JP2012518420A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2012518420A5 JP2012518420A5 JP2011551315A JP2011551315A JP2012518420A5 JP 2012518420 A5 JP2012518420 A5 JP 2012518420A5 JP 2011551315 A JP2011551315 A JP 2011551315A JP 2011551315 A JP2011551315 A JP 2011551315A JP 2012518420 A5 JP2012518420 A5 JP 2012518420A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- amino acid
- residue
- polypeptide
- recombinant polypeptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001184 polypeptide Polymers 0.000 claims 18
- 102000004196 processed proteins & peptides Human genes 0.000 claims 18
- 108090000765 processed proteins & peptides Proteins 0.000 claims 18
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 11
- 125000000539 amino acid group Chemical group 0.000 claims 10
- 125000003275 alpha amino acid group Chemical group 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 210000001519 tissue Anatomy 0.000 claims 2
- 210000000988 bone and bone Anatomy 0.000 claims 1
- 210000000845 cartilage Anatomy 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 230000002124 endocrine Effects 0.000 claims 1
- 210000005003 heart tissue Anatomy 0.000 claims 1
- 230000000926 neurological effect Effects 0.000 claims 1
- 102000040430 polynucleotide Human genes 0.000 claims 1
- 108091033319 polynucleotide Proteins 0.000 claims 1
- 239000002157 polynucleotide Substances 0.000 claims 1
- 210000002027 skeletal muscle Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15506609P | 2009-02-24 | 2009-02-24 | |
| US61/155,066 | 2009-02-24 | ||
| PCT/US2010/025260 WO2010099219A2 (en) | 2009-02-24 | 2010-02-24 | Designer ligands of tgf-beta superfamily |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012518420A JP2012518420A (ja) | 2012-08-16 |
| JP2012518420A5 true JP2012518420A5 (https=) | 2013-04-04 |
| JP5841845B2 JP5841845B2 (ja) | 2016-01-13 |
Family
ID=42666199
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011551315A Active JP5841845B2 (ja) | 2009-02-24 | 2010-02-24 | ＴＧＦ−βスーパーファミリーのデザイナーリガンド |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US8952130B2 (https=) |
| EP (1) | EP2401293B1 (https=) |
| JP (1) | JP5841845B2 (https=) |
| KR (1) | KR101558642B1 (https=) |
| CA (1) | CA2752647A1 (https=) |
| WO (1) | WO2010099219A2 (https=) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105198981B (zh) | 2010-08-20 | 2019-07-16 | 惠氏有限责任公司 | 经设计的成骨蛋白 |
| US9688735B2 (en) * | 2010-08-20 | 2017-06-27 | Wyeth Llc | Designer osteogenic proteins |
| CA2862516C (en) | 2012-03-27 | 2023-02-14 | Ngm Biopharmaceuticals, Inc. | Compositions and methods of use for treating metabolic disorders |
| US9161966B2 (en) | 2013-01-30 | 2015-10-20 | Ngm Biopharmaceuticals, Inc. | GDF15 mutein polypeptides |
| KR101993714B1 (ko) | 2013-01-30 | 2019-06-28 | 엔지엠 바이오파마슈티컬스, 아이엔씨. | 대사 장애를 치료하는데 이용하기 위한 조성물과 방법 |
| ES2924479T3 (es) | 2013-04-08 | 2022-10-07 | Harvard College | Composiciones para rejuvenecer las células madre del músculo esquelético |
| US20160220640A1 (en) * | 2013-06-11 | 2016-08-04 | The Brigham And Women's Hospital, Inc. | Methods and compositions for increasing neurogenesis and angiogenesis |
| WO2015070076A2 (en) * | 2013-11-08 | 2015-05-14 | President And Fellows Of Harvard College | Methods and compositions for rejuvenating neuromuscular junctions |
| AU2015296640B2 (en) | 2014-07-30 | 2020-05-21 | Ngm Biopharmaceuticals, Inc. | Compositions and methods of use for treating metabolic disorders |
| BR112017007962A2 (pt) * | 2014-10-24 | 2018-01-23 | Koninklijke Philips Nv | método implementado por computador, aparelho, mídia de armazenamento, programa de computador, kit, e, uso do kit |
| EP3701969A1 (en) | 2014-10-31 | 2020-09-02 | NGM Biopharmaceuticals, Inc. | Compositions and methods of use for treating metabolic disorders |
| EP3215175A4 (en) | 2014-11-06 | 2018-06-27 | Scholar Rock, Inc. | Anti-pro/latent-myostatin antibodies and uses thereof |
| AU2015374114B2 (en) | 2014-12-29 | 2018-07-26 | Bioventus, Llc | Systems and methods for improved delivery of osteoinductive molecules in bone repair |
| WO2017015622A2 (en) * | 2015-07-22 | 2017-01-26 | Scholar Rock, Inc | Gdf11 binding proteins and uses thereof |
| US20200231652A1 (en) | 2015-08-31 | 2020-07-23 | National Research Council Of Canada | Tgf-b-receptor ectodomain fusion molecules and uses thereof |
| HRP20211081T1 (hr) | 2015-09-15 | 2021-10-15 | Scholar Rock, Inc. | Anti-pro/latentna miostatinska protutijela i njihove uporabe |
| CA3010799A1 (en) | 2016-01-06 | 2017-07-13 | President And Fellows Of Harvard College | Treatment with gdf11 prevents weight gain, improves glucose tolerance and reduces hepatosteatosis |
| CN115814077A (zh) | 2016-01-08 | 2023-03-21 | 供石公司 | 抗-原肌生长抑制素/潜伏肌生长抑制素抗体及其使用方法 |
| MY194669A (en) | 2016-03-31 | 2022-12-12 | Ngm Biopharmaceuticals Inc | Binding Proteins and Methods of use Thereof |
| US11512126B2 (en) * | 2016-05-31 | 2022-11-29 | Mogam Institute For Biomedicak Research | AB6 family designer ligands of TGF-β superfamily |
| KR20190005239A (ko) * | 2016-05-31 | 2019-01-15 | 재단법인 목암생명과학연구소 | Tgf-베타 슈퍼패밀리의 ab6 패밀리 디자이너 리간드를 포함하는 간질환 치료용 조성물 및 그의 이용 |
| WO2017209523A1 (en) * | 2016-05-31 | 2017-12-07 | Mogam Institute For Biomedical Research | Composition comprising an ab6 family designer ligand of tgf-beta superfamily for treating bone and cartilage disease and use thereof |
| NZ789269A (en) | 2016-06-13 | 2026-01-30 | Scholar Rock Inc | Use of myostatin inhibitors and combination therapies |
| NZ746109A (en) | 2016-12-30 | 2022-12-23 | Biogend Therapeutics Co Ltd | Recombinant polypeptides and nucleic acid molecules, compositions, and methods of making and uses thereof |
| EP4218817A3 (en) | 2017-01-06 | 2023-09-06 | Scholar Rock, Inc. | Methods for treating metabolic diseases by inhibiting myostatin activation |
| WO2018148649A1 (en) * | 2017-02-10 | 2018-08-16 | The Institute For Cancer Research D/B/A | Chimera of bone morphogenic protein 2 and the müllerian-inhibiting substance type ii receptor binding region of mullerian-inhibiting substance |
| AU2018228435C1 (en) | 2017-03-02 | 2025-09-18 | National Research Council Of Canada | TGF-beta-receptor ectodomain fusion molecules and uses thereof |
| US20210395322A1 (en) * | 2018-11-15 | 2021-12-23 | joint Center for Biosciences | Activin/bmp7 chimeras: super-active sab704 and sab715, and their respective nogginsensitized variants, nab704 and nab715; and nab204 |
| DK4034170T3 (da) | 2019-10-23 | 2026-03-30 | Cue Biopharma Inc | Tgf-beta-polypeptider |
| US20230416321A1 (en) * | 2020-11-23 | 2023-12-28 | Cue Biopharma, Inc. | TGF-Beta Polypeptides |
| US11945856B2 (en) | 2022-01-28 | 2024-04-02 | 35Pharma Inc. | Activin receptor type IIB variants and uses thereof |
| EP4638496A1 (en) | 2022-12-22 | 2025-10-29 | Scholar Rock, Inc. | Selective and potent inhibitory antibodies of myostatin activation |
| US20260092096A1 (en) | 2024-05-14 | 2026-04-02 | 35Pharma Inc. | Activin receptor type iib variants and uses thereof |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1987005330A1 (en) | 1986-03-07 | 1987-09-11 | Michel Louis Eugene Bergh | Method for enhancing glycoprotein stability |
| US5013649A (en) | 1986-07-01 | 1991-05-07 | Genetics Institute, Inc. | DNA sequences encoding osteoinductive products |
| US4877864A (en) | 1987-03-26 | 1989-10-31 | Genetics Institute, Inc. | Osteoinductive factors |
| US5108922A (en) | 1986-07-01 | 1992-04-28 | Genetics Institute, Inc. | DNA sequences encoding BMP-1 products |
| US5106748A (en) | 1986-07-01 | 1992-04-21 | Genetics Institute, Inc. | Dna sequences encoding 5 proteins |
| ZA874681B (en) | 1986-07-01 | 1988-04-27 | Genetics Inst | Novel osteoinductive factors |
| US5155058A (en) | 1986-11-07 | 1992-10-13 | Canon Kabushiki Kaisha | Method of making semiconductor memory device |
| US5080891A (en) | 1987-08-03 | 1992-01-14 | Ddi Pharmaceuticals, Inc. | Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols |
| WO1991005802A1 (en) | 1989-10-17 | 1991-05-02 | Creative Biomolecules, Inc. | Osteogenic devices |
| AU8941791A (en) | 1990-10-18 | 1992-05-20 | Creative Biomolecules, Inc. | Osteogenic protein |
| US5677196A (en) | 1993-05-18 | 1997-10-14 | University Of Utah Research Foundation | Apparatus and methods for multi-analyte homogeneous fluoro-immunoassays |
| US6333168B1 (en) * | 1993-05-20 | 2001-12-25 | The Trustees Of Columbia University In The City Of New York | Cloning, expression and uses of dorsalin-1 |
| US5814565A (en) | 1995-02-23 | 1998-09-29 | University Of Utah Research Foundation | Integrated optic waveguide immunosensor |
| ES2320603T3 (es) | 1997-07-30 | 2009-05-25 | Emory University | Sistemas de expresion, vectores, adn, proteinas de mineralizacion osea novedosos. |
| US6846906B1 (en) * | 1998-10-07 | 2005-01-25 | Stryker Corporation | Modified proteins of the TGF-β superfamily, including morphogenic proteins |
| US6677432B1 (en) | 1998-10-07 | 2004-01-13 | Stryker Corporation | Mutations of the C-terminal portion of TGF-β superfamily proteins |
| WO2005113585A2 (en) | 2004-05-20 | 2005-12-01 | Acceleron Pharma Inc. | Modified tgf-beta superfamily polypeptides |
| US20090202638A2 (en) | 2004-10-27 | 2009-08-13 | New York Society For The Ruptured And Crippled Maintaining The Hospital For Special Surgery | Bmp gene and fusion protein |
-
2010
- 2010-02-24 JP JP2011551315A patent/JP5841845B2/ja active Active
- 2010-02-24 KR KR1020117021911A patent/KR101558642B1/ko active Active
- 2010-02-24 WO PCT/US2010/025260 patent/WO2010099219A2/en not_active Ceased
- 2010-02-24 EP EP10746779.7A patent/EP2401293B1/en active Active
- 2010-02-24 CA CA2752647A patent/CA2752647A1/en active Pending
- 2010-02-24 US US12/712,069 patent/US8952130B2/en active Active
-
2014
- 2014-12-30 US US14/586,573 patent/US20150239950A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2012518420A5 (https=) | ||
| JP2018138049A5 (https=) | ||
| JP2008508859A5 (https=) | ||
| JP2012507271A5 (https=) | ||
| RU2506274C2 (ru) | Способы скрининга с применением g-белок сопряженных рецепторов и родственных композиций | |
| JP2009268467A5 (https=) | ||
| JP2019530463A5 (https=) | ||
| JP2010166916A5 (https=) | ||
| JP2010526153A5 (https=) | ||
| JP2010519293A5 (https=) | ||
| JP2010519931A5 (https=) | ||
| FI3352776T3 (fi) | Htt-repressoreita ja niiden käyttötapoja | |
| JP2013107899A5 (https=) | ||
| EA201270713A1 (ru) | Белки на основе фибронектина с каркасными доменами, которые связывают ил-23 | |
| JP2010519252A5 (https=) | ||
| WO2009103105A3 (en) | Mimotopes of alpha-synuclein and vaccines thereof for the treatment of neurodegenerative disorders | |
| JP2011507903A5 (https=) | ||
| JP2012188436A5 (https=) | ||
| JP2018508530A5 (https=) | ||
| JP2018531624A5 (https=) | ||
| WO2009024327A3 (en) | New proteins for use in human and animal staphylococcus infections | |
| JP2012505657A5 (https=) | ||
| MX2008009493A (es) | Peptido novedoso y uso del mismo. | |
| RU2015119523A (ru) | Новый способ лечения повреждения спинного мозга с применением фрагмента hmgb1 | |
| JPWO2020149395A5 (https=) |