JP2012517242A5 - - Google Patents
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- Publication number
- JP2012517242A5 JP2012517242A5 JP2011550237A JP2011550237A JP2012517242A5 JP 2012517242 A5 JP2012517242 A5 JP 2012517242A5 JP 2011550237 A JP2011550237 A JP 2011550237A JP 2011550237 A JP2011550237 A JP 2011550237A JP 2012517242 A5 JP2012517242 A5 JP 2012517242A5
- Authority
- JP
- Japan
- Prior art keywords
- snp
- nucleotides
- polynucleotide
- polymorphic
- complement
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002773 nucleotide Substances 0.000 claims 40
- 125000003729 nucleotide group Chemical group 0.000 claims 40
- 239000002157 polynucleotide Substances 0.000 claims 30
- 102000040430 polynucleotide Human genes 0.000 claims 30
- 108091033319 polynucleotide Proteins 0.000 claims 30
- 230000000295 complement effect Effects 0.000 claims 23
- 108700028369 Alleles Proteins 0.000 claims 19
- 238000000034 method Methods 0.000 claims 18
- 238000011895 specific detection Methods 0.000 claims 18
- 239000002299 complementary DNA Substances 0.000 claims 9
- 238000009396 hybridization Methods 0.000 claims 8
- 206010028980 Neoplasm Diseases 0.000 claims 5
- 201000011510 cancer Diseases 0.000 claims 5
- 239000011541 reaction mixture Substances 0.000 claims 3
- 101150002416 Igf2 gene Proteins 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 2
- 102000004877 Insulin Human genes 0.000 claims 1
- 108090001061 Insulin Proteins 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 238000002052 colonoscopy Methods 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 229940125396 insulin Drugs 0.000 claims 1
- 102000054765 polymorphisms of proteins Human genes 0.000 claims 1
- 238000004393 prognosis Methods 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20745009P | 2009-02-11 | 2009-02-11 | |
| US61/207,450 | 2009-02-11 | ||
| PCT/US2010/023939 WO2010093820A2 (en) | 2009-02-11 | 2010-02-11 | Combinations of polymorphisms for determining allele-specific expression of igf2 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015097036A Division JP2015180207A (ja) | 2009-02-11 | 2015-05-12 | Ｉｇｆ２の対立遺伝子特異的な発現を判定するための多型の組み合わせ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012517242A JP2012517242A (ja) | 2012-08-02 |
| JP2012517242A5 true JP2012517242A5 (enExample) | 2013-03-28 |
| JP5748672B2 JP5748672B2 (ja) | 2015-07-15 |
Family
ID=42562280
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011550237A Expired - Fee Related JP5748672B2 (ja) | 2009-02-11 | 2010-02-11 | Ｉｇｆ２の対立遺伝子特異的な発現を判定するための多型の組み合わせ |
| JP2015097036A Pending JP2015180207A (ja) | 2009-02-11 | 2015-05-12 | Ｉｇｆ２の対立遺伝子特異的な発現を判定するための多型の組み合わせ |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015097036A Pending JP2015180207A (ja) | 2009-02-11 | 2015-05-12 | Ｉｇｆ２の対立遺伝子特異的な発現を判定するための多型の組み合わせ |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20100286926A1 (enExample) |
| EP (2) | EP2396429B1 (enExample) |
| JP (2) | JP5748672B2 (enExample) |
| AU (1) | AU2010213727A1 (enExample) |
| CA (1) | CA2751758A1 (enExample) |
| ES (1) | ES2544265T3 (enExample) |
| WO (1) | WO2010093820A2 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2453108T3 (es) * | 2007-08-06 | 2014-04-04 | Orion Genomics, Llc | Nuevos polimorfismos de un único nucleótido y combinaciones de polimorfismos nuevos y conocidos para determinar la expresión específica de alelo del gen IGF2 |
| EP3414340B1 (en) * | 2016-02-12 | 2023-08-09 | CureVac SE | Method for analyzing rna |
| US11920174B2 (en) | 2016-03-03 | 2024-03-05 | CureVac SE | RNA analysis by total hydrolysis and quantification of released nucleosides |
| KR101845711B1 (ko) | 2016-11-11 | 2018-04-09 | 대한민국 | Ociad2 유전자 유래의 유전체 각인 판별용 snp 마커 및 이를 이용한 판별 방법 |
| US12222354B2 (en) | 2021-03-19 | 2025-02-11 | Quest Diagnostics Investments Llc | Identification and quantitation of insulin-like growth factor-I variants by mass spectrometry |
| AU2023248408A1 (en) * | 2022-04-07 | 2024-10-31 | Quest Diagnostics Investments Llc | Detection of insulin-like growth factor-2 variants by mass spectrometry |
Family Cites Families (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL154598B (nl) | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
| US3817837A (en) | 1971-05-14 | 1974-06-18 | Syva Corp | Enzyme amplification assay |
| US3939350A (en) | 1974-04-29 | 1976-02-17 | Board Of Trustees Of The Leland Stanford Junior University | Fluorescent immunoassay employing total reflection for activation |
| US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
| US4277437A (en) | 1978-04-05 | 1981-07-07 | Syva Company | Kit for carrying out chemically induced fluorescence immunoassay |
| US4275149A (en) | 1978-11-24 | 1981-06-23 | Syva Company | Macromolecular environment control in specific receptor assays |
| US4458066A (en) | 1980-02-29 | 1984-07-03 | University Patents, Inc. | Process for preparing polynucleotides |
| US4366241A (en) | 1980-08-07 | 1982-12-28 | Syva Company | Concentrating zone method in heterogeneous immunoassays |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| NO870613L (no) | 1986-03-05 | 1987-09-07 | Molecular Diagnostics Inc | Deteksjon av mikroorganismer i en prve inneholdende nukleinsyre. |
| US5604099A (en) | 1986-03-13 | 1997-02-18 | Hoffmann-La Roche Inc. | Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids |
| CA1284931C (en) | 1986-03-13 | 1991-06-18 | Henry A. Erlich | Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids |
| US5310893A (en) | 1986-03-31 | 1994-05-10 | Hoffmann-La Roche Inc. | Method for HLA DP typing |
| US4851331A (en) | 1986-05-16 | 1989-07-25 | Allied Corporation | Method and kit for polynucleotide assay including primer-dependant DNA polymerase |
| CA1340843C (en) | 1987-07-31 | 1999-12-07 | J. Lawrence Burg | Selective amplification of target polynucleotide sequences |
| DE3803275A1 (de) | 1988-02-04 | 1989-08-17 | Dornier Medizintechnik | Piezoelektrische stosswellenquelle |
| CA1340807C (en) | 1988-02-24 | 1999-11-02 | Lawrence T. Malek | Nucleic acid amplification process |
| IE61148B1 (en) | 1988-03-10 | 1994-10-05 | Ici Plc | Method of detecting nucleotide sequences |
| EP0451141B1 (en) | 1988-05-20 | 1998-11-18 | F. Hoffmann-La Roche Ag | Immobilized sequence-specific probes |
| US5118801A (en) | 1988-09-30 | 1992-06-02 | The Public Health Research Institute | Nucleic acid process containing improved molecular switch |
| US5639611A (en) | 1988-12-12 | 1997-06-17 | City Of Hope | Allele specific polymerase chain reaction |
| CA2020958C (en) | 1989-07-11 | 2005-01-11 | Daniel L. Kacian | Nucleic acid sequence amplification methods |
| US5137806A (en) | 1989-12-11 | 1992-08-11 | Board Of Regents, The University Of Texas System | Methods and compositions for the detection of sequences in selected DNA molecules |
| US5955589A (en) | 1991-12-24 | 1999-09-21 | Isis Pharmaceuticals Inc. | Gapped 2' modified oligonucleotides |
| US5210015A (en) | 1990-08-06 | 1993-05-11 | Hoffman-La Roche Inc. | Homogeneous assay system using the nuclease activity of a nucleic acid polymerase |
| JP2985446B2 (ja) | 1990-10-31 | 1999-11-29 | 東ソー株式会社 | 核酸の検出及び測定方法 |
| IE913930A1 (en) | 1990-11-13 | 1992-06-17 | Siska Diagnostics | Nucleic acid amplification by two-enzyme, self-sustained¹sequence replication |
| YU187991A (sh) | 1990-12-11 | 1994-09-09 | Hoechst Aktiengesellschaft | 3-(2)-amino-ali tiol-modifikovani, s fluorescentnom bojom vezani nukleozidi, nukleotidi i oligonukleotidi, postupak za njihovo dobijanje i njihova upotreba |
| US5455166A (en) | 1991-01-31 | 1995-10-03 | Becton, Dickinson And Company | Strand displacement amplification |
| US5994056A (en) | 1991-05-02 | 1999-11-30 | Roche Molecular Systems, Inc. | Homogeneous methods for nucleic acid amplification and detection |
| EP0540997A1 (en) | 1991-11-05 | 1993-05-12 | F. Hoffmann-La Roche Ag | Methods and reagents for HLA class I DNA typing |
| US6033854A (en) | 1991-12-16 | 2000-03-07 | Biotronics Corporation | Quantitative PCR using blocking oligonucleotides |
| US5652099A (en) | 1992-02-12 | 1997-07-29 | Conrad; Michael J. | Probes comprising fluorescent nucleosides and uses thereof |
| EP0655090B1 (en) | 1992-04-27 | 2000-12-27 | The Trustees Of Dartmouth College | Detection of gene sequences in biological fluids |
| WO1995006137A1 (en) | 1993-08-27 | 1995-03-02 | Australian Red Cross Society | Detection of genes |
| AU8126694A (en) * | 1993-10-26 | 1995-05-22 | Affymax Technologies N.V. | Arrays of nucleic acid probes on biological chips |
| US5446137B1 (en) | 1993-12-09 | 1998-10-06 | Behringwerke Ag | Oligonucleotides containing 4'-substituted nucleotides |
| DE4415370A1 (de) | 1994-05-02 | 1995-11-09 | Hoechst Ag | Modifizierte Oligonukleotide, deren Herstellung sowie deren Verwendung |
| US5491063A (en) | 1994-09-01 | 1996-02-13 | Hoffmann-La Roche Inc. | Methods for in-solution quenching of fluorescently labeled oligonucleotide probes |
| DE4438918A1 (de) | 1994-11-04 | 1996-05-09 | Hoechst Ag | Modifizierte Oligonukleotide, deren Herstellung sowie deren Verwendung |
| US5571673A (en) | 1994-11-23 | 1996-11-05 | Hoffmann-La Roche Inc. | Methods for in-solution quenching of fluorescently labeled oligonucleotide probes |
| US6117635A (en) | 1996-07-16 | 2000-09-12 | Intergen Company | Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon |
| US6235474B1 (en) * | 1996-12-30 | 2001-05-22 | The Johns Hopkins University | Methods and kits for diagnosing and determination of the predisposition for diseases |
| EP0866071B1 (en) | 1997-03-20 | 2004-10-20 | F. Hoffmann-La Roche Ag | Modified primers |
| GB9812768D0 (en) | 1998-06-13 | 1998-08-12 | Zeneca Ltd | Methods |
| US6180349B1 (en) | 1999-05-18 | 2001-01-30 | The Regents Of The University Of California | Quantitative PCR method to enumerate DNA copy number |
| US7097976B2 (en) * | 2002-06-17 | 2006-08-29 | Affymetrix, Inc. | Methods of analysis of allelic imbalance |
| WO2004003003A1 (en) | 2002-06-27 | 2004-01-08 | The Johns Hopkins University School Of Medicine | Methods for identifying cancer risk |
| US9797005B2 (en) * | 2005-11-23 | 2017-10-24 | University Of Southern California | High throughput method of DNA methylation haplotyping |
| EP2135080A4 (en) * | 2007-03-08 | 2010-12-01 | Switchgear Genomics | FUNCTIONAL NETWORKS FOR THE CHARACTERIZATION OF TREATMENT OF REGULATORY ELEMENTS IN NON-TRANSLATED REGIONS OF GENES |
| ES2453108T3 (es) * | 2007-08-06 | 2014-04-04 | Orion Genomics, Llc | Nuevos polimorfismos de un único nucleótido y combinaciones de polimorfismos nuevos y conocidos para determinar la expresión específica de alelo del gen IGF2 |
-
2010
- 2010-02-11 CA CA2751758A patent/CA2751758A1/en not_active Abandoned
- 2010-02-11 EP EP10741738.8A patent/EP2396429B1/en active Active
- 2010-02-11 WO PCT/US2010/023939 patent/WO2010093820A2/en not_active Ceased
- 2010-02-11 EP EP15163893.9A patent/EP2955234A1/en not_active Withdrawn
- 2010-02-11 AU AU2010213727A patent/AU2010213727A1/en not_active Abandoned
- 2010-02-11 ES ES10741738.8T patent/ES2544265T3/es active Active
- 2010-02-11 JP JP2011550237A patent/JP5748672B2/ja not_active Expired - Fee Related
- 2010-02-11 US US12/704,474 patent/US20100286926A1/en not_active Abandoned
-
2015
- 2015-05-12 JP JP2015097036A patent/JP2015180207A/ja active Pending
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