JP2012526847A5 - - Google Patents
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- Publication number
- JP2012526847A5 JP2012526847A5 JP2012511017A JP2012511017A JP2012526847A5 JP 2012526847 A5 JP2012526847 A5 JP 2012526847A5 JP 2012511017 A JP2012511017 A JP 2012511017A JP 2012511017 A JP2012511017 A JP 2012511017A JP 2012526847 A5 JP2012526847 A5 JP 2012526847A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- halo
- alkyl
- trifluoromethyl
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims description 50
- 125000001475 halogen functional group Chemical group 0.000 claims description 50
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 44
- 150000001875 compounds Chemical class 0.000 claims description 42
- 229910052739 hydrogen Inorganic materials 0.000 claims description 38
- 239000001257 hydrogen Substances 0.000 claims description 38
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims description 38
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 26
- JYEUMXHLPRZUAT-UHFFFAOYSA-N 1,2,3-triazine Chemical compound C1=CN=NN=C1 JYEUMXHLPRZUAT-UHFFFAOYSA-N 0.000 claims description 9
- 125000003118 aryl group Chemical group 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 125000004442 acylamino group Chemical group 0.000 claims description 8
- -1 aminomethyleneamino Chemical class 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 8
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 8
- 125000006850 spacer group Chemical group 0.000 claims description 8
- 125000004216 fluoromethyl group Chemical group [H]C([H])(F)* 0.000 claims description 6
- 229920000233 poly(alkylene oxides) Polymers 0.000 claims description 6
- 239000000178 monomer Substances 0.000 claims description 4
- 241000124008 Mammalia Species 0.000 claims description 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 2
- 125000003545 alkoxy group Chemical group 0.000 claims description 2
- 239000002552 dosage form Substances 0.000 claims description 2
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims description 2
- PYZRQGJRPPTADH-UHFFFAOYSA-N lamotrigine Chemical compound NC1=NC(N)=NN=C1C1=CC=CC(Cl)=C1Cl PYZRQGJRPPTADH-UHFFFAOYSA-N 0.000 claims description 2
- 229960001848 lamotrigine Drugs 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 0 **c1c(*)c(-c2nnc(N)nc2*)c(*)c(*)c1* Chemical compound **c1c(*)c(-c2nnc(N)nc2*)c(*)c(*)c1* 0.000 description 2
- 238000000034 method Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17793109P | 2009-05-13 | 2009-05-13 | |
| US61/177,931 | 2009-05-13 | ||
| PCT/US2010/034770 WO2010132691A1 (en) | 2009-05-13 | 2010-05-13 | Oligomer-containing substituted aromatic triazine compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012526847A JP2012526847A (ja) | 2012-11-01 |
| JP2012526847A5 true JP2012526847A5 (enExample) | 2013-05-02 |
| JP5656980B2 JP5656980B2 (ja) | 2015-01-21 |
Family
ID=42557491
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012511017A Active JP5656980B2 (ja) | 2009-05-13 | 2010-05-13 | オリゴマー含有の置換芳香族トリアジン化合物 |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US8772479B2 (enExample) |
| EP (1) | EP2430003B1 (enExample) |
| JP (1) | JP5656980B2 (enExample) |
| KR (1) | KR101799113B1 (enExample) |
| CN (1) | CN102421763B (enExample) |
| AU (1) | AU2010248943B2 (enExample) |
| CA (1) | CA2760219C (enExample) |
| IL (1) | IL216314B (enExample) |
| MX (1) | MX2011012044A (enExample) |
| WO (1) | WO2010132691A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2010248943B2 (en) * | 2009-05-13 | 2015-05-21 | Nektar Therapeutics | Oligomer-containing substituted aromatic triazine compounds |
| WO2015092819A2 (en) | 2013-12-21 | 2015-06-25 | Nektar Therapeutics (India) Pvt. Ltd. | Derivatives of 6-(2,3-dichlorophenyl)-1,2,4-triazin-5- amine |
| KR102385665B1 (ko) | 2015-02-25 | 2022-04-14 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 질환을 치료하기 위한 5ht 작용제 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DD151309A5 (de) | 1979-06-01 | 1981-10-14 | Wellcome Found | Verfahren zur herstellung von substituierten aminotriazinen |
| US5028703A (en) | 1988-03-11 | 1991-07-02 | Massachusetts Institute Of Technology | Glucan composition and process for preparation thereof |
| US4992540A (en) | 1984-11-28 | 1991-02-12 | Massachusetts Institute Of Technology | Glucan composition and process for preparation thereof |
| US4810646A (en) | 1984-11-28 | 1989-03-07 | Massachusetts Institute Of Technology | Glucan compositions and process for preparation thereof |
| US5032401A (en) | 1989-06-15 | 1991-07-16 | Alpha Beta Technology | Glucan drug delivery system and adjuvant |
| US5672662A (en) | 1995-07-07 | 1997-09-30 | Shearwater Polymers, Inc. | Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications |
| US6153655A (en) | 1998-04-17 | 2000-11-28 | Enzon, Inc. | Terminally-branched polymeric linkers and polymeric conjugates containing the same |
| WO2002043772A2 (en) | 2000-11-30 | 2002-06-06 | Shearwater Corporation | Water-soluble polymer conjugates of triazine derivatives |
| US6835802B2 (en) | 2001-06-04 | 2004-12-28 | Nobex Corporation | Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties |
| DK1694363T3 (en) | 2003-12-16 | 2014-03-24 | Nektar Therapeutics | Monodisperse PEGylated Naloxole Compositions |
| FR2869907B1 (fr) * | 2004-05-05 | 2009-02-13 | Fabre Pierre Dermo Cosmetique | Derives dimeriques de 5,6-diphenyl-1,2,4-triazine et leurs utilisations |
| US7740861B2 (en) | 2004-06-16 | 2010-06-22 | University Of Massachusetts | Drug delivery product and methods |
| WO2006027711A2 (en) * | 2004-08-26 | 2006-03-16 | Nicholas Piramal India Limited | Prodrugs and codrugs containing bio- cleavable disulfide linkers |
| US20060115865A1 (en) * | 2004-10-25 | 2006-06-01 | Anlong Ouyang | Lamotrigine analogs |
| US7678551B2 (en) | 2004-10-25 | 2010-03-16 | Seradyn, Inc. | Immunoassays for lamotrigine |
| US20080044438A1 (en) | 2006-03-17 | 2008-02-21 | Ostroff Gary R | Yeast Cell Particles As Oral Delivery Vehicles For Antigens |
| AU2010248943B2 (en) | 2009-05-13 | 2015-05-21 | Nektar Therapeutics | Oligomer-containing substituted aromatic triazine compounds |
-
2010
- 2010-05-13 AU AU2010248943A patent/AU2010248943B2/en active Active
- 2010-05-13 JP JP2012511017A patent/JP5656980B2/ja active Active
- 2010-05-13 EP EP10721887.7A patent/EP2430003B1/en active Active
- 2010-05-13 CA CA2760219A patent/CA2760219C/en active Active
- 2010-05-13 MX MX2011012044A patent/MX2011012044A/es active IP Right Grant
- 2010-05-13 WO PCT/US2010/034770 patent/WO2010132691A1/en not_active Ceased
- 2010-05-13 US US13/319,824 patent/US8772479B2/en active Active
- 2010-05-13 CN CN201080020581.5A patent/CN102421763B/zh active Active
- 2010-05-13 KR KR1020117026044A patent/KR101799113B1/ko active Active
-
2011
- 2011-11-10 IL IL216314A patent/IL216314B/en active IP Right Grant
-
2014
- 2014-05-20 US US14/282,732 patent/US8895553B2/en active Active
- 2014-10-30 US US14/528,444 patent/US9266845B2/en active Active
-
2016
- 2016-01-15 US US14/996,801 patent/US9617228B2/en active Active
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