JP2012528624A - 薬物送達デバイス用の駆動機構 - Google Patents
薬物送達デバイス用の駆動機構 Download PDFInfo
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- JP2012528624A JP2012528624A JP2012513565A JP2012513565A JP2012528624A JP 2012528624 A JP2012528624 A JP 2012528624A JP 2012513565 A JP2012513565 A JP 2012513565A JP 2012513565 A JP2012513565 A JP 2012513565A JP 2012528624 A JP2012528624 A JP 2012528624A
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- A61M5/31548—Mechanically operated dose setting member
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- A61M5/31551—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe including axial movement of dose setting member
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- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31545—Setting modes for dosing
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- A61M5/31556—Accuracy improving means
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-
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- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
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- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31566—Means improving security or handling thereof
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-
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- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
- A61M5/31583—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
- A61M5/31585—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod performed by axially moving actuator, e.g. an injection button
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- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
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- A61M2005/2403—Ampoule inserted into the ampoule holder
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- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
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- A61M2005/3125—Details specific display means, e.g. to indicate dose setting
- A61M2005/3126—Specific display means related to dosing
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- A—HUMAN NECESSITIES
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
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- A—HUMAN NECESSITIES
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
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- A61M2205/582—Means for facilitating use, e.g. by people with impaired vision by tactile feedback
-
- A—HUMAN NECESSITIES
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- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
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- A—HUMAN NECESSITIES
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
- A61M5/31541—Means preventing setting of a dose beyond the amount remaining in the cartridge
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Abstract
【選択図】図4
Description
ここで一実施態様において、薬学的に活性な化合物は、最大で1500Daまでの分子量を有し、及び/又は、ペプチド、蛋白質、多糖類、ワクチン、DNA、RNA、抗体、酵素、抗体、ホルモン若しくはオリゴヌクレオチド、又は上述の薬学的に活性な化合物の混合物であり、
ここで、更なる実施態様において、薬学的に活性な化合物は、糖尿病、又は糖尿病性網膜症などの糖尿病関連の合併症、深部静脈又は肺血栓塞栓症などの血栓塞栓症、急性冠症候群(ACS)、狭心症、心筋梗塞、癌、黄斑変性症、炎症、枯草熱、アテローム性動脈硬化症、及び/又は、関節リウマチの処置、及び/又は、予防に有用であり、
ここで、更なる実施態様において、薬学的に活性な化合物は、糖尿病、又は糖尿病性網膜症などの糖尿病に関連する合併症の処置、及び/又は、予防のための少なくとも1つのペプチドを含み、
ここで、更なる実施態様において、薬学的に活性な化合物は、少なくとも1つのヒトインスリン、又はヒトインスリン類似体若しくは誘導体、グルカゴン様ペプチド(GLP−1)、又はその類似体若しくは誘導体、又はエキセジン−3又はエキセジン−4、若しくはエキセジン−3又はエキセジン−4の類似体若しくは誘導体を含む。
H−(Lys)4−desPro36,desPro37エキセンジン−4(1−39)−NH2、
H−(Lys)5−desPro36,desPro37エキセンジン−4(1−39)−NH2、
desPro36[Asp28]エキセンジン−4(1−39)、
desPro36[IsoAsp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,Asp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,IsoAsp28]エキセンジン−4(1−39)、
desPro36[Trp(O2)25,Asp28]エキセンジン−4(1−39)、
desPro36[Trp(O2)25,IsoAsp28]エキセンジン−4(1−39)、
desPro36[Met(O)14Trp(O2)25,Asp28]エキセンジン−4(1−39)、
desPro36[Met(O)14Trp(O2)25,IsoAsp28]エキセンジン−4(1−39);又は
desPro36[Asp28]エキセンジン−4(1−39)、
desPro36[IsoAsp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,Asp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,IsoAsp28]エキセンジン−(1−39)、
desPro36[Trp(O2)25,Asp28]エキセンジン−4(1−39)、
desPro36[Trp(O2)25,IsoAsp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,Trp(O2)25,Asp28] エキセンジン−4(1−39)、
desPro36[Met(O)14,Trp(O2)25,IsoAsp28]エキセンジン−4(1−39)、
ここで、基−Lys6−NH2は、エキセンジン−4誘導体のC−末端と結合してもよく;
H−(Lys)6−desPro36[Asp28]エキセンジン−4(1−39)−Lys6−NH2、
desAsp28,Pro36,Pro37,Pro38エキセンジン−4(1−39)−NH2、
H−(Lys)6−desPro36,Pro38[Asp28]エキセンジン−4(1−39)−NH2、
H−Asn−(Glu)5desPro36,Pro37,Pro38[Asp28]エキセンジン−4(1−39)−NH2、
desPro36,Pro37,Pro38[Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36[Trp(O2)25,Asp28]エキセンジン−4(1−39)−Lys6−NH2、
H−desAsp28 Pro36,Pro37,Pro38[Trp(O2)25]エキセンジン−4(1−39)−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−NH2、
desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−des Pro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36[Met(O)14,Asp28]エキセンジン−4(1−39)−Lys6−NH2、
desMet(O)14,Asp28,Pro36,Pro37,Pro38 エキセンジン−4(1−39)−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−NH2、
desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−Asn−(Glu)5,desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−Lys6−desPro36[Met(O)14,Trp(O2)25, Asp28]エキセンジン−4(1−39)−Lys6−NH2、
H−desAsp28,Pro36,Pro37,Pro38[Met(O)14,Trp(O2)25]エキセンジン−4(1−39)−NH2、
H−(Lys)6−des Pro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)−NH2、
desPro36,Pro37,Pro38[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(S1−39)−(Lys)6−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38 [Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2;
又は前述のエキセンジン−4誘導体のいずれか1つの薬学的に許容される塩若しくは溶媒和物;
から選択される。
Publishing社,Easton, Pa., U.S.A.,1985 及び Encyclopedia of Pharmaceutical Technologyに記載されている。
Claims (15)
- ドライバロック機構を有する薬物送達デバイスであって、
用量ダイアリングアセンブリに連結した薬物のカートリッジを含むように構成されるカートリッジホルダ(6)であって、用量ダイアリングアセンブリが、内部表面上に少なくとも1つの内部溝(30;31)を有する外部ハウジング(17)及び内部固定ハウジング(5)を含んでなる、該カートリッジホルダ(6);
内部ハウジング(5)内に置かれるドライバ(7、9);
用量をダイアル設定中、内部溝(30;31)に係合して戻り止めを形成する少なくとも1つの可撓性タブ(21);及び
ドライバが溝(30;31)の経路に従うように、用量の投与中、溝に可撓性タブ(21)をロックするドライバ(7)の内側に摺動可能に置かれる閉塞部材(11;11′);
を含んでなる、上記薬物送達デバイス。 - 可撓性タブ(21)がドライバ(7)の一体部材である、請求項1に記載の薬物送達デバイス。
- 閉塞部材(11)が非ロック位置にあるとき、閉塞部材(11)は、可撓性タブ(21)と整列する開口部(23)を有し、そしてロック位置にあるとき、可撓性タブ(21)と整列しない、請求項1又は2に記載の薬物送達デバイス。
- 溝(30)が内部ハウジング(5)の軸に平行である、請求項1〜3のいずれか1項に記載の薬物送達デバイス。
- 溝(30)が内部ハウジング(5)の軸に沿ってラセン状である、請求項1〜3のいずれか1項に記載の薬物送達デバイス。
- 請求項1〜5のいずれか1項に記載の薬物送達デバイスであって、前記ロック部材(11′)が、用量のダイアル設定中、内部溝(30;31)に係合して戻り止めを形成する少なくとも1つの可撓性タブ(21)を備える、上記薬物送達デバイス。
- ドライバ(7)が、可撓性タブ(21)を受けるための開口部を有する、請求項6に記載の薬物送達デバイス。
- 開口部が用量のダイアル設定中、可撓性タブ(21)と整列し、そして用量の送達中、可撓性タブと整列しない、請求項6又は7に記載の薬物送達デバイス。
- a.内部表面を有する前記固定内部ハウジング(5)内に置かれる近位ドライバ(7);
b.近位ドライバ(7)及び内部ハウジング(5)の内部表面間で形成されるクリッカー(21)であって、用量を設定中、内部ハウジング内の少なくとも1つの溝(30;31)と戻り止めを形成し、用量の送達中、内部ハウジングでロックされる、該クリッカー(21);
c.近位ドライバ(7)の内側で軸方向に摺動可能であり、そして、用量の設定中、クリッカーを係合して、内部ハウジング内の少なくとも1つの溝にクリッカーをロックする、ロック部材(11;11′);
を含んでなる用量設定機構を有する、請求項1〜8のいずれか1項に記載の薬物送達デバイス。 - 用量の設定中及び薬剤の投与中、近位ドライバ(7)と係合するためのコネクタ(19)を有する内部ハウジング(5)の内側に置かれる遠位ドライバ(9)を更に含んでなる、請求項9に記載の薬物送達デバイス。
- 近位ドライバ(7)とコネクタ(19)間に置かれる付勢部材(13)を更に含んでなる、請求項9又は10に記載の薬物送達デバイス。
- 薬物送達デバイスで、薬物の用量を設定し、放出する方法であって、以下:
注射デバイスの投与アセンブリを保持又は備える工程であって、投与アセンブリが、外部ハウジング(17)及び少なくとも1つの内部溝(30;31)を有する内部ハウジング(5);
内部ハウジング内に置かれるドライバ(7、9);
用量を設定中、内部溝(30;31)に係合して戻り止めを形成する、少なくとも1つの可撓性タブ(21);及び
ロック位置にあるとき、可撓性タブ(21)と係合するドライバの内側に摺動可能に置かれる閉塞部材(11;11′)を含んでなる、該工程;
用量の設定中、ドライバ(7)を、外部および内部ハウジングに対して第一の方向に回転する工程であって、それにより可撓性タブが内部溝にオーバライドする、該工程;
ドライバ(7、9)にクラッチがかかった注射ボタンを押して、ドライバを遠位に第二の方向に動かす工程;
軸方向の遠位方向にある閉塞部材(11;11′)をロック位置に動かし、可撓性タブを内部溝に解除不能に係合させる工程;及び
薬物送達デバイスから薬物を放出させる工程;
を含んでなる、方法。 - 内部溝(30)が内部ハウジングの軸に沿って直線状であり、そしてドライバの第二の方向は遠位に直線状である、請求項12に記載の方法。
- 内部溝(31)が、ラセン状であり、そしてドライバの第二の方向が遠位回転方向である、請求項12に記載の方法。
- 可撓性タブ(21)は、ドライバ(7、9)が第一の方向に回転するとき、可聴のクリック音を生じさせ、そして使用者に触知できるフィードバックを提供する請求項12〜14のいずれか1項に記載の方法。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
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US18284209P | 2009-06-01 | 2009-06-01 | |
US61/182,842 | 2009-06-01 | ||
EP09009050 | 2009-07-10 | ||
EP09009050.7 | 2009-07-10 | ||
PCT/EP2010/057481 WO2010139636A1 (en) | 2009-06-01 | 2010-05-28 | A drive mechanism for a drug delivery device |
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JP5674770B2 JP5674770B2 (ja) | 2015-02-25 |
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JP2012513565A Active JP5674770B2 (ja) | 2009-06-01 | 2010-05-28 | 薬物送達デバイス用の駆動機構 |
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AU (1) | AU2010255811B2 (ja) |
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Cited By (13)
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---|---|---|---|---|
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US9180259B2 (en) | 2005-01-24 | 2015-11-10 | Antares Pharma, Inc. | Prefilled syringe jet injector |
US9220660B2 (en) | 2011-07-15 | 2015-12-29 | Antares Pharma, Inc. | Liquid-transfer adapter beveled spike |
US9333309B2 (en) | 2002-02-11 | 2016-05-10 | Antares Pharma, Inc. | Intradermal injector |
US9364611B2 (en) | 2012-05-07 | 2016-06-14 | Antares Pharma, Inc. | Needle assisted jet injection device having reduced trigger force |
US9446195B2 (en) | 2011-07-15 | 2016-09-20 | Antares Pharma, Inc. | Injection device with cammed ram assembly |
US9486583B2 (en) | 2012-03-06 | 2016-11-08 | Antares Pharma, Inc. | Prefilled syringe with breakaway force feature |
US9561333B2 (en) | 2008-08-05 | 2017-02-07 | Antares Pharma, Inc. | Multiple dosage injector |
US9707354B2 (en) | 2013-03-11 | 2017-07-18 | Antares Pharma, Inc. | Multiple dosage injector with rack and pinion dosage system |
US9744302B2 (en) | 2013-02-11 | 2017-08-29 | Antares Pharma, Inc. | Needle assisted jet injection device having reduced trigger force |
US9808582B2 (en) | 2006-05-03 | 2017-11-07 | Antares Pharma, Inc. | Two-stage reconstituting injector |
US9867949B2 (en) | 2008-03-10 | 2018-01-16 | Antares Pharma, Inc. | Injector safety device |
US9950125B2 (en) | 2012-04-06 | 2018-04-24 | Antares Pharma, Inc. | Needle assisted jet injection administration of testosterone compositions |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
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DK2475411T3 (en) * | 2009-09-07 | 2015-04-07 | Sanofi Aventis Deutschland | A drive mechanism for device for drug delivery |
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Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3302462A (en) * | 1964-05-25 | 1967-02-07 | Dow Chemical Co | Pipetting device with stop mechanism |
JP2002527210A (ja) * | 1998-10-21 | 2002-08-27 | ビディ メディコ エッセ.ア.エッレ.エレ. | 注射液の再構成方法およびこの種の方法を実施するための注射装置 |
JP2006501036A (ja) * | 2002-10-01 | 2006-01-12 | ベクトン・ディキンソン・アンド・カンパニー | 薬物投与ペン |
JP2007509662A (ja) * | 2003-11-03 | 2007-04-19 | ハーゼルマイアー エス.アー.エル.エル. | 注入装置 |
WO2008058667A1 (en) * | 2006-11-17 | 2008-05-22 | Sanofi-Aventis Deutschland Gmbh | Dosing and drive mechanism for drug delivery device |
JP2010508114A (ja) * | 2006-11-03 | 2010-03-18 | オーウェン マンフォード リミテッド | 薬吐出装置 |
Family Cites Families (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4112259A1 (de) | 1991-04-15 | 1992-10-22 | Medico Dev Investment Co | Injektionsgeraet |
EP0678040A1 (en) | 1991-04-22 | 1995-10-25 | Nils Göran HELLDIN | A syringe, including a rod and a piston |
DK175491D0 (da) | 1991-10-18 | 1991-10-18 | Novo Nordisk As | Apparat |
US5423752A (en) | 1992-07-31 | 1995-06-13 | Habley Medical Technology Corporation | Variable proportion dispenser with cartridge replacement assembly |
DE9301334U1 (de) | 1993-02-01 | 1993-04-01 | Ing. Lang & Menke Gmbh, 5870 Hemer | Federscheibe zum Spielausgleich bei Kugellagern |
US5411377A (en) | 1993-03-17 | 1995-05-02 | Houser; Michael P. | Mass displacement wave energy conversion system |
US5584815A (en) | 1993-04-02 | 1996-12-17 | Eli Lilly And Company | Multi-cartridge medication injection device |
DK170604B1 (da) | 1993-12-07 | 1995-11-13 | Niels Erik Holm Aps | Doseringsenhed til dosering af afmålte mængder af en væske |
US5514097A (en) | 1994-02-14 | 1996-05-07 | Genentech, Inc. | Self administered injection pen apparatus and method |
US5792117A (en) | 1994-07-22 | 1998-08-11 | Raya Systems, Inc. | Apparatus for optically determining and electronically recording injection doses in syringes |
AU1860697A (en) | 1995-09-08 | 1997-07-28 | Visionary Medical Products Corporation | Pen-type injector drive mechanism |
US5688251A (en) | 1995-09-19 | 1997-11-18 | Becton Dickinson And Company | Cartridge loading and priming mechanism for a pen injector |
EP0848624B1 (de) | 1996-07-05 | 2005-10-26 | Tecpharma Licensing AG | Injektionsgerät zum injizieren von flüssigkeit |
WO1999003520A1 (en) | 1997-07-14 | 1999-01-28 | Novo Nordisk A/S | Cylinder ampoule |
DE19730999C1 (de) | 1997-07-18 | 1998-12-10 | Disetronic Licensing Ag | Dosierknopfsicherung an einer Vorrichtung zur dosierten Verabreichung eines injizierbaren Produkts |
US5957896A (en) | 1997-08-11 | 1999-09-28 | Becton, Dickinson And Company | Medication delivery pen |
US6221053B1 (en) | 1998-02-20 | 2001-04-24 | Becton, Dickinson And Company | Multi-featured medication delivery pen |
US6096010A (en) | 1998-02-20 | 2000-08-01 | Becton, Dickinson And Company | Repeat-dose medication delivery pen |
ATE318157T1 (de) | 1999-08-05 | 2006-03-15 | Becton Dickinson Co | Stiftförmige medikamentenabgabevorrichtung |
TW453884B (en) | 1999-09-16 | 2001-09-11 | Novo Nordisk As | Dose setting limiter |
JP4283545B2 (ja) | 2001-05-16 | 2009-06-24 | イーライ リリー アンド カンパニー | リセット簡易化式駆動アセンブリー付きの薬物注射装置 |
ATE289834T1 (de) | 2001-07-16 | 2005-03-15 | Lilly Co Eli | Medikamentenverabreichungsvorrichtung mit durch rotation ausführbarem priming und durch zug- /schubbewegung ausführbarer injektion |
WO2003080160A1 (en) | 2002-03-18 | 2003-10-02 | Eli Lilly And Company | Medication dispensing apparatus with gear set for mechanical advantage |
US20040225258A1 (en) | 2002-03-30 | 2004-11-11 | Ernest Balestracci | Tamper evident overcap for a container |
DE10229138B4 (de) | 2002-06-28 | 2008-01-31 | Tecpharma Licensing Ag | Produktausschüttvorrichtung mit Kolbenstangen-Eilrücksetzung |
DE10239784B4 (de) | 2002-08-29 | 2004-12-30 | Tecpharma Licensing Ag | Injektions-, Infusions- oder Inhalationsvorrichtung mit Dosisanzeigevorrichtung |
DE10302163A1 (de) | 2003-01-21 | 2004-07-29 | Tecpharma Licensing Ag | Vorrichtung zur Verabreichung einer vorgebbaren Dosis eines flüssigen Produkts |
US7329241B2 (en) | 2003-02-14 | 2008-02-12 | Valeant Pharmaceuticals North America | Drug delivery system for administering an adjustable preset dose |
GB0304823D0 (en) | 2003-03-03 | 2003-04-09 | Dca Internat Ltd | Improvements in and relating to a pen-type injector |
GB0304822D0 (en) | 2003-03-03 | 2003-04-09 | Dca Internat Ltd | Improvements in and relating to a pen-type injector |
AU2003274797A1 (en) | 2003-03-05 | 2004-09-28 | 3Ip Co., Ltd. | Electronic dart game set and metod of assembling the same |
US20040186437A1 (en) | 2003-03-20 | 2004-09-23 | Frenette Claude E. | Content-coded medical syringe, syringe set and syringe content identification method |
PT1656170T (pt) | 2003-08-12 | 2019-05-31 | Lilly Co Eli | Aparelho para dispensar medicação com parafusos com rosca tripla para vantagem mecânica |
WO2005021072A1 (en) | 2003-09-03 | 2005-03-10 | Novo Nordisk A/S | Threaded rod and nut assembly |
DE10351597A1 (de) | 2003-11-05 | 2005-06-16 | Tecpharma Licensing Ag | Vorrichtung für die Verabreichung eines injizierbaren Produkts |
EP1541185A1 (en) | 2003-12-08 | 2005-06-15 | Novo Nordisk A/S | Automatic syringe with priming mechanism |
DK1838367T3 (en) | 2004-09-02 | 2019-03-04 | Sanofi Aventis Deutschland | PROCEDURE FOR COLLECTION OF PHARMACEUTICAL ADMINISTRATION DEVICES |
EP2047878B1 (en) | 2004-12-01 | 2011-02-23 | Novo Nordisk A/S | Injection Device |
DE102004063644A1 (de) | 2004-12-31 | 2006-07-20 | Tecpharma Licensing Ag | Vorrichtung zur dosierten Verabreichung eines fluiden Produkts mit Drehfederantrieb |
ES2689536T3 (es) | 2005-01-25 | 2018-11-14 | Novo Nordisk A/S | Dispositivo de inyección con un mecanismo de realimentación al final de la dosis |
DE102005063311A1 (de) | 2005-02-23 | 2006-08-24 | Tecpharma Licensing Ag | Verabreichungsvorrichtung mit Anzeigetrommel |
DE602006004314D1 (de) | 2005-02-28 | 2009-01-29 | Novo Nordisk As | Dosiseinstellmechanismus für eine injektionsvorrichtung, mit der eine höchstdosis voreingestellt werden kann |
WO2006114395A1 (en) | 2005-04-24 | 2006-11-02 | Novo Nordisk A/S | An injection device with a gearbox |
DE102005022532A1 (de) | 2005-05-17 | 2006-11-23 | Tecpharma Licensing Ag | Verabreichungsvorrichtung mit Zwangs-Priming |
DE102005023824A1 (de) | 2005-05-24 | 2006-12-07 | Tecpharma Licensing Ag | Dosiervorrichtung für eine Injektionsvorrichtung |
DE102005032705B4 (de) | 2005-05-24 | 2009-01-08 | Tecpharma Licensing Ag | Kunststofffeder |
PL1909870T5 (pl) | 2005-07-27 | 2016-10-31 | Novo Nordisk As | Mechanizm dozujący dla przyrządu wstrzykującego do ograniczania nastawionej dawki odpowiadającej ilości pozostającego lekarstwa |
US20080269688A1 (en) | 2005-12-08 | 2008-10-30 | Jose Colucci | Dose Indicating Assembly of a Pharmaceutical Injection Device |
DE102005060928A1 (de) | 2005-12-20 | 2007-06-28 | Tecpharma Licensing Ag | Injektionsvorrichtung mit axial überlappendem Dosier- oder Anzeigeglied |
DE102007001432A1 (de) | 2006-08-14 | 2008-02-21 | Tecpharma Licensing Ag | Dosiermechaniksperrung |
DE102006038123C5 (de) | 2006-08-14 | 2012-05-03 | Tecpharma Licensing Ag | Injektionsvorrichtung mit Mechanikverriegelung |
CN101594897A (zh) | 2006-09-15 | 2009-12-02 | 特克法马许可公司 | 带有可自动复位的剂量限定组件的注射仪器 |
US8740857B2 (en) | 2006-12-21 | 2014-06-03 | Novo Nordisk A/S | Syringe device |
CN101641126B (zh) | 2007-03-23 | 2014-06-04 | 诺沃-诺迪斯克有限公司 | 包括锁定螺母的注射装置 |
DE102007019124A1 (de) | 2007-04-23 | 2008-11-06 | Tecpharma Licensing Ag | Rückdrehbare Dosiervorrichtung für eine Injektionsvorrichtung |
DE102007026083A1 (de) | 2007-05-25 | 2008-11-27 | Haselmeier S.A.R.L. | Injektionsgerät |
-
2010
- 2010-05-27 US US12/788,699 patent/US8728043B2/en active Active
- 2010-05-28 US US13/322,347 patent/US9138541B2/en active Active
- 2010-05-28 CA CA2762027A patent/CA2762027A1/en not_active Abandoned
- 2010-05-28 CN CN201080033683.0A patent/CN102481411B/zh active Active
- 2010-05-28 WO PCT/EP2010/057481 patent/WO2010139636A1/en active Application Filing
- 2010-05-28 JP JP2012513565A patent/JP5674770B2/ja active Active
- 2010-05-28 AU AU2010255811A patent/AU2010255811B2/en not_active Ceased
- 2010-05-28 BR BRPI1011730A patent/BRPI1011730A2/pt not_active IP Right Cessation
- 2010-05-28 EP EP10722348.9A patent/EP2437805B1/en active Active
-
2011
- 2011-11-20 IL IL216483A patent/IL216483A/en not_active IP Right Cessation
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3302462A (en) * | 1964-05-25 | 1967-02-07 | Dow Chemical Co | Pipetting device with stop mechanism |
JP2002527210A (ja) * | 1998-10-21 | 2002-08-27 | ビディ メディコ エッセ.ア.エッレ.エレ. | 注射液の再構成方法およびこの種の方法を実施するための注射装置 |
JP2006501036A (ja) * | 2002-10-01 | 2006-01-12 | ベクトン・ディキンソン・アンド・カンパニー | 薬物投与ペン |
JP2007509662A (ja) * | 2003-11-03 | 2007-04-19 | ハーゼルマイアー エス.アー.エル.エル. | 注入装置 |
JP2010508114A (ja) * | 2006-11-03 | 2010-03-18 | オーウェン マンフォード リミテッド | 薬吐出装置 |
WO2008058667A1 (en) * | 2006-11-17 | 2008-05-22 | Sanofi-Aventis Deutschland Gmbh | Dosing and drive mechanism for drug delivery device |
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US9333309B2 (en) | 2002-02-11 | 2016-05-10 | Antares Pharma, Inc. | Intradermal injector |
US9737670B2 (en) | 2002-02-11 | 2017-08-22 | Antares Pharma, Inc. | Intradermal injector |
US9180259B2 (en) | 2005-01-24 | 2015-11-10 | Antares Pharma, Inc. | Prefilled syringe jet injector |
US11446441B2 (en) | 2005-01-24 | 2022-09-20 | Antares Pharma, Inc. | Prefilled syringe injector |
US10478560B2 (en) | 2005-01-24 | 2019-11-19 | Antares Pharma, Inc. | Prefilled syringe injector |
US9629959B2 (en) | 2005-01-24 | 2017-04-25 | Antares Pharma, Inc. | Prefilled syringe jet injector |
US11547808B2 (en) | 2006-05-03 | 2023-01-10 | Antares Pharma, Inc. | Two-stage reconstituting injector |
US10688250B2 (en) | 2006-05-03 | 2020-06-23 | Antares Pharma, Inc. | Two-stage reconstituting injector |
US11471600B2 (en) | 2006-05-03 | 2022-10-18 | Antares Pharma, Inc. | Injector with adjustable dosing |
US10543316B2 (en) | 2006-05-03 | 2020-01-28 | Antares Pharma, Inc. | Injector with adjustable dosing |
US9144648B2 (en) | 2006-05-03 | 2015-09-29 | Antares Pharma, Inc. | Injector with adjustable dosing |
US9808582B2 (en) | 2006-05-03 | 2017-11-07 | Antares Pharma, Inc. | Two-stage reconstituting injector |
US9867949B2 (en) | 2008-03-10 | 2018-01-16 | Antares Pharma, Inc. | Injector safety device |
US10709844B2 (en) | 2008-03-10 | 2020-07-14 | Antares Pharma, Inc. | Injector safety device |
US11684723B2 (en) | 2008-03-10 | 2023-06-27 | Antares Pharma, Inc. | Injector safety device |
US9561333B2 (en) | 2008-08-05 | 2017-02-07 | Antares Pharma, Inc. | Multiple dosage injector |
US11058824B2 (en) | 2008-08-05 | 2021-07-13 | Antares Pharma, Inc. | Multiple dosage injector |
US10300212B2 (en) | 2008-08-05 | 2019-05-28 | Antares Pharma, Inc. | Multiple dosage injector |
US10568809B2 (en) | 2011-07-15 | 2020-02-25 | Ferring B.V. | Liquid-transfer adapter beveled spike |
US9446195B2 (en) | 2011-07-15 | 2016-09-20 | Antares Pharma, Inc. | Injection device with cammed ram assembly |
US10279131B2 (en) | 2011-07-15 | 2019-05-07 | Antares Pharma, Inc. | Injection device with cammed RAM assembly |
US9220660B2 (en) | 2011-07-15 | 2015-12-29 | Antares Pharma, Inc. | Liquid-transfer adapter beveled spike |
US9486583B2 (en) | 2012-03-06 | 2016-11-08 | Antares Pharma, Inc. | Prefilled syringe with breakaway force feature |
US10478559B2 (en) | 2012-03-06 | 2019-11-19 | Antares Pharma, Inc. | Prefilled syringe with breakaway force feature |
US11602597B2 (en) | 2012-03-06 | 2023-03-14 | Antares Pharma, Inc. | Prefilled syringe with breakaway force feature |
US11771646B2 (en) | 2012-04-06 | 2023-10-03 | Antares Pharma, Inc. | Needle assisted jet injection administration of testosterone compositions |
US9950125B2 (en) | 2012-04-06 | 2018-04-24 | Antares Pharma, Inc. | Needle assisted jet injection administration of testosterone compositions |
US10821072B2 (en) | 2012-04-06 | 2020-11-03 | Antares Pharma, Inc. | Needle assisted jet injection administration of testosterone compositions |
US10357609B2 (en) | 2012-05-07 | 2019-07-23 | Antares Pharma, Inc. | Needle assisted jet injection device having reduced trigger force |
US10905827B2 (en) | 2012-05-07 | 2021-02-02 | Antares Pharma, Inc. | Injection device with cammed ram assembly |
US11446440B2 (en) | 2012-05-07 | 2022-09-20 | Antares Pharma, Inc. | Needle assisted injection device having reduced trigger force |
US9364610B2 (en) | 2012-05-07 | 2016-06-14 | Antares Pharma, Inc. | Injection device with cammed ram assembly |
US9364611B2 (en) | 2012-05-07 | 2016-06-14 | Antares Pharma, Inc. | Needle assisted jet injection device having reduced trigger force |
US10881798B2 (en) | 2013-02-11 | 2021-01-05 | Antares Pharma, Inc. | Needle assisted injection device having reduced trigger force |
US9744302B2 (en) | 2013-02-11 | 2017-08-29 | Antares Pharma, Inc. | Needle assisted jet injection device having reduced trigger force |
US11813435B2 (en) | 2013-02-11 | 2023-11-14 | Antares Pharma, Inc. | Needle assisted injection device having reduced trigger force |
US10610649B2 (en) | 2013-03-11 | 2020-04-07 | Antares Pharma, Inc. | Multiple dosage injector with rack and pinion dosage system |
US9707354B2 (en) | 2013-03-11 | 2017-07-18 | Antares Pharma, Inc. | Multiple dosage injector with rack and pinion dosage system |
US11628260B2 (en) | 2013-03-11 | 2023-04-18 | Antares Pharma, Inc. | Multiple dosage injector with rack and pinion dosage system |
Also Published As
Publication number | Publication date |
---|---|
US8728043B2 (en) | 2014-05-20 |
US20120157966A1 (en) | 2012-06-21 |
AU2010255811A1 (en) | 2011-12-22 |
CN102481411A (zh) | 2012-05-30 |
CA2762027A1 (en) | 2010-12-09 |
EP2437805A1 (en) | 2012-04-11 |
US20100331806A1 (en) | 2010-12-30 |
IL216483A (en) | 2015-06-30 |
US9138541B2 (en) | 2015-09-22 |
IL216483A0 (en) | 2012-01-31 |
EP2437805B1 (en) | 2020-03-04 |
BRPI1011730A2 (pt) | 2016-03-22 |
WO2010139636A1 (en) | 2010-12-09 |
JP5674770B2 (ja) | 2015-02-25 |
CN102481411B (zh) | 2015-03-18 |
AU2010255811B2 (en) | 2014-10-02 |
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