JP2010502979A5 - - Google Patents
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- Publication number
- JP2010502979A5 JP2010502979A5 JP2009527200A JP2009527200A JP2010502979A5 JP 2010502979 A5 JP2010502979 A5 JP 2010502979A5 JP 2009527200 A JP2009527200 A JP 2009527200A JP 2009527200 A JP2009527200 A JP 2009527200A JP 2010502979 A5 JP2010502979 A5 JP 2010502979A5
- Authority
- JP
- Japan
- Prior art keywords
- individual
- liver
- liver disease
- adma
- suffering
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 15
- 208000019423 liver disease Diseases 0.000 claims 10
- HVPFXCBJHIIJGS-LURJTMIESA-N N(omega),N'(omega)-dimethyl-L-arginine Chemical compound CN\C(=N/C)NCCC[C@H](N)C(O)=O HVPFXCBJHIIJGS-LURJTMIESA-N 0.000 claims 5
- 230000003908 liver function Effects 0.000 claims 5
- YDGMGEXADBMOMJ-LURJTMIESA-N N(g)-dimethylarginine Chemical compound CN(C)C(\N)=N\CCC[C@H](N)C(O)=O YDGMGEXADBMOMJ-LURJTMIESA-N 0.000 claims 4
- YDGMGEXADBMOMJ-UHFFFAOYSA-N asymmetrical dimethylarginine Natural products CN(C)C(N)=NCCCC(N)C(O)=O YDGMGEXADBMOMJ-UHFFFAOYSA-N 0.000 claims 3
- 206010016654 Fibrosis Diseases 0.000 claims 2
- 230000007882 cirrhosis Effects 0.000 claims 2
- 208000019425 cirrhosis of liver Diseases 0.000 claims 2
- 108010023015 ischemia-modified albumin Proteins 0.000 claims 2
- 210000004185 liver Anatomy 0.000 claims 2
- 238000002054 transplantation Methods 0.000 claims 2
- 208000007788 Acute Liver Failure Diseases 0.000 claims 1
- 206010000804 Acute hepatic failure Diseases 0.000 claims 1
- 208000002467 Acute-On-Chronic Liver Failure Diseases 0.000 claims 1
- 108010088751 Albumins Proteins 0.000 claims 1
- 102000009027 Albumins Human genes 0.000 claims 1
- 208000022309 Alcoholic Liver disease Diseases 0.000 claims 1
- 206010010071 Coma Diseases 0.000 claims 1
- 208000010334 End Stage Liver Disease Diseases 0.000 claims 1
- 206010019663 Hepatic failure Diseases 0.000 claims 1
- 206010019728 Hepatitis alcoholic Diseases 0.000 claims 1
- 208000034486 Multi-organ failure Diseases 0.000 claims 1
- 206010063837 Reperfusion injury Diseases 0.000 claims 1
- 206010040047 Sepsis Diseases 0.000 claims 1
- 231100000836 acute liver failure Toxicity 0.000 claims 1
- 208000002353 alcoholic hepatitis Diseases 0.000 claims 1
- 208000011444 chronic liver failure Diseases 0.000 claims 1
- 208000007903 liver failure Diseases 0.000 claims 1
- 231100000835 liver failure Toxicity 0.000 claims 1
- 210000005228 liver tissue Anatomy 0.000 claims 1
- 208000029744 multiple organ dysfunction syndrome Diseases 0.000 claims 1
- 238000004393 prognosis Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0617581.4 | 2006-09-07 | ||
| GBGB0617581.4A GB0617581D0 (en) | 2006-09-07 | 2006-09-07 | Biomarkers for assessing liver function |
| PCT/GB2007/003362 WO2008029145A1 (en) | 2006-09-07 | 2007-09-07 | Biqmarkers for assessing liver function |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010502979A JP2010502979A (ja) | 2010-01-28 |
| JP2010502979A5 true JP2010502979A5 (enExample) | 2010-10-21 |
| JP4949473B2 JP4949473B2 (ja) | 2012-06-06 |
Family
ID=37232490
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009527200A Active JP4949473B2 (ja) | 2006-09-07 | 2007-09-07 | 肝機能を評価するためのバイオマーカー |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US8455220B2 (enExample) |
| EP (1) | EP2059817B1 (enExample) |
| JP (1) | JP4949473B2 (enExample) |
| KR (1) | KR20090083335A (enExample) |
| AT (1) | ATE488772T1 (enExample) |
| AU (1) | AU2007293302A1 (enExample) |
| CA (1) | CA2662597A1 (enExample) |
| DE (1) | DE602007010644D1 (enExample) |
| EA (1) | EA200970256A1 (enExample) |
| ES (1) | ES2353835T3 (enExample) |
| GB (1) | GB0617581D0 (enExample) |
| IL (1) | IL197271A0 (enExample) |
| MX (1) | MX2009002378A (enExample) |
| NO (1) | NO20090993L (enExample) |
| WO (1) | WO2008029145A1 (enExample) |
| ZA (1) | ZA200901432B (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2715346B1 (en) | 2011-05-31 | 2020-07-15 | The Regents of the University of Colorado, A Body Corporate | Method for assessment of hepatic function and portal blood flow |
| CA2891281C (en) * | 2012-11-12 | 2023-11-28 | The Regents Of The University Of Colorado, A Body Corporate | Disease severity index for assessment of chronic liver disease and method for diagnosis of three distinct subtypes of primary sclerosing cholangitis |
| WO2014190170A1 (en) * | 2013-05-22 | 2014-11-27 | The Regents Of The University Of California | Biomarker composite test for hepatic vein pressure gradient and cirrhosis treatment |
| CN107206049B (zh) * | 2014-10-24 | 2021-12-07 | 马林克罗特医疗产品知识产权公司 | 治疗患1型肝肾综合征的患者的方法 |
| CN105181692A (zh) * | 2015-09-30 | 2015-12-23 | 山东博科生物产业有限公司 | 一种缺血修饰白蛋白比色法检测试剂盒 |
| WO2017081073A1 (en) * | 2015-11-10 | 2017-05-18 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for predicting the survival time of patients with decompensated alcoholic cirrhosis |
| WO2020104458A1 (en) * | 2018-11-20 | 2020-05-28 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and kits for detecting liver dysfunction in a subject |
| CN121331222B (zh) * | 2025-12-15 | 2026-03-10 | 北京大学 | 基于蛋白质组的慢性肝脏疾病发病预测的蛋白组合、预测模型及应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2340397A (en) | 1996-03-21 | 1997-10-10 | Mayo Foundation For Medical Education And Research | Use of nicotine to treat liver disease |
| EP1299398A1 (en) | 2000-07-06 | 2003-04-09 | Fal Diagnostics | Methods and kits for the detection of arginine compounds |
| AU2002352959B2 (en) * | 2001-11-26 | 2008-04-10 | Ischemia Technologies, Inc. | Electrochemical detection of ischemia |
| WO2004012686A2 (en) * | 2002-08-06 | 2004-02-12 | Nitromed, Inc. | Nitrosated and/or nitrosylated ursodeoxycholic acid compounds, compositions and methods of use |
| AU2003290784A1 (en) | 2002-11-15 | 2004-06-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for detecting asymmetric dimethylarginine in a biological sample |
| WO2005039598A1 (en) | 2003-10-24 | 2005-05-06 | Intermune, Inc. | Method of treating alcoholic liver disease |
| DE10351238A1 (de) * | 2003-11-03 | 2005-06-02 | Roche Diagnostics Gmbh | Diagnosestellung von akuten myokardialen, ischämischen Erkrankungen durch Kombination von Markern |
-
2006
- 2006-09-07 GB GBGB0617581.4A patent/GB0617581D0/en not_active Ceased
-
2007
- 2007-09-07 CA CA002662597A patent/CA2662597A1/en not_active Abandoned
- 2007-09-07 EA EA200970256A patent/EA200970256A1/ru unknown
- 2007-09-07 ES ES07804163T patent/ES2353835T3/es active Active
- 2007-09-07 WO PCT/GB2007/003362 patent/WO2008029145A1/en not_active Ceased
- 2007-09-07 DE DE602007010644T patent/DE602007010644D1/de active Active
- 2007-09-07 AT AT07804163T patent/ATE488772T1/de not_active IP Right Cessation
- 2007-09-07 MX MX2009002378A patent/MX2009002378A/es not_active Application Discontinuation
- 2007-09-07 KR KR1020097007160A patent/KR20090083335A/ko not_active Ceased
- 2007-09-07 ZA ZA200901432A patent/ZA200901432B/xx unknown
- 2007-09-07 EP EP07804163A patent/EP2059817B1/en active Active
- 2007-09-07 AU AU2007293302A patent/AU2007293302A1/en not_active Abandoned
- 2007-09-07 JP JP2009527200A patent/JP4949473B2/ja active Active
- 2007-09-07 US US12/440,170 patent/US8455220B2/en active Active
-
2009
- 2009-02-26 IL IL197271A patent/IL197271A0/en unknown
- 2009-03-05 NO NO20090993A patent/NO20090993L/no not_active Application Discontinuation
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