JP2012531904A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2012531904A5 JP2012531904A5 JP2012518126A JP2012518126A JP2012531904A5 JP 2012531904 A5 JP2012531904 A5 JP 2012531904A5 JP 2012518126 A JP2012518126 A JP 2012518126A JP 2012518126 A JP2012518126 A JP 2012518126A JP 2012531904 A5 JP2012531904 A5 JP 2012531904A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- tcr
- seq
- sequence
- chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108091008874 T cell receptors Proteins 0.000 claims 56
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 53
- 235000001014 amino acid Nutrition 0.000 claims 52
- 125000003275 alpha amino acid group Chemical group 0.000 claims 46
- 150000001413 amino acids Chemical class 0.000 claims 28
- LRDIEHDJWYRVPT-UHFFFAOYSA-N 4-amino-5-hydroxynaphthalene-1-sulfonic acid Chemical group C1=CC(O)=C2C(N)=CC=C(S(O)(=O)=O)C2=C1 LRDIEHDJWYRVPT-UHFFFAOYSA-N 0.000 claims 5
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 4
- 125000000539 amino acid group Chemical group 0.000 claims 4
- 230000009258 tissue cross reactivity Effects 0.000 claims 4
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 2
- 102000025850 HLA-A2 Antigen Human genes 0.000 claims 2
- 108010074032 HLA-A2 Antigen Proteins 0.000 claims 2
- 101000662909 Homo sapiens T cell receptor beta constant 1 Proteins 0.000 claims 2
- 101000662902 Homo sapiens T cell receptor beta constant 2 Proteins 0.000 claims 2
- 102100037272 T cell receptor beta constant 1 Human genes 0.000 claims 2
- 102100037298 T cell receptor beta constant 2 Human genes 0.000 claims 2
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 108010072094 gp100(280-288) melanoma antigen peptide Proteins 0.000 claims 2
- 230000035772 mutation Effects 0.000 claims 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 1
- 230000013595 glycosylation Effects 0.000 claims 1
- 238000006206 glycosylation reaction Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0911566.8A GB0911566D0 (en) | 2009-07-03 | 2009-07-03 | T cell receptors |
| GB0911566.8 | 2009-07-03 | ||
| PCT/GB2010/001277 WO2011001152A1 (en) | 2009-07-03 | 2010-07-01 | T cell receptors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015196799A Division JP6186412B2 (ja) | 2009-07-03 | 2015-10-02 | Ｔ細胞レセプター |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012531904A JP2012531904A (ja) | 2012-12-13 |
| JP2012531904A5 true JP2012531904A5 (https=) | 2013-06-27 |
| JP5872464B2 JP5872464B2 (ja) | 2016-03-01 |
Family
ID=41008692
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012518126A Active JP5872464B2 (ja) | 2009-07-03 | 2010-07-01 | Ｔ細胞レセプター |
| JP2015196799A Active JP6186412B2 (ja) | 2009-07-03 | 2015-10-02 | Ｔ細胞レセプター |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015196799A Active JP6186412B2 (ja) | 2009-07-03 | 2015-10-02 | Ｔ細胞レセプター |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US8519100B2 (https=) |
| EP (1) | EP2448963B1 (https=) |
| JP (2) | JP5872464B2 (https=) |
| CN (3) | CN102574906A (https=) |
| AU (1) | AU2010267758C1 (https=) |
| BR (1) | BR112012000107A2 (https=) |
| CA (1) | CA2766505C (https=) |
| DK (1) | DK2448963T3 (https=) |
| EA (1) | EA026918B1 (https=) |
| ES (1) | ES2498190T3 (https=) |
| FI (1) | FIC20220037I1 (https=) |
| FR (1) | FR22C1046I2 (https=) |
| GB (1) | GB0911566D0 (https=) |
| LU (1) | LUC00278I2 (https=) |
| MX (1) | MX2012000155A (https=) |
| NL (1) | NL301193I2 (https=) |
| PT (1) | PT2448963E (https=) |
| WO (1) | WO2011001152A1 (https=) |
| ZA (1) | ZA201109522B (https=) |
Families Citing this family (82)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7994298B2 (en) | 2004-09-24 | 2011-08-09 | Trustees Of Dartmouth College | Chimeric NK receptor and methods for treating cancer |
| GB0908613D0 (en) | 2009-05-20 | 2009-06-24 | Immunocore Ltd | T Cell Reseptors |
| GB0911566D0 (en) * | 2009-07-03 | 2009-08-12 | Immunocore Ltd | T cell receptors |
| WO2011059836A2 (en) | 2009-10-29 | 2011-05-19 | Trustees Of Dartmouth College | T cell receptor-deficient t cell compositions |
| US9273283B2 (en) | 2009-10-29 | 2016-03-01 | The Trustees Of Dartmouth College | Method of producing T cell receptor-deficient T cells expressing a chimeric receptor |
| US12492376B2 (en) | 2009-10-29 | 2025-12-09 | The Trustees Of Dartmouth College | T-cell receptor-deficient T cell compositions |
| US9833476B2 (en) | 2011-08-31 | 2017-12-05 | The Trustees Of Dartmouth College | NKP30 receptor targeted therapeutics |
| EP2760892A1 (en) | 2011-09-29 | 2014-08-06 | Apo-T B.V. | Multi-specific binding molecules targeting aberrant cells |
| AU2013208364B2 (en) | 2012-01-13 | 2017-10-26 | Apo-T B.V. | Aberrant cell-restricted immunoglobulins provided with a toxic moiety |
| ES2719495T5 (en) | 2012-05-07 | 2025-09-10 | Dartmouth College | Anti-b7-h6 antibody, fusion proteins, and methods of using the same |
| EP3718556A3 (en) | 2012-08-31 | 2020-12-30 | University Of Virginia Patent Foundation | Target peptides for immunotherapy and diagnostics |
| EP4088737A3 (en) | 2012-09-05 | 2023-02-08 | University Of Virginia Patent Foundation | Target peptides for colorectal cancer therapy and diagnostics |
| GB2508414A (en) | 2012-11-30 | 2014-06-04 | Max Delbrueck Centrum | Tumour specific T cell receptors (TCRs) |
| US10377808B2 (en) * | 2013-01-29 | 2019-08-13 | Max-Delbrück-Centrum Für Molekulare Medizin (Mdc) Berlin-Buch | High avidity antigen recognizing constructs |
| RU2645256C2 (ru) * | 2013-06-26 | 2018-02-19 | Гуандун Сянсюэ Лайф Сайенсис, Лтд. | Высокостабильный т-клеточный рецептор и способ его получения и применения |
| EP3071594A4 (en) * | 2013-11-22 | 2017-05-03 | The Board of Trustees of the University of Illionis | Engineered high-affinity human t cell receptors |
| DE202014002754U1 (de) | 2014-03-31 | 2015-07-03 | Christian Piotrowski | Ausgusssystem mit Pullring der mit der Folie verbunden ist. |
| CA2945816A1 (en) | 2014-04-15 | 2015-10-22 | University Of Virginia Patent Foundation | Isolated t cell receptors and methods of use therefor |
| CN106459176B (zh) * | 2014-06-18 | 2018-07-06 | 广东香雪精准医疗技术有限公司 | 高亲和力hcv t细胞受体 |
| WO2016014725A1 (en) * | 2014-07-22 | 2016-01-28 | The University Of Notre Dame Du Lac | Molecular constructs and uses thereof |
| CN107074970B (zh) * | 2014-08-04 | 2021-07-30 | 弗雷德哈钦森癌症研究中心 | 特异性针对wt-1的t细胞免疫疗法 |
| AU2014407539B2 (en) * | 2014-10-02 | 2020-10-22 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods of isolating T cell receptors having antigenic specificity for a cancer-specific mutation |
| GB201417803D0 (en) * | 2014-10-08 | 2014-11-19 | Adaptimmune Ltd | T cell receptors |
| JP7372728B2 (ja) * | 2014-10-31 | 2023-11-01 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | 改変ｔ細胞に関する方法および組成物 |
| EP3215164A1 (en) | 2014-11-03 | 2017-09-13 | Immures S.r.l. | T cell receptors |
| GB201506642D0 (en) * | 2015-04-20 | 2015-06-03 | Ucl Business Plc | T cell receptor |
| WO2016193301A1 (en) * | 2015-06-01 | 2016-12-08 | Medigene Immunotherapies Gmbh | T-cell receptor specific antibodies |
| HK1253694A1 (zh) * | 2015-06-01 | 2019-06-28 | Medigene Immunotherapies Gmbh | T细胞受体文库 |
| NL2014935B1 (en) | 2015-06-08 | 2017-02-03 | Applied Immune Tech Ltd | T cell receptor like antibodies having fine specificity. |
| GB201515321D0 (en) * | 2015-08-28 | 2015-10-14 | Immatics Biotechnologies Gmbh | Novel peptides, combination of peptides and scaffolds for use in immunotherapeutic treatment of various cancers |
| GB201516272D0 (en) | 2015-09-15 | 2015-10-28 | Adaptimmune Ltd And Immunocore Ltd | TCR Libraries |
| GB201516277D0 (en) * | 2015-09-15 | 2015-10-28 | Adaptimmune Ltd And Immunocore Ltd | TCR libraries |
| PL3430037T3 (pl) | 2016-03-16 | 2022-12-19 | Immatics Biotechnologies Gmbh | Transfekowane komórki t oraz receptory komórek t do stosowania w immunoterapii przeciwnowotworowej |
| ES2968802T3 (es) | 2016-03-16 | 2024-05-14 | Immatics Biotechnologies Gmbh | Células T transfectadas y receptores de células T para su uso en inmunoterapia contra el cáncer |
| GB201604953D0 (en) | 2016-03-23 | 2016-05-04 | Immunocore Ltd | T cell receptors |
| EP3436497B1 (en) | 2016-03-28 | 2022-08-31 | Dow Global Technologies LLC | Two-component solventless adhesive compositions and methods of making same |
| WO2017208018A1 (en) * | 2016-06-02 | 2017-12-07 | Immunocore Limited | Dosing regimen for gp100-specific tcr - anti-cd3 scfv fusion protein |
| DE102016115246C5 (de) | 2016-08-17 | 2018-12-20 | Immatics Biotechnologies Gmbh | Neue t-zellrezeptoren und deren verwendung in immuntherapie |
| HUE057094T2 (hu) | 2016-08-17 | 2022-04-28 | Immatics Biotechnologies Gmbh | T-sejt receptorok és a velük végzett immunterápia |
| US11453726B2 (en) * | 2016-09-15 | 2022-09-27 | Quadrucept Bio Limited | Multimers, tetramers and octamers |
| GB201617714D0 (en) | 2016-10-19 | 2016-11-30 | Ucl Business Plc | T Cell receptor |
| MX2019010972A (es) | 2017-03-15 | 2019-12-02 | Hutchinson Fred Cancer Res | Receptores de linfocito t (tcr) específicos del antígeno asociado a melanoma 1 (mage-a1) de alta afinidad y usos de estos. |
| DE102017106305A1 (de) | 2017-03-23 | 2018-09-27 | Immatics Biotechnologies Gmbh | Neue T-Zellrezeptoren und deren Verwendung in Immuntherapien gegen prame-positive Krebsarten |
| GB201709866D0 (en) | 2017-06-20 | 2017-08-02 | Immunocore Ltd | T cell receptors |
| AU2018337142B2 (en) * | 2017-09-22 | 2025-07-03 | Wuxi Biologics Ireland Limited. | Novel bispecific CD3/CD19 polypeptide complexes |
| CN117843810A (zh) | 2017-09-22 | 2024-04-09 | 上海药明生物技术有限公司 | 新型双特异性多肽复合物 |
| US20200308279A1 (en) | 2017-10-06 | 2020-10-01 | Oslo Universitetssykehus Hf | Chimeric antigen receptors |
| CN109776671B (zh) * | 2017-11-14 | 2022-05-27 | 杭州康万达医药科技有限公司 | 分离的t细胞受体、其修饰的细胞、编码核酸、表达载体、制备方法、药物组合物和应用 |
| US12606816B2 (en) * | 2018-07-31 | 2026-04-21 | Janux Therapeutics, Inc. | Inhibitory T cell receptor peptides and discovery methods |
| CN113166778A (zh) * | 2018-09-05 | 2021-07-23 | 葛兰素史克知识产权开发有限公司 | T细胞修饰 |
| GB201819540D0 (en) | 2018-11-30 | 2019-01-16 | Adaptimmune Ltd | T cell modification |
| ES2974424T3 (es) | 2019-01-17 | 2024-06-27 | Immunocore Ltd | Formulaciones |
| GB201901306D0 (en) * | 2019-01-30 | 2019-03-20 | Immunocore Ltd | Multi-domain binding molecules |
| GB201901305D0 (en) | 2019-01-30 | 2019-03-20 | Immunocore Ltd | Specific binding molecules |
| GB201902277D0 (en) | 2019-02-19 | 2019-04-03 | King S College London | Therapeutic agents |
| CN114423499A (zh) * | 2019-06-06 | 2022-04-29 | 佳努克斯治疗公司 | 与肿瘤激活的t细胞衔接子相关的组合物和方法 |
| KR20220052944A (ko) * | 2019-07-30 | 2022-04-28 | 유니버시티 헬스 네트워크 | Mhc 클래스 ii 분자 및 이의 사용 방법 |
| CN111234004B (zh) * | 2020-02-28 | 2023-03-28 | 陕西九州新药评价研究有限公司(西安新药评价研究中心) | 识别wt1抗原短肽的t细胞受体及其应用 |
| GB202006629D0 (en) * | 2020-05-05 | 2020-06-17 | Immunocore Ltd | Specific binding molecules |
| WO2021236548A1 (en) * | 2020-05-18 | 2021-11-25 | Board Of Regents, The University Of Texas System | Engineered t cell receptors and methods of use |
| CN112239495B (zh) * | 2020-10-29 | 2022-04-12 | 上海药明生物技术有限公司 | 稳定的tcr结构及应用 |
| CN114853879A (zh) * | 2021-02-03 | 2022-08-05 | 香雪生命科学技术（广东）有限公司 | 一种识别hpv的t细胞受体 |
| WO2022258606A1 (en) | 2021-06-07 | 2022-12-15 | Gadeta B.V. | Delta T-cell or Gamma T-cell receptor chains or parts thereof that mediate an anti-tumour or anti-infective response |
| US12103971B2 (en) | 2022-02-20 | 2024-10-01 | Immunocore Limited | HIV specific binding molecules |
| WO2023227594A1 (en) | 2022-05-24 | 2023-11-30 | Gadeta Bv | Novel deltat-cell receptor chains, gammat-cell receptor chains, or parts thereof |
| WO2023237541A1 (en) | 2022-06-07 | 2023-12-14 | Gadeta B.V. | Delta t-cell or gamma t-cell receptor chains or parts thereof that mediate an anti-tumour or anti-infective response |
| WO2023246911A1 (zh) * | 2022-06-24 | 2023-12-28 | 北京可瑞生物科技有限公司 | 基于t细胞受体的双特异性多肽分子及其用途 |
| WO2024013402A1 (en) | 2022-07-15 | 2024-01-18 | Gadeta B.V. | Novel soluble gamma t-cell (or soluble delta t-cell) receptor chains (or soluble gammadelta t-cell receptors) or fragments thereof that mediate an anti-tumour or an anti-infective response |
| MX2025001960A (es) | 2022-08-18 | 2025-05-02 | Immunocore Ltd | Moléculas de unión multidominio |
| KR20250051727A (ko) | 2022-08-18 | 2025-04-17 | 이뮤노코어 리미티드 | 멀티-도메인 결합 분자 |
| KR20250051722A (ko) | 2022-08-18 | 2025-04-17 | 이뮤노코어 리미티드 | 멀티-도메인 결합 분자 |
| CN120225664A (zh) * | 2022-09-30 | 2025-06-27 | 瑅安生物医药（杭州）有限公司 | 一种修饰细胞及其用途 |
| EP4634216A1 (en) | 2022-12-16 | 2025-10-22 | Repertoire Immune Medicines, Inc. | T cell receptors binding hpv-16 epitopes |
| CN121532421A (zh) * | 2023-06-21 | 2026-02-13 | 北京可瑞生物科技有限公司 | 经修饰的tcr恒定区及其在tcr融合蛋白中的用途 |
| GB202315181D0 (en) | 2023-10-03 | 2023-11-15 | Immunocore Ltd | Peptide-HLA binding molecules |
| WO2025087436A1 (zh) * | 2023-10-27 | 2025-05-01 | 北京可瑞生物科技有限公司 | 基于t细胞受体的多特异性多肽分子及其组合物和用途 |
| WO2025094054A1 (en) | 2023-11-01 | 2025-05-08 | Immunocore Limited | Method for purifying small multi-domain proteins |
| GB202320012D0 (en) | 2023-12-22 | 2024-02-07 | Immunocore Ltd | Bispecific molecules |
| CN118108833B (zh) * | 2024-03-12 | 2025-05-02 | 缇纱(合肥)生物技术有限公司 | 引入外源二硫键的tcr恒定区及其产品和应用 |
| WO2025224692A1 (en) | 2024-04-25 | 2025-10-30 | Immunocore Limited | Method of treating cancer using a gene expression signature |
| GB2641580A (en) | 2024-06-07 | 2025-12-10 | T Therapeutics Ltd | Tumour-transforming multispecific proteins |
| WO2026078231A1 (en) | 2024-10-11 | 2026-04-16 | T-Therapeutics Limited | Soluble non-aggregating immune ligand |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5688747A (en) | 1994-08-22 | 1997-11-18 | Becton Dickinson And Company | Water based lubricant solution |
| US6759243B2 (en) | 1998-01-20 | 2004-07-06 | Board Of Trustees Of The University Of Illinois | High affinity TCR proteins and methods |
| WO1999060120A2 (en) * | 1998-05-19 | 1999-11-25 | Avidex Limited | Soluble t cell receptor |
| AU2002321581C1 (en) * | 2001-08-31 | 2008-09-18 | Adaptimmune Limited | Soluble T cell receptor |
| DE60327795D1 (de) | 2002-11-09 | 2009-07-09 | Immunocore Ltd | T zell rezeptor "display" |
| GB0227351D0 (en) * | 2002-11-22 | 2002-12-31 | Isis Innovation | Soluble T-cell receptors |
| US7534427B2 (en) * | 2002-12-31 | 2009-05-19 | Immunomedics, Inc. | Immunotherapy of B cell malignancies and autoimmune diseases using unconjugated antibodies and conjugated antibodies and antibody combinations and fusion proteins |
| CN101035561A (zh) * | 2004-03-24 | 2007-09-12 | 特罗斯药品公司 | 作为改善对疫苗的免疫反应的佐剂的组合物和使用方法 |
| NZ550815A (en) | 2004-05-19 | 2009-04-30 | Immunocore Ltd | Method of improving T cell receptors |
| GB0411125D0 (en) * | 2004-05-19 | 2004-06-23 | Avidex Ltd | Method of improving T-cell receptors |
| US8361794B2 (en) | 2004-06-29 | 2013-01-29 | Immunocore Limited | Cells expressing a modified T cell receptor |
| US20060045884A1 (en) * | 2004-08-26 | 2006-03-02 | Board Of Regents | Vaccines for autoimmune and infectious disease |
| US7915036B2 (en) * | 2004-09-13 | 2011-03-29 | The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Compositions comprising T cell receptors and methods of use thereof |
| JP2008520227A (ja) * | 2004-11-18 | 2008-06-19 | メディジーン リミテッド | 可溶性二官能性タンパク質 |
| ES2665422T3 (es) * | 2005-03-03 | 2018-04-25 | Immunomedics Inc. | Anticuerpos L243 humanizados |
| GB0511124D0 (en) | 2005-06-01 | 2005-07-06 | Avidex Ltd | High affinity melan-a t cell receptors |
| EP1795599A1 (en) * | 2005-12-09 | 2007-06-13 | Schuler, Gerold, Prof. Dr. | Methods for generating antigen-specific effector T cells |
| CA2651174A1 (en) | 2006-05-03 | 2007-11-15 | Government Of The United States Of America, Represented By The Secretary , Department Of Health And Human Services | Chimeric t cell receptors and related materials and methods of use |
| EP2087000A2 (en) | 2006-09-29 | 2009-08-12 | Immunocore Ltd. | T cell therapies |
| AU2008206442B2 (en) | 2007-01-12 | 2012-10-18 | Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | gp100-specific T cell receptors and related materials and methods of use |
| GB0911566D0 (en) * | 2009-07-03 | 2009-08-12 | Immunocore Ltd | T cell receptors |
-
2009
- 2009-07-03 GB GBGB0911566.8A patent/GB0911566D0/en not_active Ceased
-
2010
- 2010-07-01 MX MX2012000155A patent/MX2012000155A/es active IP Right Grant
- 2010-07-01 ES ES10734524.1T patent/ES2498190T3/es active Active
- 2010-07-01 CN CN2010800351402A patent/CN102574906A/zh active Pending
- 2010-07-01 CN CN201710535038.2A patent/CN107266560A/zh not_active Withdrawn
- 2010-07-01 WO PCT/GB2010/001277 patent/WO2011001152A1/en not_active Ceased
- 2010-07-01 CN CN201410257886.8A patent/CN104017067B/zh active Active
- 2010-07-01 DK DK10734524.1T patent/DK2448963T3/da active
- 2010-07-01 JP JP2012518126A patent/JP5872464B2/ja active Active
- 2010-07-01 EA EA201270135A patent/EA026918B1/ru not_active IP Right Cessation
- 2010-07-01 BR BR112012000107A patent/BR112012000107A2/pt not_active Application Discontinuation
- 2010-07-01 PT PT107345241T patent/PT2448963E/pt unknown
- 2010-07-01 AU AU2010267758A patent/AU2010267758C1/en active Active
- 2010-07-01 EP EP10734524.1A patent/EP2448963B1/en active Active
- 2010-07-01 CA CA2766505A patent/CA2766505C/en active Active
-
2011
- 2011-12-22 ZA ZA2011/09522A patent/ZA201109522B/en unknown
-
2012
- 2012-01-03 US US13/342,579 patent/US8519100B2/en active Active
-
2013
- 2013-07-22 US US13/947,580 patent/US9068178B2/en active Active
-
2015
- 2015-10-02 JP JP2015196799A patent/JP6186412B2/ja active Active
-
2022
- 2022-08-15 NL NL301193C patent/NL301193I2/nl unknown
- 2022-08-31 FI FIC20220037C patent/FIC20220037I1/fi unknown
- 2022-09-02 FR FR22C1046C patent/FR22C1046I2/fr active Active
- 2022-09-05 LU LU00278C patent/LUC00278I2/fr unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2012531904A5 (https=) | ||
| AU2003271904B2 (en) | Single chain recombinant T cell receptors | |
| RU2017135599A (ru) | Белки, специфичные в отношении cd137 | |
| NZ603623A (en) | Tcr complex immunotherapeutics | |
| JP2006502741A5 (https=) | ||
| NZ600278A (en) | Von willebrand factor (vwf)-containing preparations, and methods, kits, and uses related thereto | |
| JP2011501951A5 (https=) | ||
| EA201270135A1 (ru) | T-клеточные рецепторы | |
| JP2018519803A5 (https=) | ||
| JP2013519721A5 (https=) | ||
| WO2008089053A3 (en) | Gp100-specific t cell receptors and related materials and methods of use | |
| CA2516702A1 (en) | Modified t cell receptor linked by disulphide bond between constant domain cysteine residues | |
| CA2567349A1 (en) | Method of improving t cell receptors | |
| JP2018532725A5 (https=) | ||
| IL275497B (en) | Serum proteins with type iii fibronectin binding domains | |
| MX2010012695A (es) | Analogos de glucagon que exhiben solubilidad y estabilidad aumentadas en soluciones reguladoras de ph fisiologico. | |
| NZ704192A (en) | Cell-penetrating peptides and uses therof | |
| JP2008535826A5 (https=) | ||
| JP2016502512A5 (https=) | ||
| MX2007003910A (es) | Receptores de celulas t que contienen un enlace entre cadenas bisulfuro no nativo ligado a agentes terapeuticos. | |
| RU2015129640A (ru) | Связанные дисульфидом мультивалентные многофункциональные белки, содержащие молекулы гкгс класса 1 | |
| JP2014502149A5 (https=) | ||
| JP2013529080A5 (https=) | ||
| RU2015137158A (ru) | МУТЕИНЫ ЛИПОКАЛИНА 2 ЧЕЛОВЕКА (Lcn2,hNGAL) С АФФИННОСТЬЮ ДЛЯ ОПРЕДЕЛЕННОЙ МИШЕНИ | |
| Lindgren et al. | A GLP‐1 receptor agonist conjugated to an albumin‐binding domain for extended half‐life |