JP2012522994A5 - - Google Patents
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- Publication number
- JP2012522994A5 JP2012522994A5 JP2012503717A JP2012503717A JP2012522994A5 JP 2012522994 A5 JP2012522994 A5 JP 2012522994A5 JP 2012503717 A JP2012503717 A JP 2012503717A JP 2012503717 A JP2012503717 A JP 2012503717A JP 2012522994 A5 JP2012522994 A5 JP 2012522994A5
- Authority
- JP
- Japan
- Prior art keywords
- expression
- positive control
- biomarkers
- mmp
- regulated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 12
- 239000013641 positive control Substances 0.000 claims 12
- 239000000090 biomarker Substances 0.000 claims 8
- 150000001875 compounds Chemical class 0.000 claims 8
- 230000001105 regulatory effect Effects 0.000 claims 5
- 108010015302 Matrix metalloproteinase-9 Proteins 0.000 claims 4
- 102100030412 Matrix metalloproteinase-9 Human genes 0.000 claims 4
- 208000025157 Oral disease Diseases 0.000 claims 4
- 208000030194 mouth disease Diseases 0.000 claims 4
- 102100022089 Acyl-[acyl-carrier-protein] hydrolase Human genes 0.000 claims 3
- 102100026886 Beta-defensin 104 Human genes 0.000 claims 3
- 102100030401 Biglycan Human genes 0.000 claims 3
- 101000964894 Bos taurus 14-3-3 protein zeta/delta Proteins 0.000 claims 3
- 102100024966 Caspase recruitment domain-containing protein 10 Human genes 0.000 claims 3
- 102100035654 Cathepsin S Human genes 0.000 claims 3
- 102100027995 Collagenase 3 Human genes 0.000 claims 3
- 108050005238 Collagenase 3 Proteins 0.000 claims 3
- 102100038262 Epididymal-specific lipocalin-8 Human genes 0.000 claims 3
- 101000824278 Homo sapiens Acyl-[acyl-carrier-protein] hydrolase Proteins 0.000 claims 3
- 101000912243 Homo sapiens Beta-defensin 104 Proteins 0.000 claims 3
- 101000884714 Homo sapiens Beta-defensin 4A Proteins 0.000 claims 3
- 101001126865 Homo sapiens Biglycan Proteins 0.000 claims 3
- 101000761182 Homo sapiens Caspase recruitment domain-containing protein 10 Proteins 0.000 claims 3
- 101000947086 Homo sapiens Cathepsin S Proteins 0.000 claims 3
- 101000605055 Homo sapiens Epididymal-specific lipocalin-8 Proteins 0.000 claims 3
- 101001033249 Homo sapiens Interleukin-1 beta Proteins 0.000 claims 3
- 101000611023 Homo sapiens Tumor necrosis factor receptor superfamily member 6 Proteins 0.000 claims 3
- 102100039065 Interleukin-1 beta Human genes 0.000 claims 3
- 102100030698 Interleukin-12 subunit alpha Human genes 0.000 claims 3
- 101710194995 Interleukin-12 subunit alpha Proteins 0.000 claims 3
- 102000013691 Interleukin-17 Human genes 0.000 claims 3
- 108050003558 Interleukin-17 Proteins 0.000 claims 3
- 108090001005 Interleukin-6 Proteins 0.000 claims 3
- 102000004889 Interleukin-6 Human genes 0.000 claims 3
- 108090001007 Interleukin-8 Proteins 0.000 claims 3
- 102000004890 Interleukin-8 Human genes 0.000 claims 3
- 241000124008 Mammalia Species 0.000 claims 1
- 102000002274 Matrix Metalloproteinases Human genes 0.000 claims 1
- 108010000684 Matrix Metalloproteinases Proteins 0.000 claims 1
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 claims 1
- USIUVYZYUHIAEV-UHFFFAOYSA-N diphenyl ether Chemical class C=1C=CC=CC=1OC1=CC=CC=C1 USIUVYZYUHIAEV-UHFFFAOYSA-N 0.000 claims 1
- 208000007565 gingivitis Diseases 0.000 claims 1
- 210000000214 mouth Anatomy 0.000 claims 1
- 201000001245 periodontitis Diseases 0.000 claims 1
- 229960003500 triclosan Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16567409P | 2009-04-01 | 2009-04-01 | |
| US61/165,674 | 2009-04-01 | ||
| PCT/US2010/029674 WO2010115034A2 (en) | 2009-04-01 | 2010-04-01 | Protein biomarkers for soft tissue disease diagnosis and as therapeutic targets for oral care intervention |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012522994A JP2012522994A (ja) | 2012-09-27 |
| JP2012522994A5 true JP2012522994A5 (enExample) | 2013-05-16 |
| JP5643288B2 JP5643288B2 (ja) | 2014-12-17 |
Family
ID=42813186
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012503717A Expired - Fee Related JP5643288B2 (ja) | 2009-04-01 | 2010-04-01 | 軟組織疾患の診断のための、および口腔ケア介入のための療法的標的としてのタンパク質バイオマーカー |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8753820B2 (enExample) |
| EP (1) | EP2414837B1 (enExample) |
| JP (1) | JP5643288B2 (enExample) |
| CN (1) | CN102549432B (enExample) |
| AR (1) | AR076041A1 (enExample) |
| BR (1) | BRPI1013184A2 (enExample) |
| CA (1) | CA2753718C (enExample) |
| CO (1) | CO6430490A2 (enExample) |
| MX (1) | MX2011008439A (enExample) |
| MY (1) | MY179250A (enExample) |
| RU (1) | RU2523383C2 (enExample) |
| SG (1) | SG173461A1 (enExample) |
| TW (1) | TWI481870B (enExample) |
| WO (1) | WO2010115034A2 (enExample) |
| ZA (1) | ZA201106056B (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI405565B (zh) * | 2009-04-01 | 2013-08-21 | Colgate Palmolive Co | 口腔用組成物之抗－骨質流失及抗－牙周附連喪失之功效 |
| US9949671B2 (en) | 2013-03-13 | 2018-04-24 | Orthoaccel Technologies, Inc. | Diagnostic mouthpieces |
| WO2018129043A1 (en) * | 2017-01-03 | 2018-07-12 | The Trustees Of The University Of Pennsylvania | Compositions and methods for predicting risk of preterm birth |
| JP7486316B2 (ja) | 2017-05-24 | 2024-05-17 | コーニンクレッカ フィリップス エヌ ヴェ | 唾液のｉｌ－１ベータ及びｍｍｐ－９に基づく軽度の又は進行した歯周炎の診断 |
| EP3631458A1 (en) * | 2017-05-24 | 2020-04-08 | Koninklijke Philips N.V. | Diagnostics of periodontitis based on salivary hgf and mmp-8 |
| WO2018215596A1 (en) * | 2017-05-24 | 2018-11-29 | Koninklijke Philips N.V. | Diagnostics of gingivitis based on salivary il-1beta and hgf |
| WO2019084351A1 (en) | 2017-10-27 | 2019-05-02 | The Regents Of The University Of California | SALIVARY EXTRACELLULAR RNA BIOMARKERS FOR GINGIVITIS |
| EP3477306A1 (en) * | 2017-10-30 | 2019-05-01 | Koninklijke Philips N.V. | Classification of periodontitis patients |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3538230A (en) | 1966-12-05 | 1970-11-03 | Lever Brothers Ltd | Oral compositions containing silica xerogels as cleaning and polishing agents |
| US4358437A (en) | 1978-11-29 | 1982-11-09 | Beecham Group Limited | Compositions |
| US5288480A (en) | 1987-01-30 | 1994-02-22 | Colgate-Palmolive Co. | Antiplaque antibacterial oral composition |
| GB9117140D0 (en) | 1991-08-08 | 1991-09-25 | Unilever Plc | Treatment of periodontitis |
| DE4226043A1 (de) | 1992-08-06 | 1994-02-10 | Haarmann & Reimer Gmbh | Mittel mit physiologischem Kühleffekt und für diese Mittel geeignete wirksame Verbindungen |
| CA2176237A1 (en) | 1993-11-10 | 1995-05-18 | Richard P. Darveau | Treatment of bacterially-induced inflammatory diseases |
| US5578295A (en) | 1995-04-28 | 1996-11-26 | The Procter & Gamble Company | Oral care compositions comprising certain substituted diphenyl ethers |
| EP0935454B1 (de) | 1996-06-12 | 2001-08-22 | Cognis Deutschland GmbH | Kosmetische und/oder pharmazeutische zubereitungen |
| FR2794457B1 (fr) | 1999-06-01 | 2001-08-10 | Oreal | Derives carbonates de retinol, procede de preparation et utilisations |
| WO2001048481A1 (en) | 1999-12-03 | 2001-07-05 | Baxter International Inc. | Pyrogenicity test for use with automated immunoassay systems |
| GB0001704D0 (en) | 2000-01-25 | 2000-03-15 | Glaxo Group Ltd | Protein |
| WO2001078652A2 (en) | 2000-04-14 | 2001-10-25 | Metabolon, Inc. | Methods for drug discovery, disease treatment, and diagnosis using metabolomics |
| US7329489B2 (en) | 2000-04-14 | 2008-02-12 | Matabolon, Inc. | Methods for drug discovery, disease treatment, and diagnosis using metabolomics |
| US6500409B1 (en) | 2000-05-10 | 2002-12-31 | Colgate Palmolive Company | Synergistic antiplaque/antigingivitis oral composition |
| DE10059584A1 (de) | 2000-11-30 | 2002-06-06 | Beiersdorf Ag | Kosmetische oder dermatologische getränkte Tücher |
| US7005225B2 (en) | 2002-11-12 | 2006-02-28 | Samsung Electronics Company | Organosol including amphipathic copolymeric binder having crystalline material, and use of the organosol to make dry tones for electrographic applications |
| TW200902047A (en) | 2003-02-14 | 2009-01-16 | Combinatorx Inc | Methods and reagents for the treatment of diseases and disorders associated with increased levels of proinflammatory cytokines |
| GB2401865A (en) | 2003-05-22 | 2004-11-24 | Givaudan Sa | Antibacterial and antifungal glycerol monocarbonates |
| WO2005039504A2 (en) | 2003-10-24 | 2005-05-06 | Eisai Co., Ltd. | Compounds and methods for treating toll-like receptor 2-related diseases and conditions |
| US20070212686A1 (en) | 2003-12-03 | 2007-09-13 | Whitehead Institute For Biomedical Research | Use Of T-Cadherin As A Target |
| FI20040572A0 (fi) * | 2004-04-23 | 2004-04-23 | Ctt Cancer Targeting Tech Oy | Matriisi-metalloproteinaasin aktiviteetin inhibiittorit |
| US20050271601A1 (en) * | 2004-06-02 | 2005-12-08 | Nebojsa Milanovich | Anti-staining antibacterial dentifrice |
| WO2006068133A1 (ja) * | 2004-12-21 | 2006-06-29 | National University Corporation NARA Institute of Science and Technology | Ｎｆａｔ２発現抑制方法 |
| US20060141421A1 (en) | 2004-12-28 | 2006-06-29 | Kimberly-Clark Worldwide, Inc. | System and method for detecting substances related to oral health |
| WO2006074450A2 (en) | 2005-01-07 | 2006-07-13 | President And Fellows Of Harvard College | Methods and compositions for detecting and modulating periodontal disorders and periodontal diseases |
| RU2431845C2 (ru) * | 2006-01-10 | 2011-10-20 | Колгейт-Палмолив Компани | Способы модулирования рецепторов клеточных поверхностей для предотвращения или снижения воспаления |
| US20080161394A1 (en) | 2006-11-23 | 2008-07-03 | Jean-Yves Fouron | Cosmetic composition comprising at least one volatile carbonic acid ester |
| WO2008093072A2 (en) | 2007-01-29 | 2008-08-07 | Paul Webb | Topical composition against contact dermatitis due to water |
| US8333981B2 (en) | 2007-10-09 | 2012-12-18 | Humco Holding Group, Inc. | Antifungal treatment of nails |
-
2010
- 2010-03-31 TW TW099109774A patent/TWI481870B/zh not_active IP Right Cessation
- 2010-03-31 AR ARP100101093A patent/AR076041A1/es unknown
- 2010-04-01 RU RU2011144032/15A patent/RU2523383C2/ru not_active IP Right Cessation
- 2010-04-01 BR BRPI1013184A patent/BRPI1013184A2/pt not_active IP Right Cessation
- 2010-04-01 SG SG2011054509A patent/SG173461A1/en unknown
- 2010-04-01 CN CN201080015874.4A patent/CN102549432B/zh not_active Expired - Fee Related
- 2010-04-01 EP EP10712275.6A patent/EP2414837B1/en not_active Not-in-force
- 2010-04-01 WO PCT/US2010/029674 patent/WO2010115034A2/en not_active Ceased
- 2010-04-01 JP JP2012503717A patent/JP5643288B2/ja not_active Expired - Fee Related
- 2010-04-01 MX MX2011008439A patent/MX2011008439A/es active IP Right Grant
- 2010-04-01 CA CA2753718A patent/CA2753718C/en not_active Expired - Fee Related
- 2010-04-01 MY MYPI2011003578A patent/MY179250A/en unknown
- 2010-04-01 US US13/262,038 patent/US8753820B2/en active Active
-
2011
- 2011-08-17 ZA ZA2011/06056A patent/ZA201106056B/en unknown
- 2011-09-27 CO CO11126599A patent/CO6430490A2/es active IP Right Grant
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