JP2012520866A - 高用量のウルソデオキシコール酸で非アルコール性脂肪性肝炎を治療する方法 - Google Patents
高用量のウルソデオキシコール酸で非アルコール性脂肪性肝炎を治療する方法 Download PDFInfo
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Classifications
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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| PCT/IB2010/000551 WO2010106420A1 (en) | 2009-03-17 | 2010-03-16 | Method of treating nonalcoholic steatohepatitis with elevated doses of ursodeoxycholic acid |
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| JP2012520866A true JP2012520866A (ja) | 2012-09-10 |
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| US (1) | US20120071451A1 (https=) |
| EP (1) | EP2408457A1 (https=) |
| JP (1) | JP2012520866A (https=) |
| KR (1) | KR20120008034A (https=) |
| CN (1) | CN102361642A (https=) |
| AU (1) | AU2010224587A1 (https=) |
| CA (1) | CA2755708A1 (https=) |
| IL (1) | IL215195A0 (https=) |
| MX (1) | MX2011009757A (https=) |
| RU (1) | RU2011139643A (https=) |
| WO (1) | WO2010106420A1 (https=) |
| ZA (1) | ZA201107578B (https=) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017522264A (ja) * | 2014-07-29 | 2017-08-10 | シンセン ハイタイド バイオファーマシューティカル リミテッド | ベルベリン塩、ウルソデオキシコール酸塩ならびに組み合わせ、その調製および適用方法 |
| JP2018514534A (ja) * | 2015-04-27 | 2018-06-07 | インターセプト ファーマシューティカルズ， インコーポレイテッド | オベチコール酸の組成物および使用方法 |
| JP2018534323A (ja) * | 2015-11-19 | 2018-11-22 | シニュー・ファーマ・インコーポレイテッドＳｉＮｅｗ Ｐｈａｒｍａ Ｉｎｃ． | 脂肪肝の予防または処置用医薬組成物 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9719068B2 (en) | 2010-05-06 | 2017-08-01 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into intestinal tissues through directed differentiation |
| KR101401628B1 (ko) * | 2012-12-24 | 2014-06-02 | 삼성제약공업주식회사 | 간기능 개선용 정제 및 그 제조 방법 |
| US9814733B2 (en) * | 2012-12-31 | 2017-11-14 | A,arin Pharmaceuticals Ireland Limited | Compositions comprising EPA and obeticholic acid and methods of use thereof |
| SG10201801654RA (en) | 2014-05-28 | 2018-04-27 | Childrens Hospital Med Ct | Methods and systems for converting precursor cells into gastric tissues through directed differentiation |
| AU2015331848B2 (en) | 2014-10-17 | 2022-03-03 | Children's Hospital Medical Center, D/B/A Cincinnati Children's Hospital Medical Center | In vivo model of human small intestine using pluripotent stem cells and methods of making and using same |
| CN109415685B (zh) | 2016-05-05 | 2023-07-04 | 儿童医院医疗中心 | 用于体外制造胃底组织的方法和与其相关的组合物 |
| EP4553082A3 (en) | 2016-11-04 | 2025-08-20 | Children's Hospital Medical Center | Liver organoid compositions and methods of making and using same |
| EP3548507A4 (en) | 2016-12-05 | 2020-07-15 | Children's Hospital Medical Center | COLON ORGANOIDS AND PROCESSES FOR THE PREPARATION AND USE THEREOF |
| JP7248586B2 (ja) | 2017-04-14 | 2023-03-29 | チルドレンズ ホスピタル メディカル センター | 複数ドナー幹細胞組成物およびそれを作製する方法 |
| CN110958878A (zh) * | 2017-06-21 | 2020-04-03 | 诺华股份有限公司 | 用于治疗非酒精性脂肪性肝炎的licofligozin |
| EP3694603B1 (en) | 2017-10-10 | 2026-04-08 | Children's Hospital Medical Center | Esophageal tissue and/or organoid compositions and methods of making same |
| KR101887561B1 (ko) * | 2017-11-15 | 2018-09-06 | 주식회사 대웅제약 | 간염 바이러스에 의해 유발된 간 섬유화의 개선을 위한 약학 조성물 |
| EP3727394A4 (en) | 2017-12-21 | 2021-09-08 | Children's Hospital Medical Center | DIGITALIZED HUMAN ORGANOIDS AND METHOD OF USING THEREOF |
| EP4678727A3 (en) | 2018-07-26 | 2026-03-11 | Children's Hospital Medical Center | Hepato-biliary-pancreatic tissues and methods of making same |
| RU2686042C1 (ru) * | 2018-09-04 | 2019-04-23 | Федеральное государственное бюджетное образовательное учреждение дополнительного профессионального образования "Российская медицинская академия непрерывного профессионального образования" Министерства здравоохранения Российской Федерации (ФГБОУ ДПО РМАНПО Минздрава России) | Способ лечения неалкогольной жировой болезни печени при метаболическом синдроме |
| CA3112026A1 (en) | 2018-09-12 | 2020-03-19 | Children's Hospital Medical Center | Organoid compositions for the production of hematopoietic stem cells and derivatives thereof |
| US12600943B2 (en) | 2019-02-01 | 2026-04-14 | The University Of Hong Kong | Innervated organoid compositions and methods of making same |
| AU2020283048A1 (en) | 2019-05-31 | 2021-12-23 | Children's Hospital Medical Center | Shaped organoid compositions and methods of making same |
| US12497597B2 (en) | 2019-05-31 | 2025-12-16 | Children's Hospital Medical Center | Methods of generating and expanding hematopoietic stem cells |
| CN114245743B (zh) * | 2019-07-30 | 2023-12-08 | Ko生物技术有限公司 | 预防、缓解或治疗肝损伤的组合物和方法 |
| WO2021020923A1 (ko) | 2019-07-30 | 2021-02-04 | 주식회사 고바이오랩 | 간 손상 예방, 개선, 또는 치료용 조성물 및 간 손상 예방, 개선, 또는 치료방법 |
| MX2022009182A (es) * | 2020-01-28 | 2022-08-17 | Shilpa Medicare Ltd | Metodo de administracion del acido ursodeoxicolico. |
| WO2022083713A1 (en) * | 2020-10-23 | 2022-04-28 | Shenzhen Hightide Biopharmaceutical Ltd. | Compositions of berberine ursodeoxycholate and methods thereof for treating fatty liver disease, diabetes and hyperlipidemia |
| CN115137732A (zh) * | 2021-03-29 | 2022-10-04 | 中国科学院大连化学物理研究所 | Gpr120受体激动剂及熊去氧胆酸的应用 |
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| US6297229B1 (en) * | 1994-11-14 | 2001-10-02 | Mayo Foundation For Medical Education And Research | Use of ursodeoxycholic acid to treat nonalcoholic steatohepatitis |
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2010
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- 2010-03-16 KR KR1020117024296A patent/KR20120008034A/ko not_active Withdrawn
- 2010-03-16 EP EP10714958A patent/EP2408457A1/en not_active Ceased
- 2010-03-16 WO PCT/IB2010/000551 patent/WO2010106420A1/en not_active Ceased
- 2010-03-16 CA CA2755708A patent/CA2755708A1/en not_active Abandoned
- 2010-03-16 CN CN2010800119928A patent/CN102361642A/zh active Pending
- 2010-03-16 AU AU2010224587A patent/AU2010224587A1/en not_active Abandoned
- 2010-03-16 RU RU2011139643/15A patent/RU2011139643A/ru not_active Application Discontinuation
- 2010-03-16 MX MX2011009757A patent/MX2011009757A/es not_active Application Discontinuation
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- 2011-09-18 IL IL215195A patent/IL215195A0/en unknown
- 2011-10-17 ZA ZA2011/07578A patent/ZA201107578B/en unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6297229B1 (en) * | 1994-11-14 | 2001-10-02 | Mayo Foundation For Medical Education And Research | Use of ursodeoxycholic acid to treat nonalcoholic steatohepatitis |
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| JPN5012009298; ＬＩＮＤＯＲ Ｋ Ｄ: 'ＵＲＳＯＤＥＯＸＹＣＨＯＬＩＣ ＡＣＩＤ ＦＯＲ ＴＲＥＡＴＭＥＮＴ ＯＦ ＮＯＮＡＬＣＯＨＯＬＩＣ ＳＴＥＡＴＯＨＥＰＡＴＩＴＩＳ：ＲＥＳＵＬＴＳ ＯＦ Ａ ＲＡＮＤＯＭＩＺＥＤ ＴＲＩＡＬ' ＨＥＰＡＴＯＬＯＧＹ Ｖ３９, 2004, Ｐ７７０-７７８ * |
| JPN5012009299; ＣＵＬＬＥＮ Ｓ Ｎ: 'ＨＩＧＨ ＤＯＳＥ ＵＲＳＯＤＥＯＸＹＣＨＯＬＩＣ ＡＣＩＤ ＦＯＲ ＴＨＥ ＴＲＥＡＴＭＥＮＴ ＯＦ ＰＲＩＭＡＲＹ ＳＣＬＥＲＯＳＩＮＧ ＣＨＯＬＡＮＧＩＴＩＳ 以下備考' ＪＯＵＲＮＡＬ ＯＦ ＨＥＰＡＴＯＬＯＧＹ Ｖ４８, 2008, Ｐ７９２-８００ * |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017522264A (ja) * | 2014-07-29 | 2017-08-10 | シンセン ハイタイド バイオファーマシューティカル リミテッド | ベルベリン塩、ウルソデオキシコール酸塩ならびに組み合わせ、その調製および適用方法 |
| JP2020073546A (ja) * | 2014-07-29 | 2020-05-14 | シンセン ハイタイド バイオファーマシューティカル リミテッド | ベルベリン塩、ウルソデオキシコール酸塩ならびに組み合わせ、その調製および適用方法 |
| JP2022020854A (ja) * | 2014-07-29 | 2022-02-01 | シンセン ハイタイド バイオファーマシューティカル リミテッド | ベルベリン塩、ウルソデオキシコール酸塩ならびに組み合わせ、その調製および適用方法 |
| JP7285903B2 (ja) | 2014-07-29 | 2023-06-02 | シンセン ハイタイド バイオファーマシューティカル リミテッド | ベルベリン塩、ウルソデオキシコール酸塩ならびに組み合わせ、その調製および適用方法 |
| JP2023099689A (ja) * | 2014-07-29 | 2023-07-13 | シンセン ハイタイド バイオファーマシューティカル リミテッド | ベルベリン塩、ウルソデオキシコール酸塩ならびに組み合わせ、その調製および適用方法 |
| JP2018514534A (ja) * | 2015-04-27 | 2018-06-07 | インターセプト ファーマシューティカルズ， インコーポレイテッド | オベチコール酸の組成物および使用方法 |
| JP2018534323A (ja) * | 2015-11-19 | 2018-11-22 | シニュー・ファーマ・インコーポレイテッドＳｉＮｅｗ Ｐｈａｒｍａ Ｉｎｃ． | 脂肪肝の予防または処置用医薬組成物 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102361642A (zh) | 2012-02-22 |
| US20120071451A1 (en) | 2012-03-22 |
| EP2408457A1 (en) | 2012-01-25 |
| MX2011009757A (es) | 2012-02-28 |
| CA2755708A1 (en) | 2010-09-23 |
| AU2010224587A1 (en) | 2011-09-22 |
| ZA201107578B (en) | 2013-06-26 |
| WO2010106420A1 (en) | 2010-09-23 |
| KR20120008034A (ko) | 2012-01-25 |
| RU2011139643A (ru) | 2013-04-27 |
| IL215195A0 (en) | 2011-12-29 |
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