JP2012517223A5 - - Google Patents

Info

Publication number

JP2012517223A5

JP2012517223A5 JP2011548901A JP2011548901A JP2012517223A5 JP 2012517223 A5 JP2012517223 A5 JP 2012517223A5 JP 2011548901 A JP2011548901 A JP 2011548901A JP 2011548901 A JP2011548901 A JP 2011548901A JP 2012517223 A5 JP2012517223 A5 JP 2012517223A5

Authority

JP

Japan

Prior art keywords

seq

acid sequence

amino acid

region

antibody

Prior art date

2010-02-10

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 125000003275 alpha amino acid group Chemical group 0.000 claims 76
• 239000012634 fragment Substances 0.000 claims 31
• 239000000427 antigen Substances 0.000 claims 26
• 102000036639 antigens Human genes 0.000 claims 26
• 108091007433 antigens Proteins 0.000 claims 26
• 101001106413 Homo sapiens Macrophage-stimulating protein receptor Proteins 0.000 claims 17
• 102100021435 Macrophage-stimulating protein receptor Human genes 0.000 claims 17
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 10
• 150000007523 nucleic acids Chemical group 0.000 claims 10
• 210000004027 cell Anatomy 0.000 claims 8
• 230000026731 phosphorylation Effects 0.000 claims 7
• 238000006366 phosphorylation reaction Methods 0.000 claims 7
• 108090000765 processed proteins & peptides Proteins 0.000 claims 7
• 201000010099 disease Diseases 0.000 claims 5
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
• 239000008194 pharmaceutical composition Substances 0.000 claims 5
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 4
• 230000000295 complement effect Effects 0.000 claims 4
• 230000001419 dependent effect Effects 0.000 claims 4
• 239000003446 ligand Substances 0.000 claims 4
• 238000004519 manufacturing process Methods 0.000 claims 3
• 238000000034 method Methods 0.000 claims 3
• 208000005718 Stomach Neoplasms Diseases 0.000 claims 2
• 150000001413 amino acids Chemical class 0.000 claims 2
• 206010017758 gastric cancer Diseases 0.000 claims 2
• 230000002401 inhibitory effect Effects 0.000 claims 2
• 241000894007 species Species 0.000 claims 2
• 201000011549 stomach cancer Diseases 0.000 claims 2
• 206010005003 Bladder cancer Diseases 0.000 claims 1
• 206010006187 Breast cancer Diseases 0.000 claims 1
• 208000026310 Breast neoplasm Diseases 0.000 claims 1
• 241000282693 Cercopithecidae Species 0.000 claims 1
• 206010009944 Colon cancer Diseases 0.000 claims 1
• 208000032612 Glial tumor Diseases 0.000 claims 1
• 206010018338 Glioma Diseases 0.000 claims 1
• 241000282412 Homo Species 0.000 claims 1
• 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
• 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
• 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
• 206010025323 Lymphomas Diseases 0.000 claims 1
• 206010028980 Neoplasm Diseases 0.000 claims 1
• 206010033128 Ovarian cancer Diseases 0.000 claims 1
• 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
• 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
• 206010060862 Prostate cancer Diseases 0.000 claims 1
• 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
• 208000000453 Skin Neoplasms Diseases 0.000 claims 1
• 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
• 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
• 239000000654 additive Substances 0.000 claims 1
• 230000000996 additive effect Effects 0.000 claims 1
• 230000001580 bacterial effect Effects 0.000 claims 1
• 201000011510 cancer Diseases 0.000 claims 1
• 208000035269 cancer or benign tumor Diseases 0.000 claims 1
• 230000012292 cell migration Effects 0.000 claims 1
• 230000004663 cell proliferation Effects 0.000 claims 1
• 208000029742 colonic neoplasm Diseases 0.000 claims 1
• 238000012258 culturing Methods 0.000 claims 1
• 238000004090 dissolution Methods 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 201000007270 liver cancer Diseases 0.000 claims 1
• 208000014018 liver neoplasm Diseases 0.000 claims 1
• 201000005202 lung cancer Diseases 0.000 claims 1
• 208000020816 lung neoplasm Diseases 0.000 claims 1
• 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
• 210000004962 mammalian cell Anatomy 0.000 claims 1
• 238000013508 migration Methods 0.000 claims 1
• 201000002528 pancreatic cancer Diseases 0.000 claims 1
• 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
• 201000000849 skin cancer Diseases 0.000 claims 1
• 238000002198 surface plasmon resonance spectroscopy Methods 0.000 claims 1
• 230000008685 targeting Effects 0.000 claims 1
• 201000002510 thyroid cancer Diseases 0.000 claims 1
• 238000004448 titration Methods 0.000 claims 1
• 210000004881 tumor cell Anatomy 0.000 claims 1
• 201000005112 urinary bladder cancer Diseases 0.000 claims 1