいずれか1項に記載の組成物。
- 化粧品であることを特徴とする請求項2から5のいずれか1項に記載の組成物。
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KR10-2009-0064091 | 2009-07-14 | ||
KR1020090064091A KR101255050B1 (ko) | 2009-07-14 | 2009-07-14 | 신규한 락토바실러스 플란타룸 및 이를 포함하는 조성물 |
PCT/KR2009/004911 WO2011007922A1 (ko) | 2009-07-14 | 2009-09-01 | 신규한 락토바실러스 플란타룸 및 이를 포함하는 조성물 |
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JP2018082700A (ja) * | 2016-11-21 | 2018-05-31 | ロッテ コンフェクショナリー カンパニー リミテッド | ラクトバチルス菌株の安定性増進のためのプレバイオティックス組成物及びこれを用いた安定性増進方法 |
JP2022543755A (ja) * | 2020-02-13 | 2022-10-14 | シージェイ チェイルジェダン コーポレーション | 皮膚状態改善用組成物 |
JP7383120B2 (ja) | 2020-02-13 | 2023-11-17 | シージェイ チェイルジェダン コーポレーション | 皮膚状態改善用組成物 |
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CN102597215B (zh) | 2014-06-25 |
US20120282675A1 (en) | 2012-11-08 |
US9962417B2 (en) | 2018-05-08 |
KR101255050B1 (ko) | 2013-04-16 |
EP2455450B1 (en) | 2016-01-06 |
JP5718916B2 (ja) | 2015-05-13 |
CN102597215A (zh) | 2012-07-18 |
US20170035815A1 (en) | 2017-02-09 |
US9572846B2 (en) | 2017-02-21 |
HK1171473A1 (en) | 2013-03-28 |
CA2767410A1 (en) | 2011-01-20 |
EP2455450A4 (en) | 2013-01-09 |
CA2767410C (en) | 2016-01-05 |
WO2011007922A1 (ko) | 2011-01-20 |
EP2455450A1 (en) | 2012-05-23 |
DK2455450T3 (en) | 2016-03-21 |
KR20110006455A (ko) | 2011-01-20 |
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