CN110740641A - 具有改善的人先天免疫细胞发育的人源化小鼠模型 - Google Patents

具有改善的人先天免疫细胞发育的人源化小鼠模型 Download PDF

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Publication number
CN110740641A
CN110740641A CN201780083557.8A CN201780083557A CN110740641A CN 110740641 A CN110740641 A CN 110740641A CN 201780083557 A CN201780083557 A CN 201780083557A CN 110740641 A CN110740641 A CN 110740641A
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China
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human
cells
genetically modified
mouse
mice
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CN201780083557.8A
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English (en)
Chinese (zh)
Inventor
L·D·舒尔兹
J·G·凯克
D·L·格雷纳
M·A·布雷姆
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Jackson Laboratory
University of Massachusetts Amherst
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Jackson Laboratory
University of Massachusetts Amherst
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5403—IL-3
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/12—Animals modified by administration of exogenous cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/15—Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0331—Animal model for proliferative diseases

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Husbandry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN201780083557.8A 2016-11-30 2017-11-30 具有改善的人先天免疫细胞发育的人源化小鼠模型 Pending CN110740641A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662428131P 2016-11-30 2016-11-30
US62/428,131 2016-11-30
US201762565783P 2017-09-29 2017-09-29
US62/565,783 2017-09-29
PCT/US2017/063948 WO2018102546A1 (en) 2016-11-30 2017-11-30 Humanized mouse model with improved human innate immune cell development

Publications (1)

Publication Number Publication Date
CN110740641A true CN110740641A (zh) 2020-01-31

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Family Applications (1)

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CN201780083557.8A Pending CN110740641A (zh) 2016-11-30 2017-11-30 具有改善的人先天免疫细胞发育的人源化小鼠模型

Country Status (5)

Country Link
US (3) US20190320633A1 (https=)
EP (1) EP3547831B1 (https=)
JP (2) JP7458185B2 (https=)
CN (1) CN110740641A (https=)
WO (1) WO2018102546A1 (https=)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111705082A (zh) * 2020-04-14 2020-09-25 澎立生物医药技术（上海）有限公司 具有髓系免疫细胞的人源化免疫系小鼠的构建方法
WO2022222958A1 (en) * 2021-04-20 2022-10-27 Biocytogen Pharmaceuticals (Beijing) Co., Ltd. Genetically modified non-human animal with human or chimeric genes
CN116322317A (zh) * 2020-07-08 2023-06-23 杰克逊实验室 表达人hla-a201限制基因的转基因小鼠模型
EP4453222A4 (en) * 2021-12-22 2025-12-17 Jackson Lab HUMANIZED MOUSE MODELS
WO2026001958A1 (zh) * 2024-06-24 2026-01-02 黄菁 Aav载体、aav载体的组合、构建aml pdx和mm pdx非人动物的方法及构建免疫系统人源化非人动物的方法

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CN110740641A (zh) * 2016-11-30 2020-01-31 杰克逊实验室 具有改善的人先天免疫细胞发育的人源化小鼠模型
SG10202112528QA (en) 2017-05-12 2021-12-30 Jackson Lab Nsg mice lacking mhc class i and class ii
US11712026B2 (en) 2017-10-18 2023-08-01 The Jackson Laboratory Murine-MHC-deficient HLA-transgenic nod-mouse models for T1D therapy development
US20210355501A1 (en) * 2018-09-24 2021-11-18 Albert Einstein College Of Medicine Interleukin-8 for maintenance of human acute myeloid leukemia and myelodysplastic syndrome and uses thereof
CN113614238B (zh) * 2019-03-28 2024-10-22 公益财团法人实中研 免疫缺陷小鼠
US20220312749A1 (en) * 2019-08-09 2022-10-06 Biocytogen Pharmaceuticals (Beijing) Co., Ltd. Genetically modified non-human animal with human or chimeric il2ra
JP2023542539A (ja) 2020-09-24 2023-10-10 ザ ジャクソン ラボラトリー 免疫細胞療法を評価するためのヒト化マウスモデル
CA3260932A1 (en) 2022-06-30 2024-01-04 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services CD25-SPECIFIC ANTIBODIES AND THEIR USES
CA3266908A1 (en) * 2022-09-08 2024-03-14 The Jackson Laboratory HUMANIZED IMMUNODEFICIENT MURINE MODELS
EP4608969A1 (en) * 2022-10-25 2025-09-03 Lapix Therapeutics, Inc. Immune cell-engrafted non-human animals and non-human animal models
WO2025041060A1 (en) * 2023-08-21 2025-02-27 VeraVerse Co., Ltd. Patient-derived xenograft model of cancer, preparation method thereof and an apparatus and a method for analyzing drug responsiveness using the same

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WO2001015521A1 (en) * 1999-08-31 2001-03-08 Genencor International, Inc. Transgenic mammal capable of facilitating production of donor-specific functional immunity
WO2006044962A1 (en) * 2004-10-19 2006-04-27 Regeneron Pharmaceuticals, Inc. Method for generating an animal homozygous for a genetic modification
CN103547148A (zh) * 2011-02-15 2014-01-29 再生元制药公司 人源化m-csf小鼠
WO2014039782A2 (en) * 2012-09-07 2014-03-13 Yale University Genetically modified non-human animals and methods of use thereof
WO2014071397A2 (en) * 2012-11-05 2014-05-08 Regeneron Pharmaceuticals Genetically modified non-human animals and methods of use thereof
WO2015179317A2 (en) * 2014-05-19 2015-11-26 Regeneron Pharmaceuticals, Inc. Genetically modified non-human animals expressing human epo

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US20150282460A1 (en) 2014-04-04 2015-10-08 Crown Bioscience Inc. (Taicang) Animal model with human immune system
KR102658190B1 (ko) 2015-04-13 2024-04-17 리제너론 파마슈티칼스 인코포레이티드 인간화된 sirpa-il15 녹인 마우스 및 이의 이용 방법
JP6654001B2 (ja) * 2015-05-27 2020-02-26 公益財団法人実験動物中央研究所 ヒトｉｌ−１５分泌免疫不全マウス
KR102664078B1 (ko) * 2015-06-23 2024-05-10 더 잭슨 래보라토리 환자-유래 이종이식을 가지는 hla-비매칭의 인간화된 nsg 마우스 모델
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CN103547148A (zh) * 2011-02-15 2014-01-29 再生元制药公司 人源化m-csf小鼠
WO2014039782A2 (en) * 2012-09-07 2014-03-13 Yale University Genetically modified non-human animals and methods of use thereof
WO2014071397A2 (en) * 2012-11-05 2014-05-08 Regeneron Pharmaceuticals Genetically modified non-human animals and methods of use thereof
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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111705082A (zh) * 2020-04-14 2020-09-25 澎立生物医药技术（上海）有限公司 具有髓系免疫细胞的人源化免疫系小鼠的构建方法
CN116322317A (zh) * 2020-07-08 2023-06-23 杰克逊实验室 表达人hla-a201限制基因的转基因小鼠模型
WO2022222958A1 (en) * 2021-04-20 2022-10-27 Biocytogen Pharmaceuticals (Beijing) Co., Ltd. Genetically modified non-human animal with human or chimeric genes
EP4453222A4 (en) * 2021-12-22 2025-12-17 Jackson Lab HUMANIZED MOUSE MODELS
WO2026001958A1 (zh) * 2024-06-24 2026-01-02 黄菁 Aav载体、aav载体的组合、构建aml pdx和mm pdx非人动物的方法及构建免疫系统人源化非人动物的方法

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WO2018102546A1 (en) 2018-06-07
US12409237B1 (en) 2025-09-09
US20260033467A1 (en) 2026-02-05
JP2023015064A (ja) 2023-01-31
JP7458185B2 (ja) 2024-03-29
WO2018102546A8 (en) 2018-08-02
EP3547831B1 (en) 2026-04-01
JP2019536457A (ja) 2019-12-19
US20190320633A1 (en) 2019-10-24
EP3547831A1 (en) 2019-10-09

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