JP2012519484A5 - - Google Patents
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- JP2012519484A5 JP2012519484A5 JP2011552950A JP2011552950A JP2012519484A5 JP 2012519484 A5 JP2012519484 A5 JP 2012519484A5 JP 2011552950 A JP2011552950 A JP 2011552950A JP 2011552950 A JP2011552950 A JP 2011552950A JP 2012519484 A5 JP2012519484 A5 JP 2012519484A5
- Authority
- JP
- Japan
- Prior art keywords
- mir
- sequence
- seq
- mre
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 108091070501 miRNA Proteins 0.000 claims 32
- 239000002679 microRNA Substances 0.000 claims 12
- 108020004707 nucleic acids Proteins 0.000 claims 6
- 150000007523 nucleic acids Chemical class 0.000 claims 6
- 102000039446 nucleic acids Human genes 0.000 claims 6
- 241000712461 unidentified influenza virus Species 0.000 claims 6
- 108091026890 Coding region Proteins 0.000 claims 4
- 108091047577 miR-149 stem-loop Proteins 0.000 claims 4
- 108091035696 miR-149-1 stem-loop Proteins 0.000 claims 4
- 108091031096 miR-149-2 stem-loop Proteins 0.000 claims 4
- 108091027943 miR-16 stem-loop Proteins 0.000 claims 4
- 108091091751 miR-17 stem-loop Proteins 0.000 claims 4
- 108091069239 miR-17-2 stem-loop Proteins 0.000 claims 4
- 108091038599 miR-181b-2 stem-loop Proteins 0.000 claims 4
- 108091074848 miR-19 stem-loop Proteins 0.000 claims 4
- 108091085564 miR-25 stem-loop Proteins 0.000 claims 4
- 108091080167 miR-25-1 stem-loop Proteins 0.000 claims 4
- 108091083056 miR-25-2 stem-loop Proteins 0.000 claims 4
- 108091074487 miR-34 stem-loop Proteins 0.000 claims 4
- 108091092493 miR-34-1 stem-loop Proteins 0.000 claims 4
- 108091059780 miR-34-2 stem-loop Proteins 0.000 claims 4
- 108091059456 miR-92-1 stem-loop Proteins 0.000 claims 4
- 108091084336 miR-92-2 stem-loop Proteins 0.000 claims 4
- 108091032902 miR-93 stem-loop Proteins 0.000 claims 4
- 241001465754 Metazoa Species 0.000 claims 3
- 206010022000 influenza Diseases 0.000 claims 3
- 229960005486 vaccine Drugs 0.000 claims 3
- 108020005345 3' Untranslated Regions Proteins 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 108091028049 Mir-221 microRNA Proteins 0.000 claims 2
- -1 miR-1977 Proteins 0.000 claims 2
- 108091080321 miR-222 stem-loop Proteins 0.000 claims 2
- 238000002255 vaccination Methods 0.000 claims 2
- 108020004705 Codon Proteins 0.000 claims 1
- 108091036066 Three prime untranslated region Proteins 0.000 claims 1
- 210000000991 chicken egg Anatomy 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 238000012045 magnetic resonance elastography Methods 0.000 claims 1
- 108091007420 miR‐142 Proteins 0.000 claims 1
- 230000008488 polyadenylation Effects 0.000 claims 1
- 230000001681 protective effect Effects 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 241000894007 species Species 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15823309P | 2009-03-06 | 2009-03-06 | |
| US61/158,233 | 2009-03-06 | ||
| PCT/US2010/000709 WO2010101663A2 (en) | 2009-03-06 | 2010-03-08 | Live attenuated influenza virus vaccines comprising microrna response elements |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012519484A JP2012519484A (ja) | 2012-08-30 |
| JP2012519484A5 true JP2012519484A5 (enExample) | 2013-04-25 |
Family
ID=42710158
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011552950A Pending JP2012519484A (ja) | 2009-03-06 | 2010-03-08 | マイクロｒｎａ応答要素を含む弱毒化生インフルエンザウイルスワクチン |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8883995B2 (enExample) |
| EP (1) | EP2403527A4 (enExample) |
| JP (1) | JP2012519484A (enExample) |
| CA (1) | CA2754826A1 (enExample) |
| WO (1) | WO2010101663A2 (enExample) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2351844B1 (en) | 2003-04-29 | 2014-06-11 | Sarepta Therapeutics, Inc. | Compositions for enhancing transport and antisense efficacy of nucleic acid analog into cells |
| US8067571B2 (en) | 2005-07-13 | 2011-11-29 | Avi Biopharma, Inc. | Antibacterial antisense oligonucleotide and method |
| US8877206B2 (en) | 2007-03-22 | 2014-11-04 | Pds Biotechnology Corporation | Stimulation of an immune response by cationic lipids |
| US20100016215A1 (en) | 2007-06-29 | 2010-01-21 | Avi Biopharma, Inc. | Compound and method for treating myotonic dystrophy |
| WO2009129227A1 (en) | 2008-04-17 | 2009-10-22 | Pds Biotechnology Corporation | Stimulation of an immune response by enantiomers of cationic lipids |
| JP2012519484A (ja) * | 2009-03-06 | 2012-08-30 | マウント・シナイ・スクール・オヴ・メディシン | マイクロｒｎａ応答要素を含む弱毒化生インフルエンザウイルスワクチン |
| US20110269665A1 (en) | 2009-06-26 | 2011-11-03 | Avi Biopharma, Inc. | Compound and method for treating myotonic dystrophy |
| WO2011131193A1 (en) * | 2010-04-24 | 2011-10-27 | Statens Serum Institut | Diagnosing and treating fibrotic diseases using micro-rna 17 |
| TR201802741T4 (tr) | 2010-05-14 | 2018-03-21 | Univ Oregon Health & Science | Rekombinant hcmv ve rhcmv vektörleri ve bunların kullanımları. |
| WO2012051491A1 (en) * | 2010-10-14 | 2012-04-19 | The United States Of America, As Represented By The Secretary National Institutes Of Health | Compositions and methods for controlling neurotropic viral pathogenesis by micro-rna targeting |
| CN103648491B (zh) * | 2011-04-08 | 2017-07-14 | 法国国家健康医学研究院 | 用于抑制流感病毒复制的方法和药物组合物 |
| US9161948B2 (en) | 2011-05-05 | 2015-10-20 | Sarepta Therapeutics, Inc. | Peptide oligonucleotide conjugates |
| PT2691530T (pt) | 2011-06-10 | 2018-05-10 | Univ Oregon Health & Science | Glicoproteínas e vectores recombinantes cmv |
| US20130280215A1 (en) * | 2011-10-18 | 2013-10-24 | Geovax, Inc. | Mva vectors expressing polypeptides and having high level production in certain cell lines |
| WO2013182553A2 (en) | 2012-06-06 | 2013-12-12 | Boehringer Ingelheim International Gmbh | CELL ENGINEERING USING RNAs |
| CN105163753B (zh) | 2012-06-15 | 2018-12-21 | Pds生物科技公司 | 阳离子脂质疫苗组合物和使用方法 |
| EP2897639A4 (en) | 2012-09-21 | 2016-05-04 | Frank Bedu-Addo | IMPROVED VACCINATE COMPOSITIONS AND METHODS OF USE |
| AU2014225886B2 (en) | 2013-03-05 | 2020-04-16 | Oregon Health & Science University | Cytomegalovirus vectors enabling control of T cell targeting |
| CA2898130A1 (en) * | 2013-03-15 | 2014-09-18 | The Trustees Of The University Of Pennsylvania | Vaccines with biomolecular adjuvants |
| CN104694541A (zh) | 2013-12-09 | 2015-06-10 | 江苏命码生物科技有限公司 | 禽流感病毒miRNA及其鉴定、检测和应用 |
| US20170130229A1 (en) * | 2014-06-18 | 2017-05-11 | The Regents Of The University Of California | Methods and compositions for inhibiting infection by influenza and viruses |
| CN113528466B (zh) | 2014-07-16 | 2024-12-24 | 俄勒冈健康与科学大学 | 包含外源抗原的人巨细胞病毒 |
| EP3207127A4 (en) * | 2014-10-14 | 2018-06-06 | Texas Tech University System | Live attenuated viral vaccine created by self-attenuation with species-specific artificial microrna |
| JP6620294B2 (ja) * | 2014-12-03 | 2019-12-18 | 公益財団法人ヒューマンサイエンス振興財団 | ムンプスウイルスの弱毒化方法、ムンプスウイルス、及び、生ワクチン |
| SG11201706454VA (en) | 2015-02-10 | 2017-09-28 | Univ Oregon Health & Science | Methods and compositions useful in generating non canonical cd8+ t cell responses |
| US11020417B2 (en) | 2015-06-04 | 2021-06-01 | Sarepta Therapeutics, Inc | Methods and compounds for treatment of lymphocyte-related diseases and conditions |
| CA2986701A1 (en) * | 2015-06-09 | 2016-12-15 | Sanofi Pasteur, Inc. | Methods of optimizing nucleotide sequences encoding engineered influenza proteins |
| US10086063B2 (en) | 2015-09-23 | 2018-10-02 | Regents Of The University Of Minnesota | Methods of making and using live attenuated viruses |
| US10383935B2 (en) | 2015-09-23 | 2019-08-20 | Regents Of The University Of Minnesota | Methods of making and using live attenuated viruses |
| CA3005251A1 (en) | 2015-11-13 | 2017-05-18 | Pds Biotechnology Corporation | Lipids as synthetic vectors to enhance antigen processing and presentation ex-vivo in dendritic cell therapy |
| CN108474003A (zh) * | 2015-11-20 | 2018-08-31 | 俄勒冈健康与科学大学 | 包含微小rna识别元件的cmv载体 |
| JP7046848B2 (ja) * | 2016-07-08 | 2022-04-04 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 弱毒化突然変異体ジカウイルスをコードするゲノム配列 |
| BR112019007982A2 (pt) | 2016-10-18 | 2019-07-02 | Univ Oregon Health & Science | vetores de citomegalovírus elicitando células t restringidas por moléculas do complexo de histocompatibilidade e principal |
| CA3080656A1 (en) | 2017-10-30 | 2019-05-09 | Baxalta GmbH | Environmentally compatible detergents for inactivation of lipid-enveloped viruses |
| RU2020124143A (ru) | 2017-12-22 | 2022-01-24 | Кодадженикс Инк. | Рекомбинантный вирус с областью деоптимизированной пары кодонов и его применение для лечения рака |
| BR112020018188A2 (pt) | 2018-03-08 | 2021-02-02 | Codagenix Inc. | flavivírus atenuados |
| WO2019204571A1 (en) | 2018-04-20 | 2019-10-24 | Texas Tech University System | Self-attenuated prophylactic and therapeutic vaccines against pathogens |
| CN114072417B (zh) * | 2019-06-04 | 2024-05-24 | 凌斌 | 重组非结构蛋白1、含此的重组流感病毒及免疫组成物及其用于制备流感病毒疫苗组成物的用途 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040152112A1 (en) | 2002-11-13 | 2004-08-05 | Thomas Jefferson University | Compositions and methods for cancer diagnosis and therapy |
| CA2522081C (en) * | 2003-04-23 | 2013-01-29 | Wisconsin Alumni Research Foundation | Recombinant influenza viruses holding a mutation in a transmembrane protein gene |
| WO2005017111A2 (en) * | 2003-07-15 | 2005-02-24 | The Trustees Of The University Of Pennsylvania | Methods and systems for identifying micro-rna targets and synthesizing novel micro-rnas and uses of the same |
| US8106180B2 (en) | 2003-08-07 | 2012-01-31 | Whitehead Institute For Biomedical Research | Methods and products for expression of micro RNAs |
| US7279275B2 (en) | 2003-11-03 | 2007-10-09 | Washington University | Methods and compositions for detection of segmented negative strand RNA viruses |
| AU2005287395A1 (en) | 2004-07-02 | 2006-03-30 | Henry L. Niman | Copy choice recombination and uses thereof |
| US20070213293A1 (en) | 2005-04-08 | 2007-09-13 | Nastech Pharmaceutical Company Inc. | Rnai therapeutic for respiratory virus infection |
| US20070054872A1 (en) * | 2005-08-24 | 2007-03-08 | Mirus Bio Corporation | Regulatable or conditional expression systems |
| US20080045472A1 (en) * | 2006-03-31 | 2008-02-21 | Council Of Scientific And Industrial Research Bharat Biotech | Targets for human micro rnas in avian influenza virus (h5n1) genome |
| US9072701B2 (en) * | 2006-04-21 | 2015-07-07 | St. Jude Children's Research Hospital | Avian influenza viruses, vaccines, compositions, formulations, and methods |
| US7758868B2 (en) * | 2006-12-22 | 2010-07-20 | The Penn State Research Foundation | Modified polymerases and attenuated viruses and methods of use thereof |
| AU2008218813B2 (en) | 2007-02-20 | 2014-04-17 | Monsanto Technology, Llc | Invertebrate microRNAs |
| EP3431099B1 (en) * | 2007-03-30 | 2024-01-03 | The Research Foundation for The State University of New York | Attenuated viruses useful for vaccines |
| EP2527472B1 (en) * | 2007-05-31 | 2016-09-28 | Yale University | A genetic lesion associated with cancer |
| WO2009079592A2 (en) * | 2007-12-17 | 2009-06-25 | California Institute Of Technology | Modulating immune system development and function through microrna mir-146 |
| WO2009111892A1 (en) * | 2008-03-14 | 2009-09-17 | Ottawa Health Research Institute | Microrna mediated oncolytic targeting |
| JP2012519484A (ja) * | 2009-03-06 | 2012-08-30 | マウント・シナイ・スクール・オヴ・メディシン | マイクロｒｎａ応答要素を含む弱毒化生インフルエンザウイルスワクチン |
-
2010
- 2010-03-08 JP JP2011552950A patent/JP2012519484A/ja active Pending
- 2010-03-08 CA CA2754826A patent/CA2754826A1/en not_active Abandoned
- 2010-03-08 WO PCT/US2010/000709 patent/WO2010101663A2/en not_active Ceased
- 2010-03-08 EP EP10749069A patent/EP2403527A4/en not_active Withdrawn
- 2010-03-08 US US13/255,040 patent/US8883995B2/en active Active
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