JP2012531896A5 - - Google Patents

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Publication number
JP2012531896A5
JP2012531896A5 JP2012517837A JP2012517837A JP2012531896A5 JP 2012531896 A5 JP2012531896 A5 JP 2012531896A5 JP 2012517837 A JP2012517837 A JP 2012517837A JP 2012517837 A JP2012517837 A JP 2012517837A JP 2012531896 A5 JP2012531896 A5 JP 2012531896A5
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JP
Japan
Prior art keywords
human
cells
mammal
functional
human mammal
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Pending
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JP2012517837A
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English (en)
Japanese (ja)
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JP2012531896A (ja
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Priority claimed from PCT/US2010/040260 external-priority patent/WO2011002727A1/en
Publication of JP2012531896A publication Critical patent/JP2012531896A/ja
Publication of JP2012531896A5 publication Critical patent/JP2012531896A5/ja
Pending legal-status Critical Current

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JP2012517837A 2009-06-29 2010-06-28 ヒト化非ヒト哺乳動物を製造する方法 Pending JP2012531896A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22143809P 2009-06-29 2009-06-29
US61/221,438 2009-06-29
PCT/US2010/040260 WO2011002727A1 (en) 2009-06-29 2010-06-28 Methods of producing humanized non-human mammals

Publications (2)

Publication Number Publication Date
JP2012531896A JP2012531896A (ja) 2012-12-13
JP2012531896A5 true JP2012531896A5 (https=) 2013-08-15

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ID=43411395

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Application Number Title Priority Date Filing Date
JP2012517837A Pending JP2012531896A (ja) 2009-06-29 2010-06-28 ヒト化非ヒト哺乳動物を製造する方法

Country Status (6)

Country Link
US (1) US20120157667A1 (https=)
EP (1) EP2449094A4 (https=)
JP (1) JP2012531896A (https=)
CN (1) CN102725400A (https=)
SG (2) SG176118A1 (https=)
WO (1) WO2011002727A1 (https=)

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EP4502152A3 (en) 2009-10-06 2025-04-30 Regeneron Pharmaceuticals, Inc. Genetically modified mice and engraftment
SG10202008003VA (en) 2011-02-15 2020-10-29 Regeneron Pharma Humanized m-csf mice
CN104160272A (zh) * 2011-12-06 2014-11-19 麻省理工学院 利用人源化的小鼠来确定毒性
CN103387955B (zh) * 2012-05-10 2015-04-29 上海南方模式生物科技发展有限公司 非人哺乳动物b淋巴细胞缺陷动物模型的制备方法及其用途
WO2014039733A1 (en) * 2012-09-05 2014-03-13 University Of Southern California Methods and compositions for detecting, imaging, and treating small cell lung cancer utilizing post-translationally modified residues and higher molecular weight antigenic complexes in proteins
FI2892330T3 (fi) * 2012-09-07 2023-03-25 Univ Yale Geneettisesti muokattuja hiiriä ja menetelmiä niiden käyttämiseksi
MX377561B (es) 2012-11-05 2025-03-10 Regeneron Pharma Animales no humanos genéticamente modificados y métodos de uso de los mismos.
WO2014121840A1 (en) * 2013-02-07 2014-08-14 Medizinische Hochschule Hannover Induced dendritic cells and uses thereof
WO2014196929A1 (en) * 2013-06-05 2014-12-11 Agency For Science, Technology And Research A humanized mouse model for study of bona fide hepatitis virus infection and use thereof
NO2785538T3 (https=) * 2014-05-07 2018-08-04
MX2016014995A (es) * 2014-05-19 2017-03-31 Regeneron Pharma Animales no humanos geneticamente modificados que expresan eritropoyetina de humano.
ES2950399T3 (es) * 2015-04-13 2023-10-09 Regeneron Pharma Ratones humanizados Sirpa-IL15 insertados y métodos de uso de los mismos
JP6654001B2 (ja) * 2015-05-27 2020-02-26 公益財団法人実験動物中央研究所 ヒトｉｌ−１５分泌免疫不全マウス
JP2019508014A (ja) * 2015-11-30 2019-03-28 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト 免疫不全の非ヒト宿主におけるヒトマクロファージの生成
WO2019098362A1 (ja) * 2017-11-17 2019-05-23 国立大学法人筑波大学 非ヒト動物及びその製造方法
CN111172190B (zh) * 2018-12-25 2021-07-30 百奥赛图江苏基因生物技术有限公司 人源化细胞因子csf2基因改造非人动物的构建方法及应用
CN111304248B (zh) 2018-12-25 2021-08-24 百奥赛图江苏基因生物技术有限公司 人源化细胞因子il15基因改造非人动物的构建方法及应用
WO2020157997A1 (ja) * 2019-01-28 2020-08-06 公益財団法人実験動物中央研究所 ヒトｉｌ－３４を有する非ヒト動物及びその使用
US12378574B2 (en) 2019-02-13 2025-08-05 The Jackson Laboratory Transgenic mouse models supporting innate immune function
US20220192166A1 (en) * 2019-03-28 2022-06-23 Central Institute For Experimental Animals Immunodeficient rodent
CN111485001A (zh) * 2020-04-14 2020-08-04 澎立生物医药技术（上海）有限公司 具有nk细胞及adcc能力的人源化免疫系统小鼠的构建方法
KR20230037043A (ko) * 2020-07-08 2023-03-15 더 잭슨 래보라토리 인간 선천적 면역 기능을 지원하는 트랜스제닉 마우스 모델
CN112042597B (zh) * 2020-07-22 2022-04-29 南京普恩瑞生物科技有限公司 一种双人源化肿瘤异种移植模型的构建方法
WO2022222958A1 (en) * 2021-04-20 2022-10-27 Biocytogen Pharmaceuticals (Beijing) Co., Ltd. Genetically modified non-human animal with human or chimeric genes

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WO2010115115A1 (en) * 2009-04-03 2010-10-07 Inserm ( Institut National De La Sante Et De La Recherche) Dendritic cell-boosted humanized immune system mice
EP2448967B1 (en) * 2009-06-29 2015-04-15 Ilya B. Leskov Non-human mammal model of human hematopoietic cancer
EP4502152A3 (en) * 2009-10-06 2025-04-30 Regeneron Pharmaceuticals, Inc. Genetically modified mice and engraftment

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