RU2011139643A - Способ лечения неалкогольного стеатогепатита повышенными дозами урсодезоксихолевой кислоты - Google Patents
Способ лечения неалкогольного стеатогепатита повышенными дозами урсодезоксихолевой кислоты Download PDFInfo
- Publication number
- RU2011139643A RU2011139643A RU2011139643/15A RU2011139643A RU2011139643A RU 2011139643 A RU2011139643 A RU 2011139643A RU 2011139643/15 A RU2011139643/15 A RU 2011139643/15A RU 2011139643 A RU2011139643 A RU 2011139643A RU 2011139643 A RU2011139643 A RU 2011139643A
- Authority
- RU
- Russia
- Prior art keywords
- dose
- administered
- patient
- treatment
- udca
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract 27
- 239000002253 acid Substances 0.000 title 1
- RUDATBOHQWOJDD-UHFFFAOYSA-N (3beta,5beta,7alpha)-3,7-Dihydroxycholan-24-oic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)CC2 RUDATBOHQWOJDD-UHFFFAOYSA-N 0.000 claims abstract 8
- RUDATBOHQWOJDD-UZVSRGJWSA-N ursodeoxycholic acid Chemical compound C([C@H]1C[C@@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)CC1 RUDATBOHQWOJDD-UZVSRGJWSA-N 0.000 claims abstract 8
- 229960001661 ursodiol Drugs 0.000 claims abstract 8
- 229940127003 anti-diabetic drug Drugs 0.000 claims abstract 4
- 239000003472 antidiabetic agent Substances 0.000 claims abstract 4
- 208000008338 non-alcoholic fatty liver disease Diseases 0.000 claims abstract 4
- 206010053219 non-alcoholic steatohepatitis Diseases 0.000 claims abstract 4
- ZOBPZXTWZATXDG-UHFFFAOYSA-N 1,3-thiazolidine-2,4-dione Chemical compound O=C1CSC(=O)N1 ZOBPZXTWZATXDG-UHFFFAOYSA-N 0.000 claims abstract 2
- 206010016654 Fibrosis Diseases 0.000 claims abstract 2
- 206010061218 Inflammation Diseases 0.000 claims abstract 2
- 229940123464 Thiazolidinedione Drugs 0.000 claims abstract 2
- 230000037396 body weight Effects 0.000 claims abstract 2
- 230000004761 fibrosis Effects 0.000 claims abstract 2
- 230000004054 inflammatory process Effects 0.000 claims abstract 2
- 210000004185 liver Anatomy 0.000 claims abstract 2
- 150000003839 salts Chemical class 0.000 claims abstract 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims abstract 2
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16095509P | 2009-03-17 | 2009-03-17 | |
| US61/160,955 | 2009-03-17 | ||
| PCT/IB2010/000551 WO2010106420A1 (en) | 2009-03-17 | 2010-03-16 | Method of treating nonalcoholic steatohepatitis with elevated doses of ursodeoxycholic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2011139643A true RU2011139643A (ru) | 2013-04-27 |
Family
ID=42167374
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2011139643/15A RU2011139643A (ru) | 2009-03-17 | 2010-03-16 | Способ лечения неалкогольного стеатогепатита повышенными дозами урсодезоксихолевой кислоты |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20120071451A1 (https=) |
| EP (1) | EP2408457A1 (https=) |
| JP (1) | JP2012520866A (https=) |
| KR (1) | KR20120008034A (https=) |
| CN (1) | CN102361642A (https=) |
| AU (1) | AU2010224587A1 (https=) |
| CA (1) | CA2755708A1 (https=) |
| IL (1) | IL215195A0 (https=) |
| MX (1) | MX2011009757A (https=) |
| RU (1) | RU2011139643A (https=) |
| WO (1) | WO2010106420A1 (https=) |
| ZA (1) | ZA201107578B (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2686042C1 (ru) * | 2018-09-04 | 2019-04-23 | Федеральное государственное бюджетное образовательное учреждение дополнительного профессионального образования "Российская медицинская академия непрерывного профессионального образования" Министерства здравоохранения Российской Федерации (ФГБОУ ДПО РМАНПО Минздрава России) | Способ лечения неалкогольной жировой болезни печени при метаболическом синдроме |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9719068B2 (en) | 2010-05-06 | 2017-08-01 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into intestinal tissues through directed differentiation |
| KR101401628B1 (ko) * | 2012-12-24 | 2014-06-02 | 삼성제약공업주식회사 | 간기능 개선용 정제 및 그 제조 방법 |
| US9814733B2 (en) * | 2012-12-31 | 2017-11-14 | A,arin Pharmaceuticals Ireland Limited | Compositions comprising EPA and obeticholic acid and methods of use thereof |
| SG10201801654RA (en) | 2014-05-28 | 2018-04-27 | Childrens Hospital Med Ct | Methods and systems for converting precursor cells into gastric tissues through directed differentiation |
| IL282156B (en) * | 2014-07-29 | 2022-07-01 | Shenzhen Hightide Biopharmaceutical Ltd | Berberine salts, ursodeoxycholic salts and combinations, methods of preparation and application thereof |
| AU2015331848B2 (en) | 2014-10-17 | 2022-03-03 | Children's Hospital Medical Center, D/B/A Cincinnati Children's Hospital Medical Center | In vivo model of human small intestine using pluripotent stem cells and methods of making and using same |
| PE20180690A1 (es) | 2015-04-27 | 2018-04-23 | Intercept Pharmaceuticals Inc | Composiciones de acido obeticolico y metodos de uso |
| WO2017084234A1 (zh) * | 2015-11-19 | 2017-05-26 | 欣耀生医股份有限公司 | 预防或治疗脂肪肝的药物组合物 |
| CN109415685B (zh) | 2016-05-05 | 2023-07-04 | 儿童医院医疗中心 | 用于体外制造胃底组织的方法和与其相关的组合物 |
| EP4553082A3 (en) | 2016-11-04 | 2025-08-20 | Children's Hospital Medical Center | Liver organoid compositions and methods of making and using same |
| EP3548507A4 (en) | 2016-12-05 | 2020-07-15 | Children's Hospital Medical Center | COLON ORGANOIDS AND PROCESSES FOR THE PREPARATION AND USE THEREOF |
| JP7248586B2 (ja) | 2017-04-14 | 2023-03-29 | チルドレンズ ホスピタル メディカル センター | 複数ドナー幹細胞組成物およびそれを作製する方法 |
| CN110958878A (zh) * | 2017-06-21 | 2020-04-03 | 诺华股份有限公司 | 用于治疗非酒精性脂肪性肝炎的licofligozin |
| EP3694603B1 (en) | 2017-10-10 | 2026-04-08 | Children's Hospital Medical Center | Esophageal tissue and/or organoid compositions and methods of making same |
| KR101887561B1 (ko) * | 2017-11-15 | 2018-09-06 | 주식회사 대웅제약 | 간염 바이러스에 의해 유발된 간 섬유화의 개선을 위한 약학 조성물 |
| EP3727394A4 (en) | 2017-12-21 | 2021-09-08 | Children's Hospital Medical Center | DIGITALIZED HUMAN ORGANOIDS AND METHOD OF USING THEREOF |
| EP4678727A3 (en) | 2018-07-26 | 2026-03-11 | Children's Hospital Medical Center | Hepato-biliary-pancreatic tissues and methods of making same |
| CA3112026A1 (en) | 2018-09-12 | 2020-03-19 | Children's Hospital Medical Center | Organoid compositions for the production of hematopoietic stem cells and derivatives thereof |
| US12600943B2 (en) | 2019-02-01 | 2026-04-14 | The University Of Hong Kong | Innervated organoid compositions and methods of making same |
| AU2020283048A1 (en) | 2019-05-31 | 2021-12-23 | Children's Hospital Medical Center | Shaped organoid compositions and methods of making same |
| US12497597B2 (en) | 2019-05-31 | 2025-12-16 | Children's Hospital Medical Center | Methods of generating and expanding hematopoietic stem cells |
| CN114245743B (zh) * | 2019-07-30 | 2023-12-08 | Ko生物技术有限公司 | 预防、缓解或治疗肝损伤的组合物和方法 |
| WO2021020923A1 (ko) | 2019-07-30 | 2021-02-04 | 주식회사 고바이오랩 | 간 손상 예방, 개선, 또는 치료용 조성물 및 간 손상 예방, 개선, 또는 치료방법 |
| MX2022009182A (es) * | 2020-01-28 | 2022-08-17 | Shilpa Medicare Ltd | Metodo de administracion del acido ursodeoxicolico. |
| WO2022083713A1 (en) * | 2020-10-23 | 2022-04-28 | Shenzhen Hightide Biopharmaceutical Ltd. | Compositions of berberine ursodeoxycholate and methods thereof for treating fatty liver disease, diabetes and hyperlipidemia |
| CN115137732A (zh) * | 2021-03-29 | 2022-10-04 | 中国科学院大连化学物理研究所 | Gpr120受体激动剂及熊去氧胆酸的应用 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6297229B1 (en) * | 1994-11-14 | 2001-10-02 | Mayo Foundation For Medical Education And Research | Use of ursodeoxycholic acid to treat nonalcoholic steatohepatitis |
-
2010
- 2010-03-16 JP JP2012500328A patent/JP2012520866A/ja active Pending
- 2010-03-16 KR KR1020117024296A patent/KR20120008034A/ko not_active Withdrawn
- 2010-03-16 EP EP10714958A patent/EP2408457A1/en not_active Ceased
- 2010-03-16 WO PCT/IB2010/000551 patent/WO2010106420A1/en not_active Ceased
- 2010-03-16 CA CA2755708A patent/CA2755708A1/en not_active Abandoned
- 2010-03-16 CN CN2010800119928A patent/CN102361642A/zh active Pending
- 2010-03-16 AU AU2010224587A patent/AU2010224587A1/en not_active Abandoned
- 2010-03-16 RU RU2011139643/15A patent/RU2011139643A/ru not_active Application Discontinuation
- 2010-03-16 MX MX2011009757A patent/MX2011009757A/es not_active Application Discontinuation
-
2011
- 2011-08-24 US US13/217,042 patent/US20120071451A1/en not_active Abandoned
- 2011-09-18 IL IL215195A patent/IL215195A0/en unknown
- 2011-10-17 ZA ZA2011/07578A patent/ZA201107578B/en unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2686042C1 (ru) * | 2018-09-04 | 2019-04-23 | Федеральное государственное бюджетное образовательное учреждение дополнительного профессионального образования "Российская медицинская академия непрерывного профессионального образования" Министерства здравоохранения Российской Федерации (ФГБОУ ДПО РМАНПО Минздрава России) | Способ лечения неалкогольной жировой болезни печени при метаболическом синдроме |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102361642A (zh) | 2012-02-22 |
| US20120071451A1 (en) | 2012-03-22 |
| EP2408457A1 (en) | 2012-01-25 |
| MX2011009757A (es) | 2012-02-28 |
| CA2755708A1 (en) | 2010-09-23 |
| AU2010224587A1 (en) | 2011-09-22 |
| ZA201107578B (en) | 2013-06-26 |
| JP2012520866A (ja) | 2012-09-10 |
| WO2010106420A1 (en) | 2010-09-23 |
| KR20120008034A (ko) | 2012-01-25 |
| IL215195A0 (en) | 2011-12-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20140813 |