JP2012529451A5 - - Google Patents
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- Publication number
- JP2012529451A5 JP2012529451A5 JP2012514392A JP2012514392A JP2012529451A5 JP 2012529451 A5 JP2012529451 A5 JP 2012529451A5 JP 2012514392 A JP2012514392 A JP 2012514392A JP 2012514392 A JP2012514392 A JP 2012514392A JP 2012529451 A5 JP2012529451 A5 JP 2012529451A5
- Authority
- JP
- Japan
- Prior art keywords
- solid
- composition according
- solid composition
- fatty acid
- active ingredient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 239000007787 solid Substances 0.000 claims 22
- 239000008247 solid mixture Substances 0.000 claims 21
- 239000000126 substance Substances 0.000 claims 16
- 235000014113 dietary fatty acids Nutrition 0.000 claims 14
- 229930195729 fatty acid Natural products 0.000 claims 14
- 239000000194 fatty acid Substances 0.000 claims 14
- 150000004665 fatty acids Chemical class 0.000 claims 14
- 239000004480 active ingredient Substances 0.000 claims 11
- 239000003995 emulsifying agent Substances 0.000 claims 8
- 150000003626 triacylglycerols Chemical class 0.000 claims 8
- ZGXJTSGNIOSYLO-UHFFFAOYSA-N 88755TAZ87 Chemical compound NCC(=O)CCC(O)=O ZGXJTSGNIOSYLO-UHFFFAOYSA-N 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 6
- 206010028980 Neoplasm Diseases 0.000 claims 6
- 201000011510 cancer Diseases 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 6
- 210000003750 lower gastrointestinal tract Anatomy 0.000 claims 6
- 229940079593 drug Drugs 0.000 claims 5
- 125000000217 alkyl group Chemical group 0.000 claims 4
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims 4
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims 4
- DUXYWXYOBMKGIN-UHFFFAOYSA-N trimyristin Chemical compound CCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCC DUXYWXYOBMKGIN-UHFFFAOYSA-N 0.000 claims 4
- PVNIQBQSYATKKL-UHFFFAOYSA-N tripalmitin Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCC PVNIQBQSYATKKL-UHFFFAOYSA-N 0.000 claims 4
- DCXXMTOCNZCJGO-UHFFFAOYSA-N tristearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCC DCXXMTOCNZCJGO-UHFFFAOYSA-N 0.000 claims 4
- 239000000463 material Substances 0.000 claims 3
- -1 5-ALA ester Chemical class 0.000 claims 2
- 239000005635 Caprylic acid (CAS 124-07-2) Substances 0.000 claims 2
- 235000019482 Palm oil Nutrition 0.000 claims 2
- 239000002202 Polyethylene glycol Substances 0.000 claims 2
- 239000000853 adhesive Substances 0.000 claims 2
- 230000001070 adhesive effect Effects 0.000 claims 2
- 239000002738 chelating agent Substances 0.000 claims 2
- 229940110456 cocoa butter Drugs 0.000 claims 2
- 235000019868 cocoa butter Nutrition 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 238000013270 controlled release Methods 0.000 claims 2
- GHVNFZFCNZKVNT-UHFFFAOYSA-N decanoic acid Chemical compound CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 claims 2
- 238000003745 diagnosis Methods 0.000 claims 2
- 238000002405 diagnostic procedure Methods 0.000 claims 2
- 239000002702 enteric coating Substances 0.000 claims 2
- 238000009505 enteric coating Methods 0.000 claims 2
- 239000003925 fat Substances 0.000 claims 2
- 235000019197 fats Nutrition 0.000 claims 2
- 229940116364 hard fat Drugs 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 239000007788 liquid Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 125000001280 n-hexyl group Chemical group C(CCCCC)* 0.000 claims 2
- 229960002446 octanoic acid Drugs 0.000 claims 2
- 239000003921 oil Substances 0.000 claims 2
- 235000019198 oils Nutrition 0.000 claims 2
- 239000002540 palm oil Substances 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 239000003504 photosensitizing agent Substances 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- 239000002243 precursor Substances 0.000 claims 2
- 229940126589 solid medicine Drugs 0.000 claims 2
- 229940113164 trimyristin Drugs 0.000 claims 2
- 229960001947 tripalmitin Drugs 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- 239000005632 Capric acid (CAS 334-48-5) Substances 0.000 claims 1
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 claims 1
- 235000020661 alpha-linolenic acid Nutrition 0.000 claims 1
- 229960005150 glycerol Drugs 0.000 claims 1
- 229940049290 hydrogenated coco-glycerides Drugs 0.000 claims 1
- 239000012182 japan wax Substances 0.000 claims 1
- 229960004488 linolenic acid Drugs 0.000 claims 1
- KQQKGWQCNNTQJW-UHFFFAOYSA-N linolenic acid Natural products CC=CCCC=CCC=CCCCCCCCC(O)=O KQQKGWQCNNTQJW-UHFFFAOYSA-N 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000012875 nonionic emulsifier Substances 0.000 claims 1
- 239000000829 suppository Substances 0.000 claims 1
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 claims 1
- MAYCICSNZYXLHB-UHFFFAOYSA-N tricaproin Chemical compound CCCCCC(=O)OCC(OC(=O)CCCCC)COC(=O)CCCCC MAYCICSNZYXLHB-UHFFFAOYSA-N 0.000 claims 1
- 229940093609 tricaprylin Drugs 0.000 claims 1
- 125000005457 triglyceride group Chemical group 0.000 claims 1
- PJHKBYALYHRYSK-UHFFFAOYSA-N triheptanoin Chemical compound CCCCCCC(=O)OCC(OC(=O)CCCCCC)COC(=O)CCCCCC PJHKBYALYHRYSK-UHFFFAOYSA-N 0.000 claims 1
- 229940078561 triheptanoin Drugs 0.000 claims 1
- VLPFTAMPNXLGLX-UHFFFAOYSA-N trioctanoin Chemical compound CCCCCCCC(=O)OCC(OC(=O)CCCCCCC)COC(=O)CCCCCCC VLPFTAMPNXLGLX-UHFFFAOYSA-N 0.000 claims 1
- 239000001993 wax Substances 0.000 claims 1
- 239000002023 wood Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09251538 | 2009-06-11 | ||
| EP09251538.6 | 2009-06-11 | ||
| PCT/EP2010/003531 WO2010142456A1 (en) | 2009-06-11 | 2010-06-11 | Solid compositions comprising 5-aminolevulinic acid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012529451A JP2012529451A (ja) | 2012-11-22 |
| JP2012529451A5 true JP2012529451A5 (https=) | 2013-08-15 |
Family
ID=42628133
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012514392A Ceased JP2012529451A (ja) | 2009-06-11 | 2010-06-11 | ５−アミノレブリン酸を含む固体組成物 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20120134921A1 (https=) |
| EP (1) | EP2440188A1 (https=) |
| JP (1) | JP2012529451A (https=) |
| KR (1) | KR20140014401A (https=) |
| CN (1) | CN102802612A (https=) |
| AU (1) | AU2010257752B2 (https=) |
| BR (1) | BRPI1011650A2 (https=) |
| CA (1) | CA2763837A1 (https=) |
| CL (1) | CL2011003115A1 (https=) |
| CO (1) | CO6480960A2 (https=) |
| CR (1) | CR20110649A (https=) |
| MX (1) | MX2011013069A (https=) |
| NZ (1) | NZ596946A (https=) |
| PE (1) | PE20120858A1 (https=) |
| RU (1) | RU2527328C2 (https=) |
| SG (1) | SG176687A1 (https=) |
| WO (1) | WO2010142456A1 (https=) |
| ZA (1) | ZA201108850B (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2790827A1 (en) | 2010-03-01 | 2011-09-09 | Photocure Asa | Cosmetic compositions |
| DE102012105512A1 (de) * | 2012-06-25 | 2014-04-24 | Hennig Arzneimittel Gmbh & Co. Kg | Arzneiform zur verlängerten Freisetzung von Wirkstoffen |
| US20140067024A1 (en) | 2012-08-30 | 2014-03-06 | Photocure Asa | Dual panel photodynamic therapy lamp |
| GB201221123D0 (en) | 2012-11-23 | 2013-01-09 | Photocure As | Device for photodynamic treatment |
| AU2014248575A1 (en) * | 2013-03-12 | 2015-10-29 | Applied Bioresearch, Inc. | Chelation suppository for improved drug delivery |
| EP3181125B1 (en) * | 2014-07-31 | 2025-02-19 | Capsugel Belgium NV | Capsule formulation |
| JP6588193B2 (ja) * | 2014-07-31 | 2019-10-09 | カプスゲル・ベルギウム・ナムローゼ・フェンノートシャップＣａｐｓｕｇｅｌ Ｂｅｌｇｉｕｍ ＮＶ | カプセル製剤 |
| US11623008B2 (en) * | 2014-08-20 | 2023-04-11 | Professional Compounding Centers Of America | Excipient compositions for mucoadhesive pharmaceutical compositions including a synergistic combination of amylopectin, pullulan, hyaluronic acid, and xyloglucan |
| US9956426B2 (en) | 2015-02-26 | 2018-05-01 | Amol Punjabi | Upconverting nanoparticles |
| BR112018011965A2 (pt) | 2015-12-17 | 2018-12-04 | Photocure Asa | método de terapia fotodinâmica (pdt) para câncer de bexiga |
| CN105481946B (zh) * | 2015-12-18 | 2019-05-21 | 浙江工商大学 | 5-氨基酮戊酸与3-羟基吡啶-4-酮的缀合物及其制备法和用途 |
| GB201522398D0 (en) | 2015-12-18 | 2016-02-03 | Photocure As | Device for photodynamic therapy |
| US10744212B2 (en) * | 2016-03-14 | 2020-08-18 | General Electric Company | Topical application of nerve labeling dyes for image-guided surgery |
| GB2546128A (en) * | 2016-09-28 | 2017-07-12 | Photocure Asa | Pharamaceutical compositions comprising hexaminolevulinic acid and methods of using the same |
| EP3612570A4 (en) | 2017-04-17 | 2021-01-13 | The University of Chicago | POLYMERIC MATERIALS FOR THE ADMINISTRATION OF SHORT-CHAIN FATTY ACIDS TO THE INTESTINE FOR HUMAN HEALTH AND DISEASE TREATMENT APPLICATIONS |
| CN107434753A (zh) * | 2017-07-26 | 2017-12-05 | 南京大学 | 5‑氨基乙酰丙酸及其衍生物的泡腾片及其制备方法 |
| US11266619B2 (en) | 2017-12-01 | 2022-03-08 | Sbi Pharmaceuticals Co., Ltd. | Pharmaceutical composition for enhancing antitumor effect by immune checkpoint inhibitor |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3181062B2 (ja) * | 1991-01-31 | 2001-07-03 | 帝國製薬株式会社 | 下部消化管崩壊経口製剤 |
| ATE202076T1 (de) * | 1995-03-10 | 2001-06-15 | Photocure Asa | Ester der 5-aminolevulinsäure als mittel zur photosensibilisierung in der chemotherapie |
| US6492420B2 (en) * | 1995-03-10 | 2002-12-10 | Photocure As | Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy |
| EP2127642A3 (en) * | 1998-08-13 | 2010-02-24 | Cima Labs, Inc. | Microemulsions as solid dosage forms for oral administration |
| CA2376261A1 (en) * | 1999-06-09 | 2000-12-14 | Mochida Pharmaceutical Co., Ltd. | System for release in lower gastrointestinal tract |
| DE10003620A1 (de) * | 2000-01-28 | 2001-08-02 | Asat Ag Applied Science & Tech | 5-Aminolävulinsäure-Formulierung in nichtwässrigen Lösungsmitteln |
| GB0018527D0 (en) * | 2000-07-27 | 2000-09-13 | Photocure Asa | Composition |
| GB0018528D0 (en) * | 2000-07-27 | 2000-09-13 | Photocure Asa | Compounds |
| US8101209B2 (en) * | 2001-10-09 | 2012-01-24 | Flamel Technologies | Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles |
| US7264629B2 (en) * | 2001-11-09 | 2007-09-04 | Qlt, Inc. | Photodynamic therapy for the treatment of hair loss |
| TW577606U (en) * | 2001-11-20 | 2004-02-21 | Carry Computer Eng Co Ltd | Improved structure of all-in-one silicon disk |
| DE102005019628A1 (de) * | 2005-04-26 | 2006-11-09 | Technische Universität Braunschweig | Formulierung zur dermalen Anwendung |
| GB0609809D0 (en) * | 2006-05-17 | 2006-06-28 | Photocure Asa | Product |
| GB0724279D0 (en) * | 2007-12-12 | 2008-01-23 | Photocure Asa | Use |
-
2010
- 2010-06-11 JP JP2012514392A patent/JP2012529451A/ja not_active Ceased
- 2010-06-11 BR BRPI1011650A patent/BRPI1011650A2/pt not_active IP Right Cessation
- 2010-06-11 SG SG2011090040A patent/SG176687A1/en unknown
- 2010-06-11 US US13/377,692 patent/US20120134921A1/en not_active Abandoned
- 2010-06-11 MX MX2011013069A patent/MX2011013069A/es not_active Application Discontinuation
- 2010-06-11 EP EP10725043A patent/EP2440188A1/en not_active Withdrawn
- 2010-06-11 CN CN2010800256075A patent/CN102802612A/zh active Pending
- 2010-06-11 CA CA2763837A patent/CA2763837A1/en not_active Abandoned
- 2010-06-11 WO PCT/EP2010/003531 patent/WO2010142456A1/en not_active Ceased
- 2010-06-11 PE PE2011002072A patent/PE20120858A1/es not_active Application Discontinuation
- 2010-06-11 AU AU2010257752A patent/AU2010257752B2/en not_active Expired - Fee Related
- 2010-06-11 KR KR1020117030694A patent/KR20140014401A/ko not_active Withdrawn
- 2010-06-11 NZ NZ596946A patent/NZ596946A/en not_active IP Right Cessation
- 2010-06-11 RU RU2011150920/15A patent/RU2527328C2/ru not_active IP Right Cessation
-
2011
- 2011-12-01 ZA ZA2011/08850A patent/ZA201108850B/en unknown
- 2011-12-05 CR CR20110649A patent/CR20110649A/es unknown
- 2011-12-07 CL CL2011003115A patent/CL2011003115A1/es unknown
- 2011-12-27 CO CO11179486A patent/CO6480960A2/es not_active Application Discontinuation
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