JP2012522030A5 - - Google Patents
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- Publication number
- JP2012522030A5 JP2012522030A5 JP2012502640A JP2012502640A JP2012522030A5 JP 2012522030 A5 JP2012522030 A5 JP 2012522030A5 JP 2012502640 A JP2012502640 A JP 2012502640A JP 2012502640 A JP2012502640 A JP 2012502640A JP 2012522030 A5 JP2012522030 A5 JP 2012522030A5
- Authority
- JP
- Japan
- Prior art keywords
- hesperetin
- motomeko
- compound
- flavonoid compound
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- -1 flavonoid compound Chemical class 0.000 claims 11
- 239000001100 (2S)-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one Substances 0.000 claims 9
- 229930003935 flavonoid Natural products 0.000 claims 9
- 235000017173 flavonoids Nutrition 0.000 claims 9
- AIONOLUJZLIMTK-AWEZNQCLSA-N hesperetin Chemical compound C1=C(O)C(OC)=CC=C1[C@H]1OC2=CC(O)=CC(O)=C2C(=O)C1 AIONOLUJZLIMTK-AWEZNQCLSA-N 0.000 claims 8
- AIONOLUJZLIMTK-UHFFFAOYSA-N hesperetin Natural products C1=C(O)C(OC)=CC=C1C1OC2=CC(O)=CC(O)=C2C(=O)C1 AIONOLUJZLIMTK-UHFFFAOYSA-N 0.000 claims 8
- 229960001587 hesperetin Drugs 0.000 claims 8
- 235000010209 hesperetin Nutrition 0.000 claims 8
- FTODBIPDTXRIGS-UHFFFAOYSA-N homoeriodictyol Natural products C1=C(O)C(OC)=CC(C2OC3=CC(O)=CC(O)=C3C(=O)C2)=C1 FTODBIPDTXRIGS-UHFFFAOYSA-N 0.000 claims 8
- XHEFDIBZLJXQHF-UHFFFAOYSA-N fisetin Chemical compound C=1C(O)=CC=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 XHEFDIBZLJXQHF-UHFFFAOYSA-N 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 claims 3
- 230000001225 therapeutic effect Effects 0.000 claims 3
- REFJWTPEDVJJIY-UHFFFAOYSA-N Quercetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 REFJWTPEDVJJIY-UHFFFAOYSA-N 0.000 claims 2
- RTIXKCRFFJGDFG-UHFFFAOYSA-N chrysin Chemical compound C=1C(O)=CC(O)=C(C(C=2)=O)C=1OC=2C1=CC=CC=C1 RTIXKCRFFJGDFG-UHFFFAOYSA-N 0.000 claims 2
- ZQSIJRDFPHDXIC-UHFFFAOYSA-N daidzein Chemical compound C1=CC(O)=CC=C1C1=COC2=CC(O)=CC=C2C1=O ZQSIJRDFPHDXIC-UHFFFAOYSA-N 0.000 claims 2
- 235000011990 fisetin Nutrition 0.000 claims 2
- VCCRNZQBSJXYJD-UHFFFAOYSA-N galangin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=CC=C1 VCCRNZQBSJXYJD-UHFFFAOYSA-N 0.000 claims 2
- SQFSKOYWJBQGKQ-UHFFFAOYSA-N kaempferide Chemical compound C1=CC(OC)=CC=C1C1=C(O)C(=O)C2=C(O)C=C(O)C=C2O1 SQFSKOYWJBQGKQ-UHFFFAOYSA-N 0.000 claims 2
- IYRMWMYZSQPJKC-UHFFFAOYSA-N kaempferol Chemical compound C1=CC(O)=CC=C1C1=C(O)C(=O)C2=C(O)C=C(O)C=C2O1 IYRMWMYZSQPJKC-UHFFFAOYSA-N 0.000 claims 2
- VGEREEWJJVICBM-UHFFFAOYSA-N phloretin Chemical compound C1=CC(O)=CC=C1CCC(=O)C1=C(O)C=C(O)C=C1O VGEREEWJJVICBM-UHFFFAOYSA-N 0.000 claims 2
- 230000003449 preventive effect Effects 0.000 claims 2
- JVXZRQGOGOXCEC-UHFFFAOYSA-N scutellarein Chemical compound C1=CC(O)=CC=C1C1=CC(=O)C2=C(O)C(O)=C(O)C=C2O1 JVXZRQGOGOXCEC-UHFFFAOYSA-N 0.000 claims 2
- PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 claims 1
- PFTAWBLQPZVEMU-ZFWWWQNUSA-N (+)-epicatechin Natural products C1([C@@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-ZFWWWQNUSA-N 0.000 claims 1
- WMBWREPUVVBILR-WIYYLYMNSA-N (-)-Epigallocatechin-3-o-gallate Chemical compound O([C@@H]1CC2=C(O)C=C(C=C2O[C@@H]1C=1C=C(O)C(O)=C(O)C=1)O)C(=O)C1=CC(O)=C(O)C(O)=C1 WMBWREPUVVBILR-WIYYLYMNSA-N 0.000 claims 1
- PFTAWBLQPZVEMU-UKRRQHHQSA-N (-)-epicatechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-UKRRQHHQSA-N 0.000 claims 1
- ZWTDXYUDJYDHJR-UHFFFAOYSA-N (E)-1-(2,4-dihydroxyphenyl)-3-(2,4-dihydroxyphenyl)-2-propen-1-one Natural products OC1=CC(O)=CC=C1C=CC(=O)C1=CC=C(O)C=C1O ZWTDXYUDJYDHJR-UHFFFAOYSA-N 0.000 claims 1
- NYCXYKOXLNBYID-UHFFFAOYSA-N 5,7-Dihydroxychromone Natural products O1C=CC(=O)C=2C1=CC(O)=CC=2O NYCXYKOXLNBYID-UHFFFAOYSA-N 0.000 claims 1
- FXNFHKRTJBSTCS-UHFFFAOYSA-N Baicalein Natural products C=1C(=O)C=2C(O)=C(O)C(O)=CC=2OC=1C1=CC=CC=C1 FXNFHKRTJBSTCS-UHFFFAOYSA-N 0.000 claims 1
- JMGZEFIQIZZSBH-UHFFFAOYSA-N Bioquercetin Natural products CC1OC(OCC(O)C2OC(OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5)C(O)C2O)C(O)C(O)C1O JMGZEFIQIZZSBH-UHFFFAOYSA-N 0.000 claims 1
- 241000675108 Citrus tangerina Species 0.000 claims 1
- UBSCDKPKWHYZNX-UHFFFAOYSA-N Demethoxycapillarisin Natural products C1=CC(O)=CC=C1OC1=CC(=O)C2=C(O)C=C(O)C=C2O1 UBSCDKPKWHYZNX-UHFFFAOYSA-N 0.000 claims 1
- WMBWREPUVVBILR-UHFFFAOYSA-N GCG Natural products C=1C(O)=C(O)C(O)=CC=1C1OC2=CC(O)=CC(O)=C2CC1OC(=O)C1=CC(O)=C(O)C(O)=C1 WMBWREPUVVBILR-UHFFFAOYSA-N 0.000 claims 1
- QUQPHWDTPGMPEX-UHFFFAOYSA-N Hesperidine Natural products C1=C(O)C(OC)=CC=C1C1OC2=CC(OC3C(C(O)C(O)C(COC4C(C(O)C(O)C(C)O4)O)O3)O)=CC(O)=C2C(=O)C1 QUQPHWDTPGMPEX-UHFFFAOYSA-N 0.000 claims 1
- 208000035150 Hypercholesterolemia Diseases 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- GQODBWLKUWYOFX-UHFFFAOYSA-N Isorhamnetin Natural products C1=C(O)C(C)=CC(C2=C(C(=O)C3=C(O)C=C(O)C=C3O2)O)=C1 GQODBWLKUWYOFX-UHFFFAOYSA-N 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- IKMDFBPHZNJCSN-UHFFFAOYSA-N Myricetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC(O)=C(O)C(O)=C1 IKMDFBPHZNJCSN-UHFFFAOYSA-N 0.000 claims 1
- YQHMWTPYORBCMF-UHFFFAOYSA-N Naringenin chalcone Natural products C1=CC(O)=CC=C1C=CC(=O)C1=C(O)C=C(O)C=C1O YQHMWTPYORBCMF-UHFFFAOYSA-N 0.000 claims 1
- ZVOLCUVKHLEPEV-UHFFFAOYSA-N Quercetagetin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=C(O)C(O)=C(O)C=C2O1 ZVOLCUVKHLEPEV-UHFFFAOYSA-N 0.000 claims 1
- HWTZYBCRDDUBJY-UHFFFAOYSA-N Rhynchosin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=CC(O)=C(O)C=C2O1 HWTZYBCRDDUBJY-UHFFFAOYSA-N 0.000 claims 1
- 208000000558 Varicose Ulcer Diseases 0.000 claims 1
- 206010046996 Varicose vein Diseases 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 239000003963 antioxidant agent Substances 0.000 claims 1
- 235000006708 antioxidants Nutrition 0.000 claims 1
- 239000003443 antiviral agent Substances 0.000 claims 1
- XADJWCRESPGUTB-UHFFFAOYSA-N apigenin Natural products C1=CC(O)=CC=C1C1=CC(=O)C2=CC(O)=C(O)C=C2O1 XADJWCRESPGUTB-UHFFFAOYSA-N 0.000 claims 1
- 235000008714 apigenin Nutrition 0.000 claims 1
- KZNIFHPLKGYRTM-UHFFFAOYSA-N apigenin Chemical compound C1=CC(O)=CC=C1C1=CC(=O)C2=C(O)C=C(O)C=C2O1 KZNIFHPLKGYRTM-UHFFFAOYSA-N 0.000 claims 1
- 229940117893 apigenin Drugs 0.000 claims 1
- QUQPHWDTPGMPEX-UTWYECKDSA-N aurantiamarin Natural products COc1ccc(cc1O)[C@H]1CC(=O)c2c(O)cc(O[C@@H]3O[C@H](CO[C@@H]4O[C@@H](C)[C@H](O)[C@@H](O)[C@H]4O)[C@@H](O)[C@H](O)[C@H]3O)cc2O1 QUQPHWDTPGMPEX-UTWYECKDSA-N 0.000 claims 1
- UDFLTIRFTXWNJO-UHFFFAOYSA-N baicalein Chemical compound O1C2=CC(=O)C(O)=C(O)C2=C(O)C=C1C1=CC=CC=C1 UDFLTIRFTXWNJO-UHFFFAOYSA-N 0.000 claims 1
- 229940015301 baicalein Drugs 0.000 claims 1
- ADRVNXBAWSRFAJ-UHFFFAOYSA-N catechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3ccc(O)c(O)c3 ADRVNXBAWSRFAJ-UHFFFAOYSA-N 0.000 claims 1
- 235000005487 catechin Nutrition 0.000 claims 1
- 235000015838 chrysin Nutrition 0.000 claims 1
- 229940043370 chrysin Drugs 0.000 claims 1
- 229950001002 cianidanol Drugs 0.000 claims 1
- APSNPMVGBGZYAJ-GLOOOPAXSA-N clematine Natural products COc1cc(ccc1O)[C@@H]2CC(=O)c3c(O)cc(O[C@@H]4O[C@H](CO[C@H]5O[C@@H](C)[C@H](O)[C@@H](O)[C@H]5O)[C@@H](O)[C@H](O)[C@H]4O)cc3O2 APSNPMVGBGZYAJ-GLOOOPAXSA-N 0.000 claims 1
- 235000007240 daidzein Nutrition 0.000 claims 1
- GZSOSUNBTXMUFQ-YFAPSIMESA-N diosmin Chemical compound C1=C(O)C(OC)=CC=C1C(OC1=C2)=CC(=O)C1=C(O)C=C2O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@H]2[C@@H]([C@H](O)[C@@H](O)[C@H](C)O2)O)O1 GZSOSUNBTXMUFQ-YFAPSIMESA-N 0.000 claims 1
- 229960004352 diosmin Drugs 0.000 claims 1
- LPTRNLNOHUVQMS-UHFFFAOYSA-N epicatechin Natural products Cc1cc(O)cc2OC(C(O)Cc12)c1ccc(O)c(O)c1 LPTRNLNOHUVQMS-UHFFFAOYSA-N 0.000 claims 1
- 235000012734 epicatechin Nutrition 0.000 claims 1
- IVTMALDHFAHOGL-UHFFFAOYSA-N eriodictyol 7-O-rutinoside Natural products OC1C(O)C(O)C(C)OC1OCC1C(O)C(O)C(O)C(OC=2C=C3C(C(C(O)=C(O3)C=3C=C(O)C(O)=CC=3)=O)=C(O)C=2)O1 IVTMALDHFAHOGL-UHFFFAOYSA-N 0.000 claims 1
- 150000002215 flavonoids Chemical class 0.000 claims 1
- SPIUTQOUKAMGCX-UHFFFAOYSA-N flavoxate Chemical compound C1=CC=C2C(=O)C(C)=C(C=3C=CC=CC=3)OC2=C1C(=O)OCCN1CCCCC1 SPIUTQOUKAMGCX-UHFFFAOYSA-N 0.000 claims 1
- 229960000855 flavoxate Drugs 0.000 claims 1
- CIPSYTVGZURWPT-UHFFFAOYSA-N galangin Natural products OC1=C(Oc2cc(O)c(O)cc2C1=O)c3ccccc3 CIPSYTVGZURWPT-UHFFFAOYSA-N 0.000 claims 1
- 235000006539 genistein Nutrition 0.000 claims 1
- TZBJGXHYKVUXJN-UHFFFAOYSA-N genistein Natural products C1=CC(O)=CC=C1C1=COC2=CC(O)=CC(O)=C2C1=O TZBJGXHYKVUXJN-UHFFFAOYSA-N 0.000 claims 1
- 229940045109 genistein Drugs 0.000 claims 1
- ZCOLJUOHXJRHDI-CMWLGVBASA-N genistein 7-O-beta-D-glucoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC(O)=C2C(=O)C(C=3C=CC(O)=CC=3)=COC2=C1 ZCOLJUOHXJRHDI-CMWLGVBASA-N 0.000 claims 1
- 230000008821 health effect Effects 0.000 claims 1
- 208000014617 hemorrhoid Diseases 0.000 claims 1
- 229940025878 hesperidin Drugs 0.000 claims 1
- VUYDGVRIQRPHFX-UHFFFAOYSA-N hesperidin Natural products COc1cc(ccc1O)C2CC(=O)c3c(O)cc(OC4OC(COC5OC(O)C(O)C(O)C5O)C(O)C(O)C4O)cc3O2 VUYDGVRIQRPHFX-UHFFFAOYSA-N 0.000 claims 1
- QUQPHWDTPGMPEX-QJBIFVCTSA-N hesperidin Chemical compound C1=C(O)C(OC)=CC=C1[C@H]1OC2=CC(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO[C@H]4[C@@H]([C@H](O)[C@@H](O)[C@H](C)O4)O)O3)O)=CC(O)=C2C(=O)C1 QUQPHWDTPGMPEX-QJBIFVCTSA-N 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 235000008800 isorhamnetin Nutrition 0.000 claims 1
- IZQSVPBOUDKVDZ-UHFFFAOYSA-N isorhamnetin Chemical compound C1=C(O)C(OC)=CC(C2=C(C(=O)C3=C(O)C=C(O)C=C3O2)O)=C1 IZQSVPBOUDKVDZ-UHFFFAOYSA-N 0.000 claims 1
- 235000008777 kaempferol Nutrition 0.000 claims 1
- LRDGATPGVJTWLJ-UHFFFAOYSA-N luteolin Natural products OC1=CC(O)=CC(C=2OC3=CC(O)=CC(O)=C3C(=O)C=2)=C1 LRDGATPGVJTWLJ-UHFFFAOYSA-N 0.000 claims 1
- 235000009498 luteolin Nutrition 0.000 claims 1
- IQPNAANSBPBGFQ-UHFFFAOYSA-N luteolin Chemical compound C=1C(O)=CC(O)=C(C(C=2)=O)C=1OC=2C1=CC=C(O)C(O)=C1 IQPNAANSBPBGFQ-UHFFFAOYSA-N 0.000 claims 1
- UXOUKMQIEVGVLY-UHFFFAOYSA-N morin Natural products OC1=CC(O)=CC(C2=C(C(=O)C3=C(O)C=C(O)C=C3O2)O)=C1 UXOUKMQIEVGVLY-UHFFFAOYSA-N 0.000 claims 1
- PCOBUQBNVYZTBU-UHFFFAOYSA-N myricetin Natural products OC1=C(O)C(O)=CC(C=2OC3=CC(O)=C(O)C(O)=C3C(=O)C=2)=C1 PCOBUQBNVYZTBU-UHFFFAOYSA-N 0.000 claims 1
- 235000007743 myricetin Nutrition 0.000 claims 1
- 229940116852 myricetin Drugs 0.000 claims 1
- ARGKVCXINMKCAZ-UHFFFAOYSA-N neohesperidine Natural products C1=C(O)C(OC)=CC=C1C1OC2=CC(OC3C(C(O)C(O)C(CO)O3)OC3C(C(O)C(O)C(C)O3)O)=CC(O)=C2C(=O)C1 ARGKVCXINMKCAZ-UHFFFAOYSA-N 0.000 claims 1
- SUYJZKRQHBQNCA-UHFFFAOYSA-N pinobanksin Natural products O1C2=CC(O)=CC(O)=C2C(=O)C(O)C1C1=CC=CC=C1 SUYJZKRQHBQNCA-UHFFFAOYSA-N 0.000 claims 1
- 230000000069 prophylactic effect Effects 0.000 claims 1
- 235000005875 quercetin Nutrition 0.000 claims 1
- 229960001285 quercetin Drugs 0.000 claims 1
- FDRQPMVGJOQVTL-UHFFFAOYSA-N quercetin rutinoside Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 FDRQPMVGJOQVTL-UHFFFAOYSA-N 0.000 claims 1
- ALABRVAAKCSLSC-UHFFFAOYSA-N rutin Natural products CC1OC(OCC2OC(O)C(O)C(O)C2O)C(O)C(O)C1OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5 ALABRVAAKCSLSC-UHFFFAOYSA-N 0.000 claims 1
- 235000005493 rutin Nutrition 0.000 claims 1
- IKGXIBQEEMLURG-BKUODXTLSA-N rutin Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@@H]1OC[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-BKUODXTLSA-N 0.000 claims 1
- 229960004555 rutoside Drugs 0.000 claims 1
- 208000027185 varicose disease Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09156910.3 | 2009-03-31 | ||
| EP09156910A EP2241313A1 (en) | 2009-03-31 | 2009-03-31 | Use of flavonoids to increase the bioavailability of hesperetin |
| PCT/EP2010/054215 WO2010112510A1 (en) | 2009-03-31 | 2010-03-30 | Use of flavonoids to increase the bioavailability of hesperetin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012522030A JP2012522030A (ja) | 2012-09-20 |
| JP2012522030A5 true JP2012522030A5 (enExample) | 2013-05-09 |
Family
ID=40908614
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012502640A Pending JP2012522030A (ja) | 2009-03-31 | 2010-03-30 | ヘスペレチンの生体利用率を増大させるためのフラボノイドの使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8685935B2 (enExample) |
| EP (2) | EP2241313A1 (enExample) |
| JP (1) | JP2012522030A (enExample) |
| CN (1) | CN102448455A (enExample) |
| AR (1) | AR076040A1 (enExample) |
| AU (1) | AU2010230211A1 (enExample) |
| BR (1) | BRPI1014083A2 (enExample) |
| CL (1) | CL2011002451A1 (enExample) |
| MX (1) | MX2011010376A (enExample) |
| SG (1) | SG174609A1 (enExample) |
| WO (1) | WO2010112510A1 (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100234310A1 (en) * | 2009-03-11 | 2010-09-16 | Bionovo, Inc. | Estrogenic compounds and their methods of use |
| CN103462957A (zh) * | 2012-06-07 | 2013-12-25 | 上海中医药大学 | 一种异鼠李素的新用途 |
| CN102697768A (zh) * | 2012-06-07 | 2012-10-03 | 中国人民解放军第二军医大学 | 一类木犀草素类似黄酮类化合物在制备抗肿瘤药物中的用途 |
| US9053152B2 (en) | 2012-08-06 | 2015-06-09 | Sap Portals Israel Ltd | Search and context based creation in dynamic workspaces |
| CN102861090A (zh) * | 2012-10-27 | 2013-01-09 | 吴俊华 | Houttuynoid C在治疗胆管癌药物中的应用 |
| CN102861060A (zh) * | 2012-10-27 | 2013-01-09 | 吴俊华 | Houttuynoid B在治疗白血病药物中的应用 |
| CN102861048A (zh) * | 2012-10-27 | 2013-01-09 | 吴俊华 | Houttuynoid A在治疗鼻咽癌药物中的应用 |
| CN102861050A (zh) * | 2012-10-27 | 2013-01-09 | 吴俊华 | Houttuynoid A在治疗胰腺癌药物中的应用 |
| CN102861075A (zh) * | 2012-10-27 | 2013-01-09 | 吴俊华 | Houttuynoid B在治疗胃癌药物中的应用 |
| CN102861081A (zh) * | 2012-10-27 | 2013-01-09 | 吴俊华 | Houttuynoid C在治疗皮肤癌药物中的应用 |
| CN102861046A (zh) * | 2012-10-27 | 2013-01-09 | 南京大学 | Houttuynoid A在治疗卵巢癌药物中的应用 |
| CN102861053B (zh) * | 2012-10-27 | 2013-07-10 | 南京大学 | Houttuynoid D在治疗白血病药物中的应用 |
| CN102861086A (zh) * | 2012-10-27 | 2013-01-09 | 吴俊华 | Houttuynoid E在治疗卵巢癌药物中的应用 |
| CN102861092A (zh) * | 2012-10-27 | 2013-01-09 | 吴俊华 | Houttuynoid C在治疗肺癌药物中的应用 |
| US10722584B2 (en) | 2012-11-29 | 2020-07-28 | Societe Des Produits Nestle S.A. | Increasing the bioavailability of flavan-3-ols by polyphenols |
| GB201407694D0 (en) * | 2014-05-01 | 2014-06-18 | Univ Montfort | Compound |
| WO2016128503A1 (en) * | 2015-02-11 | 2016-08-18 | Bioactor Bv | Compounds and compositions for improving power output and oxygen efficiency |
| US12257231B2 (en) * | 2015-02-13 | 2025-03-25 | Global Biolife Inc. | Method and composition for preventing and treating viral infections |
| US10383842B2 (en) * | 2015-02-13 | 2019-08-20 | Global Biolife Inc. | Method and composition for preventing and treating viral infections |
| JP6881890B2 (ja) * | 2015-05-14 | 2021-06-02 | 花王株式会社 | カテキン類吸収促進剤 |
| US10123991B2 (en) * | 2015-05-15 | 2018-11-13 | Global Biolife Inc. | Electrophilically enhanced phenolic compounds for treating inflammatory related diseases and disorders |
| CN105167193B (zh) * | 2015-06-17 | 2019-02-19 | 湖北中烟工业有限责任公司 | 含黄酮香精的烟用嘴棒及其制备方法 |
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| KR101725461B1 (ko) * | 2015-12-29 | 2017-04-10 | 연세대학교 산학협력단 | 디오스민을 유효성분으로 포함하는 탈모 예방 또는 치료용, 또는 발모 또는 육모 촉진용 조성물 |
| US20220249530A1 (en) * | 2017-08-28 | 2022-08-11 | Global Biolife Inc. | Method and composition for preventing and treating viral infections |
| US11311563B2 (en) * | 2017-08-28 | 2022-04-26 | Global Biolife Inc. | Method and composition for preventing and treating viral infections |
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| KR20210021827A (ko) | 2019-08-19 | 2021-03-02 | 연세대학교 산학협력단 | 켐페라이드를 유효성분으로 포함하는 대사질환의 예방 또는 치료용 조성물 |
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| CN113679733A (zh) * | 2021-08-31 | 2021-11-23 | 广东金骏康生物技术有限公司 | 一种抑制结肠炎的化合物及其应用 |
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| CN117224530A (zh) * | 2023-09-15 | 2023-12-15 | 北京东方百奥医药开发有限公司 | 一种改善雄性哺乳动物睾酮水平的化合物 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU6666594A (en) | 1993-04-20 | 1994-11-08 | Procter & Gamble Company, The | Methods of using hesperetin for sebum control and treatment of acne |
| JPH08283154A (ja) * | 1995-04-12 | 1996-10-29 | Nippon Shinyaku Co Ltd | 脂質代謝改善剤 |
| JP4846141B2 (ja) * | 2001-08-31 | 2011-12-28 | 東洋精糖株式会社 | 即効性および持続性を有するフラボノイド配糖体を含有する経口栄養補給剤 |
| WO2003043570A2 (en) * | 2001-11-15 | 2003-05-30 | Galileo Laboratories, Inc. | Formulations and methods for treatment or amelioration of inflammatory conditions |
| JP5419366B2 (ja) * | 2008-03-03 | 2014-02-19 | 東洋精糖株式会社 | 生体吸収性に優れたヘスペレチン組成物 |
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2009
- 2009-03-31 EP EP09156910A patent/EP2241313A1/en not_active Withdrawn
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2010
- 2010-03-30 AU AU2010230211A patent/AU2010230211A1/en not_active Abandoned
- 2010-03-30 EP EP10711685A patent/EP2413928A1/en not_active Withdrawn
- 2010-03-30 JP JP2012502640A patent/JP2012522030A/ja active Pending
- 2010-03-30 US US13/260,961 patent/US8685935B2/en not_active Expired - Fee Related
- 2010-03-30 CN CN2010800226972A patent/CN102448455A/zh active Pending
- 2010-03-30 WO PCT/EP2010/054215 patent/WO2010112510A1/en not_active Ceased
- 2010-03-30 BR BRPI1014083A patent/BRPI1014083A2/pt not_active IP Right Cessation
- 2010-03-30 SG SG2011070745A patent/SG174609A1/en unknown
- 2010-03-30 MX MX2011010376A patent/MX2011010376A/es not_active Application Discontinuation
- 2010-03-31 AR ARP100101092A patent/AR076040A1/es unknown
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2011
- 2011-09-30 CL CL2011002451A patent/CL2011002451A1/es unknown
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