JP2012530578A5 - - Google Patents

Info

Publication number

JP2012530578A5

JP2012530578A5 JP2012516738A JP2012516738A JP2012530578A5 JP 2012530578 A5 JP2012530578 A5 JP 2012530578A5 JP 2012516738 A JP2012516738 A JP 2012516738A JP 2012516738 A JP2012516738 A JP 2012516738A JP 2012530578 A5 JP2012530578 A5 JP 2012530578A5

Authority

JP

Japan

Prior art keywords

needle assembly

drug

cannula

assembly according

formulation

Prior art date

2010-06-24

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 238000002347 injection Methods 0.000 claims description 8
• 239000007924 injection Substances 0.000 claims description 8
• 239000003814 drug Substances 0.000 claims 12
• 238000009472 formulation Methods 0.000 claims 10
• 239000000203 mixture Substances 0.000 claims 10
• 239000003937 drug carrier Substances 0.000 claims 7
• 229940079593 drug Drugs 0.000 claims 6
• 238000012377 drug delivery Methods 0.000 claims 6
• 239000012669 liquid formulation Substances 0.000 claims 6
• 239000000546 pharmaceutical excipient Substances 0.000 claims 6
• 239000008186 active pharmaceutical agent Substances 0.000 claims 4
• 239000003795 chemical substances by application Substances 0.000 claims 4
• 229940088679 drug related substance Drugs 0.000 claims 4
• 239000007787 solid Substances 0.000 claims 4
• 238000001035 drying Methods 0.000 claims 3
• DTHNMHAUYICORS-KTKZVXAJSA-N Glucagon-like peptide 1 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 DTHNMHAUYICORS-KTKZVXAJSA-N 0.000 claims 2
• PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 2
• 238000004090 dissolution Methods 0.000 claims 2
• 239000002657 fibrous material Substances 0.000 claims 2
• 150000004676 glycans Chemical class 0.000 claims 2
• NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 2
• 239000007788 liquid Substances 0.000 claims 2
• 150000002482 oligosaccharides Polymers 0.000 claims 2
• 229920005862 polyol Polymers 0.000 claims 2
• 150000003077 polyols Chemical class 0.000 claims 2
• 229920001282 polysaccharide Polymers 0.000 claims 2
• 239000005017 polysaccharide Substances 0.000 claims 2
• 229920002307 Dextran Polymers 0.000 claims 1
• LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 1
• 102100025101 GATA-type zinc finger protein 1 Human genes 0.000 claims 1
• 101710198884 GATA-type zinc finger protein 1 Proteins 0.000 claims 1
• 102000004877 Insulin Human genes 0.000 claims 1
• 108090001061 Insulin Proteins 0.000 claims 1
• 239000012530 fluid Substances 0.000 claims 1
• 235000011187 glycerol Nutrition 0.000 claims 1
• 239000012510 hollow fiber Substances 0.000 claims 1
• 229940125396 insulin Drugs 0.000 claims 1
• FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 claims 1
• 229960003511 macrogol Drugs 0.000 claims 1
• 239000011148 porous material Substances 0.000 claims 1
• 239000008259 solid foam Substances 0.000 claims 1
• 238000004806 packaging method and process Methods 0.000 description 1