JP2012532858A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2012532858A5 JP2012532858A5 JP2012519066A JP2012519066A JP2012532858A5 JP 2012532858 A5 JP2012532858 A5 JP 2012532858A5 JP 2012519066 A JP2012519066 A JP 2012519066A JP 2012519066 A JP2012519066 A JP 2012519066A JP 2012532858 A5 JP2012532858 A5 JP 2012532858A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- compound according
- group
- halogen
- disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 23
- 125000000217 alkyl group Chemical group 0.000 claims 11
- 229910052736 halogen Inorganic materials 0.000 claims 11
- 150000002367 halogens Chemical class 0.000 claims 11
- 125000003545 alkoxy group Chemical group 0.000 claims 7
- 241000124008 Mammalia Species 0.000 claims 5
- 208000006011 Stroke Diseases 0.000 claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 239000001257 hydrogen Substances 0.000 claims 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 125000003118 aryl group Chemical group 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 125000000623 heterocyclic group Chemical group 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 208000024827 Alzheimer disease Diseases 0.000 claims 3
- 208000019901 Anxiety disease Diseases 0.000 claims 3
- 208000020925 Bipolar disease Diseases 0.000 claims 3
- 201000006474 Brain Ischemia Diseases 0.000 claims 3
- 206010008120 Cerebral ischaemia Diseases 0.000 claims 3
- 208000028698 Cognitive impairment Diseases 0.000 claims 3
- 208000010412 Glaucoma Diseases 0.000 claims 3
- 206010019196 Head injury Diseases 0.000 claims 3
- 206010019233 Headaches Diseases 0.000 claims 3
- 208000019695 Migraine disease Diseases 0.000 claims 3
- 208000026072 Motor neurone disease Diseases 0.000 claims 3
- 208000018737 Parkinson disease Diseases 0.000 claims 3
- 208000030886 Traumatic Brain injury Diseases 0.000 claims 3
- 206010046851 Uveitis Diseases 0.000 claims 3
- 230000003432 anti-folate effect Effects 0.000 claims 3
- 229940127074 antifolate Drugs 0.000 claims 3
- 230000036506 anxiety Effects 0.000 claims 3
- 230000002567 autonomic effect Effects 0.000 claims 3
- 206010008118 cerebral infarction Diseases 0.000 claims 3
- 208000010877 cognitive disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 208000035475 disorder Diseases 0.000 claims 3
- 206010015037 epilepsy Diseases 0.000 claims 3
- 239000004052 folic acid antagonist Substances 0.000 claims 3
- 125000001188 haloalkyl group Chemical group 0.000 claims 3
- 231100000869 headache Toxicity 0.000 claims 3
- 208000014674 injury Diseases 0.000 claims 3
- 201000004792 malaria Diseases 0.000 claims 3
- 206010027599 migraine Diseases 0.000 claims 3
- 230000036651 mood Effects 0.000 claims 3
- 208000005264 motor neuron disease Diseases 0.000 claims 3
- 201000006417 multiple sclerosis Diseases 0.000 claims 3
- 208000004296 neuralgia Diseases 0.000 claims 3
- 208000015122 neurodegenerative disease Diseases 0.000 claims 3
- 208000021722 neuropathic pain Diseases 0.000 claims 3
- -1 phenyl-furyl Chemical group 0.000 claims 3
- 201000000980 schizophrenia Diseases 0.000 claims 3
- 239000003195 sodium channel blocking agent Substances 0.000 claims 3
- 239000012453 solvate Substances 0.000 claims 3
- 208000020431 spinal cord injury Diseases 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- 230000008733 trauma Effects 0.000 claims 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 2
- 206010065390 Inflammatory pain Diseases 0.000 claims 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 2
- 125000002837 carbocyclic group Chemical group 0.000 claims 2
- 230000001684 chronic effect Effects 0.000 claims 2
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 210000005036 nerve Anatomy 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims 1
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 1
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 claims 1
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 claims 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 1
- 208000002193 Pain Diseases 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- 125000002877 alkyl aryl group Chemical group 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 125000004619 benzopyranyl group Chemical group O1C(C=CC2=C1C=CC=C2)* 0.000 claims 1
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 125000002618 bicyclic heterocycle group Chemical group 0.000 claims 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 125000006378 chloropyridyl group Chemical group 0.000 claims 1
- 208000037976 chronic inflammation Diseases 0.000 claims 1
- 230000006020 chronic inflammation Effects 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 125000003963 dichloro group Chemical group Cl* 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 125000002541 furyl group Chemical group 0.000 claims 1
- 125000001041 indolyl group Chemical group 0.000 claims 1
- 125000005956 isoquinolyl group Chemical group 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 125000002950 monocyclic group Chemical group 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 1
- 125000003356 phenylsulfanyl group Chemical group [*]SC1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000005493 quinolyl group Chemical group 0.000 claims 1
- 230000001568 sexual effect Effects 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 239000011593 sulfur Substances 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
- 125000005301 thienylmethyl group Chemical group [H]C1=C([H])C([H])=C(S1)C([H])([H])* 0.000 claims 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0911993.4 | 2009-07-08 | ||
| GB0911993A GB2471713A (en) | 2009-07-08 | 2009-07-08 | 1,2,4-triazine derivatives and their use as sodium channel blockers |
| PCT/GB2010/051127 WO2011004196A1 (en) | 2009-07-08 | 2010-07-08 | Cyclic triazo sodium channel blockers |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012532858A JP2012532858A (ja) | 2012-12-20 |
| JP2012532858A5 true JP2012532858A5 (https=) | 2013-08-22 |
| JP5847079B2 JP5847079B2 (ja) | 2016-01-20 |
Family
ID=41022452
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012519066A Expired - Fee Related JP5847079B2 (ja) | 2009-07-08 | 2010-07-08 | 環状トリアゾナトリウムチャネル遮断薬 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8748600B2 (https=) |
| EP (1) | EP2451807B1 (https=) |
| JP (1) | JP5847079B2 (https=) |
| KR (1) | KR20120048593A (https=) |
| CN (1) | CN102482266B (https=) |
| AU (1) | AU2010269982B2 (https=) |
| CA (1) | CA2767298A1 (https=) |
| ES (1) | ES2550052T3 (https=) |
| GB (1) | GB2471713A (https=) |
| IL (1) | IL217330B (https=) |
| IN (1) | IN2012DN00871A (https=) |
| WO (1) | WO2011004196A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0800741D0 (en) * | 2008-01-16 | 2008-02-20 | Univ Greenwich | Cyclic triazo and diazo sodium channel blockers |
| GB2471729A (en) * | 2009-07-08 | 2011-01-12 | Univ Greenwich | 1,2,4-triazine derivatives and their use as sodium channel blockers |
| CA3021424C (en) * | 2015-06-12 | 2023-03-21 | University Of Greenwich | Triazine derivatives as interferon-gamma inhibitors |
| MA43821A (fr) | 2016-03-14 | 2018-11-28 | Afferent Pharmaceuticals Inc | Pyrimidines et variantes de celles-ci, et leurs utilisations |
| MA44489A (fr) | 2016-03-25 | 2019-01-30 | Afferent Pharmaceuticals Inc | Pyrimidines et variants de celles-ci, et leurs utilisations |
| JP6679093B1 (ja) * | 2018-11-26 | 2020-04-15 | 大学共同利用機関法人自然科学研究機構 | ナトリウムチャンネルおよび酸感受性イオンチャンネルの機能阻害を標的とした阻害剤及び治療剤のスクリーニング方法とその用途 |
| GB202006076D0 (en) * | 2020-04-24 | 2020-06-10 | Univ Greenwich | Interleukin inhibitors |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3637688A (en) * | 1970-01-09 | 1972-01-25 | American Home Prod | 6-(fluoro and trifluoromethyl phenyl)-3 5-diamino - 1 2 4 - triazines and substituted - 6 - phenylalkyl-3,5-diamino-1 2 4-triazines |
| DD151309A5 (de) | 1979-06-01 | 1981-10-14 | Wellcome Found | Verfahren zur herstellung von substituierten aminotriazinen |
| GB8328757D0 (en) * | 1983-10-27 | 1983-11-30 | Wellcome Found | Chemical compounds |
| DE10134980C2 (de) * | 2001-07-17 | 2003-05-28 | Helm Ag | Verfahren zur Herstellung von Lamotrigin |
| GB0613836D0 (en) * | 2006-07-13 | 2006-08-23 | Univ Greenwich | New medical use of triazine derivatives |
| GB0800741D0 (en) * | 2008-01-16 | 2008-02-20 | Univ Greenwich | Cyclic triazo and diazo sodium channel blockers |
-
2009
- 2009-07-08 GB GB0911993A patent/GB2471713A/en not_active Withdrawn
-
2010
- 2010-07-08 WO PCT/GB2010/051127 patent/WO2011004196A1/en not_active Ceased
- 2010-07-08 EP EP10732408.9A patent/EP2451807B1/en not_active Not-in-force
- 2010-07-08 KR KR1020127002940A patent/KR20120048593A/ko not_active Withdrawn
- 2010-07-08 JP JP2012519066A patent/JP5847079B2/ja not_active Expired - Fee Related
- 2010-07-08 AU AU2010269982A patent/AU2010269982B2/en not_active Ceased
- 2010-07-08 IN IN871DEN2012 patent/IN2012DN00871A/en unknown
- 2010-07-08 CN CN201080030801.2A patent/CN102482266B/zh not_active Expired - Fee Related
- 2010-07-08 CA CA2767298A patent/CA2767298A1/en not_active Abandoned
- 2010-07-08 ES ES10732408.9T patent/ES2550052T3/es active Active
- 2010-07-08 US US13/382,741 patent/US8748600B2/en active Active
-
2012
- 2012-01-02 IL IL217330A patent/IL217330B/en not_active IP Right Cessation
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2012532858A5 (https=) | ||
| RU2019131111A (ru) | ПРОИЗВОДНОЕ ГЕТЕРОАРИЛ[4,3-с]ПИРИМИДИН-5-АМИНА, СПОСОБ ЕГО ПОЛУЧЕНИЯ И ЕГО МЕДИЦИНСКИЕ ПРИМЕНЕНИЯ | |
| JP2015512951A5 (https=) | ||
| JP2011509992A5 (https=) | ||
| RU2015101532A (ru) | Замещенные бициклические алкокси-пиразольные аналоги в качестве аллостерических модуляторов рецепторов mglur5 | |
| JP2019511460A5 (https=) | ||
| CA2712070A1 (en) | Cyclic triazo and diazo sodium channel blockers | |
| JP2013526544A5 (https=) | ||
| JP2010529135A5 (https=) | ||
| JP2014508128A5 (https=) | ||
| RU2014145682A (ru) | Органические соединения | |
| JP2017533968A5 (https=) | ||
| RU2015101512A (ru) | Замещенные бициклические алкокси-пиразольные аналоги в качестве аллостерических модуляторов рецепторов mglur5 | |
| JP2013544277A5 (https=) | ||
| RU2012127770A (ru) | Полициклические соединения и способы их применения | |
| JP2013538801A5 (https=) | ||
| JP2010523651A5 (https=) | ||
| JP2014526435A5 (https=) | ||
| JP2014051526A5 (https=) | ||
| JP2015517981A5 (https=) | ||
| RU2016140266A (ru) | Спироциклические аминовые производные в качестве модуляторов s1p | |
| CA2798514A1 (en) | Heterocyclic sulfone mglur4 allosteric potentiators, compositions, and methods of treating neurological dysfunction | |
| JP2014507455A5 (https=) | ||
| CO6531470A2 (es) | Derivados benzamida sustituidos | |
| RU2016131875A (ru) | Производные n-фениллактама, способные стимулировать нейрогенез, и их применение при лечении заболеваний нервной системы |