JP2012529298A5 - - Google Patents
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- JP2012529298A5 JP2012529298A5 JP2012515109A JP2012515109A JP2012529298A5 JP 2012529298 A5 JP2012529298 A5 JP 2012529298A5 JP 2012515109 A JP2012515109 A JP 2012515109A JP 2012515109 A JP2012515109 A JP 2012515109A JP 2012529298 A5 JP2012529298 A5 JP 2012529298A5
- Authority
- JP
- Japan
- Prior art keywords
- loop
- antigen
- domain
- recombinant
- domain monomer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000178 monomer Substances 0.000 claims 27
- 239000000427 antigen Substances 0.000 claims 20
- 102000036639 antigens Human genes 0.000 claims 20
- 108091007433 antigens Proteins 0.000 claims 20
- 241001263478 Norovirus Species 0.000 claims 6
- 239000002245 particle Substances 0.000 claims 5
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 4
- 229920001184 polypeptide Polymers 0.000 claims 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims 4
- 235000018102 proteins Nutrition 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 3
- 229940079593 drug Drugs 0.000 claims 3
- 239000003446 ligand Substances 0.000 claims 3
- 241000702670 Rotavirus Species 0.000 claims 2
- 210000000056 organ Anatomy 0.000 claims 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 1
- 239000004472 Lysine Substances 0.000 claims 1
- 235000001014 amino acid Nutrition 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 235000018417 cysteine Nutrition 0.000 claims 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 238000012377 drug delivery Methods 0.000 claims 1
- 230000003053 immunization Effects 0.000 claims 1
- 238000002649 immunization Methods 0.000 claims 1
- 230000002163 immunogen Effects 0.000 claims 1
- 230000005847 immunogenicity Effects 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- 238000012986 modification Methods 0.000 claims 1
- 125000006850 spacer group Chemical group 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 230000008685 targeting Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18556409P | 2009-06-09 | 2009-06-09 | |
| US61/185,564 | 2009-06-09 | ||
| US22469609P | 2009-07-10 | 2009-07-10 | |
| US61/224,696 | 2009-07-10 | ||
| PCT/US2010/038008 WO2010144602A2 (en) | 2009-06-09 | 2010-06-09 | Antigen-norovirus p-domain monomers and dimers, antigen-norovirus p-particle molecules, and methods for their making and use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012529298A JP2012529298A (ja) | 2012-11-22 |
| JP2012529298A5 true JP2012529298A5 (https=) | 2013-07-25 |
| JP5894528B2 JP5894528B2 (ja) | 2016-03-30 |
Family
ID=43309459
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012515109A Active JP5894528B2 (ja) | 2009-06-09 | 2010-06-09 | 抗原−ノロウイルスｐドメインモノマーおよびダイマー、抗原−ノロウイルスｐ粒子分子、ならびにそれらの製造および使用法 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US8486421B2 (https=) |
| EP (1) | EP2440582B1 (https=) |
| JP (1) | JP5894528B2 (https=) |
| CN (2) | CN107043408B (https=) |
| WO (1) | WO2010144602A2 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8486421B2 (en) | 2009-06-09 | 2013-07-16 | Children's Hospital Medical Center | Antigen-norovirus P-domain monomers and dimers, antigen-norovirus P-particle molecules, and methods for their making and use |
| CA2787666A1 (en) * | 2010-01-21 | 2011-07-28 | Ligocyte Pharmaceuticals, Inc. | Targeted heterologous antigen presentation on calicivirus virus-like particles |
| FI122520B (fi) * | 2010-10-15 | 2012-03-15 | Vesna Blazevic | Noroviruksen kapsidi ja rotaviruksen VP6-proteiini käytettäväksi yhdistelmärokotteena |
| US9562077B2 (en) * | 2012-07-11 | 2017-02-07 | Children's Hospital Medical Center | Protein complex system for increased immunogenicity and functionality, and methods making and use |
| CN103304642B (zh) * | 2013-06-06 | 2015-01-07 | 黑龙江八一农垦大学 | 猪轮状病毒δvp8*亚单位重组蛋白及其应用 |
| US9321803B2 (en) | 2013-07-12 | 2016-04-26 | Children's Hospital Medical Center | Compositions and methods for inhibiting norovirus infection |
| CN107034198B (zh) * | 2015-07-15 | 2021-03-09 | 长春百克生物科技股份公司 | 一种嵌合诺如病毒p颗粒及其制备和应用 |
| CN106220738A (zh) * | 2016-07-31 | 2016-12-14 | 中国医学科学院医学生物学研究所 | Ev71中和抗原表位与诺如病毒p结构域嵌合载体的构建和表达方法 |
| EP3600397A4 (en) | 2017-03-28 | 2021-01-27 | Children's Hospital Medical Center | NOROVIRUS PARTICLE VACCINES AND THEIR MANUFACTURING AND USE PROCEDURES |
| WO2020014654A1 (en) * | 2018-07-13 | 2020-01-16 | The Trustees Of Indiana University | Recombinant rotavirus expression system and recombinant rotaviruses |
| JP7190674B2 (ja) * | 2018-08-23 | 2022-12-16 | パナソニックＩｐマネジメント株式会社 | ノロウイルスに結合する抗体、複合体、それを用いた検出装置及び検出方法 |
| WO2021140524A1 (en) * | 2020-01-08 | 2021-07-15 | Bharat Biotech International Limited | Viral vaccine compositions and methods of preparations thereof |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4550019A (en) | 1978-03-22 | 1985-10-29 | South Africa Inventions Development Corporation | Manufacture and use of fowl egg antibodies |
| US4769238A (en) * | 1981-08-04 | 1988-09-06 | The Regents Of The University Of California | Synthesis of human virus antigens by yeast |
| US4916213A (en) | 1983-02-22 | 1990-04-10 | Xoma Corporation | Ribosomal inhibiting protein-immunoglobulin conjugates with specificity for tumor cell surface antigens, and mixtures thereof |
| US4547367A (en) * | 1983-12-20 | 1985-10-15 | The United States Of America As Represented By The Department Of Health And Human Services | Hepatitis B core antigen vaccine |
| US5643579A (en) | 1984-11-01 | 1997-07-01 | American Home Products Corporation | Oral vaccines |
| US5338689A (en) | 1987-08-24 | 1994-08-16 | Stiftung Fur Diagnostische Forschung | Method and card for detecting antigens and/or antibodies |
| ZA896668B (en) | 1988-09-01 | 1990-06-27 | Molecular Therapeutics Inc | A human rhinovirus receptor protein that inhibits virus infectivity |
| US5068191A (en) | 1989-08-31 | 1991-11-26 | The Biomembrane Institute | Purified histo-blood group a glycosyltransferase and antibodies thereto |
| JP3310281B2 (ja) * | 1989-11-08 | 2002-08-05 | ベイラー カレッジ オブ メディシン | ノーワーク及び関連のウィルスを検出し同定するための方法と試薬 |
| US6572862B1 (en) * | 1989-11-08 | 2003-06-03 | Baylor College Of Medicine | Methods and reagents to detect and characterize Norwalk and related viruses |
| CA2029219A1 (en) * | 1989-11-08 | 1991-05-09 | Mary K. Estes | Methods and reagents to detect and characterize norwalk and related viruses |
| FR2677767B1 (fr) | 1991-06-11 | 1994-10-14 | Biotechnologie Ste Europeenne | Procede de detection de l'infection par le virus de la diarrhee bovine, sequence nucleotidique codant pour une proteine induite par l'infection par ce virus et proteines et antigenes recombinants s'y rapportant . |
| DK0590060T3 (da) | 1991-06-21 | 1998-05-11 | Univ Cincinnati | Oralt indgivelige terapeutiske proteiner samt fremgangsmåde til fremstilling |
| US5254342A (en) | 1991-09-30 | 1993-10-19 | University Of Southern California | Compositions and methods for enhanced transepithelial and transendothelial transport or active agents |
| WO1993019660A1 (en) | 1992-04-03 | 1993-10-14 | Baylor College Of Medicine | Gene therapy using the intestine |
| US5374532A (en) | 1992-08-31 | 1994-12-20 | The Biomembrane Institute | Method for determining susceptibility to escherichia coli urinary tract infections and method for diagnosing secretors and nonsecretors |
| US5367054A (en) | 1993-04-12 | 1994-11-22 | Stolle Research & Development Corp. | Large-scale purification of egg immunoglobulin |
| DE4335025A1 (de) | 1993-10-14 | 1995-04-20 | Boehringer Ingelheim Int | Endosomolytisch wirksame Partikel |
| US5750394A (en) | 1994-05-20 | 1998-05-12 | The Mount Sinai Medical Center | Identification and use of antiviral compounds that inhibit interaction of host cell proteins and viral proteins required for viral replication |
| US6300090B1 (en) | 1994-07-29 | 2001-10-09 | The Rockefeller University | Methods of use of viral vectors to deliver antigen to dendritic cells |
| US5861241A (en) * | 1995-08-16 | 1999-01-19 | University Of Massachusetts | Monoclonal antibodies for detecting Norwalk virus |
| EP0845995A1 (en) | 1995-08-18 | 1998-06-10 | Dr. Rentschler Biotechnologie GmbH | Pharmaceutical compositions for competitively inhibiting the binding of a retrovirus to the ifn-receptor and means for diagnosis of an hiv infection |
| US5891862A (en) | 1996-03-15 | 1999-04-06 | Geltex Pharmaceuticals, Inc. | Polyvalent polymers for the treatment of rotavirus infection |
| IL118625A0 (en) | 1996-06-11 | 1996-10-16 | Xtl Biopharmaceuticals Limited | Anti HBV antibodies |
| US6225290B1 (en) | 1996-09-19 | 2001-05-01 | The Regents Of The University Of California | Systemic gene therapy by intestinal cell transformation |
| US6045854A (en) | 1997-03-31 | 2000-04-04 | Abbott Laboraties | Nutritional formulations containing oligosaccharides |
| US20020019991A1 (en) | 1998-04-30 | 2002-02-14 | Abbott Laboratories | Compositions containing an alpha 1,2-fucose linkage and uses thereof |
| US6593080B1 (en) * | 1999-02-01 | 2003-07-15 | The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University | Diagnosis, prevention and treatment of calicivirus infection in humans |
| DE19963859A1 (de) | 1999-12-30 | 2001-07-12 | Apotech Res & Dev Ltd | Bi- oder Oligomer eines Di-, Tri-, Quattro- oder Pentamers von rekombinanten Fusionsproteinen |
| CN1330080A (zh) * | 2000-06-19 | 2002-01-09 | 上海博德基因开发有限公司 | 一种新的多肽——人含p结构域的蛋白10和编码这种多肽的多核苷酸 |
| US6946266B2 (en) | 2000-12-20 | 2005-09-20 | Fred Hutchinson Cancer Research Center | Gene transfer in chicken bursal stem cells |
| JP2004534088A (ja) | 2001-07-06 | 2004-11-11 | スローン−ケッタリング・インスティテュート・フォア・キャンサー・リサーチ | 癌のための多価コンジュゲートワクチン |
| US7977098B2 (en) * | 2002-05-31 | 2011-07-12 | Children's Hospital Medical Center | Antigenic binding patterns of norovirus to human histo-blood group antigens |
| WO2003101176A2 (en) | 2002-05-31 | 2003-12-11 | Children's Hospital Medical Center | Method, composition and kit for antigenic binding of norwalk-like viruses |
| US7785871B2 (en) * | 2002-10-09 | 2010-08-31 | Intrexon Corporation | DNA cloning vector plasmids and methods for their use |
| US20080050808A1 (en) | 2002-10-09 | 2008-02-28 | Reed Thomas D | DNA modular cloning vector plasmids and methods for their use |
| EP1642475B1 (en) | 2003-07-03 | 2015-08-26 | Sung-Chul Sohn | System and method for zone-based personalized information providing |
| US20070280949A1 (en) | 2003-07-10 | 2007-12-06 | Michelle Alfa | Combination Therapy for Gastroenteric Diseases Caused by Microorganisms |
| WO2005032457A2 (en) | 2003-07-21 | 2005-04-14 | Boyce Thompson Institute For Plant Research, Inc. | Vectors and methods for immunization against norwalk virus using transgenic plants |
| JP2007537137A (ja) * | 2003-09-24 | 2007-12-20 | モンタナ ステート ユニバーシティ | ノロウィルスモノクローナル抗体及びペプチド |
| WO2006138514A2 (en) | 2005-06-16 | 2006-12-28 | Children's Hospital Medical Center | Novel norovirus particle for use as an antiviral or vaccine |
| US20070231320A1 (en) | 2006-04-03 | 2007-10-04 | Cook Mark E | Eggs having increased antibody titer and methods for making same |
| US20110152263A1 (en) | 2006-11-16 | 2011-06-23 | Xi Jiang | Composition and method for inhibiting norovirus infection |
| US8475789B2 (en) | 2008-01-22 | 2013-07-02 | Multimerics Aps | Products and methods to prevent infections |
| ATE531570T1 (de) | 2009-01-14 | 2011-11-15 | Magna Auteca Ag | Antrieb für ein zu verstellendes bauteil |
| US8486421B2 (en) | 2009-06-09 | 2013-07-16 | Children's Hospital Medical Center | Antigen-norovirus P-domain monomers and dimers, antigen-norovirus P-particle molecules, and methods for their making and use |
-
2010
- 2010-06-09 US US12/797,396 patent/US8486421B2/en active Active
- 2010-06-09 CN CN201710198133.8A patent/CN107043408B/zh active Active
- 2010-06-09 JP JP2012515109A patent/JP5894528B2/ja active Active
- 2010-06-09 WO PCT/US2010/038008 patent/WO2010144602A2/en not_active Ceased
- 2010-06-09 CN CN2010800353022A patent/CN102612525A/zh active Pending
- 2010-06-09 EP EP10786797.0A patent/EP2440582B1/en active Active
-
2013
- 2013-06-24 US US13/924,906 patent/US9096644B2/en active Active
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