JP2012528867A5 - - Google Patents
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- JP2012528867A5 JP2012528867A5 JP2012514047A JP2012514047A JP2012528867A5 JP 2012528867 A5 JP2012528867 A5 JP 2012528867A5 JP 2012514047 A JP2012514047 A JP 2012514047A JP 2012514047 A JP2012514047 A JP 2012514047A JP 2012528867 A5 JP2012528867 A5 JP 2012528867A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- nucleotide
- guanosine
- deaza
- cytosine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18292809P | 2009-06-01 | 2009-06-01 | |
| US61/182,928 | 2009-06-01 | ||
| PCT/US2010/036923 WO2010141483A2 (en) | 2009-06-01 | 2010-06-01 | Potentiation of autoimmune and inflammatory disease treatments by immune regulatory oligonucleotide (iro) antagonists of tlr7 and tlr9 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012528867A JP2012528867A (ja) | 2012-11-15 |
| JP2012528867A5 true JP2012528867A5 (https=) | 2017-09-07 |
| JP6275380B2 JP6275380B2 (ja) | 2018-02-07 |
Family
ID=43298446
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012514047A Expired - Fee Related JP6275380B2 (ja) | 2009-06-01 | 2010-06-01 | Ｔｌｒ７およびｔｌｒ９の免疫調節オリゴヌクレオチド（ｉｒｏ）アンタゴニストによる自己免疫および炎症性疾患治療の強化 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8987221B2 (https=) |
| EP (1) | EP2437791B1 (https=) |
| JP (1) | JP6275380B2 (https=) |
| CN (1) | CN102612561A (https=) |
| CA (1) | CA2762206C (https=) |
| ES (1) | ES2624767T3 (https=) |
| WO (1) | WO2010141483A2 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100233270A1 (en) | 2009-01-08 | 2010-09-16 | Northwestern University | Delivery of Oligonucleotide-Functionalized Nanoparticles |
| JP5813778B2 (ja) | 2010-11-19 | 2015-11-17 | イデラ ファーマシューティカルズ インコーポレイテッドＩｄｅｒａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | トール様受容体に基づく免疫反応を調節するための免疫調節オリゴヌクレオチド（ｉｒｏ）化合物 |
| US20130096938A1 (en) * | 2011-10-10 | 2013-04-18 | Abbott Biotechnology Ltd. | Managing healthcare services |
| WO2013177367A2 (en) | 2012-05-23 | 2013-11-28 | The Johns Hopkins University | Compounds and methods of use thereof for treating neurodegenerative disorders |
| RU2015120365A (ru) * | 2012-11-29 | 2017-01-10 | ЭсБиАй БАЙОТЕК. КО., ЛТД. | Ингибирующие олигонуклеотиды и их применение |
| JP6385957B2 (ja) * | 2013-01-08 | 2018-09-05 | イデラ ファーマシューティカルズ インコーポレイテッドＩｄｅｒａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | トール様受容体に基づく免疫応答を調節するための免疫調節オリゴヌクレオチド（ｉｒｏ）化合物 |
| EP2754714A1 (en) * | 2013-01-14 | 2014-07-16 | Sarepta Therapeutics, Inc. | Inhibitory oligonucleotides and their use in therapy |
| US11213593B2 (en) | 2014-11-21 | 2022-01-04 | Northwestern University | Sequence-specific cellular uptake of spherical nucleic acid nanoparticle conjugates |
| WO2017173334A1 (en) | 2016-04-01 | 2017-10-05 | Checkmate Pharmaceuticals, Inc. | Fc receptor-mediated drug delivery |
| JP7034951B2 (ja) | 2016-06-08 | 2022-03-14 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 操作されたウイルスベクターは炎症および免疫応答の誘導を低減する |
| WO2018039629A2 (en) | 2016-08-25 | 2018-03-01 | Northwestern University | Micellar spherical nucleic acids from thermoresponsive, traceless templates |
| WO2018209270A1 (en) | 2017-05-11 | 2018-11-15 | Northwestern University | Adoptive cell therapy using spherical nucleic acids (snas) |
| JP2021502381A (ja) | 2017-11-08 | 2021-01-28 | プレジデント アンド フェローズ オブ ハーバード カレッジ | ウイルスベクター誘発性炎症反応を阻害するための組成物および方法 |
| WO2019160866A2 (en) | 2018-02-13 | 2019-08-22 | Checkmate Pharmaceuticals, Inc. | Compositions and methods for tumor immunotherapy |
| BR112020020479A2 (pt) | 2018-04-09 | 2021-01-12 | Checkmate Pharmaceuticals | Empacotamento de oligonucleotídeos em partículas similares a vírus |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5399676A (en) * | 1989-10-23 | 1995-03-21 | Gilead Sciences | Oligonucleotides with inverted polarity |
| US6096722A (en) * | 1990-08-14 | 2000-08-01 | Isis Pharmaceuticals Inc. | Antisense modulation of cell adhesion molecule expression and treatment of cell adhesion molecule-associated diseases |
| US7276489B2 (en) * | 2002-10-24 | 2007-10-02 | Idera Pharmaceuticals, Inc. | Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5′ ends |
| US7973016B2 (en) * | 2004-01-23 | 2011-07-05 | Joslin Diebetes Center | Methods of treating, reducing, or preventing autoimmune conditions |
| WO2007038720A2 (en) * | 2005-09-27 | 2007-04-05 | Coley Pharmaceutical Gmbh | Modulation of tlr-mediated immune responses using adaptor oligonucleotides |
| US8383598B2 (en) * | 2005-10-12 | 2013-02-26 | Idera Pharmaceuticals, Inc. | Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response |
| EP2982679A1 (en) * | 2005-10-12 | 2016-02-10 | Idera Pharmaceuticals, Inc. | Immune regulatory oligonucleotide (iro) compounds to modulate toll-like receptor based immune response |
| US8426375B2 (en) * | 2005-10-12 | 2013-04-23 | Idera Pharmaceuticals, Inc. | Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response |
| ES2478012T3 (es) | 2008-08-06 | 2014-07-18 | Changchun Huapu Biotechnology Co., Ltd. | Oligonucleótidos y uso de los mismos |
-
2010
- 2010-06-01 ES ES10783933.4T patent/ES2624767T3/es active Active
- 2010-06-01 US US12/791,636 patent/US8987221B2/en active Active
- 2010-06-01 CA CA2762206A patent/CA2762206C/en active Active
- 2010-06-01 EP EP10783933.4A patent/EP2437791B1/en not_active Not-in-force
- 2010-06-01 WO PCT/US2010/036923 patent/WO2010141483A2/en not_active Ceased
- 2010-06-01 JP JP2012514047A patent/JP6275380B2/ja not_active Expired - Fee Related
- 2010-06-01 CN CN2010800243380A patent/CN102612561A/zh active Pending
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