JP2012527447A5 - - Google Patents
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- Publication number
- JP2012527447A5 JP2012527447A5 JP2012511409A JP2012511409A JP2012527447A5 JP 2012527447 A5 JP2012527447 A5 JP 2012527447A5 JP 2012511409 A JP2012511409 A JP 2012511409A JP 2012511409 A JP2012511409 A JP 2012511409A JP 2012527447 A5 JP2012527447 A5 JP 2012527447A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- pharmaceutically acceptable
- liquid composition
- levodopa
- kit
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000007788 liquid Substances 0.000 claims 9
- WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 claims 5
- WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 claims 5
- 229960004502 levodopa Drugs 0.000 claims 5
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 3
- 239000004475 Arginine Substances 0.000 claims 2
- 208000018737 Parkinson disease Diseases 0.000 claims 2
- 206010034010 Parkinsonism Diseases 0.000 claims 2
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 2
- 229960003337 entacapone Drugs 0.000 claims 2
- JRURYQJSLYLRLN-BJMVGYQFSA-N entacapone Chemical compound CCN(CC)C(=O)C(\C#N)=C\C1=CC(O)=C(O)C([N+]([O-])=O)=C1 JRURYQJSLYLRLN-BJMVGYQFSA-N 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 229960004603 tolcapone Drugs 0.000 claims 2
- MIQPIUSUKVNLNT-UHFFFAOYSA-N tolcapone Chemical compound C1=CC(C)=CC=C1C(=O)C1=CC(O)=C(O)C([N+]([O-])=O)=C1 MIQPIUSUKVNLNT-UHFFFAOYSA-N 0.000 claims 2
- IVTMXOXVAHXCHI-YXLMWLKOSA-N (2s)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid;(2s)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1.NN[C@@](C(O)=O)(C)CC1=CC=C(O)C(O)=C1 IVTMXOXVAHXCHI-YXLMWLKOSA-N 0.000 claims 1
- 208000023105 Huntington disease Diseases 0.000 claims 1
- 208000001089 Multiple system atrophy Diseases 0.000 claims 1
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 claims 1
- 208000012902 Nervous system disease Diseases 0.000 claims 1
- 208000025966 Neurological disease Diseases 0.000 claims 1
- 208000005793 Restless legs syndrome Diseases 0.000 claims 1
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 1
- 239000003963 antioxidant agent Substances 0.000 claims 1
- 150000001483 arginine derivatives Chemical class 0.000 claims 1
- BNQDCRGUHNALGH-UHFFFAOYSA-N benserazide Chemical compound OCC(N)C(=O)NNCC1=CC=C(O)C(O)=C1O BNQDCRGUHNALGH-UHFFFAOYSA-N 0.000 claims 1
- 229960000911 benserazide Drugs 0.000 claims 1
- 229960004205 carbidopa Drugs 0.000 claims 1
- TZFNLOMSOLWIDK-JTQLQIEISA-N carbidopa (anhydrous) Chemical compound NN[C@@](C(O)=O)(C)CC1=CC=C(O)C(O)=C1 TZFNLOMSOLWIDK-JTQLQIEISA-N 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 238000001802 infusion Methods 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
- 201000002212 progressive supranuclear palsy Diseases 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17951109P | 2009-05-19 | 2009-05-19 | |
| US61/179,511 | 2009-05-19 | ||
| PCT/IL2010/000400 WO2010134074A1 (en) | 2009-05-19 | 2010-05-17 | Compositions for continuous administration of dopa decarboxylase inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014221786A Division JP5921002B2 (ja) | 2009-05-19 | 2014-10-30 | ドーパデカルボキシラーゼ阻害剤の連続投与のための組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012527447A JP2012527447A (ja) | 2012-11-08 |
| JP2012527447A5 true JP2012527447A5 (cg-RX-API-DMAC10.html) | 2014-05-29 |
| JP5643297B2 JP5643297B2 (ja) | 2014-12-17 |
Family
ID=42320738
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012511409A Active JP5643297B2 (ja) | 2009-05-19 | 2010-05-17 | ドーパデカルボキシラーゼ阻害剤の連続投与のための組成物 |
| JP2014221786A Active JP5921002B2 (ja) | 2009-05-19 | 2014-10-30 | ドーパデカルボキシラーゼ阻害剤の連続投与のための組成物 |
| JP2016078121A Active JP6157678B2 (ja) | 2009-05-19 | 2016-04-08 | ドーパデカルボキシラーゼ阻害剤の連続投与のための組成物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014221786A Active JP5921002B2 (ja) | 2009-05-19 | 2014-10-30 | ドーパデカルボキシラーゼ阻害剤の連続投与のための組成物 |
| JP2016078121A Active JP6157678B2 (ja) | 2009-05-19 | 2016-04-08 | ドーパデカルボキシラーゼ阻害剤の連続投与のための組成物 |
Country Status (26)
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
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| IN192600B (cg-RX-API-DMAC10.html) * | 1996-10-18 | 2004-05-08 | Hoechst Celanese Corp | |
| PT3192500T (pt) | 2009-05-19 | 2021-01-05 | Neuroderm Ltd | Composições para a administração contínua de inibidores da dopa decarboxilase |
| DK2640358T3 (en) * | 2010-11-15 | 2018-04-16 | Neuroderm Ltd | CONTINUOUS ADMINISTRATION OF L-DOPA, DOPA-DECARBOXYLASE INHIBITORS, CATECHOL-O-METHYL TRANSFERASE INHIBITORS AND COMPOSITIONS THEREOF |
| EP2854764B1 (en) | 2012-06-05 | 2018-12-12 | Neuroderm Ltd | Compositions comprising apomorphine and organic acids and uses thereof |
| ITBO20120368A1 (it) | 2012-07-06 | 2014-01-07 | Alfa Wassermann Spa | Composizioni comprendenti rifaximina e amminoacidi, cristalli di rifaximina derivanti da tali composizioni e loro uso. |
| CN103845318A (zh) * | 2012-12-07 | 2014-06-11 | 天津市汉康医药生物技术有限公司 | 恩他卡朋分散片 |
| HUE056006T2 (hu) * | 2013-03-13 | 2022-01-28 | Neuroderm Ltd | Kombináció Parkinson-kór kezelésére |
| US20160278899A1 (en) * | 2013-11-05 | 2016-09-29 | Synagile Corporation | Devices and methods for continuous drug delivery via the mouth |
| US10258585B2 (en) | 2014-03-13 | 2019-04-16 | Neuroderm, Ltd. | DOPA decarboxylase inhibitor compositions |
| PL3777833T3 (pl) | 2014-03-13 | 2024-03-25 | Neuroderm Ltd. | Kompozycje inhibitorów dekarboksylazy dopa |
| PT3782617T (pt) * | 2014-09-04 | 2024-02-29 | Lobsor Pharmaceuticals Ab | Composições farmacêuticas de gel compreendendo levodopa, carbidopa e entacapona |
| ES2739536T3 (es) | 2014-10-21 | 2020-01-31 | Abbvie Inc | Profármacos de carbidopa y L-dopa y su uso para tratar la enfermedad de Parkinson |
| MA41377A (fr) | 2015-01-20 | 2017-11-28 | Abbvie Inc | Gel intestinal de lévodopa et de carbidona et procédés d'utilisation |
| CN113197851A (zh) | 2015-05-06 | 2021-08-03 | 辛纳吉勒公司 | 包含药物粒子的药用悬浮液、用于其配给的装置、以及其使用方法 |
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| WO2017177262A1 (en) * | 2016-04-11 | 2017-10-19 | University Of Canberra | Ophthalmic compositions comprising levodopa, an antioxidant and an aqueous carrier |
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| EP3773532A4 (en) * | 2018-03-29 | 2022-11-02 | Avion Pharmaceuticals, LLC | FRACTIONAL LEVODOPA DOSAGE AND USE |
| TW202031265A (zh) | 2018-11-15 | 2020-09-01 | 美商艾伯維有限公司 | 用於皮下投藥之醫藥調配物 |
| US20220226269A1 (en) * | 2019-06-12 | 2022-07-21 | President And Fellows Of Harvard College | Methods and compositions for modulation of an interspecies gut bacterial pathway for levodopa metabolism |
| WO2022047298A1 (en) * | 2020-08-31 | 2022-03-03 | Purdue Pharma L.P. | Compositions and methods for levodopa delivery |
| US11213502B1 (en) | 2020-11-17 | 2022-01-04 | Neuroderm, Ltd. | Method for treatment of parkinson's disease |
| US11331293B1 (en) | 2020-11-17 | 2022-05-17 | Neuroderm, Ltd. | Method for treatment of Parkinson's disease |
| US11844754B2 (en) | 2020-11-17 | 2023-12-19 | Neuroderm, Ltd. | Methods for treatment of Parkinson's disease |
| US11986449B2 (en) | 2020-12-22 | 2024-05-21 | Amneal Pharmaceuticals Llc | Levodopa dosing regimen |
| US12194150B2 (en) | 2020-12-22 | 2025-01-14 | Amneal Pharmaceuticals Llc | Levodopa dosing regimen |
| KR20240131429A (ko) * | 2022-01-03 | 2024-08-30 | 뉴로덤 엘티디 | 파킨슨병을 치료하기 위한 방법 및 조성물 |
| US12161612B2 (en) | 2023-04-14 | 2024-12-10 | Neuroderm, Ltd. | Methods and compositions for reducing symptoms of Parkinson's disease |
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2010
- 2010-05-17 PT PT171583602T patent/PT3192500T/pt unknown
- 2010-05-17 HR HRP20170805TT patent/HRP20170805T1/hr unknown
- 2010-05-17 RU RU2015115064A patent/RU2678839C2/ru active
- 2010-05-17 CN CN201080022208.3A patent/CN102438587B/zh active Active
- 2010-05-17 PL PL10725880T patent/PL2432454T3/pl unknown
- 2010-05-17 WO PCT/IL2010/000400 patent/WO2010134074A1/en not_active Ceased
- 2010-05-17 NZ NZ596963A patent/NZ596963A/en not_active IP Right Cessation
- 2010-05-17 KR KR1020167019114A patent/KR101709904B1/ko active Active
- 2010-05-17 CN CN201410800432.0A patent/CN104546700B/zh active Active
- 2010-05-17 JP JP2012511409A patent/JP5643297B2/ja active Active
- 2010-05-17 HU HUE17158360A patent/HUE052685T2/hu unknown
- 2010-05-17 EP EP17158360.2A patent/EP3192500B1/en active Active
- 2010-05-17 AU AU2010250766A patent/AU2010250766B2/en active Active
- 2010-05-17 ES ES17158360T patent/ES2840748T3/es active Active
- 2010-05-17 BR BRPI1011031A patent/BRPI1011031B8/pt active IP Right Grant
- 2010-05-17 CA CA2761624A patent/CA2761624C/en active Active
- 2010-05-17 SG SG2011085297A patent/SG176159A1/en unknown
- 2010-05-17 MX MX2011012315A patent/MX2011012315A/es active IP Right Grant
- 2010-05-17 LT LTEP10725880.8T patent/LT2432454T/lt unknown
- 2010-05-17 SI SI201031466T patent/SI2432454T1/sl unknown
- 2010-05-17 DK DK10725880.8T patent/DK2432454T3/en active
- 2010-05-17 SG SG10201505101VA patent/SG10201505101VA/en unknown
- 2010-05-17 US US12/781,357 patent/US8193243B2/en active Active
- 2010-05-17 HU HUE10725880A patent/HUE033388T2/en unknown
- 2010-05-17 PT PT107258808T patent/PT2432454T/pt unknown
- 2010-05-17 SG SG10201709016RA patent/SG10201709016RA/en unknown
- 2010-05-17 EP EP20197759.2A patent/EP3777839A1/en active Pending
- 2010-05-17 MX MX2015001674A patent/MX364974B/es unknown
- 2010-05-17 KR KR1020117030315A patent/KR101641401B1/ko active Active
- 2010-05-17 EP EP10725880.8A patent/EP2432454B1/en active Active
- 2010-05-17 DK DK17158360.2T patent/DK3192500T3/da active
- 2010-05-17 ES ES10725880.8T patent/ES2627655T3/es active Active
- 2010-05-17 PL PL17158360T patent/PL3192500T3/pl unknown
- 2010-05-17 RU RU2011149976/15A patent/RU2559083C9/ru active
- 2010-05-19 AR ARP100101735A patent/AR078413A1/es not_active Application Discontinuation
- 2010-07-14 US US12/836,130 patent/US7863336B2/en active Active
- 2010-12-07 US US12/961,534 patent/US9101663B2/en active Active
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2011
- 2011-11-15 IL IL216383A patent/IL216383A/en active IP Right Grant
- 2011-11-17 CL CL2011002895A patent/CL2011002895A1/es unknown
- 2011-12-08 ZA ZA2011/09037A patent/ZA201109037B/en unknown
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2014
- 2014-05-13 US US14/276,235 patent/US9040590B2/en active Active
- 2014-05-13 US US14/276,211 patent/US9040589B2/en active Active
- 2014-10-30 JP JP2014221786A patent/JP5921002B2/ja active Active
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2015
- 2015-07-01 US US14/789,214 patent/US9993451B2/en active Active
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2016
- 2016-04-08 JP JP2016078121A patent/JP6157678B2/ja active Active
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2017
- 2017-05-31 CY CY20171100573T patent/CY1119495T1/el unknown
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2018
- 2018-05-30 US US15/992,979 patent/US20190125708A1/en not_active Abandoned
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2019
- 2019-01-16 RU RU2019101159A patent/RU2019101159A/ru unknown
- 2019-03-28 AR ARP190100805A patent/AR117412A2/es unknown
- 2019-12-23 AR ARP190103847A patent/AR117502A2/es not_active Application Discontinuation
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2020
- 2020-04-30 US US16/863,459 patent/US20210077442A1/en not_active Abandoned
- 2020-12-21 HR HRP20202038TT patent/HRP20202038T1/hr unknown
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2022
- 2022-11-11 US US17/985,556 patent/US20230321019A1/en active Pending
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