JP2012532718A - 可撓性内層及び剛性外層を備えた薬剤容器 - Google Patents
可撓性内層及び剛性外層を備えた薬剤容器 Download PDFInfo
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- 229940034610 toothpaste Drugs 0.000 description 1
- 239000000606 toothpaste Substances 0.000 description 1
- 229960004824 triptorelin Drugs 0.000 description 1
- VXKHXGOKWPXYNA-PGBVPBMZSA-N triptorelin Chemical compound C([C@@H](C(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 VXKHXGOKWPXYNA-PGBVPBMZSA-N 0.000 description 1
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Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
- A61M5/148—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons flexible, e.g. independent bags
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
- A61M5/2422—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule
- A61M5/2425—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule by compression of deformable ampoule or carpule wall
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3331—Pressure; Flow
- A61M2205/3334—Measuring or controlling the flow rate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/30—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
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- General Health & Medical Sciences (AREA)
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- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Abstract
【選択図】 図1
Description
ここで一実施態様において、薬学的に活性な化合物は、最大で1500Daまでの分子量を有し、及び/又は、ペプチド、蛋白質、多糖類、ワクチン、DNA、RNA、抗体、酵素、抗体、ホルモン、若しくはオリゴヌクレオチド、又は上記の薬学的に活性な化合物の混合物であり、
ここで更なる実施態様において、薬学的に活性な化合物は、糖尿病、又は糖尿病性網膜症などの糖尿病関連の合併症、深部静脈又は肺血栓塞栓症などの血栓塞栓症、急性冠症候群(ACS)、狭心症、心筋梗塞、癌、黄斑変性症、炎症、枯草熱、アテローム性動脈硬化症、及び/又は、関節リウマチの治療、及び/又は、予防に有用であり、
ここで更なる実施態様において、薬学的に活性な化合物は、糖尿病、又は糖尿病性網膜症などの糖尿病に関連する合併症の治療、及び/又は、予防のための少なくとも1つのペプチドを含み、
ここで更なる実施態様において、薬学的に活性な化合物は、少なくとも1つのヒトインスリン、又はヒトインスリン類似体若しくは誘導体、グルカゴン様ペプチド(GLP−1)、又はその類似体若しくは誘導体、又はエキセンジン−3又はエキセンジン−4、若しくはエキセンジン−3又はエキセンジン−4の類似体若しくは誘導体を含む。
H−(Lys)4−desPro36,desPro37エキセンジン−4(1−39)−NH2;
H−(Lys)5−desPro36,desPro37エキセンジン−4(1−39)−NH2;
desPro36[Asp28]エキセンジン−4(1−39);
desPro36[IsoAsp28]エキセンジン−4(1−39);
desPro36[Met(O)14,Asp28]エキセンジン−4(1−39);
desPro36[Met(O)14,IsoAsp28]エキセンジン−4(1−39);
desPro36[Trp(O2)25,Asp28]エキセンジン−4(1−39);
desPro36[Trp(O2)25,IsoAsp28]エキセンジン−4(1−39);
desPro36[Met(O)14Trp(O2)25,Asp28]エキセンジン−4(1−39);
desPro36[Met(O)14Trp(O2)25,IsoAsp28]エキセンジン−4(1−39);又は
desPro36[Asp28]エキセンジン−4(1−39);
desPro36[IsoAsp28]エキセンジン−4(1−39);
desPro36[Met(O)14,Asp28]エキセンジン−4(1−39);
desPro36[Met(O)14,IsoAsp28]エキセンジン−(1−39);
desPro36[Trp(O2)25,Asp28]エキセンジン−4(1−39);
desPro36[Trp(O2)25,IsoAsp28]エキセンジン−4(1−39);
desPro36[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39);
desPro36[Met(O)14,Trp(O2)25,IsoAsp28]エキセンジン−4(1−39);
ここで、基−Lys6−NH2は、エキセンジン−4誘導体のC−末端と連結してもよく;
H−(Lys)6−desPro36[Asp28]エキセンジン−4(1−39)−Lys6−NH2;
desAsp28,Pro36,Pro37,Pro38エキセンジン−4(1−39)−NH2;
H−(Lys)6−desPro36,Pro38[Asp28]エキセンジン−4(1−39)−NH2;
H−Asn−(Glu)5desPro36,Pro37,Pro38[Asp28]エキセンジン−4(1−39)−NH2;
desPro36,Pro37,Pro38[Asp28]エキセンジン−4(1−39)−(Lys)6−NH2;
H−(Lys)6−desPro36,Pro37,Pro38[Asp28]エキセンジン−4(1−39)−(Lys)6−NH2;
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Asp28]エキセンジン−4(1−39)−(Lys)6−NH2;
H−(Lys)6−desPro36[Trp(O2)25,Asp28]エキセンジン−4(1−39)−Lys6−NH2;
H−desAsp28 Pro36,Pro37,Pro38[Trp(O2)25]エキセンジン−4(1−39)−NH2;
H−(Lys)6−desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−NH2;
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−NH2;
desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2;
H−(Lys)6−des Pro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2;
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2;
H−(Lys)6−desPro36[Met(O)14,Asp28]エキセンジン−4(1−39)−Lys6−NH2;
desMet(O)14,Asp28,Pro36,Pro37,Pro38 エキセンジン−4(1−39)−NH2;
H−(Lys)6−desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−NH2;
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−NH2;
desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2;
H−(Lys)6−desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2;
H−Asn−(Glu)5,desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2;
H−Lys6−desPro36[Met(O)14,Trp(O2)25, Asp28]エキセンジン−4(1−39)−Lys6−NH2;
H−desAsp28,Pro36,Pro37,Pro38[Met(O)14,Trp(O2)25]エキセンジン−4(1−39)−NH2;
H−(Lys)6−des Pro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−NH2;
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)−NH2;
desPro36,Pro37,Pro38[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2;
H−(Lys)6−desPro36,Pro37,Pro38[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(S1−39)−(Lys)6−NH2;
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2;
又は前述のいずれかのエキセンジン−4誘導体の薬学的に許容可能な塩若しくは溶媒和物;
から選択される。
Publishing社,Easton, Pa., U.S.A.,1985 及び Encyclopedia of Pharmaceutical Technologyに記載されている。
2 空洞
3 容器壁
4 支持体
5 注射装置
6 ポンプ
7 薬剤出口
8 ポンプユニット
薬剤入口
流量センサ
9 再使用可能なバックエンド
制御ユニット
駆動ユニット
エネルギ源
使用者インターフェース
10 中空注射針
Claims (12)
- 内層及び外層を含んでなる容器壁(3)によって少なくとも部分的に画成される空洞(2)を含んでなり、両層がワンピース部材として配置される薬剤容器(1)であって、内層は軟質材料からなる軟質可撓性層であり、外層は剛性材料からなる剛性層であり、両層が二成分射出成形によって配置される、上記薬剤容器(1)。
- 空洞(2)が容器壁(3)及び剛性材料からなる剛性支持体(4)の間で画成され、ここで、両層及び支持体(4)は二成分射出成形によってワンピース部材として配置されることを特徴とする、請求項1に記載の薬剤容器(1)。
- 中空の針(10)又はポンプ(6)を空洞(2)に連結するためのインターフェースが配置されることを特徴とする、請求項1又は2に記載の薬剤容器(1)。
- 開口部が容器壁(3)に配置され、ここで、開口部はセプタムで密閉されることを特徴とする、請求項1〜3のいずれか1項に記載の薬剤容器(1)。
- セプタムが開口部にクリンプされることを特徴とする、請求項3に記載の薬剤容器(1)。
- 剛性材料がポリプロピレン又はポリエチレンであることを特徴とする、請求項1〜5のいずれか1項に記載の薬剤容器(1)。
- 容器壁の内部及び/又は外部がシリコンでコーティングされることを特徴とする、請求項1〜6のいずれか1項に記載の薬剤容器(1)。
- 請求項2〜7のいずれか1項に記載の薬剤容器(1)を含んでなり、更に、容器壁(3)を剛性支持体(4)に対して押圧し、それによって液体薬剤を薬剤容器から移動させるための圧縮手段を含んでなる、液体薬剤を患者(P)に送達するための注射装置(5)。
- 圧縮手段がローラー、ワイパー、シュー、又はアクチュエータであり、それが薬剤容器(1)の体積を徐々に減少させるように前進し得ることを特徴とする、請求項8に記載の注射装置(5)。
- 請求項1〜7のいずれか1項に記載の薬剤容器(1)を含んでなり、更に、液体薬剤を薬剤容器(1)から薬剤出口(7)にポンプ輸送するためのポンプ(6)を含んでなる、液体薬剤を患者(P)に送達するための注射装置(5)。
- 患者(P)の皮膚に突き刺して薬剤を投与するための中空の針(10)を備えることを特徴とする、請求項8〜10のいずれか1項に記載の注射装置(5)。
- 薬剤を投与するためにジェットノズルを備えることを特徴とする、請求項8〜10のいずれか1項に記載の注射装置(5)。
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2010
- 2010-07-14 DK DK10742106.7T patent/DK2453953T3/en active
- 2010-07-14 JP JP2012520020A patent/JP5734290B2/ja active Active
- 2010-07-14 EP EP10742106.7A patent/EP2453953B1/en active Active
- 2010-07-14 CA CA2765444A patent/CA2765444A1/en not_active Abandoned
- 2010-07-14 WO PCT/EP2010/060124 patent/WO2011006922A1/en active Application Filing
- 2010-07-14 AU AU2010272597A patent/AU2010272597B2/en not_active Ceased
- 2010-07-14 US US13/384,038 patent/US8679395B2/en active Active
- 2010-07-14 BR BR112012000919A patent/BR112012000919A2/pt not_active IP Right Cessation
- 2010-07-14 CN CN2010800315529A patent/CN102470209A/zh active Pending
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2012
- 2012-01-08 IL IL217419A patent/IL217419A/en not_active IP Right Cessation
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JP2019088811A (ja) * | 2013-03-15 | 2019-06-13 | ドクター ピー インスティチュート エルエルシー | 制御された非分離充填器具および方法 |
Also Published As
Publication number | Publication date |
---|---|
AU2010272597B2 (en) | 2014-09-11 |
CN102470209A (zh) | 2012-05-23 |
EP2453953B1 (en) | 2018-04-25 |
US20120179094A1 (en) | 2012-07-12 |
IL217419A0 (en) | 2012-02-29 |
DK2453953T3 (en) | 2018-08-06 |
IL217419A (en) | 2014-04-30 |
CA2765444A1 (en) | 2011-01-20 |
WO2011006922A1 (en) | 2011-01-20 |
BR112012000919A2 (pt) | 2016-03-01 |
AU2010272597A1 (en) | 2012-02-02 |
US8679395B2 (en) | 2014-03-25 |
JP5734290B2 (ja) | 2015-06-17 |
EP2453953A1 (en) | 2012-05-23 |
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