SG176118A1 - Methods of producing humanized non-human mammals - Google Patents

Methods of producing humanized non-human mammals Download PDF

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Publication number
SG176118A1
SG176118A1 SG2011084647A SG2011084647A SG176118A1 SG 176118 A1 SG176118 A1 SG 176118A1 SG 2011084647 A SG2011084647 A SG 2011084647A SG 2011084647 A SG2011084647 A SG 2011084647A SG 176118 A1 SG176118 A1 SG 176118A1
Authority
SG
Singapore
Prior art keywords
human
cells
mammal
cytokines
human mammal
Prior art date
Application number
SG2011084647A
Other languages
English (en)
Inventor
Qingfeng Chen
Jianzhu Chen
Original Assignee
Qingfeng Chen
Jianzhu Chen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Qingfeng Chen, Jianzhu Chen filed Critical Qingfeng Chen
Publication of SG176118A1 publication Critical patent/SG176118A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2893—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD52
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/12—Animals modified by administration of exogenous cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0331—Animal model for proliferative diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0381—Animal model for diseases of the hematopoietic system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Environmental Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Husbandry (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Mycology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
SG2011084647A 2009-06-29 2010-06-28 Methods of producing humanized non-human mammals SG176118A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22143809P 2009-06-29 2009-06-29
PCT/US2010/040260 WO2011002727A1 (en) 2009-06-29 2010-06-28 Methods of producing humanized non-human mammals

Publications (1)

Publication Number Publication Date
SG176118A1 true SG176118A1 (en) 2011-12-29

Family

ID=43411395

Family Applications (2)

Application Number Title Priority Date Filing Date
SG2011084647A SG176118A1 (en) 2009-06-29 2010-06-28 Methods of producing humanized non-human mammals
SG10201403703XA SG10201403703XA (en) 2009-06-29 2010-06-28 Methods of producing humanized non-human mammals

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG10201403703XA SG10201403703XA (en) 2009-06-29 2010-06-28 Methods of producing humanized non-human mammals

Country Status (6)

Country Link
US (1) US20120157667A1 (https=)
EP (1) EP2449094A4 (https=)
JP (1) JP2012531896A (https=)
CN (1) CN102725400A (https=)
SG (2) SG176118A1 (https=)
WO (1) WO2011002727A1 (https=)

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PT2485583T (pt) 2009-10-06 2016-09-22 Univ Yale Ratinhos geneticamente modificados e enxerto
MX350385B (es) 2011-02-15 2017-09-04 Regeneron Pharma Ratones de m-csf humanizada.
WO2013086019A1 (en) * 2011-12-06 2013-06-13 Massachusetts Institute Of Technology Use of humanized mice to determine toxicity
CN103387955B (zh) * 2012-05-10 2015-04-29 上海南方模式生物科技发展有限公司 非人哺乳动物b淋巴细胞缺陷动物模型的制备方法及其用途
WO2014039733A1 (en) * 2012-09-05 2014-03-13 University Of Southern California Methods and compositions for detecting, imaging, and treating small cell lung cancer utilizing post-translationally modified residues and higher molecular weight antigenic complexes in proteins
IN2015DN02032A (https=) * 2012-09-07 2015-08-14 Univ Yale
CA2887706C (en) 2012-11-05 2022-08-02 Regeneron Pharmaceuticals Genetically modified non-human animals and methods of use thereof
WO2014121840A1 (en) * 2013-02-07 2014-08-14 Medizinische Hochschule Hannover Induced dendritic cells and uses thereof
US20160135437A1 (en) * 2013-06-05 2016-05-19 Agency For Science, Technology And Research Humanized mouse model for study of bona fide hepatitis virus infection and use thereof
NO2785538T3 (https=) * 2014-05-07 2018-08-04
SG10202002187WA (en) * 2014-05-19 2020-04-29 Regeneron Pharma Genetically modified non-human animals expressing human epo
KR102658190B1 (ko) 2015-04-13 2024-04-17 리제너론 파마슈티칼스 인코포레이티드 인간화된 sirpa-il15 녹인 마우스 및 이의 이용 방법
JP6654001B2 (ja) * 2015-05-27 2020-02-26 公益財団法人実験動物中央研究所 ヒトｉｌ−１５分泌免疫不全マウス
JP2019508014A (ja) * 2015-11-30 2019-03-28 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト 免疫不全の非ヒト宿主におけるヒトマクロファージの生成
CN111315881B (zh) * 2017-11-17 2023-10-10 国立大学法人筑波大学 非人类动物及其生产方法
CN111304248B (zh) 2018-12-25 2021-08-24 百奥赛图江苏基因生物技术有限公司 人源化细胞因子il15基因改造非人动物的构建方法及应用
CN111172190B (zh) * 2018-12-25 2021-07-30 百奥赛图江苏基因生物技术有限公司 人源化细胞因子csf2基因改造非人动物的构建方法及应用
US11419317B2 (en) 2019-01-28 2022-08-23 Central Institute For Experimental Animals Non-human animal having human IL-34 and use Thereof
US12378574B2 (en) 2019-02-13 2025-08-05 The Jackson Laboratory Transgenic mouse models supporting innate immune function
CN113614238B (zh) * 2019-03-28 2024-10-22 公益财团法人实中研 免疫缺陷小鼠
CN111485001A (zh) * 2020-04-14 2020-08-04 澎立生物医药技术（上海）有限公司 具有nk细胞及adcc能力的人源化免疫系统小鼠的构建方法
JP2023533979A (ja) * 2020-07-08 2023-08-07 ザ ジャクソン ラボラトリー ヒト自然免疫機能を支えるトランスジェニックマウスモデル
CN112042597B (zh) * 2020-07-22 2022-04-29 南京普恩瑞生物科技有限公司 一种双人源化肿瘤异种移植模型的构建方法
CN114853871B (zh) * 2021-04-20 2024-04-05 百奥赛图(北京)医药科技股份有限公司 Csf1和/或csf1r基因人源化的非人动物及其构建方法和应用

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Also Published As

Publication number Publication date
WO2011002727A1 (en) 2011-01-06
US20120157667A1 (en) 2012-06-21
EP2449094A4 (en) 2013-07-10
CN102725400A (zh) 2012-10-10
JP2012531896A (ja) 2012-12-13
WO2011002727A9 (en) 2011-02-24
SG10201403703XA (en) 2014-10-30
EP2449094A1 (en) 2012-05-09

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