JP2012531896A5 - - Google Patents
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- Publication number
- JP2012531896A5 JP2012531896A5 JP2012517837A JP2012517837A JP2012531896A5 JP 2012531896 A5 JP2012531896 A5 JP 2012531896A5 JP 2012517837 A JP2012517837 A JP 2012517837A JP 2012517837 A JP2012517837 A JP 2012517837A JP 2012531896 A5 JP2012531896 A5 JP 2012531896A5
- Authority
- JP
- Japan
- Prior art keywords
- human
- cells
- mammal
- functional
- human mammal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22143809P | 2009-06-29 | 2009-06-29 | |
| US61/221,438 | 2009-06-29 | ||
| PCT/US2010/040260 WO2011002727A1 (en) | 2009-06-29 | 2010-06-28 | Methods of producing humanized non-human mammals |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012531896A JP2012531896A (ja) | 2012-12-13 |
| JP2012531896A5 true JP2012531896A5 (https=) | 2013-08-15 |
Family
ID=43411395
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012517837A Pending JP2012531896A (ja) | 2009-06-29 | 2010-06-28 | ヒト化非ヒト哺乳動物を製造する方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20120157667A1 (https=) |
| EP (1) | EP2449094A4 (https=) |
| JP (1) | JP2012531896A (https=) |
| CN (1) | CN102725400A (https=) |
| SG (2) | SG176118A1 (https=) |
| WO (1) | WO2011002727A1 (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2485583T (pt) | 2009-10-06 | 2016-09-22 | Univ Yale | Ratinhos geneticamente modificados e enxerto |
| MX350385B (es) | 2011-02-15 | 2017-09-04 | Regeneron Pharma | Ratones de m-csf humanizada. |
| WO2013086019A1 (en) * | 2011-12-06 | 2013-06-13 | Massachusetts Institute Of Technology | Use of humanized mice to determine toxicity |
| CN103387955B (zh) * | 2012-05-10 | 2015-04-29 | 上海南方模式生物科技发展有限公司 | 非人哺乳动物b淋巴细胞缺陷动物模型的制备方法及其用途 |
| WO2014039733A1 (en) * | 2012-09-05 | 2014-03-13 | University Of Southern California | Methods and compositions for detecting, imaging, and treating small cell lung cancer utilizing post-translationally modified residues and higher molecular weight antigenic complexes in proteins |
| IN2015DN02032A (https=) * | 2012-09-07 | 2015-08-14 | Univ Yale | |
| CA2887706C (en) | 2012-11-05 | 2022-08-02 | Regeneron Pharmaceuticals | Genetically modified non-human animals and methods of use thereof |
| WO2014121840A1 (en) * | 2013-02-07 | 2014-08-14 | Medizinische Hochschule Hannover | Induced dendritic cells and uses thereof |
| US20160135437A1 (en) * | 2013-06-05 | 2016-05-19 | Agency For Science, Technology And Research | Humanized mouse model for study of bona fide hepatitis virus infection and use thereof |
| NO2785538T3 (https=) * | 2014-05-07 | 2018-08-04 | ||
| SG10202002187WA (en) * | 2014-05-19 | 2020-04-29 | Regeneron Pharma | Genetically modified non-human animals expressing human epo |
| KR102658190B1 (ko) | 2015-04-13 | 2024-04-17 | 리제너론 파마슈티칼스 인코포레이티드 | 인간화된 sirpa-il15 녹인 마우스 및 이의 이용 방법 |
| JP6654001B2 (ja) * | 2015-05-27 | 2020-02-26 | 公益財団法人実験動物中央研究所 | ヒトｉｌ−１５分泌免疫不全マウス |
| JP2019508014A (ja) * | 2015-11-30 | 2019-03-28 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | 免疫不全の非ヒト宿主におけるヒトマクロファージの生成 |
| CN111315881B (zh) * | 2017-11-17 | 2023-10-10 | 国立大学法人筑波大学 | 非人类动物及其生产方法 |
| CN111304248B (zh) | 2018-12-25 | 2021-08-24 | 百奥赛图江苏基因生物技术有限公司 | 人源化细胞因子il15基因改造非人动物的构建方法及应用 |
| CN111172190B (zh) * | 2018-12-25 | 2021-07-30 | 百奥赛图江苏基因生物技术有限公司 | 人源化细胞因子csf2基因改造非人动物的构建方法及应用 |
| US11419317B2 (en) | 2019-01-28 | 2022-08-23 | Central Institute For Experimental Animals | Non-human animal having human IL-34 and use Thereof |
| US12378574B2 (en) | 2019-02-13 | 2025-08-05 | The Jackson Laboratory | Transgenic mouse models supporting innate immune function |
| CN113614238B (zh) * | 2019-03-28 | 2024-10-22 | 公益财团法人实中研 | 免疫缺陷小鼠 |
| CN111485001A (zh) * | 2020-04-14 | 2020-08-04 | 澎立生物医药技术（上海）有限公司 | 具有nk细胞及adcc能力的人源化免疫系统小鼠的构建方法 |
| JP2023533979A (ja) * | 2020-07-08 | 2023-08-07 | ザ ジャクソン ラボラトリー | ヒト自然免疫機能を支えるトランスジェニックマウスモデル |
| CN112042597B (zh) * | 2020-07-22 | 2022-04-29 | 南京普恩瑞生物科技有限公司 | 一种双人源化肿瘤异种移植模型的构建方法 |
| CN114853871B (zh) * | 2021-04-20 | 2024-04-05 | 百奥赛图(北京)医药科技股份有限公司 | Csf1和/或csf1r基因人源化的非人动物及其构建方法和应用 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5639939A (en) * | 1987-12-23 | 1997-06-17 | The Board Of Trustees For The Leland Stanford Junior University | Chimeric immunocompromised mammal comprosing vascularized fetal organ tissue |
| ES2071620T3 (es) * | 1987-12-23 | 1995-07-01 | Univ Leland Stanford Junior | Mamiferos inmunodeficientes quimericos y su utilizacion. |
| AU1402495A (en) * | 1993-12-17 | 1995-07-03 | Systemix, Inc. | Use of macrophage depleting agents for prolonging the survival of non-autologus hematopoietic cell transplants and animal model assay systems |
| US6015554A (en) * | 1995-06-07 | 2000-01-18 | Systemix, Inc. | Method of reconstituting human lymphoid and dendritic cells |
| US6060643A (en) * | 1995-08-04 | 2000-05-09 | Emory University | Mouse model with human immune system |
| US20070021364A1 (en) * | 1995-12-13 | 2007-01-25 | Hans Herweijer | Methods for genetic immunization |
| AU4214799A (en) * | 1998-05-28 | 1999-12-13 | St. Jude Children's Research Hospital | Expansion of hematopoietic stem cells transduced with mdr-1 and methods of use thereof |
| CA2330208A1 (en) * | 1998-05-29 | 1999-12-02 | Thomas Jefferson University | Compositions and methods for use in affecting hematopoietic stem cell populations in mammals |
| AU2003256280A1 (en) * | 2002-06-24 | 2004-01-06 | Genzyme Corporation | Methods of delivering gene therapy agents |
| GB0406728D0 (en) * | 2004-03-25 | 2004-04-28 | Hydrodynamic Gene Delivery Ltd | Gene therapy |
| CN105168250B (zh) * | 2004-10-25 | 2019-02-05 | 塞勒兰特治疗公司 | 增殖骨髓细胞群体的方法及其应用 |
| KR102651433B1 (ko) * | 2006-04-14 | 2024-03-25 | 아스텔라스 인스티튜트 포 리제너러티브 메디슨 | 혈관 콜로니 형성 세포 |
| EP2134852A4 (en) * | 2007-03-13 | 2010-04-28 | Nat Jewish Health | PROCESS FOR THE PRODUCTION OF ANTIBODIES |
| US20090215875A1 (en) * | 2008-02-25 | 2009-08-27 | Deneault Eric | Methods and kits for expanding hematopoietic stem cells |
| WO2010115115A1 (en) * | 2009-04-03 | 2010-10-07 | Inserm ( Institut National De La Sante Et De La Recherche) | Dendritic cell-boosted humanized immune system mice |
| DK2448967T3 (en) * | 2009-06-29 | 2015-07-20 | Ilya B Leskov | NON-HUMAN MAMMALS MODEL OF CANCER human hematopoietic |
| PT2485583T (pt) * | 2009-10-06 | 2016-09-22 | Univ Yale | Ratinhos geneticamente modificados e enxerto |
-
2010
- 2010-06-28 CN CN2010800388479A patent/CN102725400A/zh active Pending
- 2010-06-28 SG SG2011084647A patent/SG176118A1/en unknown
- 2010-06-28 US US13/381,313 patent/US20120157667A1/en not_active Abandoned
- 2010-06-28 JP JP2012517837A patent/JP2012531896A/ja active Pending
- 2010-06-28 SG SG10201403703XA patent/SG10201403703XA/en unknown
- 2010-06-28 EP EP10794611.3A patent/EP2449094A4/en not_active Withdrawn
- 2010-06-28 WO PCT/US2010/040260 patent/WO2011002727A1/en not_active Ceased
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