JP2010535507A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2010535507A5 JP2010535507A5 JP2010520284A JP2010520284A JP2010535507A5 JP 2010535507 A5 JP2010535507 A5 JP 2010535507A5 JP 2010520284 A JP2010520284 A JP 2010520284A JP 2010520284 A JP2010520284 A JP 2010520284A JP 2010535507 A5 JP2010535507 A5 JP 2010535507A5
- Authority
- JP
- Japan
- Prior art keywords
- snp
- allele
- polynucleotide
- rna
- polymorphic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108091033319 polynucleotide Proteins 0.000 claims description 56
- 239000002157 polynucleotide Substances 0.000 claims description 56
- 102000040430 polynucleotide Human genes 0.000 claims description 56
- 239000002773 nucleotide Substances 0.000 claims description 50
- 125000003729 nucleotide group Chemical group 0.000 claims description 50
- 108700028369 Alleles Proteins 0.000 claims description 40
- 230000000295 complement effect Effects 0.000 claims description 36
- 238000000034 method Methods 0.000 claims description 25
- 239000011541 reaction mixture Substances 0.000 claims description 18
- 239000002299 complementary DNA Substances 0.000 claims description 14
- 108010014303 DNA-directed DNA polymerase Proteins 0.000 claims description 10
- 102000016928 DNA-directed DNA polymerase Human genes 0.000 claims description 10
- 238000009396 hybridization Methods 0.000 claims description 8
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims description 8
- 206010028980 Neoplasm Diseases 0.000 claims description 6
- 201000011510 cancer Diseases 0.000 claims description 6
- 101150002416 Igf2 gene Proteins 0.000 claims description 4
- 102000004877 Insulin Human genes 0.000 claims description 4
- 108090001061 Insulin Proteins 0.000 claims description 4
- 239000008280 blood Substances 0.000 claims description 4
- 210000004369 blood Anatomy 0.000 claims description 4
- 229940125396 insulin Drugs 0.000 claims description 4
- 108090000623 proteins and genes Proteins 0.000 claims description 4
- 238000010839 reverse transcription Methods 0.000 claims description 4
- 101001076292 Homo sapiens Insulin-like growth factor II Proteins 0.000 claims description 2
- 102100025947 Insulin-like growth factor II Human genes 0.000 claims description 2
- 102100034343 Integrase Human genes 0.000 claims description 2
- 108010092799 RNA-directed DNA polymerase Proteins 0.000 claims description 2
- 238000003745 diagnosis Methods 0.000 claims description 2
- 229940079593 drug Drugs 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 229940068935 insulin-like growth factor 2 Drugs 0.000 claims description 2
- 102000054765 polymorphisms of proteins Human genes 0.000 claims description 2
- 238000004393 prognosis Methods 0.000 claims description 2
- 238000011144 upstream manufacturing Methods 0.000 claims description 2
- 230000002759 chromosomal effect Effects 0.000 description 1
- 238000005204 segregation Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95429007P | 2007-08-06 | 2007-08-06 | |
| US60/954,290 | 2007-08-06 | ||
| US98871507P | 2007-11-16 | 2007-11-16 | |
| US60/988,715 | 2007-11-16 | ||
| PCT/US2008/072356 WO2009021054A2 (en) | 2007-08-06 | 2008-08-06 | Novel single nucleotide polymorphisms and combinations of novel and known polymorphisms for determining the allele-specific expression of the igf2 gene |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015070799A Division JP5902843B2 (ja) | 2007-08-06 | 2015-03-31 | Ｉｇｆ２遺伝子の対立遺伝子特異的な発現を判定するための一塩基多型ならびに新規および公知の多型の組み合わせ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010535507A JP2010535507A (ja) | 2010-11-25 |
| JP2010535507A5 true JP2010535507A5 (enExample) | 2011-09-22 |
| JP5777340B2 JP5777340B2 (ja) | 2015-09-09 |
Family
ID=39925054
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010520284A Expired - Fee Related JP5777340B2 (ja) | 2007-08-06 | 2008-08-06 | Ｉｇｆ２遺伝子の対立遺伝子特異的な発現を判定するための一塩基多型ならびに新規および公知の多型の組み合わせ |
| JP2015070799A Expired - Fee Related JP5902843B2 (ja) | 2007-08-06 | 2015-03-31 | Ｉｇｆ２遺伝子の対立遺伝子特異的な発現を判定するための一塩基多型ならびに新規および公知の多型の組み合わせ |
| JP2016046545A Pending JP2016116534A (ja) | 2007-08-06 | 2016-03-10 | Ｉｇｆ２遺伝子の対立遺伝子特異的な発現を判定するための一塩基多型ならびに新規および公知の多型の組み合わせ |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015070799A Expired - Fee Related JP5902843B2 (ja) | 2007-08-06 | 2015-03-31 | Ｉｇｆ２遺伝子の対立遺伝子特異的な発現を判定するための一塩基多型ならびに新規および公知の多型の組み合わせ |
| JP2016046545A Pending JP2016116534A (ja) | 2007-08-06 | 2016-03-10 | Ｉｇｆ２遺伝子の対立遺伝子特異的な発現を判定するための一塩基多型ならびに新規および公知の多型の組み合わせ |
Country Status (7)
| Country | Link |
|---|---|
| US (7) | US8420315B2 (enExample) |
| EP (3) | EP2185726B1 (enExample) |
| JP (3) | JP5777340B2 (enExample) |
| AU (1) | AU2008283902B2 (enExample) |
| CA (1) | CA2694832A1 (enExample) |
| ES (2) | ES2453108T3 (enExample) |
| WO (1) | WO2009021054A2 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11001881B2 (en) | 2006-08-24 | 2021-05-11 | California Institute Of Technology | Methods for detecting analytes |
| US11525156B2 (en) | 2006-07-28 | 2022-12-13 | California Institute Of Technology | Multiplex Q-PCR arrays |
| US8048626B2 (en) | 2006-07-28 | 2011-11-01 | California Institute Of Technology | Multiplex Q-PCR arrays |
| US11560588B2 (en) | 2006-08-24 | 2023-01-24 | California Institute Of Technology | Multiplex Q-PCR arrays |
| PE20090368A1 (es) | 2007-06-19 | 2009-04-28 | Boehringer Ingelheim Int | Anticuerpos anti-igf |
| ES2453108T3 (es) | 2007-08-06 | 2014-04-04 | Orion Genomics, Llc | Nuevos polimorfismos de un único nucleótido y combinaciones de polimorfismos nuevos y conocidos para determinar la expresión específica de alelo del gen IGF2 |
| CN103396487A (zh) | 2008-12-12 | 2013-11-20 | 贝林格尔.英格海姆国际有限公司 | 抗igf抗体 |
| CA2751758A1 (en) * | 2009-02-11 | 2010-08-19 | Orion Genomics Llc | Combinations of polymorphisms for determining allele-specific expression of igf2 |
| US20140255413A1 (en) | 2013-03-07 | 2014-09-11 | Boehringer Ingelheim International Gmbh | Combination therapy for neoplasia treatment |
| US9708647B2 (en) | 2015-03-23 | 2017-07-18 | Insilixa, Inc. | Multiplexed analysis of nucleic acid hybridization thermodynamics using integrated arrays |
| US9499861B1 (en) | 2015-09-10 | 2016-11-22 | Insilixa, Inc. | Methods and systems for multiplex quantitative nucleic acid amplification |
| WO2017155858A1 (en) | 2016-03-07 | 2017-09-14 | Insilixa, Inc. | Nucleic acid sequence identification using solid-phase cyclic single base extension |
| CN119510370A (zh) | 2019-03-14 | 2025-02-25 | 因斯利克萨公司 | 基于时间门控的荧光检测的方法和系统 |
| US12222354B2 (en) | 2021-03-19 | 2025-02-11 | Quest Diagnostics Investments Llc | Identification and quantitation of insulin-like growth factor-I variants by mass spectrometry |
| AU2023248408A1 (en) * | 2022-04-07 | 2024-10-31 | Quest Diagnostics Investments Llc | Detection of insulin-like growth factor-2 variants by mass spectrometry |
Family Cites Families (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL154598B (nl) | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
| US3817837A (en) | 1971-05-14 | 1974-06-18 | Syva Corp | Enzyme amplification assay |
| US3939350A (en) | 1974-04-29 | 1976-02-17 | Board Of Trustees Of The Leland Stanford Junior University | Fluorescent immunoassay employing total reflection for activation |
| US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
| US4277437A (en) | 1978-04-05 | 1981-07-07 | Syva Company | Kit for carrying out chemically induced fluorescence immunoassay |
| US4275149A (en) | 1978-11-24 | 1981-06-23 | Syva Company | Macromolecular environment control in specific receptor assays |
| US4458066A (en) | 1980-02-29 | 1984-07-03 | University Patents, Inc. | Process for preparing polynucleotides |
| US4366241A (en) | 1980-08-07 | 1982-12-28 | Syva Company | Concentrating zone method in heterogeneous immunoassays |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| NO870613L (no) | 1986-03-05 | 1987-09-07 | Molecular Diagnostics Inc | Deteksjon av mikroorganismer i en prve inneholdende nukleinsyre. |
| US5604099A (en) | 1986-03-13 | 1997-02-18 | Hoffmann-La Roche Inc. | Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids |
| CA1284931C (en) | 1986-03-13 | 1991-06-18 | Henry A. Erlich | Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids |
| US5310893A (en) | 1986-03-31 | 1994-05-10 | Hoffmann-La Roche Inc. | Method for HLA DP typing |
| US4851331A (en) | 1986-05-16 | 1989-07-25 | Allied Corporation | Method and kit for polynucleotide assay including primer-dependant DNA polymerase |
| CA1340843C (en) | 1987-07-31 | 1999-12-07 | J. Lawrence Burg | Selective amplification of target polynucleotide sequences |
| DE3803275A1 (de) | 1988-02-04 | 1989-08-17 | Dornier Medizintechnik | Piezoelektrische stosswellenquelle |
| CA1340807C (en) | 1988-02-24 | 1999-11-02 | Lawrence T. Malek | Nucleic acid amplification process |
| IE61148B1 (en) | 1988-03-10 | 1994-10-05 | Ici Plc | Method of detecting nucleotide sequences |
| EP0451141B1 (en) | 1988-05-20 | 1998-11-18 | F. Hoffmann-La Roche Ag | Immobilized sequence-specific probes |
| US5118801A (en) | 1988-09-30 | 1992-06-02 | The Public Health Research Institute | Nucleic acid process containing improved molecular switch |
| US5639611A (en) | 1988-12-12 | 1997-06-17 | City Of Hope | Allele specific polymerase chain reaction |
| CA2020958C (en) | 1989-07-11 | 2005-01-11 | Daniel L. Kacian | Nucleic acid sequence amplification methods |
| US5137806A (en) | 1989-12-11 | 1992-08-11 | Board Of Regents, The University Of Texas System | Methods and compositions for the detection of sequences in selected DNA molecules |
| US5955589A (en) | 1991-12-24 | 1999-09-21 | Isis Pharmaceuticals Inc. | Gapped 2' modified oligonucleotides |
| US5210015A (en) | 1990-08-06 | 1993-05-11 | Hoffman-La Roche Inc. | Homogeneous assay system using the nuclease activity of a nucleic acid polymerase |
| JP2985446B2 (ja) | 1990-10-31 | 1999-11-29 | 東ソー株式会社 | 核酸の検出及び測定方法 |
| IE913930A1 (en) | 1990-11-13 | 1992-06-17 | Siska Diagnostics | Nucleic acid amplification by two-enzyme, self-sustained¹sequence replication |
| YU187991A (sh) | 1990-12-11 | 1994-09-09 | Hoechst Aktiengesellschaft | 3-(2)-amino-ali tiol-modifikovani, s fluorescentnom bojom vezani nukleozidi, nukleotidi i oligonukleotidi, postupak za njihovo dobijanje i njihova upotreba |
| US5455166A (en) | 1991-01-31 | 1995-10-03 | Becton, Dickinson And Company | Strand displacement amplification |
| US5994056A (en) | 1991-05-02 | 1999-11-30 | Roche Molecular Systems, Inc. | Homogeneous methods for nucleic acid amplification and detection |
| EP0540997A1 (en) | 1991-11-05 | 1993-05-12 | F. Hoffmann-La Roche Ag | Methods and reagents for HLA class I DNA typing |
| US6033854A (en) | 1991-12-16 | 2000-03-07 | Biotronics Corporation | Quantitative PCR using blocking oligonucleotides |
| US5652099A (en) | 1992-02-12 | 1997-07-29 | Conrad; Michael J. | Probes comprising fluorescent nucleosides and uses thereof |
| EP0655090B1 (en) | 1992-04-27 | 2000-12-27 | The Trustees Of Dartmouth College | Detection of gene sequences in biological fluids |
| WO1995006137A1 (en) | 1993-08-27 | 1995-03-02 | Australian Red Cross Society | Detection of genes |
| AU8126694A (en) | 1993-10-26 | 1995-05-22 | Affymax Technologies N.V. | Arrays of nucleic acid probes on biological chips |
| US5446137B1 (en) | 1993-12-09 | 1998-10-06 | Behringwerke Ag | Oligonucleotides containing 4'-substituted nucleotides |
| DE4415370A1 (de) | 1994-05-02 | 1995-11-09 | Hoechst Ag | Modifizierte Oligonukleotide, deren Herstellung sowie deren Verwendung |
| US5491063A (en) | 1994-09-01 | 1996-02-13 | Hoffmann-La Roche Inc. | Methods for in-solution quenching of fluorescently labeled oligonucleotide probes |
| DE4438918A1 (de) | 1994-11-04 | 1996-05-09 | Hoechst Ag | Modifizierte Oligonukleotide, deren Herstellung sowie deren Verwendung |
| US5571673A (en) | 1994-11-23 | 1996-11-05 | Hoffmann-La Roche Inc. | Methods for in-solution quenching of fluorescently labeled oligonucleotide probes |
| US6117635A (en) | 1996-07-16 | 2000-09-12 | Intergen Company | Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon |
| US5900481A (en) * | 1996-11-06 | 1999-05-04 | Sequenom, Inc. | Bead linkers for immobilizing nucleic acids to solid supports |
| US6235474B1 (en) | 1996-12-30 | 2001-05-22 | The Johns Hopkins University | Methods and kits for diagnosing and determination of the predisposition for diseases |
| EP0866071B1 (en) | 1997-03-20 | 2004-10-20 | F. Hoffmann-La Roche Ag | Modified primers |
| DE19818619A1 (de) * | 1998-04-21 | 1999-10-28 | Metagen Gesellschaft Fuer Genomforschung Mbh | Menschliche Nukleinsäuresequenzen aus Blase-Tumor |
| GB9812768D0 (en) | 1998-06-13 | 1998-08-12 | Zeneca Ltd | Methods |
| US6180349B1 (en) | 1999-05-18 | 2001-01-30 | The Regents Of The University Of California | Quantitative PCR method to enumerate DNA copy number |
| US7097976B2 (en) | 2002-06-17 | 2006-08-29 | Affymetrix, Inc. | Methods of analysis of allelic imbalance |
| WO2004003003A1 (en) | 2002-06-27 | 2004-01-08 | The Johns Hopkins University School Of Medicine | Methods for identifying cancer risk |
| EP2135080A4 (en) | 2007-03-08 | 2010-12-01 | Switchgear Genomics | FUNCTIONAL NETWORKS FOR THE CHARACTERIZATION OF TREATMENT OF REGULATORY ELEMENTS IN NON-TRANSLATED REGIONS OF GENES |
| ES2453108T3 (es) | 2007-08-06 | 2014-04-04 | Orion Genomics, Llc | Nuevos polimorfismos de un único nucleótido y combinaciones de polimorfismos nuevos y conocidos para determinar la expresión específica de alelo del gen IGF2 |
| CA2751758A1 (en) * | 2009-02-11 | 2010-08-19 | Orion Genomics Llc | Combinations of polymorphisms for determining allele-specific expression of igf2 |
-
2008
- 2008-08-06 ES ES08797299.8T patent/ES2453108T3/es active Active
- 2008-08-06 EP EP08797299.8A patent/EP2185726B1/en not_active Not-in-force
- 2008-08-06 CA CA2694832A patent/CA2694832A1/en not_active Abandoned
- 2008-08-06 ES ES13193708.8T patent/ES2543684T3/es active Active
- 2008-08-06 AU AU2008283902A patent/AU2008283902B2/en not_active Ceased
- 2008-08-06 EP EP15170550.6A patent/EP2952588A1/en not_active Withdrawn
- 2008-08-06 WO PCT/US2008/072356 patent/WO2009021054A2/en not_active Ceased
- 2008-08-06 US US12/672,066 patent/US8420315B2/en not_active Expired - Fee Related
- 2008-08-06 EP EP13193708.8A patent/EP2700723B1/en not_active Not-in-force
- 2008-08-06 JP JP2010520284A patent/JP5777340B2/ja not_active Expired - Fee Related
-
2013
- 2013-03-08 US US13/791,336 patent/US20130177911A1/en not_active Abandoned
- 2013-08-07 US US13/961,794 patent/US20140162255A1/en not_active Abandoned
- 2013-08-07 US US13/961,802 patent/US20130317125A1/en not_active Abandoned
- 2013-08-07 US US13/961,788 patent/US20130317124A1/en not_active Abandoned
-
2014
- 2014-02-18 US US14/182,503 patent/US20140162270A1/en not_active Abandoned
- 2014-02-18 US US14/182,495 patent/US20140163119A1/en not_active Abandoned
-
2015
- 2015-03-31 JP JP2015070799A patent/JP5902843B2/ja not_active Expired - Fee Related
-
2016
- 2016-03-10 JP JP2016046545A patent/JP2016116534A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2010535507A5 (enExample) | ||
| KR101494185B1 (ko) | 한국인의 유전성 난청 진단용 마커 조성물 | |
| WO2008147930A3 (en) | Methods and kits for linking polymorphic sequences to expanded repeat mutations | |
| Saarela et al. | PRKCA and multiple sclerosis: association in two independent populations | |
| Sims et al. | Sub‐populations within the major European and African derived haplogroups R1b3 and E3a are differentiated by previously phylogenetically undefined Y‐SNPs | |
| CN101545005A (zh) | 利用单核苷酸多态性分析辅助确定中国汉族患者华发林使用剂量的方法和生物芯片 | |
| JP5727694B2 (ja) | Ｃ型肝炎の治療効果を予測するためのマーカー及びｃ型肝炎の治療効果の予測を行う方法並びにｃ型肝炎の予防又は治療剤 | |
| JP2012517242A5 (enExample) | ||
| Lim et al. | Genetic polymorphism and haplotype analysis of 4 tightly linked X-STR duos in Koreans | |
| Bonk et al. | Molecular diagnosis of familial adenomatous polyposis (FAP): genotyping of adenomatous polyposis coli (APC) alleles by MALDI-TOF mass spectrometry | |
| WO2008143367A1 (en) | Haplotyping method by multiplex amplification | |
| Shi et al. | Application of kinetic polymerase chain reaction and molecular beacon assays to pooled analyses and high‐throughput genotyping for candidate genes | |
| JP2003508074A5 (enExample) | ||
| US7833710B2 (en) | Polynucleotide associated with breast cancer comprising single nucleotide polymorphism, microarray and diagnostic kit comprising the same and method for diagnosing breast cancer using the same | |
| KR20150092937A (ko) | 한국인의 고혈압 예측용 ｓｎｐ 마커 | |
| KR101617612B1 (ko) | 한국인의 고혈압 예측용 ｓｎｐ 마커 | |
| AU2004293807A1 (en) | NTRK1 genetic markers associated with progression of Alzheimer's Disease | |
| KR102751992B1 (ko) | 뇌동맥류 진단용 rs3826442 마커 조성물 및 이의 이용 | |
| KR102751991B1 (ko) | 뇌동맥류 진단용 rs12935558 마커 조성물 및 이의 이용 | |
| KR102751990B1 (ko) | 뇌동맥류 진단용 rs1522095 마커 조성물 및 이의 이용 | |
| KR102751993B1 (ko) | 뇌동맥류 진단용 rs2440154 마커 조성물 및 이의 이용 | |
| KR102751989B1 (ko) | 뇌동맥류 진단용 rs3120004 마커 조성물 및 이의 이용 | |
| KR102751988B1 (ko) | 뇌동맥류 진단용 rs7779989 마커 조성물 및 이의 이용 | |
| KR20110011306A (ko) | 텔로미어 유지 유전자를 이용한 폐암 감수성 진단용 마커 및 폐암 감수성 예측 및 판단 방법 | |
| KR101054517B1 (ko) | Ｉｇｆｂｐ―３ 유전자를 이용한 폐암 감수성 진단용 마커 및 이를 이용한 폐암 감수성 예측 및 판단 방법 |