JP2019536457A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019536457A5 JP2019536457A5 JP2019529204A JP2019529204A JP2019536457A5 JP 2019536457 A5 JP2019536457 A5 JP 2019536457A5 JP 2019529204 A JP2019529204 A JP 2019529204A JP 2019529204 A JP2019529204 A JP 2019529204A JP 2019536457 A5 JP2019536457 A5 JP 2019536457A5
- Authority
- JP
- Japan
- Prior art keywords
- human
- recombinant
- cells
- mouse
- immunodeficient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022166015A JP2023015064A (ja) | 2016-11-30 | 2022-10-17 | 改善されたヒト自然免疫細胞の発生を有するヒト化マウスモデル |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662428131P | 2016-11-30 | 2016-11-30 | |
| US62/428,131 | 2016-11-30 | ||
| US201762565783P | 2017-09-29 | 2017-09-29 | |
| US62/565,783 | 2017-09-29 | ||
| PCT/US2017/063948 WO2018102546A1 (en) | 2016-11-30 | 2017-11-30 | Humanized mouse model with improved human innate immune cell development |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022166015A Division JP2023015064A (ja) | 2016-11-30 | 2022-10-17 | 改善されたヒト自然免疫細胞の発生を有するヒト化マウスモデル |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019536457A JP2019536457A (ja) | 2019-12-19 |
| JP2019536457A5 true JP2019536457A5 (https=) | 2021-01-21 |
| JP7458185B2 JP7458185B2 (ja) | 2024-03-29 |
Family
ID=60935945
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019529204A Active JP7458185B2 (ja) | 2016-11-30 | 2017-11-30 | 改善されたヒト自然免疫細胞の発生を有するヒト化マウスモデル |
| JP2022166015A Pending JP2023015064A (ja) | 2016-11-30 | 2022-10-17 | 改善されたヒト自然免疫細胞の発生を有するヒト化マウスモデル |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022166015A Pending JP2023015064A (ja) | 2016-11-30 | 2022-10-17 | 改善されたヒト自然免疫細胞の発生を有するヒト化マウスモデル |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US20190320633A1 (https=) |
| EP (1) | EP3547831B1 (https=) |
| JP (2) | JP7458185B2 (https=) |
| CN (1) | CN110740641A (https=) |
| WO (1) | WO2018102546A1 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110740641A (zh) * | 2016-11-30 | 2020-01-31 | 杰克逊实验室 | 具有改善的人先天免疫细胞发育的人源化小鼠模型 |
| SG10202112528QA (en) | 2017-05-12 | 2021-12-30 | Jackson Lab | Nsg mice lacking mhc class i and class ii |
| US11712026B2 (en) | 2017-10-18 | 2023-08-01 | The Jackson Laboratory | Murine-MHC-deficient HLA-transgenic nod-mouse models for T1D therapy development |
| US20210355501A1 (en) * | 2018-09-24 | 2021-11-18 | Albert Einstein College Of Medicine | Interleukin-8 for maintenance of human acute myeloid leukemia and myelodysplastic syndrome and uses thereof |
| CN113614238B (zh) * | 2019-03-28 | 2024-10-22 | 公益财团法人实中研 | 免疫缺陷小鼠 |
| US20220312749A1 (en) * | 2019-08-09 | 2022-10-06 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Genetically modified non-human animal with human or chimeric il2ra |
| CN111705082A (zh) * | 2020-04-14 | 2020-09-25 | 澎立生物医药技术（上海）有限公司 | 具有髓系免疫细胞的人源化免疫系小鼠的构建方法 |
| CN116322317B (zh) * | 2020-07-08 | 2025-12-12 | 杰克逊实验室 | 表达人hla-a201限制基因的转基因小鼠模型 |
| JP2023542539A (ja) | 2020-09-24 | 2023-10-10 | ザ ジャクソン ラボラトリー | 免疫細胞療法を評価するためのヒト化マウスモデル |
| CN114853871B (zh) * | 2021-04-20 | 2024-04-05 | 百奥赛图(北京)医药科技股份有限公司 | Csf1和/或csf1r基因人源化的非人动物及其构建方法和应用 |
| AU2022421979A1 (en) * | 2021-12-22 | 2024-08-01 | The Jackson Laboratory | Humanized mouse models |
| CA3260932A1 (en) | 2022-06-30 | 2024-01-04 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | CD25-SPECIFIC ANTIBODIES AND THEIR USES |
| CA3266908A1 (en) * | 2022-09-08 | 2024-03-14 | The Jackson Laboratory | HUMANIZED IMMUNODEFICIENT MURINE MODELS |
| EP4608969A1 (en) * | 2022-10-25 | 2025-09-03 | Lapix Therapeutics, Inc. | Immune cell-engrafted non-human animals and non-human animal models |
| WO2025041060A1 (en) * | 2023-08-21 | 2025-02-27 | VeraVerse Co., Ltd. | Patient-derived xenograft model of cancer, preparation method thereof and an apparatus and a method for analyzing drug responsiveness using the same |
| WO2026001958A1 (zh) * | 2024-06-24 | 2026-01-02 | 黄菁 | Aav载体、aav载体的组合、构建aml pdx和mm pdx非人动物的方法及构建免疫系统人源化非人动物的方法 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001015521A1 (en) * | 1999-08-31 | 2001-03-08 | Genencor International, Inc. | Transgenic mammal capable of facilitating production of donor-specific functional immunity |
| AU2005295269B2 (en) | 2004-10-19 | 2010-05-13 | Regeneron Pharmaceuticals, Inc. | Method for generating an animal homozygous for a genetic modification |
| MX350385B (es) * | 2011-02-15 | 2017-09-04 | Regeneron Pharma | Ratones de m-csf humanizada. |
| IN2015DN02032A (https=) | 2012-09-07 | 2015-08-14 | Univ Yale | |
| CA2887706C (en) * | 2012-11-05 | 2022-08-02 | Regeneron Pharmaceuticals | Genetically modified non-human animals and methods of use thereof |
| ES2715949T3 (es) | 2013-10-15 | 2019-06-07 | Regeneron Pharma | Animales con IL-15 humanizada |
| US20150282460A1 (en) | 2014-04-04 | 2015-10-08 | Crown Bioscience Inc. (Taicang) | Animal model with human immune system |
| SG10202002187WA (en) * | 2014-05-19 | 2020-04-29 | Regeneron Pharma | Genetically modified non-human animals expressing human epo |
| KR102658190B1 (ko) | 2015-04-13 | 2024-04-17 | 리제너론 파마슈티칼스 인코포레이티드 | 인간화된 sirpa-il15 녹인 마우스 및 이의 이용 방법 |
| JP6654001B2 (ja) * | 2015-05-27 | 2020-02-26 | 公益財団法人実験動物中央研究所 | ヒトｉｌ−１５分泌免疫不全マウス |
| KR102664078B1 (ko) * | 2015-06-23 | 2024-05-10 | 더 잭슨 래보라토리 | 환자-유래 이종이식을 가지는 hla-비매칭의 인간화된 nsg 마우스 모델 |
| EP3367787A1 (en) | 2015-10-30 | 2018-09-05 | The Jackson Laboratory | Compositions and methods relating to tumor analysis |
| RU2019115976A (ru) | 2016-10-27 | 2020-11-27 | Зэ Джэксон Лэборэтори | Модель с использованием генетически модифицированной мыши для ксенотрансплантации гепатоцитов человека |
| CN110740641A (zh) * | 2016-11-30 | 2020-01-31 | 杰克逊实验室 | 具有改善的人先天免疫细胞发育的人源化小鼠模型 |
| US11084863B2 (en) * | 2017-06-30 | 2021-08-10 | Xencor, Inc. | Targeted heterodimeric Fc fusion proteins containing IL-15 IL-15alpha and antigen binding domains |
| WO2019032836A1 (en) | 2017-08-09 | 2019-02-14 | The Jackson Laboratory | IMMUNODEFICIENT MOUSE EXPRESSING THE HUMAN INTERLEUKINE 15 |
| TWI838389B (zh) | 2018-07-19 | 2024-04-11 | 美商再生元醫藥公司 | 雙特異性抗-BCMAｘ抗-CD3抗體及其用途 |
| JP2022512781A (ja) | 2018-10-30 | 2022-02-07 | マジェンタ セラピューティクス インコーポレイテッド | 同種造血幹細胞移植の方法 |
-
2017
- 2017-11-30 CN CN201780083557.8A patent/CN110740641A/zh active Pending
- 2017-11-30 WO PCT/US2017/063948 patent/WO2018102546A1/en not_active Ceased
- 2017-11-30 EP EP17825653.3A patent/EP3547831B1/en active Active
- 2017-11-30 JP JP2019529204A patent/JP7458185B2/ja active Active
- 2017-11-30 US US16/465,006 patent/US20190320633A1/en not_active Abandoned
-
2022
- 2022-10-17 JP JP2022166015A patent/JP2023015064A/ja active Pending
-
2024
- 2024-06-28 US US18/758,838 patent/US12409237B1/en active Active
-
2025
- 2025-08-15 US US19/301,265 patent/US20260033467A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2019536457A5 (https=) | ||
| Chuprin et al. | Humanized mouse models for immuno-oncology research | |
| Katano et al. | Predominant development of mature and functional human NK cells in a novel human IL-2–producing transgenic NOG mouse | |
| Mian et al. | Advances in human immune system mouse models for studying human hematopoiesis and cancer immunotherapy | |
| Hanazawa et al. | Generation of human immunosuppressive myeloid cell populations in human interleukin-6 transgenic NOG mice | |
| Beaulieu et al. | The transcription factor Zbtb32 controls the proliferative burst of virus-specific natural killer cells responding to infection | |
| McCaughtry et al. | Conditional deletion of cytokine receptor chains reveals that IL-7 and IL-15 specify CD8 cytotoxic lineage fate in the thymus | |
| EP3475413B1 (en) | Genetically modified t lymphocytes | |
| JP2012531896A5 (https=) | ||
| JP2017525364A5 (https=) | ||
| Bascuas et al. | Salmonella immunotherapy improves the outcome of CHOP chemotherapy in non-Hodgkin lymphoma-bearing mice | |
| US20220226379A1 (en) | Dnmt3a knock-out stat5 activated genetically engineered t-cells | |
| US20150282460A1 (en) | Animal model with human immune system | |
| Stacey et al. | IL-10 restricts activation-induced death of NK cells during acute murine cytomegalovirus infection | |
| Kumari et al. | Humanized mouse models for immuno‐oncology drug discovery | |
| Takahashi et al. | Enhanced antibody responses in a novel NOG transgenic mouse with restored lymph node organogenesis | |
| Volk et al. | Multidimensional analysis integrating human T-cell signatures in lymphatic tissues with sex of humanized mice for prediction of responses after dendritic cell immunization | |
| Li et al. | Thymic selection pathway regulates the effector function of CD4 T cells | |
| Morokawa et al. | Autologous non‐human primate model for safety assessment of piggyBac transposon‐mediated chimeric antigen receptor T cells on granulocyte–macrophage colony‐stimulating factor receptor | |
| Prlic et al. | Dissociating markers of senescence and protective ability in memory T cells | |
| US11725187B2 (en) | Selection of human hematopoetic stem cells using EPCR | |
| KR102581970B1 (ko) | 면역 부전 마우스 | |
| Panjwani et al. | Single-cell profiling aligns CD56bright and cytomegalovirus-induced adaptive natural killer cells to a naïve-memory relationship | |
| WO2017049002A1 (en) | A humanized mouse model of de novo human acute myeloid leukemia with a matching human immune system | |
| Kim et al. | A humanized mouse model to study NK cell biology during HIV infection |