JP2012532899A5 - - Google Patents
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- JP2012532899A5 JP2012532899A5 JP2012519900A JP2012519900A JP2012532899A5 JP 2012532899 A5 JP2012532899 A5 JP 2012532899A5 JP 2012519900 A JP2012519900 A JP 2012519900A JP 2012519900 A JP2012519900 A JP 2012519900A JP 2012532899 A5 JP2012532899 A5 JP 2012532899A5
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- JP
- Japan
- Prior art keywords
- het
- conr
- hal
- atoms
- absent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000004433 nitrogen atom Chemical group N* 0.000 claims 5
- 125000004430 oxygen atom Chemical group O* 0.000 claims 5
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims 4
- 125000002619 bicyclic group Chemical group 0.000 claims 4
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 125000002950 monocyclic group Chemical group 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 229920006395 saturated elastomer Polymers 0.000 claims 4
- 125000004434 sulfur atom Chemical group 0.000 claims 4
- 125000004432 carbon atom Chemical group C* 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 2
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical compound C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 235000010290 biphenyl Nutrition 0.000 claims 1
- 239000004305 biphenyl Substances 0.000 claims 1
- 125000006367 bivalent amino carbonyl group Chemical group [H]N([*:1])C([*:2])=O 0.000 claims 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 1
- 125000001624 naphthyl group Chemical group 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102009033208.1 | 2009-07-15 | ||
| DE102009033208A DE102009033208A1 (de) | 2009-07-15 | 2009-07-15 | Aminopyridinderivate |
| PCT/EP2010/003659 WO2011006567A1 (de) | 2009-07-15 | 2010-06-17 | Aminopyridinderivate zur behandlung von tumoren und entzündungskrankheiten |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012532899A JP2012532899A (ja) | 2012-12-20 |
| JP2012532899A5 true JP2012532899A5 (cg-RX-API-DMAC7.html) | 2013-08-29 |
| JP5681182B2 JP5681182B2 (ja) | 2015-03-04 |
Family
ID=42665826
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012519900A Expired - Fee Related JP5681182B2 (ja) | 2009-07-15 | 2010-06-17 | 腫瘍および炎症性疾患の処置のためのアミノピリジン誘導体 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8648201B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2454253B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5681182B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN102471317B (cg-RX-API-DMAC7.html) |
| AR (1) | AR077567A1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2010272920B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2768169C (cg-RX-API-DMAC7.html) |
| DE (1) | DE102009033208A1 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2534095T3 (cg-RX-API-DMAC7.html) |
| IL (1) | IL217467A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2011006567A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2414328B1 (en) * | 2009-04-02 | 2021-05-26 | Merck Serono S.A. | Dihydroorotate dehydrogenase inhibitors |
| EP2499117B1 (en) * | 2009-11-12 | 2015-10-21 | Selvita S.A. | A compound, a process for its preparation, a pharmaceutical composition, use of a compound, a method for modulating or regulating serine/threonine kinases and a serine/threonine kinases modulating agent |
| US8420655B2 (en) * | 2009-12-04 | 2013-04-16 | Boehringer Ingelheim International Gmbh | Benzimidazole inhibitors of leukotriene production |
| KR20140014205A (ko) * | 2011-03-04 | 2014-02-05 | 렉시컨 파마슈티컬스 인코퍼레이티드 | Mst1 키나제 억제제 및 그의 사용 방법 |
| US20140315881A1 (en) * | 2011-07-29 | 2014-10-23 | Tempero Pharmaceuticals, Inc. | Compounds and methods |
| ES2630705T3 (es) * | 2012-01-13 | 2017-08-23 | Bristol-Myers Squibb Company | Compuestos de piridilo sustituidos con triazolilo útiles como inhibidores de cinasas |
| RU2015104123A (ru) * | 2012-07-10 | 2016-08-27 | Арес Трейдинг С.А. | Производные пиримидинпиразолила |
| EP2903617B1 (en) * | 2012-10-08 | 2019-01-30 | Merck Sharp & Dohme Corp. | Inhibitors of irak4 activity |
| EP2903613B1 (en) | 2012-10-08 | 2017-11-22 | Merck Sharp & Dohme Corp. | Pyrazole derivatives useful as inhibitors of irak4 activity |
| WO2015006181A1 (en) | 2013-07-11 | 2015-01-15 | Merck Sharp & Dohme Corp. | Substituted amidopyrazole inhibitors of interleukin receptor-associated kinases (irak-4) |
| US10227360B2 (en) | 2014-02-19 | 2019-03-12 | Piramal Enterprises Limited | Compounds for use as GPR120 agonists |
| AU2015293541B2 (en) | 2014-07-25 | 2019-11-21 | Piramal Enterprises Limited | Substituted phenyl alkanoic acid compounds as GPR120 agonists and uses thereof |
| US10214521B2 (en) | 2014-09-11 | 2019-02-26 | Piramal Enterprises Limited | Fused heterocyclic compounds as GPR120 agonists |
| US9359336B2 (en) | 2014-10-09 | 2016-06-07 | Allergan, Inc. | Heterocycle-substituted pyridyl benzothiophenes as kinase inhibitors |
| EP3325100A4 (en) | 2015-07-17 | 2019-02-20 | Memorial Sloan-Kettering Cancer Center | COMBINATION THERAPY WITH PDK1 AND PI3K INHIBITORS |
| JOP20180011A1 (ar) | 2017-02-16 | 2019-01-30 | Gilead Sciences Inc | مشتقات بيرولو [1، 2-b]بيريدازين |
| TWI721483B (zh) | 2018-07-13 | 2021-03-11 | 美商基利科學股份有限公司 | 吡咯并[1,2-b]嗒𠯤衍生物 |
| CN112457308B (zh) * | 2019-09-09 | 2024-01-02 | 上海长森药业有限公司 | 新型三环芳香杂环化合物，及其制备方法、药物组合物和应用 |
| JP7588224B2 (ja) | 2020-10-05 | 2024-11-21 | エンライブン インコーポレイテッド | Ｂｃｒ－ａｂｌチロシンキナーゼの阻害のための５－及び６－アザインドール化合物 |
| EP4488267A4 (en) * | 2022-03-02 | 2025-06-11 | Hangzhou Bio-Sincerity Pharma-tech Co., Ltd. | HISTAMINE H3 RECEPTOR ANTAGONIST AND ITS MEDICAL USE |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5747469A (en) | 1991-03-06 | 1998-05-05 | Board Of Regents, The University Of Texas System | Methods and compositions comprising DNA damaging agents and p53 |
| GB9904387D0 (en) | 1999-02-25 | 1999-04-21 | Pharmacia & Upjohn Spa | Antitumour synergistic composition |
| US6818419B2 (en) | 2000-01-13 | 2004-11-16 | Tularik Inc. | IRAK-4: compositions and methods of use |
| US7132438B2 (en) | 2001-10-09 | 2006-11-07 | Amgen Inc. | Benzimidazole derivatives |
| MXPA04007697A (es) * | 2002-02-06 | 2004-11-10 | Vertex Pharma | Compuestos de heteroarilo utiles como inhibidores de gsk-3. |
| JP2006512313A (ja) | 2002-10-31 | 2006-04-13 | アムジェン インコーポレイテッド | 抗炎症剤 |
| WO2004069160A2 (en) | 2003-01-28 | 2004-08-19 | Smithkline Beecham Corporation | Chemical compounds |
| JP2008510792A (ja) | 2004-08-26 | 2008-04-10 | ファイザー・インク | タンパク質チロシンキナーゼ阻害剤としてのアミノヘテロアリール化合物 |
| JP2009533327A (ja) * | 2006-03-22 | 2009-09-17 | バーテックス ファーマシューティカルズ インコーポレイテッド | 増殖性疾患を処置するためのｃ−ＭＥＴキナーゼ阻害剤 |
| CN101795739B (zh) | 2007-06-29 | 2012-08-08 | 维科马乘骑工程公司 | 娱乐装置座椅组件 |
| WO2009024825A1 (en) * | 2007-08-21 | 2009-02-26 | Astrazeneca Ab | 2-pyrazinylbenzimidazole derivatives as receptor tyrosine kinase inhibitors |
| MX2010004491A (es) | 2007-10-25 | 2010-06-21 | Astrazeneca Ab | Derivados de piridina y pirazina utiles en el tratamiento de trastornos proliferativos celulares. |
| JP2011511005A (ja) | 2008-02-04 | 2011-04-07 | オーエスアイ・フアーマスーテイカルズ・インコーポレーテツド | ２−アミノピリジン系キナーゼ阻害薬 |
| KR100979439B1 (ko) | 2008-04-10 | 2010-09-02 | 한국화학연구원 | 신규 피라졸 및 벤즈옥사졸 치환된 피리딘 유도체 또는이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를유효성분으로 함유하는 이상세포 성장 질환의 예방 및치료용 약학적 조성물 |
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2009
- 2009-07-15 DE DE102009033208A patent/DE102009033208A1/de not_active Withdrawn
-
2010
- 2010-06-17 EP EP10730073.3A patent/EP2454253B1/de not_active Not-in-force
- 2010-06-17 JP JP2012519900A patent/JP5681182B2/ja not_active Expired - Fee Related
- 2010-06-17 US US13/383,605 patent/US8648201B2/en not_active Expired - Fee Related
- 2010-06-17 CA CA2768169A patent/CA2768169C/en not_active Expired - Fee Related
- 2010-06-17 WO PCT/EP2010/003659 patent/WO2011006567A1/de not_active Ceased
- 2010-06-17 ES ES10730073.3T patent/ES2534095T3/es active Active
- 2010-06-17 CN CN201080031604.2A patent/CN102471317B/zh not_active Expired - Fee Related
- 2010-06-17 AU AU2010272920A patent/AU2010272920B2/en not_active Ceased
- 2010-07-14 AR ARP100102541A patent/AR077567A1/es unknown
-
2012
- 2012-01-10 IL IL217467A patent/IL217467A/en active IP Right Grant