CA2762206C - Potentiation of autoimmune and inflammatory disease treatments by immune regulatory oligonucleotide (iro) antagonists of tlr7 and tlr9 - Google Patents

Potentiation of autoimmune and inflammatory disease treatments by immune regulatory oligonucleotide (iro) antagonists of tlr7 and tlr9 Download PDF

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CA2762206C
CA2762206C CA2762206A CA2762206A CA2762206C CA 2762206 C CA2762206 C CA 2762206C CA 2762206 A CA2762206 A CA 2762206A CA 2762206 A CA2762206 A CA 2762206A CA 2762206 C CA2762206 C CA 2762206C
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nucleotide
substituted
seq
iro
tnf
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CA2762206A1 (en
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Fu-Gang Zhu
Ekambar R. Kandimalla
Sudhir Agrawal
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Aceragen Inc
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Idera Pharmaceuticals Inc
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA2762206A 2009-06-01 2010-06-01 Potentiation of autoimmune and inflammatory disease treatments by immune regulatory oligonucleotide (iro) antagonists of tlr7 and tlr9 Active CA2762206C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18292809P 2009-06-01 2009-06-01
US61/182,928 2009-06-01
PCT/US2010/036923 WO2010141483A2 (en) 2009-06-01 2010-06-01 Potentiation of autoimmune and inflammatory disease treatments by immune regulatory oligonucleotide (iro) antagonists of tlr7 and tlr9

Publications (2)

Publication Number Publication Date
CA2762206A1 CA2762206A1 (en) 2010-12-09
CA2762206C true CA2762206C (en) 2017-06-27

Family

ID=43298446

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CA2762206A Active CA2762206C (en) 2009-06-01 2010-06-01 Potentiation of autoimmune and inflammatory disease treatments by immune regulatory oligonucleotide (iro) antagonists of tlr7 and tlr9

Country Status (7)

Country Link
US (1) US8987221B2 (https=)
EP (1) EP2437791B1 (https=)
JP (1) JP6275380B2 (https=)
CN (1) CN102612561A (https=)
CA (1) CA2762206C (https=)
ES (1) ES2624767T3 (https=)
WO (1) WO2010141483A2 (https=)

Families Citing this family (15)

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US20100233270A1 (en) 2009-01-08 2010-09-16 Northwestern University Delivery of Oligonucleotide-Functionalized Nanoparticles
KR101985382B1 (ko) 2010-11-19 2019-06-03 이데라 파마슈티칼즈, 인코포레이티드 톨-유사 수용체 기반 면역 반응을 조절하기 위한 면역 조절 올리고뉴클레오타이드(ｉｒｏ) 화합물
US20130096938A1 (en) * 2011-10-10 2013-04-18 Abbott Biotechnology Ltd. Managing healthcare services
WO2013177367A2 (en) 2012-05-23 2013-11-28 The Johns Hopkins University Compounds and methods of use thereof for treating neurodegenerative disorders
KR102027023B1 (ko) 2012-11-29 2019-09-30 에스비아이 바이오테크 가부시키가이샤 저해성 올리고뉴클레오티드 및 그의 용도
KR101898177B1 (ko) * 2013-01-08 2018-09-12 이데라 파마슈티칼즈, 인코포레이티드 톨－유사 수용체 기반 면역 반응을 조절하기 위한 면역 조절 올리고누클레오티드 （ｉｒｏ） 화합물
EP2754714A1 (en) * 2013-01-14 2014-07-16 Sarepta Therapeutics, Inc. Inhibitory oligonucleotides and their use in therapy
KR20170078843A (ko) 2014-11-21 2017-07-07 노오쓰웨스턴 유니버시티 구형 핵산 나노입자 접합체의 서열 특이적 세포 흡수
WO2017173334A1 (en) 2016-04-01 2017-10-05 Checkmate Pharmaceuticals, Inc. Fc receptor-mediated drug delivery
US11339396B2 (en) 2016-06-08 2022-05-24 President And Fellows Of Harvard College Engineered viral vector reduces induction of inflammatory and immune responses
US11364304B2 (en) 2016-08-25 2022-06-21 Northwestern University Crosslinked micellar spherical nucleic acids
WO2018209270A1 (en) 2017-05-11 2018-11-15 Northwestern University Adoptive cell therapy using spherical nucleic acids (snas)
AU2018364542A1 (en) 2017-11-08 2020-04-16 President And Fellows Of Harvard College Compositions and methods for inhibiting viral vector-induced inflammatory responses
US12246031B2 (en) 2018-02-13 2025-03-11 Checkmate Pharmaceuticals, Inc. Compositions and methods for tumor immunotherapy
KR102890791B1 (ko) 2018-04-09 2025-11-24 체크메이트 파마슈티칼스, 인크. 바이러스-유사 입자 내로의 올리고뉴클레오타이드의 포장

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US5399676A (en) * 1989-10-23 1995-03-21 Gilead Sciences Oligonucleotides with inverted polarity
US6096722A (en) * 1990-08-14 2000-08-01 Isis Pharmaceuticals Inc. Antisense modulation of cell adhesion molecule expression and treatment of cell adhesion molecule-associated diseases
US7276489B2 (en) * 2002-10-24 2007-10-02 Idera Pharmaceuticals, Inc. Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5′ ends
WO2005072290A2 (en) * 2004-01-23 2005-08-11 Joslin Diabetes Center Methods of treating, reducing, or preventing autoimmune conditions
KR20080059595A (ko) * 2005-09-27 2008-06-30 콜리 파마슈티칼 게엠베하 어댑터 올리고뉴클레오티드를 사용하는 ｔｌｒ-매개 면역반응의 조절
US8426375B2 (en) * 2005-10-12 2013-04-23 Idera Pharmaceuticals, Inc. Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response
ES2544877T3 (es) * 2005-10-12 2015-09-04 Idera Pharmaceuticals Compuestos oligonucleótidos inmuno reguladores (IRO) para modular la respuesta inmune basada en receptor semejante a Toll
US8383598B2 (en) * 2005-10-12 2013-02-26 Idera Pharmaceuticals, Inc. Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response
PL2154144T3 (pl) * 2008-08-06 2015-04-30 Changchun Huapu Biotechnology Co Ltd Oligonukleotydy i ich zastosowanie

Also Published As

Publication number Publication date
WO2010141483A2 (en) 2010-12-09
EP2437791B1 (en) 2017-03-22
US20110171209A1 (en) 2011-07-14
JP6275380B2 (ja) 2018-02-07
JP2012528867A (ja) 2012-11-15
ES2624767T3 (es) 2017-07-17
CN102612561A (zh) 2012-07-25
CA2762206A1 (en) 2010-12-09
WO2010141483A3 (en) 2012-03-01
US8987221B2 (en) 2015-03-24
EP2437791A2 (en) 2012-04-11

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