JP2012527447A5 - - Google Patents
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- Publication number
- JP2012527447A5 JP2012527447A5 JP2012511409A JP2012511409A JP2012527447A5 JP 2012527447 A5 JP2012527447 A5 JP 2012527447A5 JP 2012511409 A JP2012511409 A JP 2012511409A JP 2012511409 A JP2012511409 A JP 2012511409A JP 2012527447 A5 JP2012527447 A5 JP 2012527447A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- pharmaceutically acceptable
- liquid composition
- levodopa
- kit
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 22
- 239000007788 liquid Substances 0.000 claims 9
- WTDRDQBEARUVNC-LURJTMIESA-N 3-hydroxy-L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 claims 6
- 229960004502 levodopa Drugs 0.000 claims 6
- 239000004475 Arginine Substances 0.000 claims 2
- 229960004205 CARBIDOPA Drugs 0.000 claims 2
- TZFNLOMSOLWIDK-JTQLQIEISA-N Carbidopa Chemical compound NN[C@@](C(O)=O)(C)CC1=CC=C(O)C(O)=C1 TZFNLOMSOLWIDK-JTQLQIEISA-N 0.000 claims 2
- JRURYQJSLYLRLN-BJMVGYQFSA-N Entacapone Chemical compound CCN(CC)C(=O)C(\C#N)=C\C1=CC(O)=C(O)C([N+]([O-])=O)=C1 JRURYQJSLYLRLN-BJMVGYQFSA-N 0.000 claims 2
- 206010061536 Parkinson's disease Diseases 0.000 claims 2
- 206010034010 Parkinsonism Diseases 0.000 claims 2
- MIQPIUSUKVNLNT-UHFFFAOYSA-N Tasmar Chemical compound C1=CC(C)=CC=C1C(=O)C1=CC(O)=C(O)C([N+]([O-])=O)=C1 MIQPIUSUKVNLNT-UHFFFAOYSA-N 0.000 claims 2
- 229960003337 entacapone Drugs 0.000 claims 2
- 239000000546 pharmaceutic aid Substances 0.000 claims 2
- DNIAPMSPPWPWGF-UHFFFAOYSA-N propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000011780 sodium chloride Substances 0.000 claims 2
- 229960004603 tolcapone Drugs 0.000 claims 2
- 206010002026 Amyotrophic lateral sclerosis Diseases 0.000 claims 1
- 229960000911 Benserazide Drugs 0.000 claims 1
- 201000001971 Huntington's disease Diseases 0.000 claims 1
- 208000001089 Multiple System Atrophy Diseases 0.000 claims 1
- 208000009025 Nervous System Disease Diseases 0.000 claims 1
- 206010029305 Neurological disorder Diseases 0.000 claims 1
- 208000005793 Restless Legs Syndrome Diseases 0.000 claims 1
- 230000000111 anti-oxidant Effects 0.000 claims 1
- 239000003963 antioxidant agent Substances 0.000 claims 1
- 125000000511 arginine group Chemical class N[C@@H](CCCNC(N)=N)C(=O)* 0.000 claims 1
- BNQDCRGUHNALGH-UHFFFAOYSA-N benserazide Chemical compound OCC(N)C(=O)NNCC1=CC=C(O)C(O)=C1O BNQDCRGUHNALGH-UHFFFAOYSA-N 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 238000001802 infusion Methods 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- SECXISVLQFMRJM-UHFFFAOYSA-N n-methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 claims 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
- 201000002212 progressive supranuclear palsy Diseases 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17951109P | 2009-05-19 | 2009-05-19 | |
| US61/179,511 | 2009-05-19 | ||
| PCT/IL2010/000400 WO2010134074A1 (en) | 2009-05-19 | 2010-05-17 | Compositions for continuous administration of dopa decarboxylase inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014221786A Division JP5921002B2 (ja) | 2009-05-19 | 2014-10-30 | ドーパデカルボキシラーゼ阻害剤の連続投与のための組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012527447A JP2012527447A (ja) | 2012-11-08 |
| JP2012527447A5 true JP2012527447A5 (ru) | 2014-05-29 |
| JP5643297B2 JP5643297B2 (ja) | 2014-12-17 |
Family
ID=42320738
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012511409A Active JP5643297B2 (ja) | 2009-05-19 | 2010-05-17 | ドーパデカルボキシラーゼ阻害剤の連続投与のための組成物 |
| JP2014221786A Active JP5921002B2 (ja) | 2009-05-19 | 2014-10-30 | ドーパデカルボキシラーゼ阻害剤の連続投与のための組成物 |
| JP2016078121A Active JP6157678B2 (ja) | 2009-05-19 | 2016-04-08 | ドーパデカルボキシラーゼ阻害剤の連続投与のための組成物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014221786A Active JP5921002B2 (ja) | 2009-05-19 | 2014-10-30 | ドーパデカルボキシラーゼ阻害剤の連続投与のための組成物 |
| JP2016078121A Active JP6157678B2 (ja) | 2009-05-19 | 2016-04-08 | ドーパデカルボキシラーゼ阻害剤の連続投与のための組成物 |
Country Status (26)
| Country | Link |
|---|---|
| US (9) | US8193243B2 (ru) |
| EP (3) | EP3192500B1 (ru) |
| JP (3) | JP5643297B2 (ru) |
| KR (2) | KR101709904B1 (ru) |
| CN (2) | CN102438587B (ru) |
| AR (3) | AR078413A1 (ru) |
| AU (1) | AU2010250766B2 (ru) |
| BR (1) | BRPI1011031B8 (ru) |
| CA (1) | CA2761624C (ru) |
| CL (1) | CL2011002895A1 (ru) |
| CY (1) | CY1119495T1 (ru) |
| DK (2) | DK2432454T3 (ru) |
| ES (2) | ES2840748T3 (ru) |
| HR (2) | HRP20170805T1 (ru) |
| HU (2) | HUE052685T2 (ru) |
| IL (1) | IL216383A (ru) |
| LT (1) | LT2432454T (ru) |
| MX (2) | MX364974B (ru) |
| NZ (1) | NZ596963A (ru) |
| PL (2) | PL2432454T3 (ru) |
| PT (2) | PT2432454T (ru) |
| RU (3) | RU2678839C2 (ru) |
| SG (3) | SG176159A1 (ru) |
| SI (1) | SI2432454T1 (ru) |
| WO (1) | WO2010134074A1 (ru) |
| ZA (1) | ZA201109037B (ru) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IN192600B (ru) * | 1996-10-18 | 2004-05-08 | Hoechst Celanese Corp | |
| ES2840748T3 (es) | 2009-05-19 | 2021-07-07 | Neuroderm Ltd | Composiciones para la administración continua de inhibidores de dopa decarboxilasa |
| MX348225B (es) * | 2010-11-15 | 2017-05-31 | Neuroderm Ltd | Administracion continua de levodopa, inhibidores de dopa decarboxilasa, inhibidores de catecol-o-metil transferasa y composiciones para la misma. |
| CN107693486A (zh) | 2012-06-05 | 2018-02-16 | 纽罗德姆有限公司 | 包含阿朴吗啡和有机酸的组合物及其用途 |
| ITBO20120368A1 (it) | 2012-07-06 | 2014-01-07 | Alfa Wassermann Spa | Composizioni comprendenti rifaximina e amminoacidi, cristalli di rifaximina derivanti da tali composizioni e loro uso. |
| CN103845318A (zh) * | 2012-12-07 | 2014-06-11 | 天津市汉康医药生物技术有限公司 | 恩他卡朋分散片 |
| SG10201911731YA (en) | 2013-03-13 | 2020-02-27 | Neuroderm Ltd | Method for treatment of parkinson's disease |
| EP3065808B1 (en) * | 2013-11-05 | 2023-08-30 | SynAgile Corporation | Continuous drug delivery via the mouth |
| PT3116475T (pt) * | 2014-03-13 | 2020-12-15 | Neuroderm Ltd | Composições de inibidores de dopa-descarboxilase |
| US10258585B2 (en) | 2014-03-13 | 2019-04-16 | Neuroderm, Ltd. | DOPA decarboxylase inhibitor compositions |
| WO2016036308A1 (en) * | 2014-09-04 | 2016-03-10 | Lobsor Pharmaceuticals Aktiebolag | Pharmaceutical compositions comprising levodopa, a dopamine decarboxylase inhibitor and a comt inhibitor and method of administration thereof |
| AR102389A1 (es) | 2014-10-21 | 2017-02-22 | Abbvie Inc | Profármacos de carbidopa y l-dopa y métodos de uso de los mismos, kit |
| MA41377A (fr) | 2015-01-20 | 2017-11-28 | Abbvie Inc | Gel intestinal de lévodopa et de carbidona et procédés d'utilisation |
| AU2016258179B2 (en) | 2015-05-06 | 2021-07-01 | Synagile Corporation | Pharmaceutical suspensions containing drug particles, devices for their administration, and methods of their use |
| US10555922B2 (en) | 2015-09-04 | 2020-02-11 | Lobsor Pharmaceuticals Aktiebolag | Method of treating a dopamine related disorder in a subject by administering levodopa, in combination with a dopamine decarboxylase inhibitor and a catechol-o-methyltransferase inhibitor |
| BR112018010564A2 (pt) | 2015-11-24 | 2018-11-21 | Neuroderm Ltd. | composições farmacêuticas compreendendo levodopa amida e usos das mesmas |
| JP7095873B2 (ja) * | 2016-04-11 | 2022-07-05 | ユニバーシティ・オブ・キャンベラ | レボドパ、抗酸化剤及び水性担体を含む眼科用組成物 |
| US10064834B2 (en) | 2016-05-09 | 2018-09-04 | Texas Tech University System | Carbidopa for the treatment of cancer |
| PT3634384T (pt) * | 2017-06-05 | 2021-04-29 | Dizlin Pharmaceuticals Ab | Solução para infusão de levodopa |
| US20230123806A1 (en) * | 2017-07-07 | 2023-04-20 | Neuroderm, Ltd. | Device for subcutaneous delivery of fluid medicament |
| CA3095341A1 (en) * | 2018-03-29 | 2019-10-03 | Avion Pharmaceuticals, Llc | Levodopa fractionated dose composition and use |
| WO2020252257A1 (en) * | 2019-06-12 | 2020-12-17 | President And Fellows Of Harvard College | Methods and compositions for modulation of an interspecies gut bacterial pathway for levodopa metabolism |
| US11331293B1 (en) | 2020-11-17 | 2022-05-17 | Neuroderm, Ltd. | Method for treatment of Parkinson's disease |
| US11844754B2 (en) | 2020-11-17 | 2023-12-19 | Neuroderm, Ltd. | Methods for treatment of Parkinson's disease |
| US11213502B1 (en) | 2020-11-17 | 2022-01-04 | Neuroderm, Ltd. | Method for treatment of parkinson's disease |
| WO2023126945A1 (en) * | 2022-01-03 | 2023-07-06 | Neuroderm, Ltd. | Methods and compositions for treating parkinson's disease |
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| PT3116475T (pt) | 2014-03-13 | 2020-12-15 | Neuroderm Ltd | Composições de inibidores de dopa-descarboxilase |
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2010
- 2010-05-17 ES ES17158360T patent/ES2840748T3/es active Active
- 2010-05-17 SG SG2011085297A patent/SG176159A1/en unknown
- 2010-05-17 DK DK10725880.8T patent/DK2432454T3/en active
- 2010-05-17 DK DK17158360.2T patent/DK3192500T3/da active
- 2010-05-17 CA CA2761624A patent/CA2761624C/en active Active
- 2010-05-17 BR BRPI1011031A patent/BRPI1011031B8/pt active IP Right Grant
- 2010-05-17 SG SG10201505101VA patent/SG10201505101VA/en unknown
- 2010-05-17 ES ES10725880.8T patent/ES2627655T3/es active Active
- 2010-05-17 CN CN201080022208.3A patent/CN102438587B/zh active Active
- 2010-05-17 EP EP17158360.2A patent/EP3192500B1/en active Active
- 2010-05-17 NZ NZ596963A patent/NZ596963A/en not_active IP Right Cessation
- 2010-05-17 LT LTEP10725880.8T patent/LT2432454T/lt unknown
- 2010-05-17 HU HUE17158360A patent/HUE052685T2/hu unknown
- 2010-05-17 US US12/781,357 patent/US8193243B2/en active Active
- 2010-05-17 RU RU2015115064A patent/RU2678839C2/ru active
- 2010-05-17 PT PT107258808T patent/PT2432454T/pt unknown
- 2010-05-17 CN CN201410800432.0A patent/CN104546700B/zh active Active
- 2010-05-17 RU RU2011149976/15A patent/RU2559083C9/ru active
- 2010-05-17 SG SG10201709016RA patent/SG10201709016RA/en unknown
- 2010-05-17 JP JP2012511409A patent/JP5643297B2/ja active Active
- 2010-05-17 PL PL10725880T patent/PL2432454T3/pl unknown
- 2010-05-17 KR KR1020167019114A patent/KR101709904B1/ko active IP Right Grant
- 2010-05-17 KR KR1020117030315A patent/KR101641401B1/ko active IP Right Grant
- 2010-05-17 EP EP20197759.2A patent/EP3777839A1/en active Pending
- 2010-05-17 EP EP10725880.8A patent/EP2432454B1/en active Active
- 2010-05-17 PL PL17158360T patent/PL3192500T3/pl unknown
- 2010-05-17 HU HUE10725880A patent/HUE033388T2/en unknown
- 2010-05-17 SI SI201031466T patent/SI2432454T1/sl unknown
- 2010-05-17 AU AU2010250766A patent/AU2010250766B2/en active Active
- 2010-05-17 MX MX2015001674A patent/MX364974B/es unknown
- 2010-05-17 PT PT171583602T patent/PT3192500T/pt unknown
- 2010-05-17 WO PCT/IL2010/000400 patent/WO2010134074A1/en active Application Filing
- 2010-05-17 MX MX2011012315A patent/MX2011012315A/es active IP Right Grant
- 2010-05-19 AR ARP100101735A patent/AR078413A1/es not_active Application Discontinuation
- 2010-07-14 US US12/836,130 patent/US7863336B2/en active Active
- 2010-12-07 US US12/961,534 patent/US9101663B2/en active Active
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2011
- 2011-11-15 IL IL216383A patent/IL216383A/en active IP Right Grant
- 2011-11-17 CL CL2011002895A patent/CL2011002895A1/es unknown
- 2011-12-08 ZA ZA2011/09037A patent/ZA201109037B/en unknown
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2014
- 2014-05-13 US US14/276,211 patent/US9040589B2/en active Active
- 2014-05-13 US US14/276,235 patent/US9040590B2/en active Active
- 2014-10-30 JP JP2014221786A patent/JP5921002B2/ja active Active
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2015
- 2015-07-01 US US14/789,214 patent/US9993451B2/en active Active
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2016
- 2016-04-08 JP JP2016078121A patent/JP6157678B2/ja active Active
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2017
- 2017-05-30 HR HRP20170805TT patent/HRP20170805T1/hr unknown
- 2017-05-31 CY CY20171100573T patent/CY1119495T1/el unknown
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2018
- 2018-05-30 US US15/992,979 patent/US20190125708A1/en not_active Abandoned
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2019
- 2019-01-16 RU RU2019101159A patent/RU2019101159A/ru unknown
- 2019-03-28 AR ARP190100805A patent/AR117412A2/es unknown
- 2019-12-23 AR ARP190103847A patent/AR117502A2/es unknown
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2020
- 2020-04-30 US US16/863,459 patent/US20210077442A1/en not_active Abandoned
- 2020-12-21 HR HRP20202038TT patent/HRP20202038T1/hr unknown
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2022
- 2022-11-11 US US17/985,556 patent/US20230321019A1/en active Pending
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